The Innovation最新文献

{"title":"AI needs a new philosophy of science.","authors":"Gustau Camps-Valls","doi":"10.1016/j.xinn.2026.101311","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101311","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101311"},"PeriodicalIF":25.7,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory risks of microplastics and nanoplastics: Where? What? How?","authors":"Yaxin Guo, Yao Guo, Xingde Du, Yunwei Yan, Dong Ding, Jun Yang, Kangfeng Ge, Ruiyang Meng, Zhenfei Wang, Haohao Liu","doi":"10.1016/j.xinn.2026.101309","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101309","url":null,"abstract":"<p><p>Microplastics (MPs) and nanoplastics (NPs) are pervasive and persistent environmental pollutants raising growing concerns regarding their potential hazards to human respiratory health. This review systematically summarizes current epidemiological evidence and experimental findings concerning the respiratory toxicity of MPs and NPs. Exposure to these particles is associated with various pulmonary disorders, including pneumonia, chronic obstructive pulmonary disease, asthma, and other pathological lung injury. At the molecular level, MP- and NP-induced toxicity primarily involves oxidative stress, leading to mitochondrial dysfunction and endoplasmic reticulum stress. This oxidative damage triggers diverse forms of cell death, such as apoptosis, pyroptosis, ferroptosis, and autophagy. Furthermore, MPs and NPs induce pulmonary inflammation, disrupt the integrity of the alveolar-capillary barrier, promote pulmonary fibrosis, and cause DNA damage, mainly via oxidative stress pathways. This review also identifies critical directions for future research on the respiratory toxicity of MPs and NPs. Overall, this review highlights the respiratory health risks associated with MPs and NPs, emphasizing mechanisms involving oxidative stress, inflammation, and fibrosis, and underscores the urgent need for further investigation. It provides essential toxicological evidence and insights that could inform the development of effective protective strategies.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101309"},"PeriodicalIF":25.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine.","authors":"Long Li, Jing Ji, He Ren, Lilan Gao, Xiaona Li, Ning Li, Songbai Zhang, Kai Tang, Zedong Li, Weiyan Ren, Qing-Ping Yao, Kai Huang, He Gong, Yingfeng Shao, Xianglong Lin, Xin Wang, Xiuqing Qian, Jie Song, Yiran Jiang, Hui Chen, Bo Che, Dongyuan Lü, Yu Du, Fan Feng, Yanli Liu, Yan Li, Meiying Luo, Ruotian Du, Cunyu Zhang, Guanshuo Hu, Yufei Ma, Shutong Wang, Rui Yang, Fang Pu, Bingjie Xiang, Ming Zhang, Xinghua Shi, Lizhen Wang, Bo Li, Damir Kračun, Qian Chen, Ahmed Elsheikh, Zi-Jun Liu, Baoyu Liu, Chuanrong Zhao, Yonggang Lü, Zhu Zeng, Zhiyong Li, Yiyao Liu, Guixue Wang, Wenchang Tan, Chunqiu Zhang, Min Zhang, Jizhong Lou, Youhua Tan, Linhong Deng, Mian Long, Ying-Xin Qi, Weiyi Chen, Feng Xu, Yubo Fan, Fan Song","doi":"10.1016/j.xinn.2026.101307","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101307","url":null,"abstract":"<p><p>The mechanical environments endured by the human body profoundly influence life activities across different scales, from single molecules to complicated systems. Gaining insight into the mechanical factors and their biological implications is crucial for deciphering physiological and pathological processes and advancing innovations in drug development and therapeutic approaches for various diseases. Recently, we have witnessed rapid advances in biomechanics and mechanobiology, which, however, are not fully recognized by the clinical community and effectively integrated into medical decision-making, highlighting a translational gap between mechano-based discovery and therapeutic application. Here, we first provide a comprehensive review of research progress in biomechanics and mechanobiology, focusing on key areas such as the cardiovascular system, bone and joints, ocular tissues, liver, lung, the craniomandibular system, cancer, and immunology. We demonstrate how mechanical cues drive health and disease across biological levels, offering insights into complex physiological and pathological mechanisms. Further, we explore the diverse applications of biomechanics and mechanobiology in disease diagnosis, treatment, and rehabilitation. Mechanical insights fuel medical innovations through advanced diagnostic tools, novel therapies, and effective rehabilitation protocols, enhancing clinical outcomes. Looking ahead, we outline future directions of biomechanics and mechanobiology, emphasizing interdisciplinary integration, artificial intelligence, model development, and extreme environments, which hold the promise to deepen scientific understanding and propel technological innovations. This review highlights the transformative potential of biomechanics and mechanobiology in driving scientific and clinical advancements and helps bridge the long-standing gap between biomechanical research and clinical practice.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 4","pages":"101307"},"PeriodicalIF":25.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive benefits of air purification among schoolchildren: A randomized, double-blind, crossover trial.","authors":"Yanwen Wang, Yue Sun, Jie Ban, Jianlong Fang, Qinghua Sun, Yanjun Du, Yuanyuan Liu, Haoran Dong, Qing Wang, Chen Chen, Yi Zhang, Runmei Ma, Renjie Chen, Haidong Kan, Tiantian Li","doi":"10.1016/j.xinn.2026.101304","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101304","url":null,"abstract":"<p><p>Particulate matter was shown to significantly affect children's cognition through intermediate-term to long-term exposure; however, whether and to what extent air purification can improve the neurodevelopment of schoolchildren remains unclear. We conducted a randomized, controlled, double-blind, crossover trial for cognitive health among primary children aged 10-12 years through a multi-setting, mid-term air-purification intervention in Henan Province, China. The intervention and control groups received alternative true or sham purification in classrooms and bedrooms in a random manner. The two intervention phases (76 days) were separated by a washout period of 88 days. Among 57 participants, air purification reduced personal exposure to PM_2.5 from 35.13 to 18.19 μg/m³. For academic performance, compared to the control group, the intervention group showed significant increases (0.22, 0.20, 5.19, and 4.11, respectively) in the improvement of standardized Chinese score (derived from raw scores through <i>Z</i> score transformation), total score (including Chinese and math), Chinese ranking, and total ranking. Regarding the cognitive-function test, executive function was significantly improved in the intervention group. For example, there were greater reductions in total errors (10.58) and non-perseverative errors (10.31) and more pronounced improvements in completed categories (12.94) and conceptualized thinking (2.02). We also observed significant increases in plasma amyloid β42 associated with the intervention. The improvements in cognitive health were also associated with reduced personal PM_2.5 concentrations. Collectively, this trial provides robust evidence that mid-term, multi-setting indoor air purification can significantly enhance cognitive health in children in areas with high air-pollution levels.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101304"},"PeriodicalIF":25.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updating global green-hydrogen production costs and configurations under future climates.","authors":"Haochi Wu, Mingyang Sun, Michael T Craig","doi":"10.1016/j.xinn.2026.101303","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101303","url":null,"abstract":"<p><p>Meeting global decarbonization targets requires large-scale, low-carbon hydrogen (H₂) production around mid-century. A crucial pathway for this production is electrolysis driven by renewables, tying hydrogen production and costs to spatially varying renewable resources. The potential, variability, and complementarity of renewable resources, though, will be affected by climate change. We quantify the impact of climate change on renewable-energy generation for H₂ production globally. We use an investment and operations optimization model for hydrogen systems to estimate geographically explicit and regionally aggregated levelized cost of hydrogens (LCOHs) under historical and future climates. We find climate change could raise the cost of green-hydrogen production by up to 20% in some global locations, and about 16% of global locations could see LCOH increases or decreases exceeding 5%. Southeast Asia and Europe in particular see LCOH reductions due to climate change, while North America sees LCOH increase. Most locations, though, see modest impacts of climate change on hydrogen costs. We also find modest cost consequences from climate change for locations with active hydrogen development. Our results highlight the need for proactive investment strategies to accommodate the climatic variations affecting renewable hydrogen production, especially in countries with stricter H₂ power-grid import limits and with firm H₂ demand for industrial processes.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 3","pages":"101303"},"PeriodicalIF":25.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the glassy state: Ultrafast detection of amorphous liquid-solid transition.","authors":"Jing Guo, Peng Liu, X-D Xiang","doi":"10.1016/j.xinn.2026.101301","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101301","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 4","pages":"101301"},"PeriodicalIF":25.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-immune interactions in gastrointestinal oncology: Mechanisms, challenges, and therapeutic potential.","authors":"Xueying Wang, Wentong Mei, Zifan Wang, Mengmeng Ma, Jianbo Wang, Jiafu Ji, Xiaofang Xing","doi":"10.1016/j.xinn.2026.101300","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101300","url":null,"abstract":"<p><p>Gastrointestinal (GI) cancers represent a leading cause of cancer-related mortality globally, characterized by a complex tumor microenvironment where bidirectional neuro-cancer-immune interactions critically influence disease progression. The CNS integrates ascending gut-derived signals and transmits descending regulatory responses through distinct autonomic neural pathways, while peripheral sensory, sympathetic, parasympathetic, and enteric neurons modulate innate and adaptive immune cell functions through specialized neurotransmitter circuits. This coordinated neural-immune crosstalk operates within the neuro-endocrine-immune axis, forming an integrated regulatory network that governs tissue homeostasis and tumor surveillance. Emerging evidence demonstrates that neural dysregulation promotes GI tumorigenesis through immunosuppressive mechanisms, while therapeutic neural interventions show promising efficacy in preclinical cancer models. The gut-brain axis represents a paradigmatic framework for understanding how neuroimmune signaling influences cancer progression and metastasis, revealing previously unrecognized diagnostic, prognostic, and therapeutic opportunities. Here, we review the molecular mechanisms underlying neuroimmune interactions in GI cancer pathogenesis and evaluate the therapeutic potential of neurally targeted interventions for cancer management.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101300"},"PeriodicalIF":25.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microdroplet surfaces interface organic molecule formation and the origins of life.","authors":"Shuai Chen, Nikolay Kornienko","doi":"10.1016/j.xinn.2026.101278","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101278","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 4","pages":"101278"},"PeriodicalIF":25.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-induction of stromal and epithelial progenitors for renal regeneration.","authors":"Thomas Vincent, Samera Nademi, Michael Namestnikov, Osnat Cohen-Zontag, Benjamin Dekel, Benjamin S Freedman","doi":"10.1016/j.xinn.2026.101281","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101281","url":null,"abstract":"<p><p>Multiple pools of developmental progenitors are needed for kidney regeneration, but directing differentiation of each of these independently is rate limiting and disruptive to the process. We demonstrate that a mere 4 days of differentiation generates an induced metanephric mesenchyme (iMM) containing both nephron progenitor cells and renal stromal progenitor cells. When implanted beneath the kidney capsule of immunodeficient mice, iMM differentiates into podocytes, mesangial cells, and tubules that recruit host blood vessels to form glomeruli and peritubular capillaries. In contrast, mature organoids rapidly lose differentiated features after implantation and fail to become productively vascularized by the host. By examining morphological changes and gene expression patterns, we demarcate a window of opportunity for successful implantation during which iMM exists <i>in vitro</i>. Young organoid cultures containing epithelial and stromal progenitor cells thus provide a rapid, one-pot starting material for nephron regeneration, a concept that may be broadly applicable to many organ systems.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101281"},"PeriodicalIF":25.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal information-fused embodied intelligence toward autonomous robotic microsurgery.","authors":"Yawen Deng, Zhen Li, Qiang Ye, Yupeng Zhai, Zhangguo Yu, Gui-Bin Bian","doi":"10.1016/j.xinn.2026.101298","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101298","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 5","pages":"101298"},"PeriodicalIF":25.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}