The Innovation最新文献

{"title":"The evolutionary tale of lilies: Giant genomes derived from transposon insertions and polyploidization.","authors":"Sujuan Xu, Runzhou Chen, Xinqi Zhang, Yufeng Wu, Liuyan Yang, Zongyi Sun, Zhitao Zhu, Aiping Song, Ze Wu, Ting Li, Biao Jin, Shihui Niu, Xin-Cheng Huang, Si-Jie Liu, Cheng-Ao Yang, Guixia Jia, Yanhong He, Fang Du, Minmin Chen, Fei Chen, Wenhe Wang, Hongmei Sun, Yongyao Fu, Weibiao Liao, Huaidi Pei, Xuewei Wu, Sixiang Zheng, Jia-Yu Xue, Guogui Ning, Ray Ming, Nianjun Teng","doi":"10.1016/j.xinn.2024.100726","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100726","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100726"},"PeriodicalIF":33.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of non-vdW moiré superlattices.","authors":"Zicheng Li, Xinyu Duan, Zehui Zhou, Linjun Li, Beibei Xu","doi":"10.1016/j.xinn.2024.100723","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100723","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100723"},"PeriodicalIF":33.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence is restructuring a new world.","authors":"Yongjun Xu, Fei Wang, Tangtang Zhang","doi":"10.1016/j.xinn.2024.100725","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100725","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100725"},"PeriodicalIF":33.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial life under Martian permafrost layer.","authors":"Xiuqi Shang, Ruifang Huang, Weidong Sun","doi":"10.1016/j.xinn.2024.100724","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100724","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100724"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirteen years of clusterProfiler.","authors":"Guangchuang Yu","doi":"10.1016/j.xinn.2024.100722","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100722","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100722"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving risk stratification for 2022 European LeukemiaNet favorable-risk patients with acute myeloid leukemia.","authors":"Kellie J Archer, Han Fu, Krzysztof Mrózek, Deedra Nicolet, Alice S Mims, Geoffrey L Uy, Wendy Stock, John C Byrd, Wolfgang Hiddemann, Klaus H Metzeler, Christian Rausch, Utz Krug, Cristina Sauerland, Dennis Görlich, Wolfgang E Berdel, Bernhard J Woermann, Jan Braess, Karsten Spiekermann, Tobias Herold, Ann-Kathrin Eisfeld","doi":"10.1016/j.xinn.2024.100719","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100719","url":null,"abstract":"<p><p>Assignment of patients diagnosed with acute myeloid leukemia (AML) to the 2022 European LeukemiaNet (ELN) favorable genetic risk group has important clinical implications, as allogeneic stem cell transplantation in first complete remission (CR) is not advised due to a relatively good outcome of patients receiving chemotherapy alone and transplant-associated mortality. However, not all favorable genetic risk patients experience long-term relapse-free survival (RFS), making recognition of patients who would most likely be cured of high importance. We analyzed 297 patients aged <60 years with <i>de novo</i> AML classified as 2022 ELN favorable genetic risk who achieved a CR and had RNA sequencing (RNA-seq) and gene mutation data from diagnostic samples available (Alliance trial A152010). To identify prognostically relevant transcripts that can distinguish patients cured from patients susceptible to lower or higher risk of relapse or death, we fit a regularized mixture cure model (MCM) where RNA-seq expression values were our candidate covariates. To validate the identified transcripts, we analyzed 75 patients with <i>de novo</i> AML aged <60 years included in the 2022 ELN favorable genetic risk group who achieved a CR in an independent test set from Gene Expression Omnibus (GSE37642). Our MCM identified 145 transcripts associated with cure or long-term RFS and 149 transcripts associated with latency or shorter-term time to relapse. The area under the curve and C-statistic were, respectively, 0.946 and 0.856 for our training set and 0.877 and 0.857 for our test set. Our results suggest that the favorable risk group includes distinct transcriptionally defined subgroups with different biological properties, which may be useful for refining this genetic risk category.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100719"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brainstem opioid peptidergic neurons regulate cough reflexes in mice.","authors":"Haicheng Lu, Guoqing Chen, Miao Zhao, Huating Gu, Wenxuan Zheng, Xiating Li, Meizhu Huang, Dandan Geng, Minhui Yu, Xuyan Guan, Li Zhang, Huimeng Song, Yaning Li, Menghua Wu, Fan Zhang, Dapeng Li, Qingfeng Wu, Congping Shang, Zhiyong Xie, Peng Cao","doi":"10.1016/j.xinn.2024.100721","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100721","url":null,"abstract":"<p><p>Cough is a vital defensive reflex for expelling harmful substances from the airway. The sensory afferents for the cough reflex have been intensively studied. However, the brain mechanisms underlying the cough reflex remain poorly understood. Here, we developed a paradigm to quantitatively measure cough-like reflexes in mice. Using this paradigm, we found that <i>prodynorphin</i>-expressing (<i>Pdyn</i>+) neurons in the nucleus of the solitary tract (NTS) are critical for capsaicin-induced cough-like reflexes. These neurons receive cough-related neural signals from <i>Trpv1</i>+ vagal sensory neurons. The activation of <i>Pdyn</i>+ NTS neurons triggered respiratory responses resembling cough-like reflexes. Among the divergent projections of <i>Pdyn</i>+ NTS neurons, a glutamatergic pathway projecting to the caudal ventral respiratory group (cVRG), the canonical cough center, was necessary and sufficient for capsaicin-induced cough-like reflexes. These results reveal that <i>Pdyn</i>+ NTS neurons, as a key neuronal population at the entry point of the vagus nerve to the brainstem, initiate cough-like reflexes in mice.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100721"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The initiative for consensus and standards in pig-to-human xenotransplantation in China.","authors":"Dong Niu, Yulong Yin","doi":"10.1016/j.xinn.2024.100717","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100717","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100717"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct imaging of pulmonary gas exchange with hyperpolarized xenon MRI.","authors":"Haidong Li, Hongchuang Li, Ming Zhang, Chaolin Huang, Xin Zhou","doi":"10.1016/j.xinn.2024.100720","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100720","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100720"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical knowledge modeling: An essential step in the digital transformation of healthcare.","authors":"Eric Edelman, Fabian Tijssen, Popke Rein Munniksma, Wim Bast, Harold Ten Bohmer, Nicole van Eldik, Marieke Spreeuwenberg, Wolfgang Buhre, Frits van Merode","doi":"10.1016/j.xinn.2024.100718","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100718","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100718"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}