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Boosting the oxygen reduction activity on metal surfaces by fine-tuning interfacial water with midinfrared stimulation.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100754
Qilin Zhang, Yu Wu, Hao Sun, Zhongjie Zhu, Hongwei Zhao, Jinrong Yang, Jie Wang, Min Chen, Sanzhao Song, Shiyou Zheng, Dengsong Zhang, Hui Yang, Zhi Zhu, Chunlei Wang
{"title":"Boosting the oxygen reduction activity on metal surfaces by fine-tuning interfacial water with midinfrared stimulation.","authors":"Qilin Zhang, Yu Wu, Hao Sun, Zhongjie Zhu, Hongwei Zhao, Jinrong Yang, Jie Wang, Min Chen, Sanzhao Song, Shiyou Zheng, Dengsong Zhang, Hui Yang, Zhi Zhu, Chunlei Wang","doi":"10.1016/j.xinn.2024.100754","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100754","url":null,"abstract":"<p><p>Heterogeneous catalysis at the metal surface generally involves the transport of molecules through the interfacial water layer to access the surface, which is a rate-determining step at the nanoscale. In this study, taking the oxygen reduction reaction on a metal electrode in aqueous solution as an example, using accurate molecular dynamic simulations, we propose a novel long-range regulation strategy in which midinfrared stimulation (MIRS) with a frequency of approximately 1,000 cm<sup>-1</sup> is applied to nonthermally induce the structural transition of interfacial water from an ordered to disordered state, facilitating the access of oxygen molecules to metal surfaces at room temperature and increasing the oxygen reduction activity 50-fold. Impressively, the theoretical prediction is confirmed by the experimental observation of a significant discharge voltage increase in zinc-air batteries under MIRS. This MIRS approach can be seamlessly integrated into existing strategies, offering a new approach for accelerating heterogeneous reactions and gas sensing within the interfacial water system.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100754"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100745
Luoyan Ai, Qian Li, Shilong Zhang, Yu Dong, Mudan Yang, Jin Li, Yueyin Pan, Ying Yuan, Shanyong Yi, Junsheng Wang, Ying Cheng, Jifeng Feng, Shegan Gao, Xicheng Wang, Song Qu, Xizhi Zhang, Jin Lu, Peng Xiu, Shuni Wang, Xinfeng Yang, Yiyi Yu, Tianshu Liu
{"title":"Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.","authors":"Luoyan Ai, Qian Li, Shilong Zhang, Yu Dong, Mudan Yang, Jin Li, Yueyin Pan, Ying Yuan, Shanyong Yi, Junsheng Wang, Ying Cheng, Jifeng Feng, Shegan Gao, Xicheng Wang, Song Qu, Xizhi Zhang, Jin Lu, Peng Xiu, Shuni Wang, Xinfeng Yang, Yiyi Yu, Tianshu Liu","doi":"10.1016/j.xinn.2024.100745","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100745","url":null,"abstract":"<p><p>Concurrent inhibition of angiogenesis and immune checkpoints represents a potent therapeutic approach. We conducted a phase 2, multicenter, basket study to assess the efficacy and safety of combination therapy of famitinib (anti-angiogenic agent) plus camrelizumab (PD-1 antagonist) in patients with metastatic solid tumors across 11 cohorts (this study was registered at Clinicaltrials.gov [NCT04346381]). This report focuses on the cohort of patients with metastatic or advanced colorectal cancer. Eligible patients, who had previously received ≥2 lines of systemic treatments for their metastatic disease, were treated with famitinib (20 mg once daily) in combination with camrelizumab (200 mg intravenously every 3 weeks). The primary endpoint was the objective response rate, with secondary endpoints encompassing progression-free survival, overall survival, duration of response, safety and exploratory biomarkers. A total of 44 patients were enrolled and treated. With a median follow-up time of 9.46 months (range 2.0-22.5 months), objective responses were observed in 6 patients (13.6%; 95% confidence interval [CI], 5.2%-27.4%), all of whom had rectal cancer. The median duration of response is 6.2 months (95% CI, 2.3-10.6 months). Median progression-free survival was 3.3 months (95% CI, 2.1-4.1 months), and median overall survival was 10.9 months (95% CI, 7.6-15.2 months). Among the 44 patients, 29 (65.9%) experienced grade 3 or 4 treatment-related adverse events, predominantly hypertension and proteinuria. In conclusion, the combination of famitinib and camrelizumab demonstrates promising antitumor activity with a manageable safety profile in metastatic colorectal cancer patients. Further research is warranted to confirm and extend these findings.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100745"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate effects of ecosystem change converge according to the ratio of the daytime to daily vapor flux.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100733
Langqin Hua, Lin Li, Wenjing Chen, Xuemeng Wang, Xin Xiong, Guoyi Zhou
{"title":"Climate effects of ecosystem change converge according to the ratio of the daytime to daily vapor flux.","authors":"Langqin Hua, Lin Li, Wenjing Chen, Xuemeng Wang, Xin Xiong, Guoyi Zhou","doi":"10.1016/j.xinn.2024.100733","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100733","url":null,"abstract":"<p><p>Ecosystem changes can simultaneously generate various climate-related effects, such as evapotranspiration (vapor flux) effects, carbon-cycle effects, and surface temperature effects. These effects are coupled with one another because they are generated through the same biophysical and biogeochemical processes. Consequently, given an easily measurable effect, other effects can be predicted from the measured effect. Here, based on global eddy covariance (EC) observations, we show that the ratio of the daytime to daily vapor flux (RATIO) reflects the complexity of various ecosystem types and is highly coupled with climate effects of ecosystem changes. For the same daily RATIO, the magnitudes of the same EC variable remain unchanged across all of the ecosystems and, thus, EC observations for an ecosystem or place can be mapped to other ecosystems or places in accordance with their daily RATIO values. By applying the daily RATIO, the effects of ecosystem changes on the surface temperature in different climatic zones (including the Tibetan Plateau) can be predicted, which is highly consistent with all previous studies. We found that cooling or warming effects are controlled by the RATIO, not by enhanced or reduced evapotranspiration as many studies have suggested. This study provides a new and simple approach for evaluating the climate effects of ecosystem changes at all spatial-temporal scales worldwide.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100733"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urban sensing in the era of large language models.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100749
Ce Hou, Fan Zhang, Yong Li, Haifeng Li, Gengchen Mai, Yuhao Kang, Ling Yao, Wenhao Yu, Yao Yao, Song Gao, Min Chen, Yu Liu
{"title":"Urban sensing in the era of large language models.","authors":"Ce Hou, Fan Zhang, Yong Li, Haifeng Li, Gengchen Mai, Yuhao Kang, Ling Yao, Wenhao Yu, Yao Yao, Song Gao, Min Chen, Yu Liu","doi":"10.1016/j.xinn.2024.100749","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100749","url":null,"abstract":"<p><p>Urban sensing has become increasingly important as cities evolve into the centers of human activities. Large language models (LLMs) offer new opportunities for urban sensing based on commonsense and worldview that emerged through their language-centric framework. This paper illustrates the transformative impact of LLMs, particularly in the potential of advancing next-generation urban sensing for exploring urban mechanisms. The discussion navigates through several key aspects, including enhancing knowledge transfer between humans and LLM, urban mechanisms awareness, and achieve automated decision-making with LLM agents. We emphasize the potential of LLMs to revolutionize urban sensing, offering a more comprehensive, efficient, and in-depth understanding of urban dynamics, and also acknowledge challenges in multi-modal data utilization, spatial-temporal cognition, cultural adaptability, and privacy preservation. The future of urban sensing with LLMs lies in leveraging their emerged intelligent and addressing these challenges to achieve more intelligent, responsible, and sustainable urban development.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100749"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A robust reduction in near-surface wind speed after volcanic eruptions: Implications for wind energy generation.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100734
Cheng Shen, Zhi-Bo Li, Fei Liu, Hans W Chen, Deliang Chen
{"title":"A robust reduction in near-surface wind speed after volcanic eruptions: Implications for wind energy generation.","authors":"Cheng Shen, Zhi-Bo Li, Fei Liu, Hans W Chen, Deliang Chen","doi":"10.1016/j.xinn.2024.100734","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100734","url":null,"abstract":"<p><p>Near-surface wind speed (NSWS), a determinant of wind energy, is influenced by both natural and anthropogenic factors. However, the specific impacts of volcanic eruptions on NSWS, remain unexplored. Our simulations spanning the last millennium reveal a consistent 2-year global NSWS reduction following 10 major historical eruptions. This equates to an NSWS decrease of approximately two inter-annual standard deviations from AD 851 to 1849. This reduction is linked to the weakening of subtropical descending air and a decrease in downward momentum flux, triggered by volcanic aerosol forcing. The 1815 Tambora eruption, one of the most powerful in recent history, led to a ∼9.2% reduction in global wind power density in the subsequent 2 years. Our research fills a knowledge gap, establishes a theoretical foundation for empirical studies, and highlights the potential wind energy risks linked to large atmospheric aerosol injections, including volcanic eruptions, nuclear warfare, and climate intervention.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100734"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying dehydration-induced shear velocity anomaly in the Earth's core-mantle boundary.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100740
Songsong Han, Xiaoming Cui, Baolong Zhang, Xiaohong Li, Sidao Ni, Heping Sun, Mingqiang Hou, Qingyang Hu
{"title":"Identifying dehydration-induced shear velocity anomaly in the Earth's core-mantle boundary.","authors":"Songsong Han, Xiaoming Cui, Baolong Zhang, Xiaohong Li, Sidao Ni, Heping Sun, Mingqiang Hou, Qingyang Hu","doi":"10.1016/j.xinn.2024.100740","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100740","url":null,"abstract":"<p><p>The steep temperature gradient near the bottom of the mantle is known to generate a negative correlation between the shear wave velocity (<i>V</i> <sub><i>S</i></sub> ) and the depth in most regions of the D″ layer, as detected by seismological observations. However, increasing <i>V</i> <sub><i>S</i></sub> with depth is observed at the D″ layer beneath Central America, where the Farallon slab sinks, and the origin of this anomaly has not been well constrained. Here, we calculate the thermoelastic constants and obtain the elastic wave velocities of hydrous phase H with various Al contents and cation configurations, which may act as a water carrier to the D″ layer. We find its <i>V</i> <sub><i>S</i></sub> to be substantially lower than the post-perovskite-type bridgmanite. The dehydration of Al-enriched phase H and the redistribution of Al from the hydrous component to dry silicates would gradually raise the <i>V</i> <sub><i>S</i></sub> below the top of the D″ layer. The presence of 3.5 wt % water is sufficient to compensate for the thermal effects to match the seismic anomaly at the bottom of the mantle beneath Central America. The positive slope of <i>V</i> <sub><i>S</i></sub> versus depth in the D″ layer may fingerprint deep water recycling.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100740"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100750
Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu
{"title":"Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation.","authors":"Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu","doi":"10.1016/j.xinn.2024.100750","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100750","url":null,"abstract":"<p><p>Predicting free energy changes (ΔΔG) is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development. While traditional methods offer valuable insights, they are often constrained by computational speed and reliance on biased training datasets. These constraints become particularly evident when aiming for accurate ΔΔG predictions across a diverse array of protein sequences. Herein, we introduce Pythia, a self-supervised graph neural network specifically designed for zero-shot ΔΔG predictions. Our comparative benchmarks demonstrate that Pythia outperforms other self-supervised pretraining models and force field-based approaches while also exhibiting competitive performance with fully supervised models. Notably, Pythia shows strong correlations and achieves a remarkable increase in computational speed of up to 10<sup>5</sup>-fold. We further validated Pythia's performance in predicting the thermostabilizing mutations of limonene epoxide hydrolase, leading to higher experimental success rates. This exceptional efficiency has enabled us to explore 26 million high-quality protein structures, marking a significant advancement in our ability to navigate the protein sequence space and enhance our understanding of the relationships between protein genotype and phenotype. In addition, we established a web server at https://pythia.wulab.xyz to allow users to easily perform such predictions.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100750"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100751
Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin
{"title":"Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials.","authors":"Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin","doi":"10.1016/j.xinn.2024.100751","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100751","url":null,"abstract":"<p><p>Transmission electron microscopy (TEM) is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics, phase transitions, and nanoscale structural details. While numerous intriguing physical properties have been revealed in recently discovered two-dimensional (2D) quantum materials, many exhibit significant sensitivity to water and oxygen under ambient conditions. This inherent instability complicates sample preparation for TEM analysis and hinders accurate property measurements. This review highlights recent technical advancements to preserve the intrinsic structures of water- and oxygen-sensitive 2D materials for atomic-scale characterizations. A critical development discussed in this review is implementing an inert gas-protected glovebox integrated system (GIS) designed specifically for TEM experiments. In addition, this review emphasizes air-sensitive materials such as 2D transition metal dichalcogenides, transition metal dihalides and trihalides, and low-dimensional magnetic materials, demonstrating breakthroughs in overcoming their environmental sensitivity. Furthermore, the progress in TEM characterization enabled by the GIS is analyzed to provide a comprehensive overview of state-of-the-art methodologies in this rapidly advancing field.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100751"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of visual cortex excitatory microcircuit organization.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2024-12-12 eCollection Date: 2025-01-06 DOI: 10.1016/j.xinn.2024.100735
Christina Y C Chou, Hovy H W Wong, Connie Guo, Kiminou E Boukoulou, Cleo Huang, Javid Jannat, Tal Klimenko, Vivian Y Li, Tasha A Liang, Vivian C Wu, P Jesper Sjöström
{"title":"Principles of visual cortex excitatory microcircuit organization.","authors":"Christina Y C Chou, Hovy H W Wong, Connie Guo, Kiminou E Boukoulou, Cleo Huang, Javid Jannat, Tal Klimenko, Vivian Y Li, Tasha A Liang, Vivian C Wu, P Jesper Sjöström","doi":"10.1016/j.xinn.2024.100735","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100735","url":null,"abstract":"<p><p>Synapse-specific connectivity and dynamics determine microcircuit function but are challenging to explore with classic paired recordings due to their low throughput. We therefore implemented optomapping, a ∼100-fold faster two-photon optogenetic method. In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells. Across these cell types, log-normal distribution of synaptic efficacies emerged as a principle. For pyramidal cells, optomapping reproduced the canonical circuit but unexpectedly uncovered that the excitation of basket cells concentrated to layer 5 and that of Martinotti cells dominated in layer 2/3. The excitation of basket cells was stronger and reached farther than the excitation of pyramidal cells, which may promote stability. Short-term plasticity surprisingly depended on cortical layer in addition to target cell. Finally, optomapping revealed an overrepresentation of shared inputs for interconnected layer-6 pyramidal cells. Thus, by resolving the throughput problem, optomapping uncovered hitherto unappreciated principles of V1 structure.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100735"},"PeriodicalIF":33.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photopyroelectric tweezers for versatile manipulation.
IF 33.2 1区 综合性期刊
The Innovation Pub Date : 2024-12-12 eCollection Date: 2025-01-06 DOI: 10.1016/j.xinn.2024.100742
Fang Wang, Cong Liu, Zhengjin Dai, Weizhong Xu, Xinyue Ma, Yufeng Gao, Xuewu Ge, Wei Zheng, Xuemin Du
{"title":"Photopyroelectric tweezers for versatile manipulation.","authors":"Fang Wang, Cong Liu, Zhengjin Dai, Weizhong Xu, Xinyue Ma, Yufeng Gao, Xuewu Ge, Wei Zheng, Xuemin Du","doi":"10.1016/j.xinn.2024.100742","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100742","url":null,"abstract":"<p><p>Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical, biological, and medical fields. However, certain critical requirements, such as high-intensity laser beams, sophisticated electrode designs, additional electric sources, or low-conductive media, significantly impede their flexibility and adaptability, thus hindering their practical applications. Here, we report innovative photopyroelectric tweezers (PPT) that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability, enabling diverse manipulation in various working scenarios. These PPTs allow for remote and programmable manipulation of objects with diverse materials (polymer, inorganic, and metal), different phases (bubble, liquid, and solid), and various geometries (sphere, cuboid, and wire). Furthermore, the PPT is not only adaptable to high-conductivity media but also applicable to both portable macroscopic manipulation platforms and microscopic manipulation systems, enabling cross-scale manipulations for solid objects, liquid droplets, and biological samples. The high-level flexibility and adaptability of the PPT extend to broad applications in manipulating hydrogel robots, sorting particles, assembling cells, and stimulating cells. By surpassing the limitations of conventional tweezers, the PPT bridges the gap between macroscopic and microscopic manipulations, offering a revolutionary tool in robotics, colloidal science, biomedical fields, and beyond.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100742"},"PeriodicalIF":33.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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