The Innovation最新文献_第3页

Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100745

Luoyan Ai, Qian Li, Shilong Zhang, Yu Dong, Mudan Yang, Jin Li, Yueyin Pan, Ying Yuan, Shanyong Yi, Junsheng Wang, Ying Cheng, Jifeng Feng, Shegan Gao, Xicheng Wang, Song Qu, Xizhi Zhang, Jin Lu, Peng Xiu, Shuni Wang, Xinfeng Yang, Yiyi Yu, Tianshu Liu

{"title":"Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.","authors":"Luoyan Ai, Qian Li, Shilong Zhang, Yu Dong, Mudan Yang, Jin Li, Yueyin Pan, Ying Yuan, Shanyong Yi, Junsheng Wang, Ying Cheng, Jifeng Feng, Shegan Gao, Xicheng Wang, Song Qu, Xizhi Zhang, Jin Lu, Peng Xiu, Shuni Wang, Xinfeng Yang, Yiyi Yu, Tianshu Liu","doi":"10.1016/j.xinn.2024.100745","DOIUrl":"10.1016/j.xinn.2024.100745","url":null,"abstract":"Concurrent inhibition of angiogenesis and immune checkpoints represents a potent therapeutic approach. We conducted a phase 2, multicenter, basket study to assess the efficacy and safety of combination therapy of famitinib (anti-angiogenic agent) plus camrelizumab (PD-1 antagonist) in patients with metastatic solid tumors across 11 cohorts (this study was registered at Clinicaltrials.gov [NCT04346381]). This report focuses on the cohort of patients with metastatic or advanced colorectal cancer. Eligible patients, who had previously received ≥2 lines of systemic treatments for their metastatic disease, were treated with famitinib (20 mg once daily) in combination with camrelizumab (200 mg intravenously every 3 weeks). The primary endpoint was the objective response rate, with secondary endpoints encompassing progression-free survival, overall survival, duration of response, safety and exploratory biomarkers. A total of 44 patients were enrolled and treated. With a median follow-up time of 9.46 months (range 2.0-22.5 months), objective responses were observed in 6 patients (13.6%; 95% confidence interval [CI], 5.2%-27.4%), all of whom had rectal cancer. The median duration of response is 6.2 months (95% CI, 2.3-10.6 months). Median progression-free survival was 3.3 months (95% CI, 2.1-4.1 months), and median overall survival was 10.9 months (95% CI, 7.6-15.2 months). Among the 44 patients, 29 (65.9%) experienced grade 3 or 4 treatment-related adverse events, predominantly hypertension and proteinuria. In conclusion, the combination of famitinib and camrelizumab demonstrates promising antitumor activity with a manageable safety profile in metastatic colorectal cancer patients. Further research is warranted to confirm and extend these ﬁndings.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100745"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate effects of ecosystem change converge according to the ratio of the daytime to daily vapor flux.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100733

Langqin Hua, Lin Li, Wenjing Chen, Xuemeng Wang, Xin Xiong, Guoyi Zhou

{"title":"Climate effects of ecosystem change converge according to the ratio of the daytime to daily vapor flux.","authors":"Langqin Hua, Lin Li, Wenjing Chen, Xuemeng Wang, Xin Xiong, Guoyi Zhou","doi":"10.1016/j.xinn.2024.100733","DOIUrl":"10.1016/j.xinn.2024.100733","url":null,"abstract":"Ecosystem changes can simultaneously generate various climate-related effects, such as evapotranspiration (vapor flux) effects, carbon-cycle effects, and surface temperature effects. These effects are coupled with one another because they are generated through the same biophysical and biogeochemical processes. Consequently, given an easily measurable effect, other effects can be predicted from the measured effect. Here, based on global eddy covariance (EC) observations, we show that the ratio of the daytime to daily vapor flux (RATIO) reflects the complexity of various ecosystem types and is highly coupled with climate effects of ecosystem changes. For the same daily RATIO, the magnitudes of the same EC variable remain unchanged across all of the ecosystems and, thus, EC observations for an ecosystem or place can be mapped to other ecosystems or places in accordance with their daily RATIO values. By applying the daily RATIO, the effects of ecosystem changes on the surface temperature in different climatic zones (including the Tibetan Plateau) can be predicted, which is highly consistent with all previous studies. We found that cooling or warming effects are controlled by the RATIO, not by enhanced or reduced evapotranspiration as many studies have suggested. This study provides a new and simple approach for evaluating the climate effects of ecosystem changes at all spatial-temporal scales worldwide.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100733"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urban sensing in the era of large language models.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100749

Ce Hou, Fan Zhang, Yong Li, Haifeng Li, Gengchen Mai, Yuhao Kang, Ling Yao, Wenhao Yu, Yao Yao, Song Gao, Min Chen, Yu Liu

{"title":"Urban sensing in the era of large language models.","authors":"Ce Hou, Fan Zhang, Yong Li, Haifeng Li, Gengchen Mai, Yuhao Kang, Ling Yao, Wenhao Yu, Yao Yao, Song Gao, Min Chen, Yu Liu","doi":"10.1016/j.xinn.2024.100749","DOIUrl":"10.1016/j.xinn.2024.100749","url":null,"abstract":"Urban sensing has become increasingly important as cities evolve into the centers of human activities. Large language models (LLMs) offer new opportunities for urban sensing based on commonsense and worldview that emerged through their language-centric framework. This paper illustrates the transformative impact of LLMs, particularly in the potential of advancing next-generation urban sensing for exploring urban mechanisms. The discussion navigates through several key aspects, including enhancing knowledge transfer between humans and LLM, urban mechanisms awareness, and achieve automated decision-making with LLM agents. We emphasize the potential of LLMs to revolutionize urban sensing, offering a more comprehensive, efficient, and in-depth understanding of urban dynamics, and also acknowledge challenges in multi-modal data utilization, spatial-temporal cognition, cultural adaptability, and privacy preservation. The future of urban sensing with LLMs lies in leveraging their emerged intelligent and addressing these challenges to achieve more intelligent, responsible, and sustainable urban development.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100749"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A robust reduction in near-surface wind speed after volcanic eruptions: Implications for wind energy generation.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100734

Cheng Shen, Zhi-Bo Li, Fei Liu, Hans W Chen, Deliang Chen

引用次数: 0

Identifying dehydration-induced shear velocity anomaly in the Earth's core-mantle boundary.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100740

Songsong Han, Xiaoming Cui, Baolong Zhang, Xiaohong Li, Sidao Ni, Heping Sun, Mingqiang Hou, Qingyang Hu

{"title":"Identifying dehydration-induced shear velocity anomaly in the Earth's core-mantle boundary.","authors":"Songsong Han, Xiaoming Cui, Baolong Zhang, Xiaohong Li, Sidao Ni, Heping Sun, Mingqiang Hou, Qingyang Hu","doi":"10.1016/j.xinn.2024.100740","DOIUrl":"10.1016/j.xinn.2024.100740","url":null,"abstract":"The steep temperature gradient near the bottom of the mantle is known to generate a negative correlation between the shear wave velocity (V S ) and the depth in most regions of the D″ layer, as detected by seismological observations. However, increasing V S with depth is observed at the D″ layer beneath Central America, where the Farallon slab sinks, and the origin of this anomaly has not been well constrained. Here, we calculate the thermoelastic constants and obtain the elastic wave velocities of hydrous phase H with various Al contents and cation configurations, which may act as a water carrier to the D″ layer. We find its V S to be substantially lower than the post-perovskite-type bridgmanite. The dehydration of Al-enriched phase H and the redistribution of Al from the hydrous component to dry silicates would gradually raise the V S below the top of the D″ layer. The presence of 3.5 wt % water is sufficient to compensate for the thermal effects to match the seismic anomaly at the bottom of the mantle beneath Central America. The positive slope of V S versus depth in the D″ layer may fingerprint deep water recycling.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100740"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global-local strategy for global open access.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2025.100799

Wei Yang, Jin-Xia Huang

引用次数: 0

Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100750

Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu

{"title":"Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation.","authors":"Jinyuan Sun, Tong Zhu, Yinglu Cui, Bian Wu","doi":"10.1016/j.xinn.2024.100750","DOIUrl":"10.1016/j.xinn.2024.100750","url":null,"abstract":"Predicting free energy changes (ΔΔG) is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development. While traditional methods offer valuable insights, they are often constrained by computational speed and reliance on biased training datasets. These constraints become particularly evident when aiming for accurate ΔΔG predictions across a diverse array of protein sequences. Herein, we introduce Pythia, a self-supervised graph neural network specifically designed for zero-shot ΔΔG predictions. Our comparative benchmarks demonstrate that Pythia outperforms other self-supervised pretraining models and force field-based approaches while also exhibiting competitive performance with fully supervised models. Notably, Pythia shows strong correlations and achieves a remarkable increase in computational speed of up to 105-fold. We further validated Pythia's performance in predicting the thermostabilizing mutations of limonene epoxide hydrolase, leading to higher experimental success rates. This exceptional efficiency has enabled us to explore 26 million high-quality protein structures, marking a significant advancement in our ability to navigate the protein sequence space and enhance our understanding of the relationships between protein genotype and phenotype. In addition, we established a web server at https://pythia.wulab.xyz to allow users to easily perform such predictions.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100750"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-06 DOI: 10.1016/j.xinn.2024.100751

Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin

{"title":"Unified transmission electron microscopy with the glovebox integrated system for investigating air-sensitive two-dimensional quantum materials.","authors":"Qishuo Yang, Xingxing Li, Ludan Zhao, Gang Wang, Zenglong Guo, Kangdi Niu, Shaolong Jiang, Fuchen Hou, Junhao Lin","doi":"10.1016/j.xinn.2024.100751","DOIUrl":"10.1016/j.xinn.2024.100751","url":null,"abstract":"Transmission electron microscopy (TEM) is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics, phase transitions, and nanoscale structural details. While numerous intriguing physical properties have been revealed in recently discovered two-dimensional (2D) quantum materials, many exhibit significant sensitivity to water and oxygen under ambient conditions. This inherent instability complicates sample preparation for TEM analysis and hinders accurate property measurements. This review highlights recent technical advancements to preserve the intrinsic structures of water- and oxygen-sensitive 2D materials for atomic-scale characterizations. A critical development discussed in this review is implementing an inert gas-protected glovebox integrated system (GIS) designed specifically for TEM experiments. In addition, this review emphasizes air-sensitive materials such as 2D transition metal dichalcogenides, transition metal dihalides and trihalides, and low-dimensional magnetic materials, demonstrating breakthroughs in overcoming their environmental sensitivity. Furthermore, the progress in TEM characterization enabled by the GIS is analyzed to provide a comprehensive overview of state-of-the-art methodologies in this rapidly advancing field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100751"},"PeriodicalIF":33.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rainstorm-induced organic matter pulses: A key driver of carbon emissions from inland waters.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-04 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100746

Lei Zhou, Yongqiang Zhou, Yunlin Zhang, Erik Jeppesen, Gesa A Weyhenmeyer

引用次数: 0

Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures.

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-04 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100764

Shuai Fu, Heng Zhang, Klaas-Jan Tielrooij, Mischa Bonn, Hai I Wang

{"title":"Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures.","authors":"Shuai Fu, Heng Zhang, Klaas-Jan Tielrooij, Mischa Bonn, Hai I Wang","doi":"10.1016/j.xinn.2024.100764","DOIUrl":"10.1016/j.xinn.2024.100764","url":null,"abstract":"Low-dimensional materials have left a mark on modern materials science, creating new opportunities for next-generation optoelectronic applications. Integrating disparate nanoscale building blocks into heterostructures offers the possibility of combining the advantageous features of individual components and exploring the properties arising from their interactions and atomic-scale proximity. The sensitization of graphene using semiconductors provides a highly promising platform for advancing optoelectronic applications through various hybrid systems. A critical aspect of achieving superior performance lies in understanding and controlling the fate of photogenerated charge carriers, including generation, transfer, separation, and recombination. Here, we review recent advances in understanding charge carrier dynamics in graphene-semiconductor heterostructures by ultrafast laser spectroscopies. First, we present a comprehensive overview of graphene-based heterostructures and their state-of-the-art optoelectronic applications. This is succeeded by an introduction to the theoretical frameworks that elucidate the fundamental principles and determinants influencing charge transfer and energy transfer-two critical interfacial processes that are vital for both fundamental research and device performance. We then outline recent efforts aimed at investigating ultrafast charge/energy flow in graphene-semiconductor heterostructures, focusing on illustrating the trajectories, directions, and mechanisms of transfer and recombination processes. Subsequently, we discuss effective control knobs that allow fine-tuning of these processes. Finally, we address the challenges and prospects for further investigation in this field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100764"},"PeriodicalIF":33.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0