Journal of Food and Drug Analysis最新文献_第3页

Glycine-rich peptides from fermented Chenopodium formosanum sprout as an antioxidant to modulate the oxidative stress 从发酵陈皮芽中提取富含甘氨酸的肽作为抗氧化剂调节氧化应激

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-12-15 DOI: 10.38212/2224-6614.3476

Chen-Che Hsieh, Shu-Han Yu, Hsing-Chun Kuo, Darin Khumsupan, Hsiao-Chu Huang, Yu-Wei Liou, Chen-Yu Kao, Szu-Chuan Shen, Kuan-Chen Cheng

引用次数: 0

Attenuation of diabetes-mediated muscle atrophy in rats by fish oil enriched omega-3 polyunsaturated fatty acids supplementation 通过补充富含omega-3多不饱和脂肪酸的鱼油减轻大鼠糖尿病介导的肌肉萎缩

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3468

Shing-Hwa Liu, Wei-Hsuan Lin, Huei‐Ping Tzeng, Meng-Tsan Chiang

{"title":"Attenuation of diabetes-mediated muscle atrophy in rats by fish oil enriched omega-3 polyunsaturated fatty acids supplementation","authors":"Shing-Hwa Liu, Wei-Hsuan Lin, Huei‐Ping Tzeng, Meng-Tsan Chiang","doi":"10.38212/2224-6614.3468","DOIUrl":"https://doi.org/10.38212/2224-6614.3468","url":null,"abstract":"Diabetes is associated with an increased risk of muscle wasting/atrophy, which adversely affects quality of life. We hypothesized that long term supplementation of ﬁ sh oil may have protective effects against sarcopenia or muscle atrophy in streptozotocin (STZ) and high-fat (HF) diet-induced diabetic rat model. Wistar rats at age of 7 weeks were injected with saline or STZ to induce hyperglycemia. After one week, they were fed on a normal control diet or HF diet with/without supplementation of ﬁ sh oil for 18 weeks. Feeding diabetic rats with a ﬁ sh oil-enriched diet alleviated body weight loss and the impaired glucose tolerance using OGTT test. Although ﬁ sh oil did not improve the decreased muscle mass, the muscle atrophy induced by diabetes was attenuated by ﬁ sh oil in gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles. Fish oil supplementation reversed the decreased expression of phospho (p)-AKT, p-mTOR, and p-p70s6k, which are molecules related to protein synthesis. Besides, protein degradation-related signaling pathways were inhibited by ﬁ sh oil, such as increasing p-FoxO1 and decreasing Atrogin-1 and MURF1 protein expression. Fish oil down-regulated the expression of autophagy-related molecules including ATG5, p62, and LC3B II/I ratio, which may result in less muscle atrophy. In ﬂ ammation-related signaling regulators including TNF-a , NF-k B, AGEs, and RAGE were suppressed by ﬁ sh oil supplementation as well. Moreover, the down-regulated p-AMPK a , SIRT1, and PGC-1 in diabetic rats were counteracted by ﬁ sh oil, which may improve mitochondrial function and further block FoxO action. These data suggest that long-term ﬁ sh oil supplementation exerts protective effects against diabetes-induced muscle atrophy, which may in turn ameliorate insulin resistance and impaired glucose tolerance.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45874333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy-urea cycle pathway is essential for the statin-mediated nitric oxide bioavailability in endothelial cells 自噬-尿素循环途径对于他汀介导的内皮细胞一氧化氮的生物利用度至关重要

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3472

Wen-Hua Chen, Bei‐Chia Guo, Chia-Hui Chen, Man-Chen Hsu, Chih-Hsien Wang, Tzong-Shyuan Lee

{"title":"Autophagy-urea cycle pathway is essential for the statin-mediated nitric oxide bioavailability in endothelial cells","authors":"Wen-Hua Chen, Bei‐Chia Guo, Chia-Hui Chen, Man-Chen Hsu, Chih-Hsien Wang, Tzong-Shyuan Lee","doi":"10.38212/2224-6614.3472","DOIUrl":"https://doi.org/10.38212/2224-6614.3472","url":null,"abstract":"Statins induce nitric oxide (NO) bioavailability by activating endothelial nitric oxide synthase via kinase-and calcium-dependent pathways in endothelial cells (ECs). However, their effect on the metabolism of L-arginine, the precursor for NO biosynthesis, and regulatory mechanism have not yet been investigated. In this study, we investigated the role of the autophagy e urea cycle-L-arginine pathway in simvastatin-mediated NO bioavailability in ECs. Griess ' s assay was used to determine the NO bioavailability. Protein expression was assessed using Western blot analysis. Further, immuno-cytochemistry was performed to observe autophagosome formation, while conventional assay kits were used to quantify the levels of different intermediate substrates of the urea cycle. In ECs, treatment with simvastatin induced the activation of autophagy ﬂ ux, as evidenced by the increased levels of microtubule-associated protein 1A/1B-light chain 3 II and autophagolysosome formation and decreased levels of p62. Inhibition of autophagy by ATG7 small interfering RNA (siRNA), chloroquine and ba ﬁ lomycin A1 abolished simvastatin-induced NO bioavailability, EC proliferation, migration, and tube formation. Additionally, simvastatin increased the intermediate substrates levels of the urea cycle, including glutamate, acetyl-CoA, urea, and L-arginine, all of which were abrogated by chloroquine or ba ﬁ lomycin A1. Genetic knockdown of argininosuccinate lyase using siRNA abrogated simvastatin-induced increase in NO bioavailability and EC-related functions. Moreover, inhibition of AMP-activated protein kinase (AMPK) and transient receptor potential vanilloid 1 (TRPV1) prevented simvastatin-induced activation of the autophagy e urea cycle pathway and NO production. Our ﬁ ndings suggest that simvastatin activates the autophagy e urea cycle pathway via TRPV1-AMPK signaling, which increases L-arginine bioavailability and ultimately promotes NO production in ECs.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46176454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification for metabolism profiles and pharmacokinetic studies of tradition Chinese prescription Ji-Ming-San and its major metabolites in rats by UHPLC-Q-TOF-MS/MS and UHPLC-MS/MS 采用UHPLC-Q-TOF-MS/MS和UHPLC-MS/MS对中药复方吉明散及其主要代谢物在大鼠体内的代谢谱及药动学进行鉴定

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3473

Cheng-Yang Hsieh, Ching-Chiung Wang, L. Tayo, Po-Wei Tsai, Chia-Jung Lee

{"title":"Identification for metabolism profiles and pharmacokinetic studies of tradition Chinese prescription Ji-Ming-San and its major metabolites in rats by UHPLC-Q-TOF-MS/MS and UHPLC-MS/MS","authors":"Cheng-Yang Hsieh, Ching-Chiung Wang, L. Tayo, Po-Wei Tsai, Chia-Jung Lee","doi":"10.38212/2224-6614.3473","DOIUrl":"https://doi.org/10.38212/2224-6614.3473","url":null,"abstract":"Ji-Ming-Shan (JMS) is a traditional prescription use for patients with rheumatism, tendons swelling, athlete ' s foot, diuresis and even gout. This study developed a rapid and sensitive method for the analysis of JMS chemical components in the Traditional Chinese medicine (TCM) prescription and in the serum samples of rats which were administered with the herbal extract. Two mass spectrometric approaches were used namely Ultra-performance liquid chromatography-quadrupole time-of-ﬂ ight-mass spectrometry (UPLC-Q-TOF-MS) method for the major metabolites of the JMS extract while Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was employed for the detection of the JMS metabolites in the sera of rats. It was revealed that the major components in the JMS extract were identi ﬁ ed to be narirutin and hesperidin. It was con ﬁ rmed that 17 compounds were determined in JMS prescription extract and 16 metabolites resulting from the biotransformation of narirutin and hesperidin were identi ﬁ ed in the serum samples. In silico analyses also revealed that the metabolite hersperidin-7-glucoside exhibited the best binding ability with respect to the Cyclooxygenase-2 (COX-2) enzyme target. This study showcased the possible biochemical mechanism involved in the therapeutic ef ﬁ ciency of JMS components and their biotransformation products.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44744436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells 虫草素抑制ERK通路抑制MA-10小鼠Leydig肿瘤细胞FGF9诱导的肿瘤发生

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3464

Li-Ching Chen, Chin-Ying Chen, Yi-Ping Lee, Bu-Miin Huang

{"title":"Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells","authors":"Li-Ching Chen, Chin-Ying Chen, Yi-Ping Lee, Bu-Miin Huang","doi":"10.38212/2224-6614.3464","DOIUrl":"https://doi.org/10.38212/2224-6614.3464","url":null,"abstract":"Fibroblast growth factor 9 (FGF9) is a member of FGF family, and abnormal expression of FGF9 can promote tumorigenesis. Cordycepin, a major bioactive component in fungus Cordyceps sinensis , could suppress various tumors. We have shown that cordycepin could inhibit FGF9-induced testicular tumor growth in vitro and in vivo with MA-10 mouse Leydig tumor cells. In the present study, the mechanisms related to apoptosis and autophagy were determined. Results show that cordycepin signi ﬁ cantly suppressed cell viability and colony formation with correlatedly morphological change related to cell death in FGF9-treated MA-10 cells. Flow cytometry and western blotting results further demonstrate that cordycepin induced apoptosis through the cleavage of caspase-8, -9, -3 and PARP in FGF9-treated MA-10 cells. However, the expressions of LC3-II, beclin-1 and p62 were not stimulated by cordycepin with the presence of FGF9, suggesting cordycepin would activate apoptosis, but not autophagy, in FGF9-treated MA-10 cells. Moreover, inhibition of ERK signal pathway and autophagy would enhance cordycepin-induced cell death effects in FGF9-treated MA-10 cells, referring that ERK signaling was regulated under cordycepin and FGF9 treatments. In NOD-SCID mouse allograft model inoculated with MA-10 cells, cordycepin signi ﬁ cantly suppressed tumor growth with the presence of FGF9, and the cleavage of caspase-3 could be observed in tumor tissue, implying cordycepin induced caspase cascade to suppress tumor growth. Moreover, cordycepin plus U0126, ERK inhibitor, further signi ﬁ cantly suppressed tumor growth with the presence of FGF9 as compared to the FGF9 only group, con ﬁ rming the involvement of ERK signaling in this event. In conclusion, cordycepin induced caspase and ERK pathways to promote MA-10 cell apoptosis, but not auto-phagy, with the presence of FGF9.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47268617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy 如何应对友敌NRF2:靶向NRF2进行化学预防和癌症治疗

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3463

Ya‐Chu Tang, Yung-Jen Chuang, Hsin-Huei Chang, Shin-Hun Juang, G. Yen, Jang-Yang Chang, Ching-Chuan Kuo

{"title":"How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy","authors":"Ya‐Chu Tang, Yung-Jen Chuang, Hsin-Huei Chang, Shin-Hun Juang, G. Yen, Jang-Yang Chang, Ching-Chuan Kuo","doi":"10.38212/2224-6614.3463","DOIUrl":"https://doi.org/10.38212/2224-6614.3463","url":null,"abstract":"Induction of antioxidant proteins and phase 2 detoxifying enzymes that neutralize reactive electrophiles are important mechanisms for protection against carcinogenesis. Normal cells provide multifaceted pathways to tightly control NF-E2-related factor 2 (NRF2)-mediated gene expression in response to an assault by a range of endogenous and exogenous oncogenic molecules. Transient activation of NRF2 by its activators is able to induce ARE-mediated cytoprotective proteins which are essential for protection against various toxic and oxidative damages, and NRF2 activators thereby have ef ﬁ cacy in cancer chemoprevention. Because NRF2 has a cytoprotective function, it can protect normal cells from carcinogens like an angel, but when the protective effect acts on cancer cells, it will give rise to invincible cancer cells and play a devilish role in tumor progression. Indeed, aberrant activation of NRF2 has been found in a variety of cancers that create a favorable environment for the proliferation and survival of cancer cells and leads to drug resistance, ultimately leading to the poor clinical prognosis of patients. Therefore, pharmacological inhibition of NRF2 signaling has emerged as a promising approach for cancer therapy. This review aims to compile the regulatory mechanisms of NRF2 and its double-edged role in cancer. In addition, we also summarize the research progress of NRF2 modulators, especially phytochemicals, in chemoprevention and cancer therapy.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41790952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation 金华清肝颗粒UHPLC-Q-提取-Orbitrap-MS分析：45种潜在抗Covid-19成分的推定鉴定、保密添加和药典质量标志物推荐

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3466

Jingyuan Zeng, Xican Li, Rongxin Cai, Chunhou Li, Shaoman Chen

引用次数: 1

Determination and evaluation of EPA and DHA ethyl esters in fish oils using the TMAH transesterification method TMAH酯交换法测定和评价鱼油中的EPA和DHA乙酯

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3469

Pai-Wen Wu, Ching-Hsuan Tsai, Ching-Yu Hsu, Shu-Han Chang, Y. Kao, S. Tseng, Der-Yuan Wang

{"title":"Determination and evaluation of EPA and DHA ethyl esters in fish oils using the TMAH transesterification method","authors":"Pai-Wen Wu, Ching-Hsuan Tsai, Ching-Yu Hsu, Shu-Han Chang, Y. Kao, S. Tseng, Der-Yuan Wang","doi":"10.38212/2224-6614.3469","DOIUrl":"https://doi.org/10.38212/2224-6614.3469","url":null,"abstract":"A simple and dependable technique, known as THAM method, has been developed to detect and measure ethyl eicosapentaenoate (EE-EPA) and ethyl docosahexaenoate (EE-DHA) in encapsulated ﬁ sh oils. This technique involves using tetramethylammonium hydroxide (TMAH) as a catalyst, followed by analysis using gas chromatography equipped with a ﬂ ame ionization detector. Recoveries of EE-EPA and EE-DHA spiked between 5 mg/g and 20 mg/g were found to be between 90.8% and 95.2%, with coef ﬁ cients of variation ranging from 0.2% to 2.5%, demonstrating the accuracy and precision of the technique. Additionally, its limitation of quantitation of EE-EPA and EE-DHA in ﬁ sh oil samples was 0.2%. When compared with the direct injection method, the TMAH method yielded relative percent differences of no more than 3.8% in the amounts of ethyl esters of EPA and DHA in ﬁ sh oil, while preventing contamination and maintaining its performance over time. Furthermore, when compared the total amounts of EPA and DHA with the boron tri ﬂ uoride method, the relative percent differences were no more than 4.7% by the TMAH method. The advantages of using the TMAH method in distinguishing the ester forms of EPA and DHA and determining the total content of fatty acids in ﬁ sh oils, which can provide an auxiliary check for evaluating the compliance of applications with the regulation related to the purity and form of EPA and DHA.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43831380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrative approach for compressive quality control of RespireAidTM, a traditional Chinese medicine formula against SARS-CoV-2 抗严重急性呼吸系统综合征冠状病毒2型中药配方RespireAidTM的压缩质量综合控制方法

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3467

Kun-Teng Wang, Chia-Jung Lee, Ming-Chung Lee, Chao-yu Chen, Yun-Chen Tsai, Wu-Chang Chuang

{"title":"An integrative approach for compressive quality control of RespireAidTM, a traditional Chinese medicine formula against SARS-CoV-2","authors":"Kun-Teng Wang, Chia-Jung Lee, Ming-Chung Lee, Chao-yu Chen, Yun-Chen Tsai, Wu-Chang Chuang","doi":"10.38212/2224-6614.3467","DOIUrl":"https://doi.org/10.38212/2224-6614.3467","url":null,"abstract":"RespireAid ™ (NRICM101) is an effective anti-SARS-CoV-2 traditional Chinese medicine formula and has been licensed as a drug or dietary supplement in Taiwan, Luxembourg, Australia, Singapore, Cambodia, Philippines, and Canada. In this study, we provided integrated quality control strategy to analyze the ingredient of RespireAid ™ . In addition, the lot-to-lot ef ﬁ cacy stabilities were also evaluated. We found that RespireAid ™ comprised of mono-saccharides and disaccharides (34.0%), maltodextrin (23.5%), inorganic elements and ash (12.2%), oligosaccharides and polysaccharides (11.4%), principal components (4.4%), moisture (4.0%), amino acids (3.5%), b -Cyclodextrin (0.25%), menthol (0.25%), and nucleotides (0.14%), while the remainder was unidenti ﬁ ed (6.36%). This is the ﬁ rst time that the chemical composition of a complex traditional Chinese medicine was clari ﬁ ed using various analytical instruments. The lot-to-lot anti-oxidation and anti-in ﬂ ammation ef ﬁ cacies of RespireAid ™ were consistent, with average 50% scavenging concentrations of 0.22 ± 0.02 mg/mL and 5.76 ± 0.59 mg/mL, respectively. From a comprehensive quality control strategy point of view, RespireAid ™ , designed from a traditional Chinese medicine formula, displayed high quality, trans-parency, and ef ﬁ cacy. This integrated strategy provides a clear and reliable way to evaluate the quality of complex traditional Chinese medicines.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45548305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis sativa L.: A Comprehensive review on legislation, decriminalization, phytochemistry, antimicrobial activity, and safety 大麻:立法，非犯罪化，植物化学，抗菌活性和安全性的综合综述

IF 3.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI: 10.38212/2224-6614.3471

Mohammed Dalli, Salah-eddine Azizi, Ali Azghar, Abderrazak Saddari, E. Benaissa, Y. Lahlou, Mostafa Elouennass, A. Maleb

{"title":"Cannabis sativa L.: A Comprehensive review on legislation, decriminalization, phytochemistry, antimicrobial activity, and safety","authors":"Mohammed Dalli, Salah-eddine Azizi, Ali Azghar, Abderrazak Saddari, E. Benaissa, Y. Lahlou, Mostafa Elouennass, A. Maleb","doi":"10.38212/2224-6614.3471","DOIUrl":"https://doi.org/10.38212/2224-6614.3471","url":null,"abstract":"Throughout history, medicinal and aromatic plants have been used extensively to cure a variety of ailments. This article provides a comprehensive overview of Cannabis sativa , speci ﬁ cally focusing on its legislative status, decrimi-nalization, phytochemistry, antimicrobial activity, and safety. The study begins by brie ﬂ y outlining the plant ' s history, including its cultivation, harvesting, and storage methods. The review analyzes extensively the antimicrobial properties of Cannabis sativa and its derivatives, speci ﬁ cally examining their reported antiviral, antibacterial, antifungal, and antiparasitic capabilities, which have been documented in databases such as Scopus, ScienceDirect, PubMed, and Web of Science. The paper also discusses trends in studies about the plant object of the study, the different bioactive compounds that were identi ﬁ ed in the plant (phenolic acids, ﬂ avonoids, alkaloids, cannabinoids, and terpenes), and safe consumption in several cannabis-based products including candies, desserts, wine and as food ﬂ avoring. Furthermore, this study has reported information about the legalization and decriminalization of cannabis use across the globe with a speci ﬁ c focus on Morocco because it has the largest cultivated area of C. sativa plant. However, some substances with potential antimicrobial properties were not investigated in this review due to the lack of data on their activity. The authors hope that their efforts will inspire future studies on the therapeutic uses of Cannabis sativa and its derivatives, ultimately leading to improved health outcomes.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42827218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0