The Innovation最新文献

{"title":"Single-cell profiling reveals immunoregulation of artemisinin on CD8⁺GZMB⁺ T cells via JAK2-STAT3 in malaria-infected mice.","authors":"Jiayun Chen, Peng Gao, Xueling He, Yanwei Hu, Wei Zhou, Yanxia Liu, Jianyou Wang, Xiaohong Liu, Yunmeng Bai, Lina Chen, Chen Wang, Guangqing Cheng, Xing Zhang, Yin Kwan Wong, Fulong Liao, Chengchao Xu, Juanjuan Ou, Yiqiang Wu, Wei Zhang, Yue Gao, Youyou Tu, Jigang Wang","doi":"10.1016/j.xinn.2025.101080","DOIUrl":"10.1016/j.xinn.2025.101080","url":null,"abstract":"<p><p>Malaria, a pervasive and devastating disease, is characterized by systemic complications and dysregulated host immune responses to <i>Plasmodium</i> infection. Artemisinin derivatives, particularly artesunate (ART), are a cornerstone in malaria treatment strategies. Although the precise immunomodulatory mechanisms remain unclear, ART not only kills parasites but also impacts host immune homeostasis. In this study, we employed single-cell RNA sequencing to characterize the cellular landscape of 241,837 cells from multiple murine tissues (including liver, spleen, and peripheral blood) upon <i>Plasmodium berghei ANKA</i> (PbA) infection and after ART treatment. Meanwhile, we observed significant transcriptomic shifts across diverse immune cell types, with the liver exhibiting the most pronounced changes in response to PbA infection. Notably, CD8⁺GZMB⁺ T lymphocytes, characterized by elevated cytokine and cytotoxic module scores, play a pivotal role in driving hepatic injury. Furthermore, ART modulated this pathogenic subtype via the JAK2-STAT3 pathway, reducing its frequency and mitigating its inflammatory response. Our research provides a valuable dataset resource for exploring malaria immunopathogenesis and elucidates a novel immunoregulatory mechanism of ART within the infected host.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"101080"},"PeriodicalIF":25.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Firsekibart versus compound betamethasone in acute gout patients unsuitable for standard therapy: A randomized phase 3 trial.","authors":"Yu Xue, Tianshu Chu, Jiankang Hu, Wei Gou, Ning Zhang, Juan Li, Jing Yu, Rongping Li, Rongbin Li, Long Qian, Xinwang Duan, Lihua Duan, Xu Zhang, Yuling Lian, Yi Li, Chuang Qi, Dongzhe Huang, Hejian Zou","doi":"10.1016/j.xinn.2025.101015","DOIUrl":"10.1016/j.xinn.2025.101015","url":null,"abstract":"<p><p>This phase 3 trial evaluated the efficacy and safety of Firsekibart, a novel, fully human anti-interleukin-1β monoclonal antibody, in patients with frequent acute gout flares unsuitable for standard therapy. Patients were randomized (1:1, stratified by baseline pain visual analog scale [VAS]) to the Firsekibart (200 mg) or compound betamethasone (CB; 7 mg) group. Co-primary endpoints included change in pain intensity in the target joint at 72 h (non-inferiority testing) and time to first new flare within 12 weeks (superiority testing). The non-inferiority margin was 10 mm. The full analysis set included 311 patients (Firsekibart: <i>N</i> = 156; CB: <i>N</i> = 155). At 72 h, the least squares mean change in pain VAS scores from baseline was -57.09 mm (95% confidence interval [CI]: -60.08 to -54.10) for Firsekibart and -53.77 mm (95% CI: -56.77 to -50.77) for CB, with treatment difference of -3.32 mm (95% CI: -7.56 to 0.91), establishing non-inferiority. The median time to first new flare was not reached within 12 weeks in the Firsekibart group compared with 45.0 days (95% CI: 28.00 to 63.00) in the CB group. Firsekibart significantly reduced the risk of new flare by 90% vs. CB (hazard ratio: 0.10; 95% CI: 0.06 to 0.17; stratified log rank <i>p</i> < 0.0001). Efficacy was consistent across subgroups. Treatment-emergent adverse events occurred in 71.2% of Firsekibart-treated patients and 69.9% of those receiving CB. In conclusion, Firsekibart is effective and well tolerated for acute gout flares in patients unsuitable for standard therapy, demonstrating non-inferiority in rapid pain relief and significant superiority in preventing flare compared with CB.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 8","pages":"101015"},"PeriodicalIF":25.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics, chemistry, and modeling studies in the aviation and aerospace transition zone.","authors":"Zheng Sheng, Yang He, Sicheng Wang, Shujie Chang, Hongze Leng, Ju Wang, Jie Zhang, Ying Wang, Huanwei Zhang, Haoyang Sui, Yuyang Song, Gangyao Wu, Sheng Guo, Jing Chai, Wuhu Feng, Junqiang Song","doi":"10.1016/j.xinn.2025.101012","DOIUrl":"10.1016/j.xinn.2025.101012","url":null,"abstract":"<p><p>In this review, the concept of the aviation and aerospace transition zone (AATZ), that is, the area between the highest altitude of aviation vehicles and the lowest altitude of space vehicles, is introduced. It is 50-150 km away from the Earth's surface, and the coupling between the AATZ and its upper and lower atmosphere causes complex and unique physical and chemical processes. As a transition zone between space weather and Earth weather, the AATZ has great scientific research value and broad application prospects. Focusing on the dynamics, chemistry, and modeling studies of the atmosphere in this region, we comprehensively analyze and discuss the current research status, current challenges, and future prospects of this region. The propagation, dissipation, and momentum deposition of the atmospheric wave force change the surrounding wind field and temperature structure, forming complex dynamical processes. The mutation enhancement and redistribution of metal atoms and metal ions, as well as the occurrence of airglow, directly or indirectly show the changes in composition and energy transfer caused by complex chemical processes. The modeling studies of the above phenomena are conducive to the deepening of understanding, and the defects of the simulation also reflect the lack of observation on understanding. The discussion in this review encourages more research on the AATZ as well as the development and enrichment of existing observational tools and techniques to fill in the knowledge gaps and enhance the ability to apply the region in the aerospace industry.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 8","pages":"101012"},"PeriodicalIF":25.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early career ocean professionals' declaration on ocean negative carbon emissions for our ocean and future.","authors":"Shenghui Li, Charles I Addey, Raphaël Roman, Hakase Hayashida, Chunhua Jiang, Chen Hu, Luz de Lourdes Aurora Coronado-Álvarez, Hyung-Gyu Lim, Surya Gentha Akmal, Chukwuka Moses Orji, Parth Arora, Ruiqi Li, Sohan Pm, Rasheed B Adesina, Christian Lindemann, Deqiang Ma, Saydul Sarkar, Martina Mascioni, Thiago Monteiro, Chao Liu, Renis Auma Ojwala, Matthew Vincent Tabilog, Kakaskasen Andreas Roeroe, Hafeez O Oladejo, Samuel O Daramola, Delio Da Costa, Ting Guo, Cristhian Chicaiza-Ortiz, Abiola A Adebiyi, Md Rasel Ahmed, Aidah Baloch, Santiago Thomé Andueza, Joseph Kofi Ansong, Sura Appalanaidu, Furqan Asif, Andrew Taylor Awa, Elnalee Baguya, Matheus Batista, Okeke Ebuka Benedict, Fulton Bobby, Peter Teye Busumprah, Marta Cardoso, Andréa da Consolação de Oliveira Carvalho, Terrence Daniel Crea, Ky Channimol, Wee Cheah, Igbodiegwu Gloria Chinwendu, Alessia Dinoi, King-James I Egbe, Joseph Eshun, Juan Diego Gaitan Espitia, Dorcas Akua Essel, Natalie Fox, Kate Fraser, Martina Gaglioti, Koren Gerbrand, Laura Gusatu, Diego Alexander Hernández Contreras, Theddy-Michel Iradukunda, Zahor Mwalim Khalfan, Laura Khatib, Minkyoung Kim, Marta Koch, Jihua Liu, Shailendra K Mandal, Soukphansa Manivong, Benedict McAteer, Chiamaka Linda Mgbechidinma, Thuy Hao Ngo, Manasi Suhas Nirmale, Ronnie Noonan Birch, Tolulope E Oginni, Isa Elegbede Olalekan, Lord Offei-Darko, Viena Puigcorbé, Rishi Rajendra Gandhi, Mohammad Rozaimi, Edmond Sanganyado, Debarati Sengupta, Priyatma Singh, Dumpala Sridhar, N Sunanda, Falguni Tailor, Beatriz Tintoré, Okoli Moses Ugochukwu, Khanittha Uthaipan, O Alejandra Vargas-Fonseca, Anmol Verma, Clara R Vives, Sina Wallschuss, Lin Wang, Yuhao Wang, Yuntao Wang, Yabing Meng, María Schoenbeck, Wei Yan, Hanna Yen, Tingwei Luo","doi":"10.1016/j.xinn.2025.101007","DOIUrl":"10.1016/j.xinn.2025.101007","url":null,"abstract":"<p><p>This paper highlights the urgent need to accelerate research and action on ocean carbon sinks through human intervention, known as the Global Ocean Negative Carbon Emissions (Global-ONCE) Programme, as a vital strategy in global efforts to mitigate climate change. Achieving \"net zero\" by 2050 cannot rely on emission reductions alone, emphasizing the necessity of complementary approaches. Global-ONCE's mission extends beyond scientific exploration. It embodies a profound commitment to protecting and restoring blue carbon ecosystems, as well as implementing ocean-based solutions that are sustainable, equitable, and inclusive. Early career ocean professionals (ECOPs) are at the heart of these efforts, and their innovative approaches, technical expertise, and passion make them indispensable leaders in advancing ONCE initiatives. ECOPs bridge the gap between science and society, playing a relevant role in integrating cutting-edge research, technological advancements, and community-driven action to address climate threats. By bringing together diverse perspectives and leveraging their interdisciplinary expertise, ECOPs ensure that ONCE strategies are grounded in scientific rigor and practical feasibility. Through advocacy, education, and collaboration, ECOPs not only spearhead research and innovation but also inspire collective action to safeguard our oceans. This paper amplifies the critical role of ECOPs as agents of change and calls for a unified global commitment to harness the ocean's potential for a climate-resilient future.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"101007"},"PeriodicalIF":25.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of anomalous Nernst thermoelectric generators for giant power output.","authors":"Mengzhao Chen, Sheng Qian, Ziheng Gao, Shuo Liu, Shen Han, Tiejun Zhu, Yan Sun, Chenguang Fu","doi":"10.1016/j.xinn.2025.100995","DOIUrl":"10.1016/j.xinn.2025.100995","url":null,"abstract":"<p><p>Topological magnets have shown great potential for transverse thermoelectric (TE) conversion with structural advantages, utilizing the anomalous Nernst effect. To facilitate such applications, the development of exceptional topological magnet-based Nernst devices is a crucial step that requires both high-performance topological magnets and the design of low-resistance interfaces in the devices. Here, we report that the anomalous Nernst effect in topological magnets can be ubiquitously enhanced by synergistically tuning the entropy-density-weighted Berry curvature and the Fermi surface, as evidenced by a giant anomalous Nernst power factor of 47.8 μW m^-1 K^-2 at room temperature in electron-doped Co₂MnGa. In addition, we achieved an ultralow interfacial resistivity in the Nernst device by designing reactive wetting interfacial layers, enabling an ultrahigh power output of 69.7 μW at a temperature difference of 16.1 K, the highest value yet reported to date. We have also experimentally corroborated the structural advantages of transverse TE technology by developing Nernst devices with different length-to-thickness ratios. Our work demonstrates a paradigm for designing exceptional topological magnet-based Nernst generators for transverse TE conversion.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100995"},"PeriodicalIF":25.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Policy-aware cross-city learning: A framework for sustainable urban governance.","authors":"Ying Yang, Jiahao Zhan, Yang Liu, Xiaobo Qu","doi":"10.1016/j.xinn.2025.100986","DOIUrl":"10.1016/j.xinn.2025.100986","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100986"},"PeriodicalIF":25.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers in earth observation for global soil properties assessment linked to environmental and socio-economic factors.","authors":"José A M Demattê, Raul R Poppiel, Jean Jesus Macedo Novais, Nícolas Augusto Rosin, Budiman Minasny, Igor Y Savin, Sabine Grunwald, Songchao Chen, Yongsheng Hong, Jingyi Huang, Sabine Chabrillat, Quirijn de Jong van Lier, Eyal Ben-Dor, Cecile Gomez, Zhang Ganlin, Merilyn Taynara Accorsi Amorim, Letícia Guadagnin Vogel, Jorge Tadeu Fim Rosas, Robert Milewski, Asa Gholizadeh, Arseniy V Zhogolev, José Padarian Campusano, Yuxin Ma, Ho Jun Jang, Rudiyanto, Changkun Wang, Rodnei Rizzo, Nikolaos Tziolas, Nikolaos Tsakiridis, Masakazu Kodaira, D Nagesh Kumar, Subramanian Dharumarajan, Yufeng Ge, Emmanuelle Vaudour, Shamsollah Ayoubi, James Kobina Mensah Biney, Abdelaziz Belal, Salman Naimi Marandi, Najmeh Asgari Hafshejani, Eleni Kalopesa, Danilo Cesar Mello, Marcio Rocha Francelino, Elsayed Said Mohamed Salama, Asmaa Abdelbaki","doi":"10.1016/j.xinn.2025.100985","DOIUrl":"10.1016/j.xinn.2025.100985","url":null,"abstract":"<p><p>Soil has garnered global attention for its role in food security and climate change. Fine-scale soil-mapping techniques are urgently needed to support food, water, and biodiversity services. A global soil dataset integrated into an Earth observation system and supported by cloud computing enabled the development of the first global soil grid of six key properties at a 90-m spatial resolution. Assessing them from environmental and socio-economic perspectives, we demonstrated that 64% of the world's topsoils are primarily sandy, with low fertility and high susceptibility to degradation. These conditions limit crop productivity and highlight potential risks to food security. Results reveal that approximately 900 Gt of soil organic carbon (SOC) is stored up to 20 cm deep. Arid biomes store three times more SOC than mangroves based on total areas. SOC content in agricultural soils is reduced by at least 60% compared to soils under natural vegetation. Most agricultural areas are being fertilized while simultaneously experiencing a depletion of the carbon pool. By integrating soil capacity with economic and social factors, we highlight the critical role of soil in supporting societal prosperity. The top 10 largest countries in area per continent store 75% of the global SOC stock. However, the poorest countries face rapid organic matter degradation. We indicate an interconnection between societal growth and spatially explicit mapping of soil properties. This soil-human nexus establishes a geographically based link between soil health and human development. It underscores the importance of soil management in enhancing agricultural productivity and promotes sustainable-land-use planning.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100985"},"PeriodicalIF":25.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid metals power advanced nuclear energy systems.","authors":"Lin Zhang, Chang Deng, Xu Ji, Xiaojing Liu","doi":"10.1016/j.xinn.2025.100959","DOIUrl":"10.1016/j.xinn.2025.100959","url":null,"abstract":"<p><p>The development of advanced nuclear energy systems, known for their cleanliness and sustainability, is a key strategy for achieving a low-carbon energy transition. Liquid metal (LM)-powered advanced nuclear energy systems demonstrate sustainability and environmental friendliness, as well as being irreplaceable in specific areas. This paper charts a comprehensive scene of applications, challenges, and prospects of LMs in advanced nuclear energy (fusion and fission). First, next-generation fission reactors that use LM coolants, such as sodium or lead, are currently under design and construction. However, the coupling mechanisms of multiphase and multiphysics interactions remain unresolved due to various challenges, including corrosion and lead-water interactions. Second, the exploration of new LM-cooled reactors should emphasize sustainable development while ensuring basic performance. Lastly, the unique properties of LMs, including efficient energy transport and tritium breeding, position them as crucial materials in fusion system design. However, surface characteristics and the magnetohydrodynamic (MHD) effect remain major technical challenges. LMs have already left their mark in nuclear energy and are expected to be an effective solution to overcoming the energy crisis.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100959"},"PeriodicalIF":25.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"aplot: Simplifying the creation of complex graphs to visualize associations across diverse data types.","authors":"Shuangbin Xu, Qianwen Wang, Shaodi Wen, Junrui Li, Nan He, Ming Li, Thomas Hackl, Rui Wang, Dongqiang Zeng, Shixiang Wang, Shensuo Li, Chun-Hui Gao, Lang Zhou, Shaoguo Tao, Zijing Xie, Lin Deng, Guangchuang Yu","doi":"10.1016/j.xinn.2025.100958","DOIUrl":"10.1016/j.xinn.2025.100958","url":null,"abstract":"<p><p>Effective data visualization is crucial for researchers, revealing patterns, trends, and insights that might otherwise remain hidden. Integrating related visualizations can reveal correlations and relationships that are not evident when analyzing datasets separately. Despite increasing demand, there is a shortage of general tools to seamlessly combine diverse datasets to create complex visual representations. The <i>aplot</i> package addresses this by allowing users to independently create subplots and assemble them into a cohesive composite figure. It automatically reorders datasets for coordinate consistency, removing the need for manual adjustment. This modular approach simplifies the creation of complex visualizations, allowing customization to meet specific needs. <i>Aplot</i>'s versatility is ideal for integrating multi-omics datasets and analytical results for biological insights. The package is freely available on CRAN at https://cran.r-project.org/package=aplot, offering researchers a powerful tool for enhanced data exploration and visualizing workflows.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100958"},"PeriodicalIF":25.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical guideline for recurrent or metastatic adenoid cystic carcinoma.","authors":"Jiawei Zhou, Zhen Yu, Shuhang Wang, Ning Li","doi":"10.1016/j.xinn.2025.100957","DOIUrl":"10.1016/j.xinn.2025.100957","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100957"},"PeriodicalIF":25.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}