The Innovation最新文献_第5页

Trends and strategies of global cardiovascular diseases during the process of carbon neutrality. 碳中和过程中全球心血管疾病的趋势和策略。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-21 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100887

Hua Li, Junbo Ge

引用次数: 0

Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study. 在中国，体育活动与发病率和死亡率风险的全现象关联：一项前瞻性队列研究。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-20 eCollection Date: 2025-07-07 DOI: 10.1016/j.xinn.2025.100886

Yalei Ke, Yuxuan Zhao, Derrick A Bennett, Neil Wright, Pek Kei Im, Dianjianyi Sun, Pei Pei, Yiping Chen, Ling Yang, Daniel Avery, Feng Ning, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li, Huaidong Du, Canqing Yu

{"title":"Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study.","authors":"Yalei Ke, Yuxuan Zhao, Derrick A Bennett, Neil Wright, Pek Kei Im, Dianjianyi Sun, Pei Pei, Yiping Chen, Ling Yang, Daniel Avery, Feng Ning, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li, Huaidong Du, Canqing Yu","doi":"10.1016/j.xinn.2025.100886","DOIUrl":"10.1016/j.xinn.2025.100886","url":null,"abstract":"Research in high-income countries has established the health benefits of physical activity (PA), but evidence from low- and middle-income countries, including China, where PA patterns vary from those in high-income countries, remains limited. Moreover, previous research, mainly focused on specific diseases, failing to fully capture the health impacts of PA. We investigated the associations of PA with 425 distinct diseases and 53 causes of death using data from 511,088 participants aged 30-79 years in the China Kadoorie Biobank. Baseline PA was assessed using a questionnaire between 2004 and 2008, and usual PA levels were estimated using the resurvey data in 2013-2014. Cox regression was employed to estimate the associations between PA and outcomes, adjusting for potential confounders. During a median follow-up time of 12 years, 722,183 incident events and 39,320 deaths were recorded across 18 chapters of the International Classification of Diseases, 10th Revision (ICD-10). Total PA was significantly and inversely associated with incidence risks of 14 ICD-10 chapters, specifically 65 diseases and 19 causes of death, with the highest quintile group of PA showing a 14% lower disease incidence and 40% lower all-cause mortality compared with the lowest group. Of these diseases, 54 were not highlighted in World Health Organization PA guidelines. Dose-response analyses revealed L-shaped associations for most PA types, except moderate-to-vigorous intensity PA, which showed a U-shaped relationship. In this population, physical inactivity accounted for 12.8% of PA-related deaths. The findings underscore the broad health benefits of PA across a variety of body systems and the significant disease burden due to inactivity in China, highlighting the urgent need for PA promotion.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 7","pages":"100886"},"PeriodicalIF":33.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI for education: Trends and insights. 人工智能教育：趋势和见解。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-19 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100872

Yuanzhuo Wang, Xuhui Jiang

引用次数: 0

Is a data deluge dampening our idea generation capability? 数据洪流是否削弱了我们的创意生成能力？

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-18 eCollection Date: 2025-07-07 DOI: 10.1016/j.xinn.2025.100883

Gautam R Desiraju, Deekhit Bhattacharya

引用次数: 0

Modulating CO₂ electroreduction pathways through controlled ionomer arrangement on catalyst surfaces via solvent dispersion. 通过溶剂分散控制催化剂表面的离聚体排列来调节CO2电还原途径。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-18 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100882

Yaoyu Yin, Zhongnan Ling, Shiqiang Liu, Jiapeng Jiao, Meng Zhou, Pei Zhang, Xing Tong, Yueqian Fan, Jiahao Yang, Huanyan Liu, Xueqing Xing, Jianling Zhang, Yi Xu, Hongyan Liang, Xinchen Kang, Buxing Han

{"title":"Modulating CO2 electroreduction pathways through controlled ionomer arrangement on catalyst surfaces via solvent dispersion.","authors":"Yaoyu Yin, Zhongnan Ling, Shiqiang Liu, Jiapeng Jiao, Meng Zhou, Pei Zhang, Xing Tong, Yueqian Fan, Jiahao Yang, Huanyan Liu, Xueqing Xing, Jianling Zhang, Yi Xu, Hongyan Liang, Xinchen Kang, Buxing Han","doi":"10.1016/j.xinn.2025.100882","DOIUrl":"10.1016/j.xinn.2025.100882","url":null,"abstract":"Ionomers play a vital role in the preparation of electrodes for CO2 electroreduction, and controlling the ionomer configuration on the catalyst surface offers an effective strategy for adjusting the surface microenvironment of the electrode, thereby influencing the distribution of CO2 electroreduction products. In this study, we demonstrate that Nafion, a commonly used ionomer, exhibits distinct aggregation behaviors in solvents with different dielectric constant (ε) values. These differences in aggregation result in varied Nafion arrangements on the catalyst surface, which in turn affect the binding of ∗CO and ∗H intermediates, enabling control over product distribution. For example, over a Cu nanosheet catalyst at 800 mA cm-2, the Faradaic efficiency for multicarbon products increases from 67.5% to 90.5% simply by changing the dispersion solvent from low-ε dimethyl sulfoxide to moderate-ε isopropanol. This work introduces a novel approach for fine-tuning CO2 electroreduction product distribution through manipulation of the dispersion solvent without requiring modifications to the catalyst or ionomer.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100882"},"PeriodicalIF":33.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conductive dendrite engineering of single-crystalline two-dimensional dielectric memristors. 单晶二维介质忆阻器的导电枝晶工程。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-18 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100885

Yu Kang, Xingyu Zhai, Quan Yang, Baoshi Qiao, Zheng Bian, Haohan Chen, Huan Hu, Yang Xu, Ming Tian, Neng Wan, Wenchao Chen, Yang Chai, Yuda Zhao, Bin Yu

{"title":"Conductive dendrite engineering of single-crystalline two-dimensional dielectric memristors.","authors":"Yu Kang, Xingyu Zhai, Quan Yang, Baoshi Qiao, Zheng Bian, Haohan Chen, Huan Hu, Yang Xu, Ming Tian, Neng Wan, Wenchao Chen, Yang Chai, Yuda Zhao, Bin Yu","doi":"10.1016/j.xinn.2025.100885","DOIUrl":"10.1016/j.xinn.2025.100885","url":null,"abstract":"Ultralow-power non-volatile memristors are key elements in electronics. Generally, power reduction of memristors compromises data retention, a challenge known as the \"power-retention dilemma,\" due to the stochastic formation of conductive dendrites in resistive-switching materials. Here, we report the results of conductive dendrite engineering in single-crystalline two-dimensional (2D) dielectrics in which directional control of filamentary distribution is possible. We find that the single-vacancy density (nSV) of single-crystalline hexagonal boron nitride (h-BN) plays an essential role in regulating conductive dendrite growth, supported by scanning joule expansion microscopy (SJEM). With optimized nSV, random dendrite growth is largely limited, and electrons hop between the neighboring Ag nanoclusters in vertical channels. The corresponding model was established to probe the relationship between nSV and memristor operating voltage. The conductive channel confinement in the vertical orientation contributes to long-retention non-volatile memristors with ultralow switch voltages (set: 26 mV; reset: -135 mV), excellent power efficiency (4 fW standby and a switching energy of 72 pJ) while keeping a high on/off resistance ratio of 108. Even at a record-low compliance current of 10 nA, memristors retains very robust non-volatile, multiple resistive states with an operating voltage less than 120 mV (the per-transition power low as 900 pW).","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100885"},"PeriodicalIF":33.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyrene-based aggregation-induced emission: A bridge model to regulate aggregation. 基于比利牛斯的聚集诱导排放：调节聚集的桥梁模型。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-17 eCollection Date: 2025-07-07 DOI: 10.1016/j.xinn.2025.100884

Yuting Lin, Jianyu Zhang, Wen-Jin Wang, Zhenguo Tang, Xianying Fang, Xu Xu, Fritz E Kühn, Zheng Zhao, Qiang Yong, Ben Zhong Tang, Xu-Min Cai

{"title":"Pyrene-based aggregation-induced emission: A bridge model to regulate aggregation.","authors":"Yuting Lin, Jianyu Zhang, Wen-Jin Wang, Zhenguo Tang, Xianying Fang, Xu Xu, Fritz E Kühn, Zheng Zhao, Qiang Yong, Ben Zhong Tang, Xu-Min Cai","doi":"10.1016/j.xinn.2025.100884","DOIUrl":"10.1016/j.xinn.2025.100884","url":null,"abstract":"The aggregation process plays a significant role in regulating the aggregate structures from molecules toward macroscopic photophysical properties. Pyrene (Py), as the simplest dimer candidate, serves as a suitable model for studying the aggregation. Herein, a series of Py-based aggregation-induced emission (AIE) materials have been investigated by clarifying the comprehensive roles of oxygen, substituents, molecular motion, and packing during aggregation, initially realizing the aim of controlling aggregate structures. With a largely planar and conjugated conformation, Py shows anomalous AIE characteristics due to the oxygen quenching at the molecular level but turn-on fluorescence in the aggregate state because of the oxygen isolation. Although introducing substituents induces molecular motion and similarly weakened luminescence in the molecular state, the impact of substituents on the aggregate-state photophysical properties enormously differs, exhibiting from weak blue, strong cyan, and strong green to weak yellow emissions, due to variable aggregate structures. Interestingly, the natural alicycle-substituted Py-dehydroabietylamine (Py-DAA) exhibits both mechanochromism and acidichromism, which can be synergistically applied in dynamic encryption-decryption. This work not only elucidates the unique AIE property of Py for the first time but also clarifies the bridging role of aggregation between single-molecular and aggregate states, achieving preliminary control over the aggregate structures.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 7","pages":"100884"},"PeriodicalIF":33.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the interplay: Helicobacter pylori infection, tumor immune microenvironment, and immunotherapy outcomes in gastrointestinal cancers. 解码相互作用：幽门螺杆菌感染、肿瘤免疫微环境和胃肠道癌症的免疫治疗结果。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-14 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100880

Raquel Mejias-Luque, Markus Gerhard

引用次数: 0

Mesoscopy: Innovations in high-resolution and large-field imaging. 介观镜：高分辨率和大视场成像的创新。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-13 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100879

Xin Xu, Jixiang Wang, Qin Luo, Yahui Song, Yi He, Jing Lu, Guohua Shi

引用次数: 0

Deep potential-driven structure exploration of ice polymorphs. 深部电位驱动的冰多晶结构勘探。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-03-13 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100881

Yuefeng Lei, Xiangyang Liu, Yaochen Yu, Haiyang Niu

{"title":"Deep potential-driven structure exploration of ice polymorphs.","authors":"Yuefeng Lei, Xiangyang Liu, Yaochen Yu, Haiyang Niu","doi":"10.1016/j.xinn.2025.100881","DOIUrl":"10.1016/j.xinn.2025.100881","url":null,"abstract":"Ice, a ubiquitous substance in nature, exhibits diverse forms under varying temperature and pressure conditions. However, our understanding of ice polymorphs remains incomplete. The directional nature of hydrogen bonding and the complexity of the networks they form pose significant challenges to computational studies of ice structures. In this work, we present an extensive exploration of ice polymorphs under pressure conditions ranging from 1 bar to 10 GPa. We employ an advanced crystal-structure-prediction scheme that integrates an evolutionary algorithm, an active-learning deep neural network potential, and molecular dynamics simulations with ab initio accuracy. Among the 131,481 predicted structures, we successfully identify all experimentally known ice phases within the target pressure range, including the particularly challenging ice IV and V. These phases feature highly intricate H-bond networks, which have hindered previous efforts to fully explore ice structures. Additionally, we identify 34 new ice polymorphs that are potential candidates for experimental discovery. Notably, we predict the existence of a new stable ice phase, ice L, within the temperature range of 253-291 K and pressure range of 0.38-0.57 GPa, exhibiting a unique topology unseen in any known crystals. Our findings highlight the potential for experimental discovery of new ice phases. Furthermore, our approach can be applied to other complex systems, particularly those with network structures.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 5","pages":"100881"},"PeriodicalIF":33.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0