The Innovation最新文献_第9页

Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming. 新型癌症干细胞靶向类维甲酸ZSH-512通过kdm3a介导的表观遗传重编程阻碍结直肠癌的进展。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-30 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100831

Suyao Li, Wenrui Zhao, Quanlin An, Lei Wang, Mengxuan Zhu, Junjie Ni, Xuan Huang, Yudong Jiang, Min Li, Jiayun Hou, Yiyi Yu, Shan Yu, Lai Wei, Heng Jiao, Tianshu Liu, Xin Cao

{"title":"Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming.","authors":"Suyao Li, Wenrui Zhao, Quanlin An, Lei Wang, Mengxuan Zhu, Junjie Ni, Xuan Huang, Yudong Jiang, Min Li, Jiayun Hou, Yiyi Yu, Shan Yu, Lai Wei, Heng Jiao, Tianshu Liu, Xin Cao","doi":"10.1016/j.xinn.2025.100831","DOIUrl":"10.1016/j.xinn.2025.100831","url":null,"abstract":"Advanced colorectal cancer (CRC) exhibits weak responses to multiple therapies, primarily due to the presence of cancer stem cells (CSCs), which drive high recurrence rates, metastasis, and drug resistance. We have previously systematically conducted CSC-targeted compound discovery and evaluation studies to inhibit CSC-mediated tumorigenesis and metastasis. Here, we identified ZSH-512, a novel synthetic retinoid that selectively targets retinoic acid receptor (RAR)γ, demonstrating its ability to effectively inhibit CRC-CSCs and patient-derived organoids (PDOs) in vitro and significantly reduce CSC-mediated tumor formation and liver metastasis in mouse models without noticeable toxicity. Mechanistically, integrated analysis of Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) and RNA sequencing (RNA-seq) revealed that ZSH-512 exerted its effect by modulating the RARγ-KDM3A axis to mediate epigenetic reprogramming and broadly suppress stemness-related signaling pathways, including Wnt, Hippo, and Hedgehog. ZSH-512 efficiently inhibited tumorigenesis in CRC-patient-derived tumor xenografts (PDXs) with high KDM3A expression, suggesting KDM3A as a potential predictive biomarker. Collectively, ZSH-512 is a promising therapeutic candidate for targeting CRC-CSCs with high efficacy.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 4","pages":"100831"},"PeriodicalIF":33.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence facilitates information fusion for perception in complex environments. 人工智能促进了复杂环境中感知的信息融合。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-29 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100814

Xunpeng Yi, Yong Ma, Yansheng Li, Han Xu, Jiayi Ma

引用次数: 0

Manipulation of a strigolactone transporter in tomato confers resistance to the parasitic weed broomrape. 操纵番茄中独角孤内酯转运体赋予对寄生杂草扫帚花的抗性。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-29 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2025.100815

Xinwei Ban, Li Qin, Jijun Yan, Jianxin Wu, Qianjin Li, Xiao Su, Yanrong Hao, Qingliang Hu, Liquan Kou, Zongyun Yan, Peiyong Xin, Yuqin Zhang, Lemeng Dong, Harro Bouwmeester, Hong Yu, Qinghui Yu, Sanwen Huang, Tao Lin, Qi Xie, Yuhang Chen, Jinfang Chu, Xia Cui, Jiayang Li, Bing Wang

{"title":"Manipulation of a strigolactone transporter in tomato confers resistance to the parasitic weed broomrape.","authors":"Xinwei Ban, Li Qin, Jijun Yan, Jianxin Wu, Qianjin Li, Xiao Su, Yanrong Hao, Qingliang Hu, Liquan Kou, Zongyun Yan, Peiyong Xin, Yuqin Zhang, Lemeng Dong, Harro Bouwmeester, Hong Yu, Qinghui Yu, Sanwen Huang, Tao Lin, Qi Xie, Yuhang Chen, Jinfang Chu, Xia Cui, Jiayang Li, Bing Wang","doi":"10.1016/j.xinn.2025.100815","DOIUrl":"10.1016/j.xinn.2025.100815","url":null,"abstract":"Parasitic weeds of the Orobanchaceae family cause substantial economic losses and pose significant threats to global agriculture. However, management of such parasitism is challenging, and very few resistance genes have been cloned and characterized in depth. Here, we performed a genome-wide association study using 152 tomato accessions and identified SlABCG45 as a key gene that mediates host resistance to Phelipanche aegyptiaca by affecting the level of strigolactones (SLs) in root exudates. SLs are synthesized and released by host plants and act as germination stimulants for parasitic weeds. We found that SlABCG45 and its close homolog SlABCG44 were membrane-localized SL transporters with essential roles in exudation of SLs to the rhizosphere, resistance to Phelipanche and Orobanche, and upward transport of SLs from roots to shoots. As a predominant environmental stimulant exacerbates parasitism, phosphorus deficiency dramatically induced SlABCG45 expression and weakly induced SlABCG44 expression via the transcription factors SlNSP1 and SlNSP2. Knockout of SlABCG45 in tomato had little effect on yield traits in a broomrape-free field, but conferred increased resistance to different Phelipanche and Orobanche species, resulting in an ∼30% yield increase in a Phelipanche-infested field. Our findings reveal that targeting a single gene by genome editing can confer broad-spectrum parasite resistance in tomato, providing an effective strategy for the sustainable control of parasitic plants in agriculture.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100815"},"PeriodicalIF":33.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-media liquid metal 3D printing. 泛介质液态金属3D打印。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-27 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100813

Xiaohui Shan, Weichen Feng, Minghui Guo, Xuelin Wang, Jing Liu

引用次数: 0

Self-calibrating multiplexed microneedle electrode array for continuous mapping of subcutaneous multi-analytes in diabetes. 用于糖尿病皮下多种分析物连续测绘的自校准多路微针电极阵列。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-25 eCollection Date: 2025-02-03 DOI: 10.1016/j.xinn.2024.100781

Xiangling Li, Shantao Zheng, Mengyi He, Xinshuo Huang, Cheng Yang, Jingshan Mo, Jingbo Yang, Chengduan Yang, Huijiuan Chen, Xi Xie

{"title":"Self-calibrating multiplexed microneedle electrode array for continuous mapping of subcutaneous multi-analytes in diabetes.","authors":"Xiangling Li, Shantao Zheng, Mengyi He, Xinshuo Huang, Cheng Yang, Jingshan Mo, Jingbo Yang, Chengduan Yang, Huijiuan Chen, Xi Xie","doi":"10.1016/j.xinn.2024.100781","DOIUrl":"10.1016/j.xinn.2024.100781","url":null,"abstract":"Monitoring multiplexed biochemical markers is beneficial for the comprehensive evaluation of diabetes-associated complications. Techniques for multiplexed analyses in interstitial fluids have often been restricted by the difficulties of electrode materials in accurately detecting chemicals in complex subcutaneous spaces. In particular, the signal stability of enzyme-based sensing electrodes often inevitably decreases due to enzyme degradation or interference in vivo. In this study, we developed a self-calibrating multiplexed microneedle (MN) electrode array (SC-MMNEA) capable of continuous, real-time monitoring of multiple types of bioanalytes (glucose, cholesterol, uric acid, lactate, reactive oxygen species [ROSs], Na+, K+, Ca2+, and pH) in the subcutaneous space. Each type of analyte was detected by a discrete MN electrode assembled in an integrated array with single-MN resolution. Moreover, this device utilized an MN-delivery-mediated self-calibration technique to address the inherent problem of decreased accuracy of implantable electrodes caused by long-term tissue variation and enzyme degradation, and this technique might increase the reliability of the MN sensors. Our results indicated that SC-MMNEA could provide real-time monitoring of multiplexed analyte concentrations in a rat model with good accuracy, especially after self-calibration. SC-MMNEA has the advantages of in situ and minimally invasive monitoring of physiological states and the potential to promote wearable devices for long-term monitoring of chemical species in vivo.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100781"},"PeriodicalIF":33.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevating traditional Chinese medicine in global health research: The case for Chinese herbal medicine formulas in mainstream therapeutics. 提升中医药在全球健康研究中的地位：中草药方剂在主流疗法中的案例。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-24 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100811

Aiping Lu

引用次数: 0

The rise of single-atom catalysts in hematite photoanodes for photoelectrochemical water splitting. 赤铁矿光阳极中单原子催化剂在光电化学水分解中的应用。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-23 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100810

Peng-Yi Tang, Jordi Arbiol

引用次数: 0

Erratum: A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body. 勘误：单细胞转录组图谱的运动诱导的抗炎和老年保护作用在整个身体。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-23 eCollection Date: 2025-02-03 DOI: 10.1016/j.xinn.2025.100806

Shuhui Sun, Shuai Ma, Yusheng Cai, Si Wang, Jie Ren, Yuanhan Yang, Jiale Ping, Xuebao Wang, Yiyuan Zhang, Haoteng Yan, Wei Li, Concepcion Rodriguez Esteban, Yan Yu, Feifei Liu, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu

引用次数: 0

Topological insulators for thermoelectrics: A perspective from beneath the surface. 热电学的拓扑绝缘体：从表面下的视角。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-22 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100782

Michael Y Toriyama, G Jeffrey Snyder

{"title":"Topological insulators for thermoelectrics: A perspective from beneath the surface.","authors":"Michael Y Toriyama, G Jeffrey Snyder","doi":"10.1016/j.xinn.2024.100782","DOIUrl":"10.1016/j.xinn.2024.100782","url":null,"abstract":"Thermoelectric properties of topological insulators have traditionally been examined in the context of their metallic surface states. However, recent studies have begun to unveil intriguing thermoelectric effects emerging from the bulk electronic states of topological insulators, which have largely been overlooked in the past. Charge transport phenomena through the bulk are especially important under typical operating conditions of thermoelectric devices, necessitating a comprehensive review of both surface and bulk transport in topological insulators. Here, we review thermoelectric properties that are uniquely observed in topological insulators, placing special emphasis on unconventional phenomena emerging from bulk states. We demonstrate that unusual thermoelectric effects arising from bulk states, such as band inversion-driven warping, can be discerned in experiments through a simple analysis of the weighted mobility. We believe that there is still plenty to uncover within the bulk of topological insulators, yet our current understanding can already inspire new strategies for designing and discovering new materials for next-generation thermoelectrics.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100782"},"PeriodicalIF":33.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidant-free cross-dehydrogenative oxyalkylation enables late-stage functionalization of drugs. 无氧化剂的交叉脱氢氧烷基化使药物的后期功能化。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-22 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100809

Weiqiu Liang, Jiahao Li, Jianbin Li, Chengda Wu, Zhiyu Tu, Bo-Shuai Mu, Yang Xu, Longlong Song, Mengxin Xu, Xi-Yang Cui, Chao-Jun Li, Zhibo Liu

引用次数: 0