The Innovation最新文献_第4页

Moss surviving Mars-like extreme conditions 在火星般的极端条件下生存的苔藓

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-18 DOI: 10.1016/j.xinn.2024.100689

Yongxin Pan, Wei Lin

引用次数: 0

Touchable gustatory sensing 可触摸的味觉传感

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-18 DOI: 10.1016/j.xinn.2024.100688

Zilong He, Yonghuan Chen, Nan Cheng, Chunbao Li, Fengyu Li

引用次数: 0

Drug development in the AI era: AlphaFold 3 is coming! 人工智能时代的药物开发：AlphaFold 3即将问世

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-14 DOI: 10.1016/j.xinn.2024.100685

Yi Shi

引用次数: 0

Microplastome visualizations: From spatiotemporal distribution to risk assessment 微塑体可视化：从时空分布到风险评估

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-12 DOI: 10.1016/j.xinn.2024.100684

Chao Zhao, Bailin Zhao, Fengbang Wang, Guangbo Qu, Qian Luo, Ling Guo, Xiaotian Tan, Xiaona Li, Peng Zhou, Zongwei Cai

引用次数: 0

Twice-yearly lenacapavir demonstrated exceptional efficacy for HIV prevention 来那卡韦一年两次的预防艾滋病疗效显著

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-08 DOI: 10.1016/j.xinn.2024.100683

Shujing Xu, Peng Zhan

引用次数: 0

Interpretable foundation models as decryptors peering into the Earth system 可解释的地基模型是窥视地球系统的解密器

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-08-05 DOI: 10.1016/j.xinn.2024.100682

Chenyu Li, Danfeng Hong, Bing Zhang, Tianjun Liao, Naoto Yokoya, Pedram Ghamisi, Min Chen, Lizhe Wang, Jon Atli Benediktsson, Jocelyn Chanussot

引用次数: 0

Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex 基于泛组学的疫情真菌物种复合体高度多药适应菌株的特征描述与预测

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-07-31 DOI: 10.1016/j.xinn.2024.100681

Xin Fan, Lei Chen, Min Chen, Na Zhang, Hong Chang, Mingjie He, Zhenghao Shen, Lanyue Zhang, Hao Ding, Yuyan Xie, Yemei Huang, Weixin Ke, Meng Xiao, Xuelei Zang, Heping Xu, Wenxia Fang, Shaojie Li, Cunwei Cao, Yingchun Xu, Shiguang Shan, Wenjuan Wu, Changbin Chen, Xinying Xue, Linqi Wang

{"title":"Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex","authors":"Xin Fan, Lei Chen, Min Chen, Na Zhang, Hong Chang, Mingjie He, Zhenghao Shen, Lanyue Zhang, Hao Ding, Yuyan Xie, Yemei Huang, Weixin Ke, Meng Xiao, Xuelei Zang, Heping Xu, Wenxia Fang, Shaojie Li, Cunwei Cao, Yingchun Xu, Shiguang Shan, Wenjuan Wu, Changbin Chen, Xinying Xue, Linqi Wang","doi":"10.1016/j.xinn.2024.100681","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100681","url":null,"abstract":"Strains from the species complex (CGSC) have caused the Pacific Northwest cryptococcosis outbreak, the largest cluster of life-threatening fungal infections in otherwise healthy human hosts known to date. In this study, we utilized a pan-phenome-based method to assess the fitness outcomes of CGSC strains under 31 stress conditions, providing a comprehensive overview of 2,821 phenotype-strain associations within this pathogenic clade. Phenotypic clustering analysis revealed a strong correlation between distinct types of stress phenotypes in a subset of CGSC strains, suggesting that shared determinants coordinate their adaptations to various stresses. Notably, a specific group of strains, including the outbreak isolates, exhibited a remarkable ability to adapt to all three of the most commonly used antifungal drugs for treating cryptococcosis (amphotericin B, 5-fluorocytosine, and fluconazole). By integrating pan-genomic and pan-transcriptomic analyses, we identified previously unrecognized genes that play crucial roles in conferring multidrug resistance in an outbreak strain with high multidrug adaptation. From these genes, we identified biomarkers that enable the accurate prediction of highly multidrug-adapted CGSC strains, achieving maximum accuracy and area under the curve (AUC) of 0.79 and 0.86, respectively, using machine learning algorithms. Overall, we developed a pan-omic approach to identify cryptococcal multidrug resistance determinants and predict highly multidrug-adapted CGSC strains that may pose significant clinical concern.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"18 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141969450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking Mytilus edulis foot protein: A versatile strategy for robust biomedical coatings 模仿贻贝足蛋白：坚固生物医学涂层的通用策略

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-06-29 DOI: 10.1016/j.xinn.2024.100671

Zeyu Du, Feng Qiao, Liping Tong, Wentai Zhang, Xiaohui Mou, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Nan Huang, Zhilu Yang

{"title":"Mimicking Mytilus edulis foot protein: A versatile strategy for robust biomedical coatings","authors":"Zeyu Du, Feng Qiao, Liping Tong, Wentai Zhang, Xiaohui Mou, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Nan Huang, Zhilu Yang","doi":"10.1016/j.xinn.2024.100671","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100671","url":null,"abstract":"Universal coatings with versatile surface adhesion, good mechanochemical robustness, and the capacity for secondary modification are of great scientific interest. However, incorporating these advantages into a system is still a great challenge. Here, we report a series of catechol-decorated polyallylamines (CPAs), denoted as pseudo- foot protein 5 (-Mefp-5), that mimic not only the catechol and amine groups but also the backbone of Mefp-5. CPAs can fabricate highly adhesive, robust, multifunctional polyCPA (PCPA) coatings based on synergetic catechol-polyamine chemistry as universal building blocks. Due to the interpenetrating entangled network architectures, these coatings exhibit high chemical robustness against harsh conditions (HCl, pH 1; NaOH, pH 14; HO, 30%), good mechanical robustness, and wear resistance. In addition, PCPA coatings provide abundant grafting sites, enabling the fabrication of various functional surfaces through secondary modification. Furthermore, the versatility, multifaceted robustness, and scalability of PCPA coatings indicate their great potential for surface engineering, especially for withstanding harsh conditions in multipurpose biomedical applications.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"1 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geological context of the Chang’e-6 landing area and implications for sample analysis 嫦娥六号着陆区的地质背景及对样本分析的影响

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-06-24 DOI: 10.1016/j.xinn.2024.100663

Zongyu Yue, Sheng Gou, Shujuan Sun, Wei Yang, Yi Chen, Yexin Wang, Honglei Lin, Kaichang Di, Yangting Lin, Xianhua Li, Fuyuan Wu

{"title":"Geological context of the Chang’e-6 landing area and implications for sample analysis","authors":"Zongyu Yue, Sheng Gou, Shujuan Sun, Wei Yang, Yi Chen, Yexin Wang, Honglei Lin, Kaichang Di, Yangting Lin, Xianhua Li, Fuyuan Wu","doi":"10.1016/j.xinn.2024.100663","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100663","url":null,"abstract":"Research on returned samples can provide ground truth for the study of the geological evolution history of the Moon. However, previous missions all collected samples from the near side of the Moon, which is significantly different from the far side of the Moon in terms of the thickness of the lunar crust, magma activity, and composition. Therefore, the samples from the far side of the Moon are of great significance for a comprehensive understanding of the history of the Moon. China’s Chang’e-6 (CE-6) probe has successfully landed on the lunar far side and will return samples in the coming days. With the precise location of the CE-6 landing site, a detailed analysis of the geological background is conducted in this research. The landing site of CE-6 is within the Apollo crater, which is inside the largest impact basin on the Moon, i.e., the South Pole-Aitken (SPA) basin. According to the numerical simulation of the formation process of the SPA basin, CE-6 landed at the edge of the SPA impact melting zone, which is presumably composed of impact melt of the lunar mantle. The Apollo crater subsequently excavated deep material again, which constitutes the basement of the CE-6 landing area. Later, erupted basalt covered these basement rocks, and they also constitute the main source of the CE-6 samples. Based on the dating method of crater size-frequency distribution, we find that the basalt is ∼2.50 Ga. The CE-6 samples also possibly contain basement rocks as excavated and ejected by craters, and they can provide crucial information for our understanding of lunar geological history along with the basalt samples.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"852 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141548797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stable organic radical qubits and their applications in quantum information science 稳定的有机基量子比特及其在量子信息科学中的应用

IF 32.1 1区综合性期刊

The Innovation Pub Date : 2024-06-21 DOI: 10.1016/j.xinn.2024.100662

Aimei Zhou, Zhecheng Sun, Lei Sun

引用次数: 0