Indian Pacing and Electrophysiology Journal最新文献

Optimal strategy for very high-power short-duration atrial fibrillation ablation: Acute efficacy and safety of pulmonary vein and box isolation. 非常高功率短时间房颤消融的最佳策略：肺静脉和箱体隔离的急性疗效和安全性。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-04-24 DOI: 10.1016/j.ipej.2025.04.007

Yusuke Sakamoto, Hiroyuki Osanai, Yoshihito Nakashima, Hiroshi Asano, Masayoshi Ajioka

{"title":"Optimal strategy for very high-power short-duration atrial fibrillation ablation: Acute efficacy and safety of pulmonary vein and box isolation.","authors":"Yusuke Sakamoto, Hiroyuki Osanai, Yoshihito Nakashima, Hiroshi Asano, Masayoshi Ajioka","doi":"10.1016/j.ipej.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.ipej.2025.04.007","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal strategy for very high-power short-duration (vHPSD) ablation for atrial fibrillation (AF) is unclear. Data regarding the application of box isolation (BOXI) and its complications, particularly, pulmonary vein stenosis (PVS), remain scarce. We aimed to determine the optimal strategy for vHPSD in AF ablation by focusing on pulmonary vein isolation (PVI) and BOXI and assessing the acute efficacy and safety.</p><p><strong>Methods: </strong>Patients with drug-refractory AF (n = 97) were divided into two groups: Strategy 1 (n = 50; 90 W for 4 s with PVI for the bottom line and 50 W with an ablation index [AI] of 450 for the roof line) and Strategy 2 (n = 47; based on the outcomes of Strategy 1, using AI-guided ablation). The acute efficacy and safety were compared between the groups. Pre- and post-ablation imaging was conducted to assess PVS.</p><p><strong>Results: </strong>Strategy 1 yielded first-pass isolation (FPI) rates of 62.5 % (PVI) and 72 % (BOXI). The weak points were the thick parts of the atrial wall and the parts with epicardial connections. Strategy 2, which was improved by AI guidance, increased the FPI rates to 97.5 % (PVI) and 95 % (BOXI) and reduced the procedural and fluoroscopy times, respectively. Follow-up imaging showed that the PVS incidence remained low and did not significantly differ between the strategies.</p><p><strong>Conclusion: </strong>AI-guided ablation enhanced the efficacy of vHPSD for PVI and BOXI in Strategy 2. Furthermore, our assessment of PVS demonstrated that vHPSD maintains a favorable safety profile with a low PVS incidence.</p>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late dislodgement of left bundle branch pacing lead and failure of left ventricle capture management algorithm. 左束支起搏导联迟发性移位与左心室俘获管理算法失效。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-04-22 DOI: 10.1016/j.ipej.2025.04.004

Pugazhendhi Vijayaraman

引用次数: 0

Unusual "crosstalk" phenomenon between right pulmonary veins observed during cryoballoon ablation. 低温球囊消融术中观察到右肺静脉间异常的“串音”现象。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-04-03 DOI: 10.1016/j.ipej.2025.04.001

Yuhei Kasai, Takayuki Kitai, Junji Morita, Tsutomu Fujita

引用次数: 0

Co-existence of RBM20 and KCNQ1 gene mutations in a patient with long QT syndrome and dilated cardiomyopathy. "Which came first: Chicken or the egg?" RBM20和KCNQ1基因突变在长QT综合征合并扩张性心肌病患者中的共存“先有鸡还是先有蛋？”

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-28 DOI: 10.1016/j.ipej.2025.03.005

Jithin S Panicker, Sam Jacob Chiramel

{"title":"Co-existence of RBM20 and KCNQ1 gene mutations in a patient with long QT syndrome and dilated cardiomyopathy. \"Which came first: Chicken or the egg?\"","authors":"Jithin S Panicker, Sam Jacob Chiramel","doi":"10.1016/j.ipej.2025.03.005","DOIUrl":"10.1016/j.ipej.2025.03.005","url":null,"abstract":"<p><p>A 60-year-old female patient was taken to the emergency department with a history of syncope. ECG revealed polymorphic ventricular tachycardia which necessitated recurrent DC cardioversion. Post-reversion ECG showed sinus rhythm with prolonged corrected QTc. Bedside transthoracic echocardiogram revealed features suggestive of dilated cardiomyopathy (DCM) with severe left ventricular dysfunction. Next reversion to VT was managed with intravenous propranolol and DC cardioversion after which she remained in sinus rhythm. After the initiation of beta-blocker, she developed sinus bradycardia followed by complete heart block. The concern we had while managing this case was whether the DCM caused the VT {then why long QTc?} OR was the long QTc causing DCM {due to same gene mutation}. Genetic analysis revealed the simultaneous occurrence of KCNQ1 and RBM20 mutation. Regarding the treatment given to our patient, we continued beta-blocker, left bundle branch optimized implantable cardioverter defibrillator {LOT - Dx ICD} was done with atrial sensing, the right ventricular coil as the defibrillator, and left bundle branch area pacing. In our patient, any of the two mutations could explain the occurrence of both DCM and long QTc. However genetic analysis revealed the simultaneous presence of both RBM20 and KCNQ1 mutation. To the best of our knowledge, this is the first report in the medical literature on the co-existence of RBM20 and KCNQ1 mutation.</p>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early rhythm control compared to rate control in atrial fibrillation – A systematic review, meta-analysis, and meta-regression 早期心律控制与房颤率控制的比较——系统回顾、meta分析和meta回归。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.02.003

Katherine Hermanto, Raymond Pranata, Hawani Sasmaya Prameswari, Giky Karwiky, Chaerul Achmad, Mohammad Iqbal

{"title":"Early rhythm control compared to rate control in atrial fibrillation – A systematic review, meta-analysis, and meta-regression","authors":"Katherine Hermanto, Raymond Pranata, Hawani Sasmaya Prameswari, Giky Karwiky, Chaerul Achmad, Mohammad Iqbal","doi":"10.1016/j.ipej.2025.02.003","DOIUrl":"10.1016/j.ipej.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>This meta-analysis aimed to compare the effectiveness of early rhythm control to rate control, and whether catheter ablation derived more benefit compared to other methods of rhythm control.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted on PubMed, SCOPUS, and EuropePMC up to July 2, 2024. The primary outcome of this study was major adverse cardio-cerebrovascular events (MACCE), defined as a composite of mortality, stroke/systemic embolism, heart failure hospitalization (HFH), and acute coronary syndrome (ACS) during the follow-up period. Outcome measures were adjusted hazard ratios (aHR).</div></div><div><h3>Results</h3><div>A total of 504,124 patients from 11 studies were included in this systematic review and meta-analysis. Early rhythm control was significantly associated with reduction in MACCE (aHR 0.85 [95 % CI 0.80, 0.90], p < 0.001; I<sup>2</sup>: 23 %), stroke (aHR 0.79 [95 % CI 0.72, 0.86], p < 0.001; I<sup>2</sup>: 25 %), HFH (aHR 0.87 [95 % CI 0.78, 0.96], p = 0.008; I<sup>2</sup>: 48 %), and ACS (aHR 0.80 [95 % CI 0.66, 0.96], p = 0.018; I<sup>2</sup>: 40 %). No mortality benefit (aHR 0.93 [95 % CI 0.85, 1.01], p = 0.066; I<sup>2</sup>: 67 %) was observed; however, mortality benefit became evident (aHR 0.87 [95 % CI 0.85, 0.89], p < 0.001) upon removal of a study during a leave-one-out sensitivity analysis. Meta-regression analysis showed that the benefits of early rhythm control in terms of MACCE were more pronounced with ablation (coefficient −0.004, p = 0.010, R<sup>2</sup>: 100 %).</div></div><div><h3>Conclusion</h3><div>Early rhythm control was associated with better outcomes compared to rate control in AF, with a more pronounced benefit observed for ablation.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 2","pages":"Pages 82-90"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tachycardia induced cardiomyopathy due to ectopic atrial tachycardia originating from the atrial appendage: A case series and review of literature 源自心房附件的异位房性心动过速引起的心动过速性心肌病：一个病例系列和文献回顾。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.03.001

Abhinav Aggarwal, Anil Yadav, Ankit Jain, Anunay Gupta

引用次数: 0

Short coupled Ventricular Fibrillation in a patient with TRPM4 mutation TRPM4突变患者的短偶联心室颤动。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.03.003

Sriram Easwaran , Vedica Sethi , Vijay Surampalli , Yash Lokhandwala

{"title":"Short coupled Ventricular Fibrillation in a patient with TRPM4 mutation","authors":"Sriram Easwaran , Vedica Sethi , Vijay Surampalli , Yash Lokhandwala","doi":"10.1016/j.ipej.2025.03.003","DOIUrl":"10.1016/j.ipej.2025.03.003","url":null,"abstract":"<div><div>Inherited channelopathies are a cause of syncope in a structurally normal heart with subtle signs on baseline ECG, but sometimes these signs may be absent. The precipitant may either be a tachy or a bradyarrhythmia needing prompt diagnosis and treatment institution. One such cause is short coupled Ventricular fibrillation (VF) where the baseline ECG has a normal corrected QT interval (QTc) with multiple Ventricular Premature Complexes (VPCs) noted in the ECG especially around an event of syncope. The TRPM4 gene, encoding the Transient Receptor Potential Melastatin 4 ion channel, currently a variant of unknown significance is a calcium activated channel which is involved in regulation of the diastolic depolarization in the Sinoatrial (SA) node. Loss of function mutation of the gene may present as bradyarrhythmias or atrial arrhythmias due to conduction disturbances. We present a case of intractable short coupled VF with a coexistent tachy-brady syndrome, attributed to TRPM4 mutation. Due to persistent intractable VF despite antiarrhythmic therapy and implantable cardioverter-defibrillator (ICD), patient was given quinine instead of quinidine due to non-availability of the same, which led to significant alleviation of symptoms. This case underscores the complexity of managing ventricular arrhythmias and highlights the potential therapeutic role of quinine in select cases, in the scenario of unavailability of quinidine, offering insights into personalized treatment approaches for these challenging conditions.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 2","pages":"Pages 108-111"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conduction disease in cardiac amyloidosis patients: A case series suggesting a role for left bundle branch area pacing 心脏淀粉样变性患者的传导疾病：一个提示左束支区起搏作用的病例系列。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.01.001

Ojas H. Mehta , Keyrian Louis Le Gratiet , Markus Sikkel , Laurence D. Sterns

引用次数: 0

Real-world single-center preliminary experience of radiofrequency balloon pulmonary vein ablation for atrial fibrillation 真实世界单中心射频球囊肺静脉消融治疗房颤的初步经验。

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.01.003

Andrea Dell’Aquila , Carmelo La Greca , Amedeo Prezioso , Simone Zanchi , Joseph Antoine Kheir , Domenico Pecora

{"title":"Real-world single-center preliminary experience of radiofrequency balloon pulmonary vein ablation for atrial fibrillation","authors":"Andrea Dell’Aquila , Carmelo La Greca , Amedeo Prezioso , Simone Zanchi , Joseph Antoine Kheir , Domenico Pecora","doi":"10.1016/j.ipej.2025.01.003","DOIUrl":"10.1016/j.ipej.2025.01.003","url":null,"abstract":"<div><div>Atrial fibrillation (AF) is the most common cardiac arrhythmia and pulmonary vein isolation (PVI) by percutaneous transcatheter ablation is its pivotal treatment. Nowadays, several techniques using different energy sources are used, such as radiofrequency (RF), cryoablation and laser ablation. A new technology that combines the strengths of different techniques has been developed, in particular having both the speed of one-shot techniques and the selectivity and precision of point-by-point RF: the RF balloon (RFB). Recent clinical studies<sup>1–3</sup> have demonstrated its efficacy and safety, with good results in terms of first pass isolation, procedural duration and fluoroscopy time. However, real-world data regarding RFB ablation is scarce, therefore with this study we aimed to describe the experience of our center with this technology (one of the first adopting it in our country). We prospectively enrolled in a single-center a total of 20 consecutive patients who underwent AF ablation with RFB. The primary endpoint, i.e. PVI defined as stable absence of any electrical conduction from and into the veins, was met by 18 patient (90 %). Mean procedural and fluoroscopy times were 79 ± 30.68 min and and 15.36 ± 6.57 min, respectively, dwelling time was 30.3 ± 8.09 min. The only complication reported was a single case mild pericardial effusion 24 h after the procedure, likely of inflammatory nature, which was treated conservatively and resolved before discharge. With this study we demonstrated that PVI with RFB appears to be an effective and safe technique in a real world setting, with many upsides and a reduced atrial dwelling time that theoretically could reduce the risk of thromboembolic complications. Further studies on larger number of patients are needed to confirm the results we obtained.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 2","pages":"Pages 68-73"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EHRA 2025- A voyage into the future! EHRA 2025-未来之旅！

Indian Pacing and Electrophysiology Journal Pub Date : 2025-03-01 DOI: 10.1016/j.ipej.2025.04.006

Bharatraj Banavalikar

引用次数: 0