The Innovation最新文献_第10页

Shedding light on gene therapy of Parkinson’s disease in non-human primates 揭示非人灵长类动物帕金森病基因疗法的奥秘

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-24 DOI: 10.1016/j.xinn.2024.100581

Xunyi Yan, Xin Jin

引用次数: 0

Time for a change: Rethinking the global renewable energy transition from the Sustainable Development Goals and the Paris Climate Agreement 改变的时刻到了：从可持续发展目标和《巴黎气候协定》反思全球可再生能源转型

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-24 DOI: 10.1016/j.xinn.2024.100582

Guanglei Yang, Donglan Zha, Dongqin Cao, Guoxing Zhang

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Sungai Lembing's green tourism: Pioneering the future of resource-based urban renewal 双溪兰滨的绿色旅游：开拓资源型城市更新的未来

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-12 DOI: 10.1016/j.xinn.2024.100578

Haoxuan Yu, Ginura Gunaratna, Izni Zahidi, Chow Ming Fai

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Promoting interactions between cognitive science and large language models 促进认知科学与大型语言模型之间的互动

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-12 DOI: 10.1016/j.xinn.2024.100579

Youzhi Qu, Penghui Du, Wenxin Che, Chen Wei, Chi Zhang, Wanli Ouyang, Yatao Bian, Feiyang Xu, Bin Hu, Kai Du, Haiyan Wu, Jia Liu, Quanying Liu

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Taming heat with tiny pressure 用微小的压力控制热量

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-11 DOI: 10.1016/j.xinn.2024.100577

Kun Zhang, Zhe Zhang, Hailong Pan, Haoyu Wang, Xueting Zhao, Ji Qi, Zhao Zhang, Ruiqi Song, Chenyang Yu, Biaohong Huang, Xujing Li, Huaican Chen, Wen Yin, Changlong Tan, Weijin Hu, Michael Wübbenhorst, Jiangshui Luo, Dehong Yu, Zhidong Zhang, Bing Li

{"title":"Taming heat with tiny pressure","authors":"Kun Zhang, Zhe Zhang, Hailong Pan, Haoyu Wang, Xueting Zhao, Ji Qi, Zhao Zhang, Ruiqi Song, Chenyang Yu, Biaohong Huang, Xujing Li, Huaican Chen, Wen Yin, Changlong Tan, Weijin Hu, Michael Wübbenhorst, Jiangshui Luo, Dehong Yu, Zhidong Zhang, Bing Li","doi":"10.1016/j.xinn.2024.100577","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100577","url":null,"abstract":"Heat is almost everywhere. Unlike for electricity, which can be easily manipulated, the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of thermodynamics. Optical illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions; however, these strategies are less cost-effective and unscalable. Herein, we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol (AMP) to realise an affordable, easily manageable approach for thermal energyrecycling. The supercooled state of AMP is so sensitive to pressure that even several mega-pascals can induce crystallization to the ordered crystal, resulting in an substantial temperature increase of 48 K within 20 s. Furthermore, we demonstrate a proof-of-concept device capable of programming heat with an extremely high work-to-heat conversion efficiency of ∼383. Such delicate, efficient tuning of heat might remarkably facilitate rational utilisation of waste heat.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"10 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139458845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon preservation in sedimentary deposits: Beyond mineral protection 沉积矿床中的碳保存：超越矿物保护

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-09 DOI: 10.1016/j.xinn.2024.100576

Yunpeng Zhao, Juan Jia, Chengzhu Liu, Xiaojuan Feng

引用次数: 0

Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities 被忽视的全球范围内可持续发展目标进展不均衡的问题：挑战与机遇

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-08 DOI: 10.1016/j.xinn.2024.100573

Yali Liu, Jianqing Du, Yanfen Wang, Xiaoyong Cui, Jichang Dong, Pan Gu, Yanbin Hao, Kai Xue, Hongbo Duan, Anquan Xia, Yi Hu, Zhi Dong, Bingfang Wu, Jürgen P. Kropp, Bojie Fu

{"title":"Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities","authors":"Yali Liu, Jianqing Du, Yanfen Wang, Xiaoyong Cui, Jichang Dong, Pan Gu, Yanbin Hao, Kai Xue, Hongbo Duan, Anquan Xia, Yi Hu, Zhi Dong, Bingfang Wu, Jürgen P. Kropp, Bojie Fu","doi":"10.1016/j.xinn.2024.100573","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100573","url":null,"abstract":"Differences in progress across sustainable development goals (SDGs) are widespread globally; meanwhile, the rising call for prioritizing specific SDGs may exacerbate such gaps. Nevertheless, how these progress differences would influence global sustainable development has been long neglected. Here, we present the first quantitative assessment of SDGs’ progress differences globally by adopting the SDGs progress evenness index. Our results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because: (1) it is strongly associated with many public health risks (e.g., air pollution), social inequalities (e.g., gender inequality, modern slavery, and wealth gap), and a reduction in life expectancy; (2) it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems, increasing the challenges related to biodiversity conservation; (3) most countries with a low average SDGs performance show lower progress evenness, which further hinders their fulfillment of SDGs; (4) many countries with a high average SDGs performance also showcase stagnation or even retrogression in progress evenness, which is partly ascribed to the antagonism between climate actions and other goals. These findings highlight that while setting SDGs priorities might be more realistic under the constraints of multiple global stressors, caution must be exercised to avoid new problems from intensifying uneven progress across goals. Moreover, our study reveals that the urgent needs regarding SDGs of different regions seem complementary, emphasizing that regional collaborations (e.g., demand-oriented carbon trading between SDGs poorly-performed and well-performed countries) may promote sustainable development achievements at the global scale.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"214 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic crystal structure prediction via coupled generative adversarial networks and graph convolutional networks 通过耦合生成式对抗网络和图卷积网络预测有机晶体结构

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-08 DOI: 10.1016/j.xinn.2023.100562

Zhuyifan Ye, Nannan Wang, Jiantao Zhou, Defang Ouyang

{"title":"Organic crystal structure prediction via coupled generative adversarial networks and graph convolutional networks","authors":"Zhuyifan Ye, Nannan Wang, Jiantao Zhou, Defang Ouyang","doi":"10.1016/j.xinn.2023.100562","DOIUrl":"https://doi.org/10.1016/j.xinn.2023.100562","url":null,"abstract":"Organic crystal structures exert a profound impact on the physicochemical properties and biological effects of organic compounds. Quantum mechanics (QM) based crystal structure predictions (CSP) have somewhat alleviated the dilemma that experimental crystal structure investigations struggle to conduct complete polymorphism studies, but the high computing cost poses a challenge to its widespread application. The current study aims to construct DeepCSP, a feasible pure machine learning framework for minute-scale rapid organic crystal structure prediction. Initially, based on 177,746 data entries from the Cambridge Crystal Structure Database (CSD), a generative adversarial network was built to conditionally generate trial crystal structures under selected feature constraints for the given molecule. Simultaneously, a graph convolutional attention network was employed to predict the density of stable crystal structures for the input molecule. Subsequently, the distances between the predicted density and the definition-based calculated density would be considered as the crystal structure screening and ranking basis, and finally, the density-based crystal structure ranking would be output. Such two distinct algorithms, performing the generation and ranking functionalities respectively, collectively constitute the DeepCSP, which has demonstrated compelling performance in marketed drug validations, achieving an accuracy rate exceeding 80% and hit rate surpassing 85%. Inspiringly, the computing speed of the pure machine learning methodology demonstrates the potential of artificial intelligence in advancing CSP research.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"569 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning predicts atomistic structures of multielement solid surfaces for heterogeneous catalysts in variable environments 机器学习预测可变环境中异质催化剂多元素固体表面的原子结构

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-08 DOI: 10.1016/j.xinn.2024.100571

Huan Ma, Yueyue Jiao, Wenping Guo, Xingchen Liu, Yongwang Li, Xiaodong Wen

{"title":"Machine learning predicts atomistic structures of multielement solid surfaces for heterogeneous catalysts in variable environments","authors":"Huan Ma, Yueyue Jiao, Wenping Guo, Xingchen Liu, Yongwang Li, Xiaodong Wen","doi":"10.1016/j.xinn.2024.100571","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100571","url":null,"abstract":"Solid surfaces usually reach thermodynamic equilibrium through particle exchange with their environment under reactive conditions. A prerequisite for understanding their functionalities is detailed knowledge of the surface composition and atomistic geometry under working conditions. Owing to the large number of possible Miller indices and terminations involved in multielement solids, extensive sampling of the compositional and conformational space needed for reliable surface energy estimation is beyond the scope of ab initio calculations. Here, we demonstrate, using the case of iron carbides in environments with varied carbon chemical potentials, that the stable surface composition and geometry of multielement solids under reactive conditions, which involve large compositional and conformational spaces, can be predicted at ab initio accuracy using an approach that combines the bond valence model, Gaussian process regression, and ab initio thermodynamics. Determining the atomistic structure of surfaces under working conditions paves the way toward identifying the true active sites of multielement catalysts in heterogeneous catalysis.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"55 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases 在缺血性疾病中，GTF2H4通过NCOA3磷酸化激活NF-κB，从而调节部分EndMT

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-01-08 DOI: 10.1016/j.xinn.2024.100565

Zheyan Fang, Gang Zhao, Shuang Zhao, Xueting Yu, Runyang Feng, You-en Zhang, Haomin Li, Lei Huang, Zhenyang Guo, Zhentao Zhang, Mukaddas Abdurahman, Hangnan Hong, Peng Li, Bing Wu, Jinhang Zhu, Xin Zhong, Dong Huang, Hao Lu, Xin Zhao, Zhaoyang Chen, Hua Li

{"title":"GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases","authors":"Zheyan Fang, Gang Zhao, Shuang Zhao, Xueting Yu, Runyang Feng, You-en Zhang, Haomin Li, Lei Huang, Zhenyang Guo, Zhentao Zhang, Mukaddas Abdurahman, Hangnan Hong, Peng Li, Bing Wu, Jinhang Zhu, Xin Zhong, Dong Huang, Hao Lu, Xin Zhao, Zhaoyang Chen, Hua Li","doi":"10.1016/j.xinn.2024.100565","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100565","url":null,"abstract":"Partial endothelial-to-mesenchymal transition (EndMT) is an intermediate phenotype observed in endothelial cells (ECs) undergoing a transition toward a mesenchymal state to support neovascularization during (patho)physiological angiogenesis. Here, we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4 (GTF2H4) as a positive regulator of this process. Additionally, we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3 (ERCC3) to coregulate partial EndMT. Furthermore, by using phosphorylation proteomics and site-directed mutagenesis, we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3 (NCOA3) at serine 1330, which promoted the interaction between NCOA3 and p65, resulting in the transcriptional activation of NF-κB and the NF-κB/Snail signaling axis during partial EndMT. In vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic injury. Collectively, our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"18 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0