The Innovation最新文献

{"title":"Artificial intelligence is restructuring a new world.","authors":"Yongjun Xu, Fei Wang, Tangtang Zhang","doi":"10.1016/j.xinn.2024.100725","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100725","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100725"},"PeriodicalIF":33.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial life under Martian permafrost layer.","authors":"Xiuqi Shang, Ruifang Huang, Weidong Sun","doi":"10.1016/j.xinn.2024.100724","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100724","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100724"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirteen years of clusterProfiler.","authors":"Guangchuang Yu","doi":"10.1016/j.xinn.2024.100722","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100722","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100722"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brainstem opioid peptidergic neurons regulate cough reflexes in mice.","authors":"Haicheng Lu, Guoqing Chen, Miao Zhao, Huating Gu, Wenxuan Zheng, Xiating Li, Meizhu Huang, Dandan Geng, Minhui Yu, Xuyan Guan, Li Zhang, Huimeng Song, Yaning Li, Menghua Wu, Fan Zhang, Dapeng Li, Qingfeng Wu, Congping Shang, Zhiyong Xie, Peng Cao","doi":"10.1016/j.xinn.2024.100721","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100721","url":null,"abstract":"<p><p>Cough is a vital defensive reflex for expelling harmful substances from the airway. The sensory afferents for the cough reflex have been intensively studied. However, the brain mechanisms underlying the cough reflex remain poorly understood. Here, we developed a paradigm to quantitatively measure cough-like reflexes in mice. Using this paradigm, we found that <i>prodynorphin</i>-expressing (<i>Pdyn</i>+) neurons in the nucleus of the solitary tract (NTS) are critical for capsaicin-induced cough-like reflexes. These neurons receive cough-related neural signals from <i>Trpv1</i>+ vagal sensory neurons. The activation of <i>Pdyn</i>+ NTS neurons triggered respiratory responses resembling cough-like reflexes. Among the divergent projections of <i>Pdyn</i>+ NTS neurons, a glutamatergic pathway projecting to the caudal ventral respiratory group (cVRG), the canonical cough center, was necessary and sufficient for capsaicin-induced cough-like reflexes. These results reveal that <i>Pdyn</i>+ NTS neurons, as a key neuronal population at the entry point of the vagus nerve to the brainstem, initiate cough-like reflexes in mice.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100721"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving risk stratification for 2022 European LeukemiaNet favorable-risk patients with acute myeloid leukemia.","authors":"Kellie J Archer, Han Fu, Krzysztof Mrózek, Deedra Nicolet, Alice S Mims, Geoffrey L Uy, Wendy Stock, John C Byrd, Wolfgang Hiddemann, Klaus H Metzeler, Christian Rausch, Utz Krug, Cristina Sauerland, Dennis Görlich, Wolfgang E Berdel, Bernhard J Woermann, Jan Braess, Karsten Spiekermann, Tobias Herold, Ann-Kathrin Eisfeld","doi":"10.1016/j.xinn.2024.100719","DOIUrl":"10.1016/j.xinn.2024.100719","url":null,"abstract":"<p><p>Assignment of patients diagnosed with acute myeloid leukemia (AML) to the 2022 European LeukemiaNet (ELN) favorable genetic risk group has important clinical implications, as allogeneic stem cell transplantation in first complete remission (CR) is not advised due to a relatively good outcome of patients receiving chemotherapy alone and transplant-associated mortality. However, not all favorable genetic risk patients experience long-term relapse-free survival (RFS), making recognition of patients who would most likely be cured of high importance. We analyzed 297 patients aged <60 years with <i>de novo</i> AML classified as 2022 ELN favorable genetic risk who achieved a CR and had RNA sequencing (RNA-seq) and gene mutation data from diagnostic samples available (Alliance trial A152010). To identify prognostically relevant transcripts that can distinguish patients cured from patients susceptible to lower or higher risk of relapse or death, we fit a regularized mixture cure model (MCM) where RNA-seq expression values were our candidate covariates. To validate the identified transcripts, we analyzed 75 patients with <i>de novo</i> AML aged <60 years included in the 2022 ELN favorable genetic risk group who achieved a CR in an independent test set from Gene Expression Omnibus (GSE37642). Our MCM identified 145 transcripts associated with cure or long-term RFS and 149 transcripts associated with latency or shorter-term time to relapse. The area under the curve and C-statistic were, respectively, 0.946 and 0.856 for our training set and 0.877 and 0.857 for our test set. Our results suggest that the favorable risk group includes distinct transcriptionally defined subgroups with different biological properties, which may be useful for refining this genetic risk category.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100719"},"PeriodicalIF":33.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The initiative for consensus and standards in pig-to-human xenotransplantation in China.","authors":"Dong Niu, Yulong Yin","doi":"10.1016/j.xinn.2024.100717","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100717","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100717"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct imaging of pulmonary gas exchange with hyperpolarized xenon MRI.","authors":"Haidong Li, Hongchuang Li, Ming Zhang, Chaolin Huang, Xin Zhou","doi":"10.1016/j.xinn.2024.100720","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100720","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100720"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical knowledge modeling: An essential step in the digital transformation of healthcare.","authors":"Eric Edelman, Fabian Tijssen, Popke Rein Munniksma, Wim Bast, Harold Ten Bohmer, Nicole van Eldik, Marieke Spreeuwenberg, Wolfgang Buhre, Frits van Merode","doi":"10.1016/j.xinn.2024.100718","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100718","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100718"},"PeriodicalIF":33.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations.","authors":"Wenxian Wang, Bin Lian, Chunwei Xu, Qian Wang, Ziming Li, Nan Zheng, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Xuewen Liu, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Jian Feng, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Xin Huang, Meizhen Hu, Qing Hao, Kai Wang, Fan Wu, Binbin Song, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Shengjie Yang, Jin Kang, Jiatao Zhang, Chao Zhang, Wenfeng Li, Jianfei Fu, Lizhi Wu, Shijie Lan, Juanjuan Ou, Lin Shi, Zhanqiang Zhai, Yina Wang, Bihui Li, Zhang Zhang, Ke Wang, Xuelei Ma, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Hubing Shi, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Yong Song, Zhengbo Song, Wenfeng Fang, Yuanzhi Lu, Lu Si","doi":"10.1016/j.xinn.2024.100661","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100661","url":null,"abstract":"<p><p>The BRAF gene is an important signaling molecule in human cells that is involved in the regulation of cell growth, differentiation, and survival. When the BRAF gene mutates, it can lead to abnormal activation of the signaling pathway, which promotes cell proliferation, inhibits cell apoptosis, and ultimately contributes to the occurrence and development of cancer. BRAF mutations are widely present in various cancers, including malignant melanoma, thyroid cancer, colorectal cancer, non-small cell lung cancer, and hairy cell leukemia, among others. BRAF is an important target for the treatment of various solid tumors, and targeted combination therapies, represented by BRAF inhibitors, have become one of the main treatment modalities for a variety of BRAF-mutation-positive solid tumors. Dabrafenib plus trametinib, as the first tumor-agnostic therapy, has been approved by the US Food and Drug Administration for the treatment of adult and pediatric patients aged 6 years and older harboring a BRAF V600E mutation with unresectable or metastatic solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. This is also the first time a BRAF/MEK inhibitor combination has been approved for use in pediatric patients. As research into the diagnosis and treatment of BRAF mutations advances, standardizing the detection of BRAF mutations and the clinical application of BRAF inhibitors becomes increasingly important. Therefore, we have established a universal and systematic strategy for diagnosing and treating solid tumors with BRAF mutations. In this expert consensus, we (1) summarize the epidemiology and clinical characteristics of BRAF mutations in different solid tumors, (2) provide recommendations for the selection of genetic testing methods and platforms, and (3) establish a universal strategy for the diagnosis and treatment of patients with solid tumors harboring BRAF mutations.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100661"},"PeriodicalIF":33.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amplification editing empowers <i>in situ</i> large-scale DNA duplication.","authors":"Yali Cui, Yi Wu, Yingjin Yuan","doi":"10.1016/j.xinn.2024.100716","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100716","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100716"},"PeriodicalIF":33.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}