The InnovationPub Date : 2025-05-15eCollection Date: 2025-08-04DOI: 10.1016/j.xinn.2025.100952
Sungwan Kim, Adharsh Chellappaa, Juhyeon Chun, Jaebaek Lee, Joseph M Hardie, Manoj K Kanakasabapathy, Hemanth Kandula, Prudhvi Thirumalaraju, Gregory P Fricker, Jenna Gustafson, Raymond T Chung, Jorge Mera, Hadi Shafiee
{"title":"A fully automated, ultrasensitive luminescence cascade sensor to address hepatitis C diagnostic disparity.","authors":"Sungwan Kim, Adharsh Chellappaa, Juhyeon Chun, Jaebaek Lee, Joseph M Hardie, Manoj K Kanakasabapathy, Hemanth Kandula, Prudhvi Thirumalaraju, Gregory P Fricker, Jenna Gustafson, Raymond T Chung, Jorge Mera, Hadi Shafiee","doi":"10.1016/j.xinn.2025.100952","DOIUrl":"10.1016/j.xinn.2025.100952","url":null,"abstract":"<p><p>Viral hepatitis poses a significant global health burden, with chronic hepatitis B and C causing about 1 million annual deaths from liver cancer and cirrhosis. Over 1.5 million new hepatitis C virus (HCV) cases arise yearly, especially among vulnerable groups like American Indians and Alaska Natives (AI/AN). Despite effective direct-acting antivirals, early HCV diagnosis remains challenging, particularly in resource-limited settings. Current two-step testing methods are costly and prone to patient dropout. Point-of-care (POC) HCV antigen (Ag) testing offers a promising early detection approach, but no US Food and Drug Administration (FDA)-approved POC test meets the sensitivity and specificity needed for low viral loads. To address this, we developed a fully automated bioluminescence-based POC assay using a cascade-based signal amplification strategy. Evaluated on 71 AI/AN samples, it showed 97% sensitivity, 94% specificity, and 96% accuracy. This technology can improve health equity by enabling accessible and reliable HCV testing for disproportionately affected populations.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 8","pages":"100952"},"PeriodicalIF":25.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The InnovationPub Date : 2025-05-15eCollection Date: 2025-09-08DOI: 10.1016/j.xinn.2025.100954
Andrea Tomassi, Andrea Falegnami, Elpidio Romano
{"title":"Unveiling simplexity: A new paradigm for understanding complex adaptive systems and driving technological innovation.","authors":"Andrea Tomassi, Andrea Falegnami, Elpidio Romano","doi":"10.1016/j.xinn.2025.100954","DOIUrl":"10.1016/j.xinn.2025.100954","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100954"},"PeriodicalIF":25.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The InnovationPub Date : 2025-05-14eCollection Date: 2025-08-04DOI: 10.1016/j.xinn.2025.100950
Lifu Zhang, Sai Zhang, Arif U R Rehman, Sa Wang, Xuejian Sun, Yongxin Liu, Qingxi Tong
{"title":"A revolutionary multi-dimensional data format for remote sensing.","authors":"Lifu Zhang, Sai Zhang, Arif U R Rehman, Sa Wang, Xuejian Sun, Yongxin Liu, Qingxi Tong","doi":"10.1016/j.xinn.2025.100950","DOIUrl":"10.1016/j.xinn.2025.100950","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 8","pages":"100950"},"PeriodicalIF":25.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The InnovationPub Date : 2025-05-12eCollection Date: 2025-09-08DOI: 10.1016/j.xinn.2025.100947
Tong Li, Yan Fang, Yuting Fan, Xiaobing Zhou, Hui Yin, Michael Melkonian, Yuanming Zhang
{"title":"Migration and structural implication of cyanobacteria in biological soil crusts in response to water and particle burial.","authors":"Tong Li, Yan Fang, Yuting Fan, Xiaobing Zhou, Hui Yin, Michael Melkonian, Yuanming Zhang","doi":"10.1016/j.xinn.2025.100947","DOIUrl":"10.1016/j.xinn.2025.100947","url":null,"abstract":"<p><p>Cyanobacteria are constructors of biological soil crusts (BSCs); their motility is thought to be crucial for surviving burial and BSC expansion. In this study, X-ray computed microtomography in combination with machine-learning-based image processing was employed to investigate cyanobacteria-dominated BSCs. The structural changes in these BSCs, as well as the behaviors of the dominant cyanobacterium <i>Microcoleus vaginatus</i> therein, in response to changes in water availability and particle burial were visualized and quantitatively analyzed. Hygroscopic swelling of cyanobacteria biomaterials increased pore-network complexity and reduced the porosity and hydraulic radius. Trichomes of <i>M. vaginatus</i> inside BSCs were connected to the surface by tunnel-like structures made of extracellular polymeric substances (EPSs), through which the trichomes migrated to and from the surface in bundles. Despite the generally negative effects of EPSs on hydraulic conductivity, EPS tunnels have the potential to enhance water transfer to the trichomes. Extensive hydration and particle burial led to the spreading migration of individual trichomes, forming net-like structures inside the newly deposited layer. The results highlight the significance of the structural organization of EPSs within BSCs and the importance of cyanobacterial migration in BSC expansion.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100947"},"PeriodicalIF":25.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foundation models and intelligent decision-making: Progress, challenges, and perspectives.","authors":"Jincai Huang, Yongjun Xu, Qi Wang, Qi Cheems Wang, Xingxing Liang, Fei Wang, Zhao Zhang, Wei Wei, Boxuan Zhang, Libo Huang, Jingru Chang, Liantao Ma, Ting Ma, Yuxuan Liang, Jie Zhang, Jian Guo, Xuhui Jiang, Xinxin Fan, Zhulin An, Tingting Li, Xuefei Li, Zezhi Shao, Tangwen Qian, Tao Sun, Boyu Diao, Chuanguang Yang, Chenqing Yu, Yiqing Wu, Mengxian Li, Haifeng Zhang, Yongcheng Zeng, Zhicheng Zhang, Zhengqiu Zhu, Yiqin Lv, Aming Li, Xu Chen, Bo An, Wei Xiao, Chenguang Bai, Yuxing Mao, Zhigang Yin, Sheng Gui, Wentao Su, Yinghao Zhu, Junyi Gao, Xinyu He, Yizhou Li, Guangyin Jin, Xiang Ao, Xuehao Zhai, Haoran Tan, Lijun Yun, Hongquan Shi, Jun Li, Changjun Fan, Kuihua Huang, Ewen Harrison, Victor C M Leung, Sihang Qiu, Yanjie Dong, Xiaolong Zheng, Gang Wang, Yu Zheng, Yuanzhuo Wang, Jiafeng Guo, Lizhe Wang, Xueqi Cheng, Yaonan Wang, Shanlin Yang, Mengyin Fu, Aiguo Fei","doi":"10.1016/j.xinn.2025.100948","DOIUrl":"10.1016/j.xinn.2025.100948","url":null,"abstract":"<p><p>Intelligent decision-making (IDM) is a cornerstone of artificial intelligence (AI) designed to automate or augment decision processes. Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make effective and adaptive choices and decompose complex tasks into manageable steps, such as AI agents and high-level reinforcement learning. Recent advances in multimodal foundation-based approaches unify diverse input modalities-such as vision, language, and sensory data-into a cohesive decision-making process. Foundation models (FMs) have become pivotal in science and industry, transforming decision-making and research capabilities. Their large-scale, multimodal data-processing abilities foster adaptability and interdisciplinary breakthroughs across fields such as healthcare, life sciences, and education. This survey examines IDM's evolution, advanced paradigms with FMs and their transformative impact on decision-making across diverse scientific and industrial domains, highlighting the challenges and opportunities in building efficient, adaptive, and ethical decision systems.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100948"},"PeriodicalIF":33.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The InnovationPub Date : 2025-05-09eCollection Date: 2025-09-08DOI: 10.1016/j.xinn.2025.100944
Yongzhen Wang, Yibo Han, Kai Han, Jun Shen
{"title":"Does DeepSeek curb the surge of energy consumption in data centers?","authors":"Yongzhen Wang, Yibo Han, Kai Han, Jun Shen","doi":"10.1016/j.xinn.2025.100944","DOIUrl":"10.1016/j.xinn.2025.100944","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 9","pages":"100944"},"PeriodicalIF":25.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The InnovationPub Date : 2025-05-09eCollection Date: 2025-06-02DOI: 10.1016/j.xinn.2025.100945
Kai Sun, Liyi Zhou, Yike Guo
{"title":"Decentralized knowledge assessment.","authors":"Kai Sun, Liyi Zhou, Yike Guo","doi":"10.1016/j.xinn.2025.100945","DOIUrl":"10.1016/j.xinn.2025.100945","url":null,"abstract":"<p><p>The peer-review process, which serves as the quality-control mechanism of scientific knowledge production, has been criticized for its bias, unreliability, and inefficiency. Academic conferences and journals typically rely on a centralized mechanism for reviewer assignment and paper assessment. We argue that this centralization is a major factor contributing to the unreliability of the review process, leading to deficiencies in the current knowledge-assessment systems. To address this, we propose a novel decentralized model that democratizes peer review by shifting decision-making rights from centralized authorities to all scholars participating in a scholarly community. Our model includes a dual-rewarding incentive mechanism that motivates scholars to actively participate in peer review by recognizing both their effort and scientific contributions. This model transforms peer review from passive judgment to active collaboration. We simulated the model in conference settings and demonstrated its potential to revolutionize knowledge production and dissemination.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100945"},"PeriodicalIF":33.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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