The Innovation最新文献_第4页

Multi-level genomic convergence of secondary aquatic adaptation in marine mammals. 海洋哺乳动物次生水生适应的多层次基因组趋同。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-03 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2025.100798

Shixia Xu, Lei Shan, Ran Tian, Zhenpeng Yu, Di Sun, Zhenhua Zhang, Inge Seim, Ming Zhou, Linxia Sun, Na Liang, Qian Zhang, Simin Chai, Daiqing Yin, Luoying Deme, Tianzhen Wu, Yongjie Chen, Zhikang Xu, Yu Zheng, Wenhua Ren, Guang Yang

{"title":"Multi-level genomic convergence of secondary aquatic adaptation in marine mammals.","authors":"Shixia Xu, Lei Shan, Ran Tian, Zhenpeng Yu, Di Sun, Zhenhua Zhang, Inge Seim, Ming Zhou, Linxia Sun, Na Liang, Qian Zhang, Simin Chai, Daiqing Yin, Luoying Deme, Tianzhen Wu, Yongjie Chen, Zhikang Xu, Yu Zheng, Wenhua Ren, Guang Yang","doi":"10.1016/j.xinn.2025.100798","DOIUrl":"10.1016/j.xinn.2025.100798","url":null,"abstract":"Marine mammals provide a valuable model for studying the molecular basis of convergent evolution during secondary aquatic adaptation. Using multi-omics data and functional experiments, including CRISPR-Cas9 mouse models and luciferase reporter assays, this study explored the molecular mechanisms driving this transition across coding regions, regulatory elements, and genomic architecture. Convergent amino acid substitutions in APPL1 P378L and NEIL1 E71G were found to promote lipid accumulation and suppress cancer cell proliferation, likely contributing to the evolution of extensive blubber layers and cancer resistance. Convergently evolved conserved non-exonic elements (CNEs) and lineage-specific regulatory variations were shown to influence the activity of nearby genes (e.g., NKX3-2, SOX9, HAND2), shaping cetacean limb phenotypes. Additionally, convergent shifts in topologically associating domains (TADs) across cetaceans and pinnipeds were implicated in the regulation of ASXL3 and FAM43B expression, playing a role in the formation of thickened blubber layers and mitigating cancer susceptibility. Structural variations within conserved TADs were associated with the expression of neuronal genes, including NUP153 and ID4, potentially driving cognitive and social adaptations. These findings provide novel insights into the molecular foundations of the convergent evolution of secondary aquatic adaptations in mammals.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 3","pages":"100798"},"PeriodicalIF":33.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward the robustness of autonomous vehicles in the AI era. 走向人工智能时代自动驾驶汽车的鲁棒性。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-26 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100780

Siheng Chen, Yiyi Liao, Fei Wang, Gang Wang, Liang Wang, Yafei Wang, Xichan Zhu

引用次数: 0

Advancing human dignity: The latest updates to the Declaration of Helsinki. 促进人类尊严：《赫尔辛基宣言》的最新更新。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-26 eCollection Date: 2025-02-03 DOI: 10.1016/j.xinn.2024.100779

The Innovation Editorial Team

引用次数: 0

Underappreciated majority of solid waste: Insufficient data and unclear impacts. 大多数固体废物未得到充分重视：数据不足，影响不明确。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-26 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100776

Yao Wang, Ke Yin, Mingliang Fang, Xunchang Fei

引用次数: 0

Femtosecond laser 3D nanoprinting using inorganic nano-building blocks. 使用无机纳米构建块的飞秒激光3D纳米打印。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-24 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100772

Yi-Ke Sun, Yu-Qing Liu, Qi-Dai Chen, Yong-Lai Zhang

引用次数: 0

Pan-spatial Earth information system: A new methodology for cognizing the earth system. 泛空间地球信息系统：认识地球系统的新方法。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-17 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100770

Liufeng Tao, Yongjun Xu, Kang He, Xiaochuan Ma, Lizhe Wang

引用次数: 0

Low-cost and highly sensitive conductive polymer-based lateral flow assay for per- and polyfluoroalkyl substances detection. 低成本和高灵敏度的导电聚合物为基础的横向流动分析的每和多氟烷基物质的检测。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-13 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2024.100768

Ming Zhou, Danxian Wei, Jiaying Li, Kaicai Fan, Wenbing Wang

引用次数: 0

Principles of visual cortex excitatory microcircuit organization. 视觉皮层兴奋性微电路组织原理。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-12 eCollection Date: 2025-01-06 DOI: 10.1016/j.xinn.2024.100735

Christina Y C Chou, Hovy H W Wong, Connie Guo, Kiminou E Boukoulou, Cleo Huang, Javid Jannat, Tal Klimenko, Vivian Y Li, Tasha A Liang, Vivian C Wu, P Jesper Sjöström

{"title":"Principles of visual cortex excitatory microcircuit organization.","authors":"Christina Y C Chou, Hovy H W Wong, Connie Guo, Kiminou E Boukoulou, Cleo Huang, Javid Jannat, Tal Klimenko, Vivian Y Li, Tasha A Liang, Vivian C Wu, P Jesper Sjöström","doi":"10.1016/j.xinn.2024.100735","DOIUrl":"10.1016/j.xinn.2024.100735","url":null,"abstract":"Synapse-specific connectivity and dynamics determine microcircuit function but are challenging to explore with classic paired recordings due to their low throughput. We therefore implemented optomapping, a ∼100-fold faster two-photon optogenetic method. In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells. Across these cell types, log-normal distribution of synaptic efficacies emerged as a principle. For pyramidal cells, optomapping reproduced the canonical circuit but unexpectedly uncovered that the excitation of basket cells concentrated to layer 5 and that of Martinotti cells dominated in layer 2/3. The excitation of basket cells was stronger and reached farther than the excitation of pyramidal cells, which may promote stability. Short-term plasticity surprisingly depended on cortical layer in addition to target cell. Finally, optomapping revealed an overrepresentation of shared inputs for interconnected layer-6 pyramidal cells. Thus, by resolving the throughput problem, optomapping uncovered hitherto unappreciated principles of V1 structure.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100735"},"PeriodicalIF":33.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-temporal large models: A super hub linking multiple scientific areas with artificial intelligence. 时空大模型：连接多个科学领域与人工智能的超级枢纽。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-12 eCollection Date: 2025-02-03 DOI: 10.1016/j.xinn.2024.100763

Zezhi Shao, Tangwen Qian, Tao Sun, Fei Wang, Yongjun Xu

引用次数: 0

Photopyroelectric tweezers for versatile manipulation. 多功能操作的光电镊子。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2024-12-12 eCollection Date: 2025-01-06 DOI: 10.1016/j.xinn.2024.100742

Fang Wang, Cong Liu, Zhengjin Dai, Weizhong Xu, Xinyue Ma, Yufeng Gao, Xuewu Ge, Wei Zheng, Xuemin Du

{"title":"Photopyroelectric tweezers for versatile manipulation.","authors":"Fang Wang, Cong Liu, Zhengjin Dai, Weizhong Xu, Xinyue Ma, Yufeng Gao, Xuewu Ge, Wei Zheng, Xuemin Du","doi":"10.1016/j.xinn.2024.100742","DOIUrl":"10.1016/j.xinn.2024.100742","url":null,"abstract":"Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical, biological, and medical fields. However, certain critical requirements, such as high-intensity laser beams, sophisticated electrode designs, additional electric sources, or low-conductive media, significantly impede their flexibility and adaptability, thus hindering their practical applications. Here, we report innovative photopyroelectric tweezers (PPT) that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability, enabling diverse manipulation in various working scenarios. These PPTs allow for remote and programmable manipulation of objects with diverse materials (polymer, inorganic, and metal), different phases (bubble, liquid, and solid), and various geometries (sphere, cuboid, and wire). Furthermore, the PPT is not only adaptable to high-conductivity media but also applicable to both portable macroscopic manipulation platforms and microscopic manipulation systems, enabling cross-scale manipulations for solid objects, liquid droplets, and biological samples. The high-level flexibility and adaptability of the PPT extend to broad applications in manipulating hydrogel robots, sorting particles, assembling cells, and stimulating cells. By surpassing the limitations of conventional tweezers, the PPT bridges the gap between macroscopic and microscopic manipulations, offering a revolutionary tool in robotics, colloidal science, biomedical fields, and beyond.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 1","pages":"100742"},"PeriodicalIF":33.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0