The Innovation最新文献_第9页

Quantum evidence of nonlocal consciousness during clinical death. 临床死亡期间非局部意识的量子证据。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-25 eCollection Date: 2026-09-08 DOI: 10.1016/j.xinn.2026.101355

Álex Escolà-Gascón, Kenneth Drinkwater, Andrew Denovan, Neil Dagnall, Julián Benito-León

{"title":"Quantum evidence of nonlocal consciousness during clinical death.","authors":"Álex Escolà-Gascón, Kenneth Drinkwater, Andrew Denovan, Neil Dagnall, Julián Benito-León","doi":"10.1016/j.xinn.2026.101355","DOIUrl":"10.1016/j.xinn.2026.101355","url":null,"abstract":"If consciousness can operate under quantum principles, then the boundaries between life, death, and cognition are far more permeable than current science allows. In the first large-scale, randomized, double-blind, multicenter trial to test this possibility, conducted across 13 hospitals in the UK and Spain, we investigated whether the human mind can access information during clinical death-but only when exposed to auditory stimuli governed by quantum entanglement. The entangled stimulation circuit was implemented and synchronized with the 127-qubit IBM Brisbane quantum supercomputer and delivered during in-hospital cardiopulmonary arrest (CA), beginning 120 s after arrest onset. Quantum entanglement was verified through statistically significant violations of Mermin inequalities. During resuscitation, we measured neurophysiological biomarkers including cerebral oxygenation via near-infrared spectroscopy (NIRS), brain temperature, and blood pH, lactate, and serum concentrations of brain-derived neurotrophic factor (BDNF). After reanimation, 142 survivors completed a forced-choice recall test, near-death experience (NDE) scales, and other clinical control assessments. False memories, hallucinations, and confounding biases were successfully controlled. Notably, recall lucidity increased momentarily as NIRS values dropped, and NDEs positively correlated with neuroplasticity during CA. Biomarker models explained up to 56.8% of the variance in recall. These findings compel a radical rethinking of clinical death: consciousness may persist-quantum bound, detectable, and not yet defeated.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 9","pages":"101355"},"PeriodicalIF":39.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global cycling of dissolved organic carbon between seawater and sediments quantified using physics-based artificial intelligence. 利用基于物理的人工智能量化海水和沉积物之间溶解有机碳的全球循环。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-25 eCollection Date: 2026-09-08 DOI: 10.1016/j.xinn.2026.101354

Peyman Babakhani, Andrew W Dale, Clare Woulds, Oliver W Moore, Ke-Qing Xiao, Majid Sedighi, Mingyu Zhao, Xiaohui Chen, Tanapon Phenrat, Farhad Jazaei, Lisa Curti, Caroline L Peacock

{"title":"Global cycling of dissolved organic carbon between seawater and sediments quantified using physics-based artificial intelligence.","authors":"Peyman Babakhani, Andrew W Dale, Clare Woulds, Oliver W Moore, Ke-Qing Xiao, Majid Sedighi, Mingyu Zhao, Xiaohui Chen, Tanapon Phenrat, Farhad Jazaei, Lisa Curti, Caroline L Peacock","doi":"10.1016/j.xinn.2026.101354","DOIUrl":"10.1016/j.xinn.2026.101354","url":null,"abstract":"The origin of dissolved organic carbon (DOC) in the ocean, which represents the largest active reservoir of exchangeable carbon on Earth, remains unknown due to the complexity of determining DOC exchange between marine sediments and seawater. Here, we emulate underlying processes of DOC dynamics using physics-based artificial intelligence (AI) to quantify DOC cycling and preservation in sediments at the global scale. We conclude that up to 11% of all particulate organic carbon deposited on the global seafloor returns to seawater as DOC following hydrolysis within the sediment, which is around half of the riverine DOC flux to the ocean. Around 50% of the total solid-phase organic carbon in the upper meter of sediments is formed through the sorption of DOC to minerals. Further, we show that the contribution of the abyssal plain to global DOC efflux and preservation, which is typically entirely overlooked in carbon cycle studies, is equivalent to half the contribution of the continental margins. This study also highlights the power of simpler AI algorithms compared to more complex models and extends the principle of parsimony in mathematical modeling to the context of physics-based AI.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 9","pages":"101354"},"PeriodicalIF":39.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallmarks of lung cancer driven by inhalable particulate matter: From cell-intrinsic oncogenic traits to microenvironment remodeling. 可吸入颗粒物驱动肺癌的特征：从细胞内在致癌特征到微环境重塑。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-18 eCollection Date: 2026-08-03 DOI: 10.1016/j.xinn.2026.101347

Xiaoqiu Yuan, Xinrui Li, Chen Wang, Emilia Lim, Yunchu Wei, Ruoyi Jin, Lin Weng, Takahiro Karasaki, Hao Luo, Li Qing, Zhiwei Zhou, Qisi Jiang, Olga Chervova, Fan Yang, Fang Wu, Kai Zhang, Cheng-Yen Chang, Farrah Kheradmand, Jianpeng Sheng, David Carbone, Jun Wang, Kezhong Chen

{"title":"Hallmarks of lung cancer driven by inhalable particulate matter: From cell-intrinsic oncogenic traits to microenvironment remodeling.","authors":"Xiaoqiu Yuan, Xinrui Li, Chen Wang, Emilia Lim, Yunchu Wei, Ruoyi Jin, Lin Weng, Takahiro Karasaki, Hao Luo, Li Qing, Zhiwei Zhou, Qisi Jiang, Olga Chervova, Fan Yang, Fang Wu, Kai Zhang, Cheng-Yen Chang, Farrah Kheradmand, Jianpeng Sheng, David Carbone, Jun Wang, Kezhong Chen","doi":"10.1016/j.xinn.2026.101347","DOIUrl":"10.1016/j.xinn.2026.101347","url":null,"abstract":"Inhalable particulate matter (PM) has emerged as a critical yet underappreciated carcinogenic factor in lung cancer, especially affecting non-smokers and populations residing in heavily polluted regions. Epidemiological research has confirmed the link between PM exposure and lung cancer risk, but the underlying biological pathways and clinical relevance are still not well understood. Here, we provide a comprehensive synthesis of current advances in PM-associated lung carcinogenesis, from population-level risk patterns to molecular pathogenesis and translational strategies. We outline the epidemiological burden and unique clinical features of PM-related lung cancer. We then propose a \"Hallmarks of PM-associated lung cancer\" framework, summarizing 12 features of how lung cancer evolves under PM exposure. This involves a complex interplay of cell-intrinsic oncogenic traits induced by PM (genetic alterations, epigenetic reprogramming, metabolic remodeling, stemness) and microenvironment reshaped by PM (inflammatory responses, immune suppression, angiogenesis, and pre-metastatic niche formation). Moreover, we critically examine the technical challenges in mechanistic studies and propose future solutions. Finally, we highlight urgent opportunities for integrating PM exposure into lung cancer screening, risk stratification, and prevention policies. This review offers a comprehensive framework for strategies to downsize the impact of air pollution on global lung health.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 8","pages":"101347"},"PeriodicalIF":39.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stagewise oxygenation of the Earth's atmosphere and oceans. 地球大气和海洋的分阶段氧化。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-17 eCollection Date: 2026-09-08 DOI: 10.1016/j.xinn.2026.101353

Haiyang Wang, Chao Li

{"title":"Stagewise oxygenation of the Earth's atmosphere and oceans.","authors":"Haiyang Wang, Chao Li","doi":"10.1016/j.xinn.2026.101353","DOIUrl":"10.1016/j.xinn.2026.101353","url":null,"abstract":"Earth's surface oxygenation was a protracted, multi-step process. It is widely accepted that atmospheric O2 rose through three major steps, each closely linked to key evolutionary innovations. Recent advances, particularly in sulfate triple-oxygen isotope records, now provide new constraints on the timing, tempo, and magnitude of atmospheric oxygenation. These data reveal a positive coupling between atmospheric and oceanic oxygenation on billion-year timescales, with stagewise rises in atmospheric O2 consistently preceding oceanic responses, whereas on shorter, million-year timescales, their redox states could diverge, exhibiting negative coupling. Oceanic redox evolution was also spatially and temporally heterogeneous, progressing from localized Archean oxygen oases (>3.0 Ga) to a globally oxygenated state by the Paleozoic (<0.41 Ga). Here, we synthesize geochemical, sedimentological, and palaeobiological evidence to reconstruct this coupled and dynamic atmosphere-ocean oxygenation history and to reassess its timing, mechanisms, and ecological consequences. These deep-time perspectives illuminate the co-evolution of life and Earth's surface environments and provide a conceptual framework for evaluating planetary habitability.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 9","pages":"101353"},"PeriodicalIF":39.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GeothermalKits for modeling geothermal energy: A scenario-based and physical model-free simulation platform. GeothermalKits用于地热能建模：一个基于场景和无物理模型的仿真平台。

IF 25.7 1区综合性期刊

The Innovation Pub Date : 2026-03-13 eCollection Date: 2026-05-04 DOI: 10.1016/j.xinn.2026.101350

Yanlong Kong, Xiaoming Tian, Yonghui Huang, Wanlong Cai, Miao Yu, Boyan Meng, Chaofan Chen, Changwei Liu, Zhongpeng Wang, Yulie Gong, Haibing Shao, Zhonghe Pang, Jiyang Wang

引用次数: 0

Self-regulated optomechanics achieves ultrabroadband and high-efficiency all-optical devices. 自调节光力学实现超宽带高效全光器件。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-12 eCollection Date: 2026-08-03 DOI: 10.1016/j.xinn.2026.101348

Xuning Wang, Guodong Hou, Feiyu Zhang, Feihong Du, Ruhong Luo, Zhenhua Ma, Yezhan Lin, Chunyu Wang, Yifan Zhao, Binzhou Sun, Cenling Huang, Lu Yu, Shanyu Zheng, Qiang Li, Donglin Han, Haixin Qiu, Jiang Zou, Xin Chen, Tiannan Yang, Wei Li, Weihong Zhu, Xiangyang Zhu, Di Zhang, Yanqing Lu, Guang Meng, Xiaoshi Qian

{"title":"Self-regulated optomechanics achieves ultrabroadband and high-efficiency all-optical devices.","authors":"Xuning Wang, Guodong Hou, Feiyu Zhang, Feihong Du, Ruhong Luo, Zhenhua Ma, Yezhan Lin, Chunyu Wang, Yifan Zhao, Binzhou Sun, Cenling Huang, Lu Yu, Shanyu Zheng, Qiang Li, Donglin Han, Haixin Qiu, Jiang Zou, Xin Chen, Tiannan Yang, Wei Li, Weihong Zhu, Xiangyang Zhu, Di Zhang, Yanqing Lu, Guang Meng, Xiaoshi Qian","doi":"10.1016/j.xinn.2026.101348","DOIUrl":"10.1016/j.xinn.2026.101348","url":null,"abstract":"All-optical logic devices require nonreciprocal wave propagation, which is often achieved by resonance or nonlinear effects at the cost of limited transmitted modes, wavelengths, and overall energy efficiency. By leveraging the inherited feedback loops, the nature-inspired self-regulated soft actuators could act as \"gatekeepers\" to identify the wave propagation direction to achieve similar logic functions in linear optics. Here, we report an effective design for all-optical diodes, transistors, and logic gates using self-regulated soft waveguides. These soft optomechanical systems, which are fabricated from hydrogels and liquid crystal elastomers (LCEs), exhibit direction recognition, autonomous alignment and selective transmission, achieving wavelength- and polarization-independent processing of signals and high overall efficiency. This versatile platform presents extended capabilities of integrated soft robotics and embodied intelligent material systems.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 8","pages":"101348"},"PeriodicalIF":39.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in predicting glacial lake outburst floods and suggested pathways forward. 冰湖溃决洪水预测的挑战与建议。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-12 eCollection Date: 2026-05-04 DOI: 10.1016/j.xinn.2026.101349

Guoqing Zhang, Guoxiong Zheng, Nitesh Khadka, Sonam Rinzin, Qian Tang, Xue Wang, Jiaqi Li, Jonathan L Carrivick

引用次数: 0

Unmasking hidden high risk in RUNX1::RUNX1T1 pediatric AML: Development of a novel prognostic model. 揭示RUNX1::RUNX1T1儿童AML的隐藏高风险：一种新的预后模型的发展

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-11 eCollection Date: 2026-07-06 DOI: 10.1016/j.xinn.2026.101344

Yang Xun, Yali Shen, Hua Yang, Jinsong Yan, Yu Tao, Yance Feng, Yi Huang, Stefan K Bohlander, Li Wei, Huihan Wang, Hua You

{"title":"Unmasking hidden high risk in RUNX1::RUNX1T1 pediatric AML: Development of a novel prognostic model.","authors":"Yang Xun, Yali Shen, Hua Yang, Jinsong Yan, Yu Tao, Yance Feng, Yi Huang, Stefan K Bohlander, Li Wei, Huihan Wang, Hua You","doi":"10.1016/j.xinn.2026.101344","DOIUrl":"10.1016/j.xinn.2026.101344","url":null,"abstract":"Although pediatric acute myeloid leukemia (pAML) harboring the RUNX1::RUNX1T1 fusion is generally classified as favorable risk, some patients experience poor outcomes. To address this heterogeneity, we developed and validated a prognostic model to refine risk stratification and guide individualized therapy. We analyzed 284 RR+ pAML cases from public datasets, randomized into training and internal validation cohorts, and assessed generalizability in an independent external cohort of 214 patients from multiple centers in China. The model integrates two readily accessible variables-minimal residual disease after induction (MRD1) and peripheral blood blast percentage at diagnosis-as core predictors. It consistently identified a >30% high-risk subgroup characterized by elevated relapse rates and mortality, who derived limited benefit from transplantation. Furthermore, KIT mutations, particularly in exon 17, delineated a very-high-risk subset with significantly inferior outcomes. In this group, dasatinib treatment was associated with improved overall and event-free survival, whereas no benefit was observed in low-risk patients. For high-risk patients lacking KIT mutations, transcriptional profiling and drug sensitivity analysis identified potential therapeutic candidates, including immune checkpoint modulators (e.g., targeting TLR3 and CD200) and small-molecule inhibitors. This stratification tool provides a simple framework for individualized risk assessment and offers actionable evidence to assist treatment decision-making for RR+ pAML patients.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 7","pages":"101344"},"PeriodicalIF":39.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological hydrogels for 3D organic electrochemical transistors. 三维有机电化学晶体管的拓扑水凝胶。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-07 eCollection Date: 2026-05-04 DOI: 10.1016/j.xinn.2026.101346

Bochao Xie, Qin Xue, Wenjin Zhou, Yigang Yu, Guohua Xie, Bin Yang

引用次数: 0

Maximum utilization of all elements in biomass waste. 最大限度地利用生物质废弃物中的所有元素。

IF 39.5 1区综合性期刊

The Innovation Pub Date : 2026-03-06 eCollection Date: 2026-06-01 DOI: 10.1016/j.xinn.2026.101345

Yiping Luo, Tianjie Ao, Fang Deng, Zhijie Xie, Dong Li

引用次数: 0