Indian Pacing and Electrophysiology Journal最新文献

{"title":"Theory and practice of present clinical use of Quinidine in the management of cardiac arrhythmias","authors":"Bernard Belhassen ,&nbsp;Anat Milman","doi":"10.1016/j.ipej.2025.07.017","DOIUrl":"10.1016/j.ipej.2025.07.017","url":null,"abstract":"<div><div>At the beginning of the last century, quinidine had been shown to be highly effective in the management of atrial fibrillation and soon after, of ventricular arrhythmias. At the end of the same century, quinidine was quickly abandoned, and its manufacturing ceased, resulting in limited accessibility across numerous countries. Paradoxically, this decline in use occurred alongside accumulating evidence supporting quinidine's therapeutic benefit in managing rare, life-threatening ventricular arrhythmias occurring in patients with no organic heart disease (Idiopathic ventricular fibrillation, Brugada syndrome, Early repolarization syndrome, Short QT syndrome, Multifocal ectopic Purkinje-related premature contractions), as well as in those with organic heart disease involving the Purkinje network (acute myocardial infarction and hypertrophic cardiomyopathy). The present review will extensively deal with all these topics.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 264-273"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of Closed Loop Stimulation pacemaker for carotid sinus syndrome due to infiltrating neck cancer","authors":"Stefano Maffè,&nbsp;Paola Paffoni,&nbsp;Luca Bergamasco,&nbsp;Pierfranco Dellavesa","doi":"10.1016/j.ipej.2025.08.006","DOIUrl":"10.1016/j.ipej.2025.08.006","url":null,"abstract":"<div><div>A 64-year-old male with oropharyngeal carcinoma experienced recurrent syncope and hypotension due to neoplastic compression of the right carotid space. Despite initial treatment with atropine and fluid resuscitation, the patient continued to experience presyncope and hypotensive events. After treatment with a conventional dual-chamber pacemaker failed, the use of closed-loop stimulation (CLS) successfully resolved the syncope episodes. This case highlights the efficacy of CLS pacing in managing reflex syncope caused by extrinsic neoplastic compression of the carotid sinus. The CLS algorithm, by detecting pre-syncopal phases and increasing heart rate proactively, offers a significant advantage over conventional pacing in preventing syncope.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 249-252"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful epicardial ablation of incessant left atrial tachycardia in a child with arrhythmia induced cardiomyopathy","authors":"Vijay Yadav,&nbsp;Daljeet Kaur Saggu,&nbsp;Jasvinder Singh,&nbsp;Calambur Narasimhan","doi":"10.1016/j.ipej.2025.06.003","DOIUrl":"10.1016/j.ipej.2025.06.003","url":null,"abstract":"<div><div>Incessant supraventricular tachycardias leading to arrhythmia induced cardiomyopathy (AIC) is not uncommon. We report one such case of an incessant multidrug resistant focal left atrial tachycardia (AT) in a child who presented with AIC. During electrophysiology study this tachycardia was localized to the left atrial appendage (LAA) but, endocardial ablation at this site caused only temporary suppression of arrhythmia. The epicardial ablation at the site adjacent to the endocardial area proficiently terminated the tachycardia and improved the left ventricular function within the first 48 hours itself. Thus, this case report emphasizes the epicardial ablation of rare epicardial AT arising from LAA.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 240-242"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the silent enemy: Revisiting post-stroke AF detection","authors":"Jiaqi Mi MD,&nbsp;Dhanunjaya Lakkireddy MD, MBA, FHRS, FACC","doi":"10.1016/j.ipej.2025.07.003","DOIUrl":"10.1016/j.ipej.2025.07.003","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 218-219"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural courses of atrial fibrillation following cryptogenic stroke: A systematic review and meta-analysis","authors":"Patavee Pajareya ,&nbsp;Somkiat Phutinart ,&nbsp;Noppachai Siranart ,&nbsp;Suwit Paksin ,&nbsp;Priabprat Jansem ,&nbsp;Prakit Anukoolwittaya ,&nbsp;Piyoros Lertsanguansinchai ,&nbsp;Narut Prasitlumkum ,&nbsp;Ronpichai Chokesuwattanaskul ,&nbsp;Nithi Tokavanich","doi":"10.1016/j.ipej.2025.06.006","DOIUrl":"10.1016/j.ipej.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Cryptogenic stroke (CS) presents challenges in management and increases risk of stroke recurrence. The clinical relevance of atrial fibrillation detected after stroke (AFDAS) remains equivocal.</div></div><div><h3>Methods</h3><div>Our study was conducted in a meta-analysis design, including all observational studies and utilizing random-effects model. The objectives were to explore the association between predictors and AFDAS incidence, and clinical differences between AF and non-AF patients following CS.</div></div><div><h3>Results</h3><div>This meta-analysis included 59 studies with 18,683 patients with CS. AFDAS incidence was 20.8 %. In univariable analysis, significant predictors of AFDAS were age &gt;75 years (OR 6.94, 95 % CI: 3.12–15.43, I² = 0 %) and hypertension (OR 2.16, 95 % CI: 1.28–3.63, I² = 0.0 %). In comparison to non-AF group, individuals with AF showed significantly higher levels of left atrial volume index (MD 7.50 mL/m², 95 % CI: 6.20–8.80, I² = 0.0 %), left atrial diameter (MD 0.17 cm, 95 % CI: 0.02–0.32, I² = 48.6 %), D-dimer (MD 0.20 mg/L, 95 % CI: 0.05–0.36, I² = 0.0 %), CHA₂DS₂VASc score (MD 0.76 point, 95 % CI: 0.53–0.98, I² = 64.2 %), and P-wave duration (MD 9.49 ms, 95 % CI: 0.75–18.23, I² = 30.4 %). Significantly lower levels were observed in left atrial contractile strain (MD -5.68 %, 95 % CI: 7.45 to −3.91, I² = 58.0 %) and left atrial reservoir strain (MD -9.05 %, 95 % CI: 12.2 to −5.91, I² = 71.9 %). The mean time from CS to AF detection was 162 days and from cardiac monitoring to AF detection was 49 days.</div></div><div><h3>Conclusion</h3><div>Our study highlighted the potential link between certain comorbidities and demonstrated the delay in AF detection following CS. The significant parameters identified should be considered as new recommendations to the guideline for extended cardiac monitoring in CS patients. It is time to change the level of surveillance in this population.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 207-217"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signature ECG part 2: A normal ECG (?) and a malignant family history","authors":"Arthur Wilde ,&nbsp;Priya Chockalingam","doi":"10.1016/j.ipej.2025.07.006","DOIUrl":"10.1016/j.ipej.2025.07.006","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Page 263"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter ablation of atrial fibrillation: time to look beyond iterative pulmonary vein isolation only and “one-size-fits-all” strategies","authors":"Nicolas Johner,&nbsp;Mehdi Namdar,&nbsp;Dipen C. Shah","doi":"10.1016/j.ipej.2025.08.005","DOIUrl":"10.1016/j.ipej.2025.08.005","url":null,"abstract":"<div><div>Pulmonary vein isolation (PVI) is considered the ‘cornerstone’ of catheter ablation of atrial fibrillation (AF). Despite this, it is now acknowledged that there is a ceiling to the efficacy of PVI only strategies due to non-PV substrate and/or triggers. However, identifying patients who may benefit from PVI alone remains a major challenge. Selected clinical characteristics are helpful but poorly specific. Individualized assessment of non-PV substrate, including voltage mapping and functional endpoints such as AF non-inducibility, have shown better accuracy. Adjunctive ablation strategies that seek to eliminate non-PV AF mechanisms, either in an individualized fashion or targeting general mechanisms with anatomical approaches, have historically been limited by technical limitations or poor reproducibility. Further technological advances have improved reliability and recent multicenter randomized trials showed the superiority of two distinct strategies over PVI alone: the anatomical approach combining PVI with vein of Marshall ethanol infusion and transection of three anatomical isthmuses (Marshall Plan), and the tailored approach combining PVI with AI-assisted ablation of spatiotemporal electrogram dispersion. Data is scarcer for repeat ablation of recurrent AF. Redo PVI proved superior to medical management, but there is no established adjunctive ablation strategy for repeat ablation. A reasonable approach involves redoing PVI in case of reconnection, completing previous lesion sets (e.g. gaps in linear lesions), and, in selected patients, pursuing adjunctive ablation strategies that proved beneficial for de novo ablation. The advent of pulsed field ablation and wide-spread availability of rapid high-density mapping will likely facilitate an era of re-evaluation of substrate modification strategies.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 199-206"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited arrhythmia syndromes - Cardiogenetics","authors":"Fenna Tuijnenburg ,&nbsp;Ahmad S. Amin ,&nbsp;Arthur A.M. Wilde","doi":"10.1016/j.ipej.2025.07.004","DOIUrl":"10.1016/j.ipej.2025.07.004","url":null,"abstract":"<div><div>The inherited arrhythmia syndromes long QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia are rare cardiac channelopathies associated with a higher risk for malignant arrhythmias and sudden cardiac death. Adequate and timely clinical management of patients remains a challenge and is often based on expert opinions and (small) cohort studies. Particularly, identification of high-risk patients continues to be difficult due to limitations in diagnostic tools and risk prediction models. Importantly, underlying causes determining the large variability in disease severity, even within families, are still unknown. A combination of rare variants in causal genes associated with the arrhythmia syndromes, non-genetic factors (i.e. age, sex) and genetic modifiers (i.e. single nucleotide polymorphisms) are thought to be of influence on the clinical phenotype and variability. Although, our knowledge regarding these rare arrhythmia syndromes has grown over the past decades, there are still gaps in knowledge that remain to be elucidated. In this review, we aim to provide an overview of the current knowledge and guidance for the clinical management of the three main arrhythmia syndromes.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 255-262"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocardial transvenous atrial pacing in lateral tunnel Fontan guided by electroanatomical mapping","authors":"Carlotta Sembenini,&nbsp;Alessandro Locatelli,&nbsp;Luca Tomasi,&nbsp;Giacomo Mugnai","doi":"10.1016/j.ipej.2025.07.012","DOIUrl":"10.1016/j.ipej.2025.07.012","url":null,"abstract":"<div><div>The Fontan circulation is a palliative surgery used to treat cardiac abnormalities with only one well-developed ventricle. Although the surgical epicardial pacing is usually preferred, in a few cases the transvenous placement of a permanent atrial lead can be considered. The transvenous endocardial pacing is challenging because most of the right atrium is fibrotic and the lead positioning needs to be supported by a long sheath.</div><div>We report a case of a transvenous lead placement from a typical left pre-pectoral pocket guided by electro-anatomical mapping.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 4","pages":"Pages 243-246"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoballoon ablation for the treatment of atrial fibrillation in Kazakhstan: One year outcome from the Cryo Global Registry.","authors":"Ayan Abdrakhmanov, Omirbek Nuralinov, Gulzhaina Rashbayeva, Azat Tursunbekov, Serik Bagibayev, Abay Bakytzhanuly, Zhandos Yessilbayev, Assel Chinybayeva, Zhanar Abdrakhmanova, Alessandro Salustri, Zhanasyl Suleymen, Rano Kirkimbayeva","doi":"10.1016/j.ipej.2025.06.008","DOIUrl":"10.1016/j.ipej.2025.06.008","url":null,"abstract":"<p><strong>Introduction: </strong>Atrial fibrillation (AF) is a prevalent and potentially serious cardiac rhythm disorder. Cryoballoon ablation using the Arctic Front catheter offers a modern treatment approach. This subanalysis evaluates the safety, efficacy, and impact on quality of life for patients undergoing t this procedure in Kazakhstan. The Cryo AF Global Registry (NCT02752737) is an ongoing prospective, multi-center observational post-market registry collecting global data on CBA procedures conducted with the Arctic Front™ Family of Cardiac Cryoablation Catheters.</p><p><strong>Methods: </strong>The study included patients aged 18 and older with paroxysmal, persistent, and long-standing persistent AF. Key safety endpoints included serious adverse events related to the device or procedure. Efficacy was measured by the absence of AF, atrial flutter (AFL), and/or atrial tachycardia (AT) after a 90-day period of discontinuing antiarrhythmic medications.</p><p><strong>Results: </strong>No injuries to the phrenic nerve or serious complications were reported. Three serious adverse events occurred, but these were not related to the procedure. At 12 months, the Kaplan-Meier analysis showed a 92.9 % rate of freedom from AF or other atrial arrhythmias after the 90-day blanking period. Two repeat ablations (2.9 %) were needed for AF.</p><p><strong>Conclusion: </strong>This analysis supports the conclusion that cryoballoon ablation is both safe and effective for treating AF in Kazakhstan, resulting in significant improvements in patients' quality of life.</p><p><strong>Registration number: </strong>NCT02752737.</p>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}