The Innovation最新文献

{"title":"Transforming brain monitoring with bioresorbable wireless sensing.","authors":"Guang-Zhong Yang","doi":"10.1016/j.xinn.2024.100715","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100715","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100715"},"PeriodicalIF":33.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satellite altimeter observed surface water increase across lake-rich regions of the Arctic.","authors":"Nan Xu, Wenyu Li, Peng Gong, Hui Lu","doi":"10.1016/j.xinn.2024.100714","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100714","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100714"},"PeriodicalIF":33.2,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond low-density lipoprotein cholesterol levels: Impact of prior statin treatment on ischemic stroke outcomes.","authors":"Zi-Mo Chen, Jing-Lin Mo, Kai-Xuan Yang, Ying-Yu Jiang, Chun-Juan Wang, Xin Yang, Yong Jiang, Xia Meng, Jie Xu, Hao Li, Li-Ping Liu, Yi-Long Wang, Xing-Quan Zhao, Yong-Jun Wang, Hong-Qiu Gu, Zi-Xiao Li","doi":"10.1016/j.xinn.2024.100713","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100713","url":null,"abstract":"<p><p>Although essential for cardiovascular therapy, the pleiotropic effects of statins on ischemic stroke lack clinical evidence. This study examined the effects of statins beyond low-density lipoprotein cholesterol (LDL-C) levels on mortality and stroke severity. A total of 825,874 patients with ischemic stroke were included in this study, of whom 125,650 statin users were 1:1 matched with non-users based on their LDL-C levels (±0.05 mmol/L), forming the LDL-C-matched cohort. Associations between preceding statin treatment, in-hospital mortality, and stroke severity (National Institutes of Health Stroke Scale score ≥16) were estimated by multivariate and conditional logistic regression models in overall cohort and LDL-C-matched cohort, respectively. The overall statin effects reduced in-hospital mortality (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.65-0.79, <i>p</i> < 0.001) and moderate-to-severe stroke (OR: 0.93, 95% CI: 0.90-0.96, <i>p</i> < 0.001). After matching for LDL-C levels, the reduction in mortality persisted (OR: 0.63, 95% CI: 0.52-0.77, <i>p</i> < 0.001) but not for moderate-to-severe stroke (OR: 0.96, 95% CI: 0.90-1.02, <i>p</i> = 0.215). Stratified by LDL-C levels, the effects of statin beyond LDL-C in reducing mortality remained consistent across all LDL-C ranges but increased with LDL-C reduction for stroke severity and achieved statistical significance at LDL-C <2.60 mmol/L. Mediation analyses showed that LDL-C reduction explained 0.35% (95% CI: 0.23-0.93, <i>p</i> = 0.235) of the statin treatment-mortality relationship and 12.47% (95% CI: 6.78-18.16, <i>p</i> < 0.001) for moderate-to-severe stroke. When examining the overall statin efficacy, LDL-C <2.60 mmol/L was not necessary for mortality reduction but for reducing stroke severity. The efficacy of statins in ischemic stroke outcomes is primarily derived from their effects beyond the LDL-C levels, suggesting that their neuroprotective effects should be considered in addition to their lipid-lowering effects.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100713"},"PeriodicalIF":33.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart contact lenses: Catalysts for science fiction becoming reality.","authors":"Guang Yao, Peisi Li, Mingpeng Liu, Feiyi Liao, Yuan Lin","doi":"10.1016/j.xinn.2024.100710","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100710","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100710"},"PeriodicalIF":33.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy conversion materials need phonons.","authors":"Dandan Ma, Yuzhe Ma, Jinfu Ma, Qun Yang, Claudia Felser, Guowei Li","doi":"10.1016/j.xinn.2024.100709","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100709","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100709"},"PeriodicalIF":33.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro/nanodevice-loaded minimally invasive robot for hematoma evacuation: A novel technology for primary brainstem hemorrhage treatment.","authors":"Danyang Chen, Ping Zhang, Zhouping Tang","doi":"10.1016/j.xinn.2024.100712","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100712","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100712"},"PeriodicalIF":33.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A promising bacterium-based strategy to control dengue transmission in mosquitoes.","authors":"Xiumei Song, Li Gao, Jingwen Wang","doi":"10.1016/j.xinn.2024.100708","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100708","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100708"},"PeriodicalIF":33.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncanonical PI3Kγ signaling addiction is a therapeutic target in a subset of leukemias.","authors":"Yu Zhang, Qian Kong, Yonglong Zhang","doi":"10.1016/j.xinn.2024.100706","DOIUrl":"10.1016/j.xinn.2024.100706","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100706"},"PeriodicalIF":33.2,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.","authors":"Shuaiyin Liu, Tianqin Ning, Junlin Chen, Yanzhe Fu, Jiebo Li, Jinyu Li, Xufeng Niu, Yubo Fan","doi":"10.1016/j.xinn.2024.100705","DOIUrl":"10.1016/j.xinn.2024.100705","url":null,"abstract":"<p><p>Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fully opened, the exposed and expanded P-sponge electrode establishes excellent contact with various tissues, facilitating the collection of electrophysiological signals. Encapsulation with polylactic acid film ensures the system's flexibility and bioresorbability, thereby minimizing potential side effects on surrounding tissues. Animal experiments demonstrate the system's capability to mimic feedback modulation mechanisms, enabling real-time monitoring and timely drug administration. This integrated diagnosis and treatment system offers an effective solution for the emergency management of acute diseases in clinical settings.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 6","pages":"100705"},"PeriodicalIF":33.2,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When will dual-purpose pigs fly?","authors":"Leli Wang, Zhen Jia, Kui Xu, Feng Zhang, Yulong Yin","doi":"10.1016/j.xinn.2024.100702","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100702","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"19 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}