The Innovation最新文献_第4页

Facet-oriented SnO₂@Ni hollow fiber enables ampere-level CO₂ electroreduction to formate with 85% single-pass conversion. 面向面SnO2@Ni中空纤维使安培级CO2电还原形成85%的单次转换。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-22 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100844

Yiheng Wei, Yanfang Song, Chang Zhu, Jianing Mao, Aohui Chen, Guanghui Feng, Gangfeng Wu, Xiaohu Liu, Shoujie Li, Guihua Li, Jiangjiang Wang, Xiao Dong, Wei Wei, Wei Chen

{"title":"Facet-oriented SnO2@Ni hollow fiber enables ampere-level CO2 electroreduction to formate with 85% single-pass conversion.","authors":"Yiheng Wei, Yanfang Song, Chang Zhu, Jianing Mao, Aohui Chen, Guanghui Feng, Gangfeng Wu, Xiaohu Liu, Shoujie Li, Guihua Li, Jiangjiang Wang, Xiao Dong, Wei Wei, Wei Chen","doi":"10.1016/j.xinn.2025.100844","DOIUrl":"10.1016/j.xinn.2025.100844","url":null,"abstract":"The electrochemical conversion of CO2 into liquid fuels is a promising strategy for achieving carbon neutrality. Tin dioxide (SnO2) shows a notable ability to electrocatalytically convert CO2 into formate, though its efficiency is significantly limited by its low catalytic activity. Herein, we construct facet-oriented SnO2 nanoflowers all standing on a three-dimensional nickel hollow fiber that exhibits superior CO2-to-formate electrocatalytic performance. A formate selectivity of 94% and stability of 300 h with a current density of 1.3 A cm-2 at -1.1 V (vs. reversible hydrogen electrode [RHE]) are attained under ambient conditions. Notably, an extremely high CO2 single-pass conversion rate of 85% is achieved, outperforming prominent catalysts reported in electrocatalysis. The synergetic combination of the unique nanostructures and their advanced spatial configuration is proposed to be responsible for the facet-oriented SnO2 with a hierarchical structure, providing fully exposed active sites and facilitating mass and charge transfers. Enhanced mass transfer in the hollow fiber electrode verified by electrochemical measurements and well-retained Sn4+ species confirmed by in situ spectroscopy synergistically boost the high CO2 conversion activity. In situ spectroscopy and theoretical calculation results demonstrate that the SnO2(101) facet favors ∗OCHO intermediate formation and ∗HCOOH desorption, leading to high formate selectivity. This study provides a straightforward approach to the precise fabrication of composite hollow fiber electrodes, enabling highly efficient electrocatalytic reactions with gas molecules.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100844"},"PeriodicalIF":33.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 1-km resolution global ocean simulation promises to unveil oceanic multi-scale dynamics and climate impacts. 1公里分辨率的全球海洋模拟有望揭示海洋多尺度动力学和气候影响。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-20 eCollection Date: 2025-07-07 DOI: 10.1016/j.xinn.2025.100843

Jingwei Xie, Jiangfeng Yu, Yanzhi Zhou, Hailong Liu, Junlin Wei, Xiang Han, Kai Xu, Maoxue Yu, Zipeng Yu, Pengfei Lin, Jinrong Jiang, Weipeng Zheng, Tao Zhang, Rong Wang, Zhao Jing, Lixin Wu

引用次数: 0

Unleashing the potential of remote sensing foundation models via bridging data and computility islands. 通过桥接数据和可计算孤岛，释放遥感基础模型的潜力。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-19 eCollection Date: 2025-06-02 DOI: 10.1016/j.xinn.2025.100841

Yansheng Li, Jieyi Tan, Bo Dang, Mang Ye, Sergey A Bartalev, Stanislav Shinkarenko, Linlin Wang, Yingying Zhang, Lixiang Ru, Xin Guo, Liangqi Yuan, Lei Yu, Jingdong Chen, Ming Yang, José Marcato Junior, Yongjun Zhang

引用次数: 0

Stereoscopic remote sensing observation for mountains: Advancing monitoring, modeling, and management. 山地立体遥感观测：推进监测、建模与管理。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-11 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100838

Jinhu Bian, Ainong Li, Xi Nan, Zhengjian Zhang, Guangbin Lei, Jinping Zhao, Yi Deng, Xiaohan Lin, Limin Chen, Amin Naboureh

引用次数: 0

From primary forests to rubber plantations: A huge ecological loss. 从原始森林到橡胶种植园：巨大的生态损失。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-07 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100836

Yuxi Wang, Lin Zhang

引用次数: 0

Erratum: Fast reconstruction and optical-sectioning three-dimensional structured illumination microscopy. 勘误：快速重建和光学切片三维结构照明显微镜。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-06 eCollection Date: 2025-03-03 DOI: 10.1016/j.xinn.2025.100812

Ruijie Cao, Yaning Li, Wenyi Wang, Yunzhe Fu, Xiaoyu Bu, Dilizhatai Saimi, Jing Sun, Xichuan Ge, Shan Jiang, Yuru Pei, Baoxiang Gao, Zhixing Chen, Meiqi Li, Peng Xi

引用次数: 0

The rising threats of wildland-urban interface fires in the era of climate change: The Los Angeles 2025 fires. 气候变化时代，荒地-城市交界面火灾的威胁日益增加：洛杉矶2025年火灾。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-04 eCollection Date: 2025-05-05 DOI: 10.1016/j.xinn.2025.100835

Minghao Qiu, Deyang Chen, Makoto Kelp, Jing Li, Guanyu Huang, Mahdieh Danesh Yazdi

引用次数: 0

Toward bridging the gap between machine intelligence and machine wisdom: Dilemmas and conjectures. 在机器智能和机器智慧之间架起桥梁：困境和猜想。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-02-04 eCollection Date: 2025-07-07 DOI: 10.1016/j.xinn.2025.100834

Rui Wang, Shixuan Liu, Changjun Fan, Guozheng Li, Jincai Huang, Zhong Liu, Gang Zhou

引用次数: 0

Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming. 新型癌症干细胞靶向类维甲酸ZSH-512通过kdm3a介导的表观遗传重编程阻碍结直肠癌的进展。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-30 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100831

Suyao Li, Wenrui Zhao, Quanlin An, Lei Wang, Mengxuan Zhu, Junjie Ni, Xuan Huang, Yudong Jiang, Min Li, Jiayun Hou, Yiyi Yu, Shan Yu, Lai Wei, Heng Jiao, Tianshu Liu, Xin Cao

{"title":"Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming.","authors":"Suyao Li, Wenrui Zhao, Quanlin An, Lei Wang, Mengxuan Zhu, Junjie Ni, Xuan Huang, Yudong Jiang, Min Li, Jiayun Hou, Yiyi Yu, Shan Yu, Lai Wei, Heng Jiao, Tianshu Liu, Xin Cao","doi":"10.1016/j.xinn.2025.100831","DOIUrl":"10.1016/j.xinn.2025.100831","url":null,"abstract":"Advanced colorectal cancer (CRC) exhibits weak responses to multiple therapies, primarily due to the presence of cancer stem cells (CSCs), which drive high recurrence rates, metastasis, and drug resistance. We have previously systematically conducted CSC-targeted compound discovery and evaluation studies to inhibit CSC-mediated tumorigenesis and metastasis. Here, we identified ZSH-512, a novel synthetic retinoid that selectively targets retinoic acid receptor (RAR)γ, demonstrating its ability to effectively inhibit CRC-CSCs and patient-derived organoids (PDOs) in vitro and significantly reduce CSC-mediated tumor formation and liver metastasis in mouse models without noticeable toxicity. Mechanistically, integrated analysis of Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) and RNA sequencing (RNA-seq) revealed that ZSH-512 exerted its effect by modulating the RARγ-KDM3A axis to mediate epigenetic reprogramming and broadly suppress stemness-related signaling pathways, including Wnt, Hippo, and Hedgehog. ZSH-512 efficiently inhibited tumorigenesis in CRC-patient-derived tumor xenografts (PDXs) with high KDM3A expression, suggesting KDM3A as a potential predictive biomarker. Collectively, ZSH-512 is a promising therapeutic candidate for targeting CRC-CSCs with high efficacy.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 4","pages":"100831"},"PeriodicalIF":33.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence facilitates information fusion for perception in complex environments. 人工智能促进了复杂环境中感知的信息融合。

IF 33.2 1区综合性期刊

The Innovation Pub Date : 2025-01-29 eCollection Date: 2025-04-07 DOI: 10.1016/j.xinn.2025.100814

Xunpeng Yi, Yong Ma, Yansheng Li, Han Xu, Jiayi Ma

引用次数: 0