The Innovation最新文献_第10页

Mutually reinforcing and transpiration-dependent propagation of H₂O₂ and variation potential in plants revealed by fiber organic electrochemical transistors. 纤维有机电化学晶体管揭示H2O2在植物体内相互增强和依赖蒸腾的传播及其变异潜力。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100800

Hanqi Wen, Lingxuan Kong, Xinlu Zhu, Yansong Miao, Xing Sheng, Xiaodong Chen, Yuxin Liu, Peng Chen

{"title":"Mutually reinforcing and transpiration-dependent propagation of H2O2 and variation potential in plants revealed by fiber organic electrochemical transistors.","authors":"Hanqi Wen, Lingxuan Kong, Xinlu Zhu, Yansong Miao, Xing Sheng, Xiaodong Chen, Yuxin Liu, Peng Chen","doi":"10.1016/j.xinn.2025.100800","DOIUrl":"10.1016/j.xinn.2025.100800","url":null,"abstract":"Plants use hydrogen peroxide (H2O2) and variation potential (VP) waves as well as chemical transport by transpiration-driven xylem flow to facilitate cell signaling, cell-to-cell communication, and adaptation to environmental stresses. The underlying mechanisms and complex interplay among H2O2, VP, and transpiration are not clearly understood because of the lack of bioengineering tools for continuous in planta monitoring of the dynamic biological processes. Here, we tackle the challenge by developing microfiber-shaped organic electrochemical transistors (fOECTs) that can be threaded into the plants. The sensorized microfiber revealed that both H2O2 and VP waves propagate faster toward the leaves than toward the roots because of the directional long-distance transport of H2O2 in the xylem. In addition, the revealed interplays among VP, H2O2, and xylem flow strongly suggest a transpiration- and intensity-dependent H2O2-VP mutual-reinforcing propagation mechanism. The microfiber electronics offer a versatile platform for the in situ study of dynamic physiological processes in plants with high temporospatial resolution.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 5","pages":"100800"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials. 用于研究空气敏感二维量子材料的统一透射电子显微镜与手套箱集成系统。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100751

Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin

{"title":"Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials.","authors":"Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin","doi":"10.1016/j.xinn.2024.100751","DOIUrl":"10.1016/j.xinn.2024.100751","url":null,"abstract":"Transmission electron microscopy (TEM) is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics, phase transitions, and nanoscale structural details. While numerous intriguing physical properties have been revealed in recently discovered two-dimensional (2D) quantum materials, many exhibit significant sensitivity to water and oxygen under ambient conditions. This inherent instability complicates sample preparation for TEM analysis and hinders accurate property measurements. This review highlights recent technical advancements to preserve the intrinsic structures of water- and oxygen-sensitive 2D materials for atomic-scale characterizations. A critical development discussed in this review is implementing an inert gas-protected glovebox integrated system (GIS) designed specifically for TEM experiments. In addition, this review emphasizes air-sensitive materials such as 2D transition metal dichalcogenides, transition metal dihalides and trihalides, and low-dimensional magnetic materials, demonstrating breakthroughs in overcoming their environmental sensitivity. Furthermore, the progress in TEM characterization enabled by the GIS is analyzed to provide a comprehensive overview of state-of-the-art methodologies in this rapidly advancing field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100751"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation. 基于结构的自监督学习实现了突变时蛋白质稳定性的超快速预测。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100750

Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu

{"title":"Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation.","authors":"Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu","doi":"10.1016/j.xinn.2024.100750","DOIUrl":"10.1016/j.xinn.2024.100750","url":null,"abstract":"Predicting free energy changes (ΔΔG) is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development. While traditional methods offer valuable insights, they are often constrained by computational speed and reliance on biased training datasets. These constraints become particularly evident when aiming for accurate ΔΔG predictions across a diverse array of protein sequences. Herein, we introduce Pythia, a self-supervised graph neural network specifically designed for zero-shot ΔΔG predictions. Our comparative benchmarks demonstrate that Pythia outperforms other self-supervised pretraining models and force field-based approaches while also exhibiting competitive performance with fully supervised models. Notably, Pythia shows strong correlations and achieves a remarkable increase in computational speed of up to 105-fold. We further validated Pythia's performance in predicting the thermostabilizing mutations of limonene epoxide hydrolase, leading to higher experimental success rates. This exceptional efficiency has enabled us to explore 26 million high-quality protein structures, marking a significant advancement in our ability to navigate the protein sequence space and enhance our understanding of the relationships between protein genotype and phenotype. In addition, we established a web server at https://pythia.wulab.xyz to allow users to easily perform such predictions.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100750"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rainstorm-induced organic matter pulses: A key driver of carbon emissions from inland waters. 暴雨引起的有机物质脉冲：内陆水域碳排放的关键驱动因素。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-04 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100746

Lei Zhou, Yongqiang Zhou, Yunlin Zhang, Erik Jeppesen, Gesa A Weyhenmeyer

引用次数: 0

Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures. 石墨烯-半导体异质结构中超快电荷和能量流动的跟踪与控制。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-04 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100764

Shuai Fu, Heng Zhang, Klaas-Jan Tielrooij, Mischa Bonn, Hai I Wang

{"title":"Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures.","authors":"Shuai Fu, Heng Zhang, Klaas-Jan Tielrooij, Mischa Bonn, Hai I Wang","doi":"10.1016/j.xinn.2024.100764","DOIUrl":"10.1016/j.xinn.2024.100764","url":null,"abstract":"Low-dimensional materials have left a mark on modern materials science, creating new opportunities for next-generation optoelectronic applications. Integrating disparate nanoscale building blocks into heterostructures offers the possibility of combining the advantageous features of individual components and exploring the properties arising from their interactions and atomic-scale proximity. The sensitization of graphene using semiconductors provides a highly promising platform for advancing optoelectronic applications through various hybrid systems. A critical aspect of achieving superior performance lies in understanding and controlling the fate of photogenerated charge carriers, including generation, transfer, separation, and recombination. Here, we review recent advances in understanding charge carrier dynamics in graphene-semiconductor heterostructures by ultrafast laser spectroscopies. First, we present a comprehensive overview of graphene-based heterostructures and their state-of-the-art optoelectronic applications. This is succeeded by an introduction to the theoretical frameworks that elucidate the fundamental principles and determinants influencing charge transfer and energy transfer-two critical interfacial processes that are vital for both fundamental research and device performance. We then outline recent efforts aimed at investigating ultrafast charge/energy flow in graphene-semiconductor heterostructures, focusing on illustrating the trajectories, directions, and mechanisms of transfer and recombination processes. Subsequently, we discuss effective control knobs that allow fine-tuning of these processes. Finally, we address the challenges and prospects for further investigation in this field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100764"},"PeriodicalIF":33.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call to action to address escalating global threats to academic research. 呼吁采取行动，应对不断升级的全球学术研究威胁。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-04 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2024.100758

Gaelle Piret, Fun Man Fung, Josie Fullerton, Giuseppe Fico, Dmitriy Ponkratov, Wenxin Chen, Daniela Latorre, Kirsty Y Wan, Nima Aghaeepour, Jules Welgryn, Adeel Razi, Patricia Silveyra, Ahmet Altun, Renata Z Jurkowska, Alice C Hughes, Joy Wolfram

引用次数: 0

Multi-level genomic convergence of secondary aquatic adaptation in marine mammals. 海洋哺乳动物次生水生适应的多层次基因组趋同。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-03 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2025.100798

Shixia Xu, Lei Shan, Ran Tian, Zhenpeng Yu, Di Sun, Zhenhua Zhang, Inge Seim, Ming Zhou, Linxia Sun, Na Liang, Qian Zhang, Simin Chai, Daiqing Yin, Luoying Deme, Tianzhen Wu, Yongjie Chen, Zhikang Xu, Yu Zheng, Wenhua Ren, Guang Yang

{"title":"Multi-level genomic convergence of secondary aquatic adaptation in marine mammals.","authors":"Shixia Xu, Lei Shan, Ran Tian, Zhenpeng Yu, Di Sun, Zhenhua Zhang, Inge Seim, Ming Zhou, Linxia Sun, Na Liang, Qian Zhang, Simin Chai, Daiqing Yin, Luoying Deme, Tianzhen Wu, Yongjie Chen, Zhikang Xu, Yu Zheng, Wenhua Ren, Guang Yang","doi":"10.1016/j.xinn.2025.100798","DOIUrl":"10.1016/j.xinn.2025.100798","url":null,"abstract":"Marine mammals provide a valuable model for studying the molecular basis of convergent evolution during secondary aquatic adaptation. Using multi-omics data and functional experiments, including CRISPR-Cas9 mouse models and luciferase reporter assays, this study explored the molecular mechanisms driving this transition across coding regions, regulatory elements, and genomic architecture. Convergent amino acid substitutions in APPL1 P378L and NEIL1 E71G were found to promote lipid accumulation and suppress cancer cell proliferation, likely contributing to the evolution of extensive blubber layers and cancer resistance. Convergently evolved conserved non-exonic elements (CNEs) and lineage-specific regulatory variations were shown to influence the activity of nearby genes (e.g., NKX3-2, SOX9, HAND2), shaping cetacean limb phenotypes. Additionally, convergent shifts in topologically associating domains (TADs) across cetaceans and pinnipeds were implicated in the regulation of ASXL3 and FAM43B expression, playing a role in the formation of thickened blubber layers and mitigating cancer susceptibility. Structural variations within conserved TADs were associated with the expression of neuronal genes, including NUP153 and ID4, potentially driving cognitive and social adaptations. These findings provide novel insights into the molecular foundations of the convergent evolution of secondary aquatic adaptations in mammals.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100798"},"PeriodicalIF":33.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy. 具有中性粒细胞胞外囊泡伪装的聚合普罗布考纳米制剂用于脑缺血再灌注损伤治疗。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-27 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2024.100761

Mengjie Jia, Wenjun Miao, Yiliang Li, Yajie Guo, Jieying Zeng, Yan Gao, Xinting Li, Yufan Wang, Zhenghuan Zhao, Zichen Xu, Nancy Wang, Fang Yang, Jing Zhao, Yi Wang, Guixue Wang

{"title":"A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy.","authors":"Mengjie Jia, Wenjun Miao, Yiliang Li, Yajie Guo, Jieying Zeng, Yan Gao, Xinting Li, Yufan Wang, Zhenghuan Zhao, Zichen Xu, Nancy Wang, Fang Yang, Jing Zhao, Yi Wang, Guixue Wang","doi":"10.1016/j.xinn.2024.100761","DOIUrl":"10.1016/j.xinn.2024.100761","url":null,"abstract":"This study leverages the unique advantages of polyprodrug systems and biomimetic technology to develop a novel biomimetic nanoformulation, in which neutrophil extracellular vesicles (NEVs) are coated onto reactive oxygen species (ROS)-sensitive probucol-based polyprodrug nanoparticles (NPPBNPs). This NEV-camouflaged biomimetic nanoformulation holds significant potential for the effective treatment of cerebral ischemia-reperfusion injury (CIRI), offering multifaceted therapeutic effects, such as ROS elimination, inhibition of oxidative stress-induced neuronal apoptosis, attenuation of glial hyperactivation, and suppression of pro-inflammatory mediator secretion. In a murine CIRI model, NPPBNPs markedly enhanced neuronal viability, ameliorated the ischemic penumbra, restored behavioral functions, and exhibited an acceptable safety profile. The therapeutic mechanism of NPPBNPs involves NEV-mediated camouflage, which enables selective targeting of the pathological endothelium, thereby reducing peripheral neutrophil recruitment and facilitating blood-brain barrier (BBB) transport. Upon internalization by neurons, astrocytes, and microglia within ischemic regions, NPPBNPs respond to elevated intracellular ROS levels by releasing probucol in a controlled manner, which synergistically mitigates oxidative stress and inflammatory responses in CIRI-affected areas. Collectively, this multifunctional biomimetic nanoformulation represents a promising and practical strategy for the safe and effective treatment of CIRI.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 4","pages":"100761"},"PeriodicalIF":33.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward the robustness of autonomous vehicles in the AI era. 走向人工智能时代自动驾驶汽车的鲁棒性。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-26 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100780

Siheng Chen, Yiyi Liao, Fei Wang, Gang Wang, Liang Wang, Yafei Wang, Xichan Zhu

引用次数: 0

Advancing human dignity: The latest updates to the Declaration of Helsinki. 促进人类尊严：《赫尔辛基宣言》的最新更新。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-26 eCollection Date: 2025-02-03 DOI: 10.1016/j.xinn.2024.100779

The Innovation Editorial Team

引用次数: 0