The Innovation最新文献

{"title":"Bioinspired iontronic architectures for neuromorphic intelligence.","authors":"Xiang Li, Zhong Lin Wang, Di Wei","doi":"10.1016/j.xinn.2026.101424","DOIUrl":"10.1016/j.xinn.2026.101424","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 7","pages":"101424"},"PeriodicalIF":39.5,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the invisible audible: Soft biodegradable implants redefine deep-tissue sensing.","authors":"Liwei Wang, Qianwang Ye, Xinlin Du, Yiwei Xu, Wanlu Zhang, Guoqi Zhang, Ruiqian Guo, Hanqing Dai","doi":"10.1016/j.xinn.2026.101421","DOIUrl":"10.1016/j.xinn.2026.101421","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 6","pages":"101421"},"PeriodicalIF":39.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic controls on subsurface water chemistry and habitability on icy moons.","authors":"Chengtao Zhang, Yiran Yang, Yuxuan Cai, Shenglin Zhang, Chao He, Christopher Glein, Fang Huang, Barbara Sherwood Lollar, Jihua Hao","doi":"10.1016/j.xinn.2026.101420","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101420","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 6","pages":"101420"},"PeriodicalIF":25.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China's mangrove expansion boosts avian diversity.","authors":"Haowen Yang, Xiaodong Yang, Ke Huang, Gang Yang, Weiwei Sun","doi":"10.1016/j.xinn.2026.101400","DOIUrl":"10.1016/j.xinn.2026.101400","url":null,"abstract":"<p><p>Over the past half-century, ∼1/3 of global mangroves have been lost. To comply with international conventions, China implemented targeted mangrove restoration policies, but their effects on ecosystem functions against the backdrop of climate change remain unclear. Our study used bird diversity (a key ecological proxy) to examine whether policy-driven mangrove expansion had promoted such functions. Results showed that China's mangrove area increased by 166% over the past three decades (1998-2020). Bird diversity correlated strongly with mangrove area and coverage. The number of threatened species on the IUCN Red List increased by 91%. Climate change promoted the expansion of mangroves. Mechanistically, mangrove expansion improved marine quality, regulated phytoplankton, and synergized with climate change, boosting avian diversity. China's mangrove protection policies have effectively facilitated mangrove restoration, which in turn has enhanced bird diversity by improving marine habitat conditions. Our findings confirm policy effectiveness, validate the restoration feasibility of coastal ecosystems, and inform global coastal restoration.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 10","pages":"101400"},"PeriodicalIF":39.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Killswitch: A universal tool to link condensate microenvironments and functions.","authors":"Yiwei Han, Peng Miao","doi":"10.1016/j.xinn.2026.101404","DOIUrl":"10.1016/j.xinn.2026.101404","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 7","pages":"101404"},"PeriodicalIF":39.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eddy-resolving simulations reveal amplified marine cold spells in the Southern Ocean under greenhouse warming.","authors":"Ruijian Gou, Gerrit Lohmann, Wenju Cai, Gregor Knorr, Lixin Wu","doi":"10.1016/j.xinn.2026.101399","DOIUrl":"10.1016/j.xinn.2026.101399","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 6","pages":"101399"},"PeriodicalIF":39.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically determined heterogeneous treatment effects of <i>Helicobacter pylori</i> eradication for targeted gastric cancer prevention.","authors":"Zong-Chao Liu, Yu-Xin Wang, Heng-Min Xu, Xuan Han, Wen-Jing Zhao, Hui Ma, Yang Zhang, Jing-Ying Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li","doi":"10.1016/j.xinn.2026.101402","DOIUrl":"10.1016/j.xinn.2026.101402","url":null,"abstract":"<p><p>Population-based <i>Helicobacter pylori</i> screen-and-treat is a priority for gastric cancer (GC) prevention, yet the preventive effect varies across individuals, and the determinants of this heterogeneity remain insufficiently understood. As large-scale prevention efforts expand globally, identifying individuals most likely to benefit is increasingly important. We analyzed two randomized trials, the Mass Intervention Trial in Linqu, Shandong Province (MITS; ChiCTR-TRC-10000979; <i>n</i> = 1,740), and the Shandong Intervention Trial (SIT; NCT00339768; <i>n</i> = 1,811), to characterize genetically determined heterogeneous treatment effects of <i>H. pylori</i> eradication for GC prevention. We identified 11 genetic variants that modified the preventive efficacy of eradication and integrated their genotype-specific conditional average treatment effects into a polygenic treatment benefit score (PTBS). We further compared a benefit-based strategy prioritizing individuals predicted to derive greater benefit for GC prevention with a risk-based strategy defined by a polygenic risk score and assessed whether benefit-based subgroups exhibited differential residual GC risk post-eradication. With the PTBS, targeting the high-treatment-benefit individuals conferred stronger protection against GC (MITS, hazard ratio [HR] = 0.44, 95% confidence interval [CI] 0.35-0.54, number needed to treat [NNT] = 56; SIT, HR = 0.20, 95% CI 0.10-0.41, NNT = 26) than treating all <i>H. pylori</i>-positive participants or those of high genetic risk. PTBS further stratified residual GC risk among individuals post-treatment (MITS, HR = 0.65, 95% CI 0.52-0.81; SIT, HR = 0.27, 95% CI 0.13-0.56, for high-treatment-benefit individuals) and was associated with slower precancerous lesion progression. Our findings suggest that host genetic factors modulate the preventive efficacy of <i>H. pylori</i> eradication and that incorporating genotype-specific heterogeneous treatment effects provides a framework for enhancing the precision of population-based screen-and-treat programs while supporting post-eradication risk management.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 10","pages":"101402"},"PeriodicalIF":39.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation global scientific citation framework in progress.","authors":"","doi":"10.1016/j.xinn.2026.101387","DOIUrl":"https://doi.org/10.1016/j.xinn.2026.101387","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 7","pages":"101387"},"PeriodicalIF":39.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinex: Quantitative information extraction from text using open and lightweight LLMs.","authors":"Jan Göpfert, Patrick Kuckertz, Gian Müller, Luna Lütz, Celine Körner, Hang Khuat, Detlef Stolten, Jann Michael Weinand","doi":"10.1016/j.xinn.2026.101391","DOIUrl":"10.1016/j.xinn.2026.101391","url":null,"abstract":"<p><p>Extracting quantitative data from the growing body of scientific literature is a challenge central to modern research across disciplines. While recent advances in large language models have significantly facilitated automation of this traditionally time-consuming task, their computational demands limit scalability and accessibility. Smaller specialized systems offer reduced computational requirements but sacrifice accuracy, domain generalization, or the extraction of contextual details. To address these gaps, we present Quinex, a domain-agnostic framework for quantitative information extraction based on comparably small language models. Quinex identifies quantities and their associated entities, properties, and qualifiers using a multi-turn question-answering approach. By addressing the data bottleneck, considering implicit properties, and optimizing extraction order and question templates, Quinex achieves state-of-the-art F1 scores of over 98% for quantities, 82% for entities, and 87% for properties across diverse scientific genres. It goes beyond identification by normalizing units, aligning them with a unit ontology, and detailing critical qualifiers such as references, spatiotemporal scopes, and determination methods. By reducing the effort required to extract structured quantitative data from texts, Quinex enables transformative applications, including automated literature reviews, quantitative search, and trend monitoring, and sets a new benchmark for scalable, accurate, and domain-agnostic quantitative information extraction.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 9","pages":"101391"},"PeriodicalIF":39.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localization-based techniques for super-resolution imaging of vascular dynamics.","authors":"Quanyu Zhou, Daniil Nozdriukhin, Zhenyue Chen, Xosé Luís Deán-Ben, Daniel Razansky","doi":"10.1016/j.xinn.2026.101401","DOIUrl":"10.1016/j.xinn.2026.101401","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"7 6","pages":"101401"},"PeriodicalIF":39.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}