The Innovation最新文献

{"title":"Erratum: Fast reconstruction and optical-sectioning three-dimensional structured illumination microscopy.","authors":"Ruijie Cao, Yaning Li, Wenyi Wang, Yunzhe Fu, Xiaoyu Bu, Dilizhatai Saimi, Jing Sun, Xichuan Ge, Shan Jiang, Yuru Pei, Baoxiang Gao, Zhixing Chen, Meiqi Li, Peng Xi","doi":"10.1016/j.xinn.2025.100812","DOIUrl":"https://doi.org/10.1016/j.xinn.2025.100812","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.xinn.2024.100757.].</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100812"},"PeriodicalIF":33.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manipulation of a strigolactone transporter in tomato confers resistance to the parasitic weed broomrape.","authors":"Xinwei Ban, Li Qin, Jijun Yan, Jianxin Wu, Qianjin Li, Xiao Su, Yanrong Hao, Qingliang Hu, Liquan Kou, Zongyun Yan, Peiyong Xin, Yuqin Zhang, Lemeng Dong, Harro Bouwmeester, Hong Yu, Qinghui Yu, Sanwen Huang, Tao Lin, Qi Xie, Yuhang Chen, Jinfang Chu, Xia Cui, Jiayang Li, Bing Wang","doi":"10.1016/j.xinn.2025.100815","DOIUrl":"10.1016/j.xinn.2025.100815","url":null,"abstract":"<p><p>Parasitic weeds of the Orobanchaceae family cause substantial economic losses and pose significant threats to global agriculture. However, management of such parasitism is challenging, and very few resistance genes have been cloned and characterized in depth. Here, we performed a genome-wide association study using 152 tomato accessions and identified <i>SlABCG45</i> as a key gene that mediates host resistance to <i>Phelipanche aegyptiaca</i> by affecting the level of strigolactones (SLs) in root exudates. SLs are synthesized and released by host plants and act as germination stimulants for parasitic weeds. We found that SlABCG45 and its close homolog SlABCG44 were membrane-localized SL transporters with essential roles in exudation of SLs to the rhizosphere, resistance to <i>Phelipanche</i> and <i>Orobanche</i>, and upward transport of SLs from roots to shoots. As a predominant environmental stimulant exacerbates parasitism, phosphorus deficiency dramatically induced <i>SlABCG45</i> expression and weakly induced <i>SlABCG44</i> expression via the transcription factors SlNSP1 and SlNSP2. Knockout of <i>SlABCG45</i> in tomato had little effect on yield traits in a broomrape-free field, but conferred increased resistance to different <i>Phelipanche</i> and <i>Orobanche</i> species, resulting in an ∼30% yield increase in a <i>Phelipanche</i>-infested field. Our findings reveal that targeting a single gene by genome editing can confer broad-spectrum parasite resistance in tomato, providing an effective strategy for the sustainable control of parasitic plants in agriculture.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100815"},"PeriodicalIF":33.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-calibrating multiplexed microneedle electrode array for continuous mapping of subcutaneous multi-analytes in diabetes.","authors":"Xiangling Li, Shantao Zheng, Mengyi He, Xinshuo Huang, Cheng Yang, Jingshan Mo, Jingbo Yang, Chengduan Yang, Huijiuan Chen, Xi Xie","doi":"10.1016/j.xinn.2024.100781","DOIUrl":"10.1016/j.xinn.2024.100781","url":null,"abstract":"<p><p>Monitoring multiplexed biochemical markers is beneficial for the comprehensive evaluation of diabetes-associated complications. Techniques for multiplexed analyses in interstitial fluids have often been restricted by the difficulties of electrode materials in accurately detecting chemicals in complex subcutaneous spaces. In particular, the signal stability of enzyme-based sensing electrodes often inevitably decreases due to enzyme degradation or interference <i>in vivo</i>. In this study, we developed a self-calibrating multiplexed microneedle (MN) electrode array (SC-MMNEA) capable of continuous, real-time monitoring of multiple types of bioanalytes (glucose, cholesterol, uric acid, lactate, reactive oxygen species [ROSs], Na⁺, K⁺, Ca²⁺, and pH) in the subcutaneous space. Each type of analyte was detected by a discrete MN electrode assembled in an integrated array with single-MN resolution. Moreover, this device utilized an MN-delivery-mediated self-calibration technique to address the inherent problem of decreased accuracy of implantable electrodes caused by long-term tissue variation and enzyme degradation, and this technique might increase the reliability of the MN sensors. Our results indicated that SC-MMNEA could provide real-time monitoring of multiplexed analyte concentrations in a rat model with good accuracy, especially after self-calibration. SC-MMNEA has the advantages of <i>in situ</i> and minimally invasive monitoring of physiological states and the potential to promote wearable devices for long-term monitoring of chemical species <i>in vivo</i>.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100781"},"PeriodicalIF":33.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.","authors":"Shuhui Sun, Shuai Ma, Yusheng Cai, Si Wang, Jie Ren, Yuanhan Yang, Jiale Ping, Xuebao Wang, Yiyuan Zhang, Haoteng Yan, Wei Li, Concepcion Rodriguez Esteban, Yan Yu, Feifei Liu, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu","doi":"10.1016/j.xinn.2025.100806","DOIUrl":"https://doi.org/10.1016/j.xinn.2025.100806","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.xinn.2023.100380.].</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100806"},"PeriodicalIF":33.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topological insulators for thermoelectrics: A perspective from beneath the surface.","authors":"Michael Y Toriyama, G Jeffrey Snyder","doi":"10.1016/j.xinn.2024.100782","DOIUrl":"10.1016/j.xinn.2024.100782","url":null,"abstract":"<p><p>Thermoelectric properties of topological insulators have traditionally been examined in the context of their metallic surface states. However, recent studies have begun to unveil intriguing thermoelectric effects emerging from the bulk electronic states of topological insulators, which have largely been overlooked in the past. Charge transport phenomena through the bulk are especially important under typical operating conditions of thermoelectric devices, necessitating a comprehensive review of both surface and bulk transport in topological insulators. Here, we review thermoelectric properties that are uniquely observed in topological insulators, placing special emphasis on unconventional phenomena emerging from bulk states. We demonstrate that unusual thermoelectric effects arising from bulk states, such as band inversion-driven warping, can be discerned in experiments through a simple analysis of the weighted mobility. We believe that there is still plenty to uncover within the bulk of topological insulators, yet our current understanding can already inspire new strategies for designing and discovering new materials for next-generation thermoelectrics.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100782"},"PeriodicalIF":33.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity.","authors":"Ruiyang Zi, Kaicheng Shen, Pengfei Zheng, Xingxing Su, Yishi Yang, Yanrong Chen, Haisu Dai, Chengyi Mao, Yongling Lu, Liting Wang, Hongbo Ma, Wei Wang, Qingyun Li, Wei Lu, Chengtao Li, Shuangjia Zheng, Hui Shi, Xiaohong Liu, Zhiyu Chen, Houjie Liang, Juanjuan Ou","doi":"10.1016/j.xinn.2024.100783","DOIUrl":"10.1016/j.xinn.2024.100783","url":null,"abstract":"<p><p>Pancreatic adenocarcinoma (PAAD) is a highly lethal malignancy with an immunosuppressive microenvironment and a limited immunotherapy response<b>.</b> Cholesterol is necessary for rapid growth of cancer cells, and cholesterol metabolism reprogramming is a hallmark of PAAD. How PAAD cells initiate cholesterol reprogramming to sustain their growth demand and suppressive immunomicroenvironment remains elusive. In this study, we for the first time revealed that PAAD cells overcome cholesterol shortage and immune surveillance via ectopically overexpressing NPC1L1, a cholesterol transporter<b>,</b> but function as a two-pronged checkpoint, which not only directly suppresses TCR activation of CD8⁺T cells but also hijacks the intracellular cholesterol from CD8⁺T cells. <i>In vivo</i>, we showed that ezetimibe, an NPC1L1 inhibitor usually for hypercholesterolemia, efficiently prevented PAAD cells from depriving cholesterol of CD8⁺T cells, and improved the anti-tumor immunity of PAAD to synergize with PD-1 blockade, suggesting NPC1L1 as a promising target to rescue the anti-tumor activity in PAAD.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100783"},"PeriodicalIF":33.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.","authors":"Lei-Yun Wang, Bing Yu, Ying Peng, Kai Mou, Yan Zhan, Yi-Min Wang, Wei Ji, Chun Xu, Le-Dong Xiao, Yan Chen, Hua Wang, Zhi-Hua She, Peng Dai, Gan-Ye Zhao, Yang Wang, Lu-Lu Yu, Miao Yu, Ke Liu, Jia-Jia Cui, Rong Liu, Xi Li, Yuan-Fei Huang, Zhao-Qian Liu, Dong-Sheng Ouyang, Wei Zhang, Qing Li, Xing-Liang Xiong, Cheng-Xian Guo, Jin-Gao Li, Qiao-Li Lv, Qing-He Xing, Hai-Jian Wang, Zhi-Ling Li, Ji-Chu Wu, Long-Jian Huang, Jian He, Li-Ming Tan, Wen-Xu Hong, Xue-Chang Wang, Chao-Peng Li, Qin Lu, Long Zhang, Xiang-Dong Kong, Hong-Hao Zhou, Ji-Ye Yin","doi":"10.1016/j.xinn.2024.100773","DOIUrl":"10.1016/j.xinn.2024.100773","url":null,"abstract":"<p><p>Pharmacogenomic landscapes and related databases are important for identifying the biomarkers of drug response and toxicity. However, these data are still lacking for the Chinese population. In this study, we constructed a pharmacogenomic landscape and an associated database using whole-genome sequencing data generated by non-invasive prenatal testing in 206,640 Chinese individuals. In total, 1,577,513 variants (including 331,610 novel variants) were identified among 3,538 pharmacogenes related to 2,086 drugs. We found that the variant spectrum in the Chinese population differed among the seven major regions. Regional differences also exist among provinces in China. The average numbers of drug enzyme, transporter, and receptor variants were 258, 557, and 632, respectively. Subsequent correlation analysis indicated that the pharmacogenes affecting multiple drugs had fewer variants. Among the 16 categories of drugs, we found that nervous system, cardiovascular system, and genitourinary system/sex hormone drugs were more likely to be affected by variants of pharmacogenes. Characteristics of the variants in the enzyme, transporter, and receptor subfamilies showed specificity. To explore the clinical utility of these data, a genetic association study was conducted on 1,019 lung cancer patients. Two novel variants, <i>AKT2</i> chr19:40770621 C>G and <i>SLC19A1</i> chr21:46934171 A>C, were identified as novel platinum response biomarkers. Finally, a pharmacogenomic database, named the Chinese Pharmacogenomic Knowledge Base (CNPKB: http://www.cnpkb.com.cn/), was constructed to collect all the data. In summary, a pharmacogenomic landscape and database for the Chinese population were constructed in this study, which could support personalized Chinese medicine in the future.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100773"},"PeriodicalIF":33.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting.","authors":"Zhijie Wang, Chutian Wang, Ying Ji, Mingxin Yang, Chan Li, Mengyao Li, Jingru Yang, Hongyu Tang, Xianwei Luo, Haoyang Hao, Zhicai Liu, Kui Chen, Yanan Chang, Hui Yuan, Lin Feng, Gengmei Xing, Juan Li","doi":"10.1016/j.xinn.2024.100777","DOIUrl":"10.1016/j.xinn.2024.100777","url":null,"abstract":"<p><p>We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system to precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% ± 2% [w/w]) was encapsulated in MDNs by an imide bond. MDNs could imitate the movement mode of a school of wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) to adapt to the changing and complex physiological environment through the 3D MMP system. MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to <i>in vivo</i> imaging (magnetic resonance imaging and fluorescence) and histopathology. The performance of fabricated MDNs was verified through cells and tumor-bearing mouse models. The MDNs showed high efficiency of drug delivery and targeting at the tumor site (>10-fold), lower toxicity than free doxorubicin (5 mg/kg body weight), activated immune response in the tumor site, and significantly lengthened survival for mice. The synergistic interaction between MDNs and the 3D MMP system underscores the immense potential of this drug delivery system, indicating a potential revolution in the field of tumor chemotherapy.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100777"},"PeriodicalIF":33.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and regime state shifts of lacustrine aquatic vegetation.","authors":"Juhua Luo, Hongtao Duan, Ying Xu, Ming Shen, Yunlin Zhang, Qitao Xiao, Guigao Ni, Kang Wang, Yihao Xin, Tianci Qi, Lian Feng, Yinguo Qiu, Erik Jeppesen, R Iestyn Woolway","doi":"10.1016/j.xinn.2024.100784","DOIUrl":"10.1016/j.xinn.2024.100784","url":null,"abstract":"<p><p>Aquatic vegetation (AV) is vital for maintaining the health of lake ecosystems, with submerged aquatic vegetation (SAV) and floating/emergent aquatic vegetation (FEAV) representing clear and shaded states, respectively. However, global SAV and FEAV dynamics are poorly understood due to data scarcity. To address this gap, we developed an innovative AV mapping algorithm and workflow using satellite imagery (1.4 million Landsat images) from 1989 to 2021 and created a global database of AV across 5,587 shallow lakes. Our findings suggest that AV covers 108,186 km² on average globally, accounting for 28.9% (FEAV, 15.8%; SAV, 13.1%) of the total lake area. Over two decades, we observed a notable transition: SAV decreased by 30.4%, while FEAV increased by 15.6%, leading to a substantial net loss of AV. This global trend indicates a shift from clear to shaded conditions, increasingly progressing toward turbid states dominated by phytoplankton. We found that human-induced eutrophication was the primary driver of change until the early 2010s, after which global warming and rising lake temperatures became the dominant drivers. These trends serve as a warning sign of deteriorating lake health worldwide. With future climate warming and intensified eutrophication, these ongoing trends pose a significant risk of disrupting lake ecosystems.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100784"},"PeriodicalIF":33.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging MOFs, COFs, and their derivatives for energy and environmental applications.","authors":"Xinyue Zhang, Minjia Yan, Pei Chen, Jiaqi Li, Yuxuan Li, Hong Li, Xiaolu Liu, Zhongshan Chen, Hui Yang, Suhua Wang, Jianjun Wang, Zhenwu Tang, Qifei Huang, Jiehong Lei, Tasawar Hayat, Zhijian Liu, Liang Mao, Tao Duan, Xiangke Wang","doi":"10.1016/j.xinn.2024.100778","DOIUrl":"10.1016/j.xinn.2024.100778","url":null,"abstract":"<p><p>Traditional fossil fuels significantly contribute to energy supply, economic development, and advancements in science and technology. However, prolonged and extensive use of fossil fuels has resulted in increasingly severe environmental pollution. Consequently, it is imperative to develop new, clean, and pollution-free energy sources with high energy density and versatility as substitutes for conventional fossil fuels, although this remains a considerable challenge. Simultaneously, addressing water pollution is a critical concern. The development, design, and optimization of functional nanomaterials are pivotal to advancing new energy solutions and pollutant remediation. Emerging porous framework materials such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), recognized as exemplary crystalline porous materials, exhibit potential in energy and environmental applications due to their high specific surface area, adjustable pore sizes and structures, permanent porosity, and customizable functionalities. This work provides a comprehensive and systematic review of the applications of MOFs, COFs, and their derivatives in emerging energy technologies, including the oxygen reduction reaction, oxygen evolution reaction, hydrogen evolution reaction, lithium-ion batteries, and environmental pollution remediation such as the carbon dioxide reduction reaction and environmental pollution management. In addition, strategies for performance adjustment and the structure-effect relationships of MOFs, COFs, and their derivatives for these applications are explored. Interaction mechanisms are summarized based on experimental discussions, theoretical calculations, and advanced spectroscopy analyses. The challenges, future prospects, and opportunities for tailoring these materials for energy and environmental applications are presented.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 2","pages":"100778"},"PeriodicalIF":33.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}