Journal of Fluorine Chemistry最新文献

筛选
英文 中文
Fluorine-containing isosteres enable a structure-activity relationship study of gingerol derivatives
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110400
Shelby E. Cooper, Diarta Kabashi, Marlin E. Yacoub, Jessica A. Molen, Osman Farhan, Christina Farley, Samantha Yencha, Michelle M. Figueiredo, Nidheesh Phadnis, Wynter Henry, Julian A. Harris, Frank Wilkinson, John A. Milligan
{"title":"Fluorine-containing isosteres enable a structure-activity relationship study of gingerol derivatives","authors":"Shelby E. Cooper,&nbsp;Diarta Kabashi,&nbsp;Marlin E. Yacoub,&nbsp;Jessica A. Molen,&nbsp;Osman Farhan,&nbsp;Christina Farley,&nbsp;Samantha Yencha,&nbsp;Michelle M. Figueiredo,&nbsp;Nidheesh Phadnis,&nbsp;Wynter Henry,&nbsp;Julian A. Harris,&nbsp;Frank Wilkinson,&nbsp;John A. Milligan","doi":"10.1016/j.jfluchem.2025.110400","DOIUrl":"10.1016/j.jfluchem.2025.110400","url":null,"abstract":"<div><div>A series of fluorinated and non-fluorinated [6]-gingerol, [6]-paradol, [6]-shogaol and ferulate derivatives were synthesized. Testing these analogs in anti-proliferation assays with MCF-7, A549, HCT-116 and HEK-293 cell lines provided insight into the structural features that contribute to the anti-proliferative activity of naturally occurring ginger constituents. In particular, the use of both vinyl and alkyl trifluoromethyl isosteres allowed us to evaluate the structure-activity impact of the enone motif found in shogaols. Our results indicate that enone-containing derivatives have a higher potency, suggesting the conjugated enone motif characteristic of shogaols may be primarily responsible for the anti-cancer activity of the broader natural product family.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110400"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2-Trifluoromethoxyacetic acid – Synthesis and characterization
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110396
Thorsten Meier , Sabine Lorenzen , Tanja Knuplez , Tobias Preitschopf , Karsten Koppe , Peter Barthen , Rüdiger Bertermann , Michael Schulte , Nikolai Ignat‘ev , Maik Finze
{"title":"2-Trifluoromethoxyacetic acid – Synthesis and characterization","authors":"Thorsten Meier ,&nbsp;Sabine Lorenzen ,&nbsp;Tanja Knuplez ,&nbsp;Tobias Preitschopf ,&nbsp;Karsten Koppe ,&nbsp;Peter Barthen ,&nbsp;Rüdiger Bertermann ,&nbsp;Michael Schulte ,&nbsp;Nikolai Ignat‘ev ,&nbsp;Maik Finze","doi":"10.1016/j.jfluchem.2025.110396","DOIUrl":"10.1016/j.jfluchem.2025.110396","url":null,"abstract":"<div><div>A straightforward and high-yield synthesis of 2-trifluoromethoxyacetic acid CF<sub>3</sub>OCH<sub>2</sub>C(O)OH starting from trifluoromethyl triflate CF<sub>3</sub>SO<sub>2</sub>OCF<sub>3</sub> is described. The trifluoromethoxide anion was generated from trifluoromethyl triflate and a fluoride source followed by a nucleophilic substitution reaction with the {OCF<sub>3</sub>}<sup>–</sup> ion to yield CF<sub>3</sub>OCH<sub>2</sub>C(O)OC<sub>2</sub>H<sub>5</sub>. The ester was converted into M{CF<sub>3</sub>OCH<sub>2</sub>CO<sub>2</sub>} (M = Na, K) and the acid CF<sub>3</sub>OCH<sub>2</sub>C(O)OH was obtained from the sodium salt and HCl. In addition, the silver(I) salt of the {CF<sub>3</sub>OCH<sub>2</sub>CO<sub>2</sub>}<sup>–</sup> anion was synthesized from CF<sub>3</sub>OCH<sub>2</sub>C(O)OH and silver(I) oxide. The study includes a new synthesis for the starting compound CF<sub>3</sub>SO<sub>2</sub>OCF<sub>3</sub> and a detailed description for the preparation of [N(CH<sub>3</sub>)<sub>4</sub>]{OCF<sub>3</sub>}. Furthermore, the crystal structures of CF<sub>3</sub>OCH<sub>2</sub>C(O)OH, CF<sub>3</sub>OCH<sub>2</sub>C(O)OC<sub>2</sub>H<sub>5</sub>, M{CF<sub>3</sub>OCH<sub>2</sub>CO<sub>2</sub>} (M = K, Ag), and [N(CH<sub>3</sub>)<sub>4</sub>]{OCF<sub>3</sub>} are reported.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110396"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel synthetic method of 1,1,2,2-tetrafluoro-2-[(1,2,2-trifluoroethenyl)oxy]ethanesulfonyl fluoride
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110399
Nobuyuki Uematsu , Yasuhiro Nagato , Ken-ichi Yakigaya , Kaishi Hori , Hideki Date , Akitake Nakamura , Kazuki Maeda
{"title":"Novel synthetic method of 1,1,2,2-tetrafluoro-2-[(1,2,2-trifluoroethenyl)oxy]ethanesulfonyl fluoride","authors":"Nobuyuki Uematsu ,&nbsp;Yasuhiro Nagato ,&nbsp;Ken-ichi Yakigaya ,&nbsp;Kaishi Hori ,&nbsp;Hideki Date ,&nbsp;Akitake Nakamura ,&nbsp;Kazuki Maeda","doi":"10.1016/j.jfluchem.2025.110399","DOIUrl":"10.1016/j.jfluchem.2025.110399","url":null,"abstract":"<div><div>A novel synthetic method of 1,1,2,2-tetrafluoro-2-[(1,2,2-trifluoroethenyl)oxy]ethanesulfonyl fluoride, the raw material for perfluorinated polymer electrolyte membranes, was developed from the starting material CF<sub>3</sub>CF(COF)O(CF<sub>2</sub>)<sub>2</sub>SO<sub>2</sub>F via the ring-opening reaction of cyclic compound and the cleavage reaction of vinyl sulfonic anhydride using commercially available reagents.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110399"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of poly [2,3,5,6-tetrafluoro-4-(trifluoromethyl) phenylaminophosphazene]/LiNbO3 nanocomposites and characterization of their morphological, mechanical, and piezoelectric behavior for energy harvesting applications
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110404
Nand Kumar , Nagmani Manikpuri , Atanu Giri , Om Prakash Gautam
{"title":"Synthesis of poly [2,3,5,6-tetrafluoro-4-(trifluoromethyl) phenylaminophosphazene]/LiNbO3 nanocomposites and characterization of their morphological, mechanical, and piezoelectric behavior for energy harvesting applications","authors":"Nand Kumar ,&nbsp;Nagmani Manikpuri ,&nbsp;Atanu Giri ,&nbsp;Om Prakash Gautam","doi":"10.1016/j.jfluchem.2025.110404","DOIUrl":"10.1016/j.jfluchem.2025.110404","url":null,"abstract":"<div><div>The use of polymer nanocomposites for piezoelectric energy harvesting applications has created exciting opportunities in flexible electronics. In this research, we synthesized poly [2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenylaminophosphazene (PTPP)]/LiNbO₃ nanocomposites by incorporating trigonal crystalline lithium niobate nanoparticles (average particle size ∼ 45 nm) into PTPP via solution casting method. Further, we investigated the effects of different concentrations of lithium niobate (LiNbO₃) nanoparticles on the thermal, mechanical, and piezoelectric performance of the PTPP nanocomposites. The synthesized nanocomposites exhibited strong interfacial interactions between the organic and inorganic phases, resulting in a uniform morphology across all compositions, except for the 8 % loading, which showed some agglomeration. Additionally, both PTPP and its nanocomposites demonstrated high thermal stability, with the highest char yield of 64.1 % observed at 8 % LiNbO₃ loading. Mechanical testing revealed a significant improvement in tensile strength (224 %) and a reduction in elongation at break (34.4 %) with 8 % LiNbO₃ loading. These enhancements in thermal and mechanical properties were attributed to the presence of strong C-F bonds and LiNbO₃ content in the nanocomposites. Besides this, dynamic mechanical analysis indicated that 8 % LiNbO₃-loaded PTPP nanocomposite also exhibited the lowest tan δ value of 0.68 and the highest energy storage capacity with minimal loss over a high-temperature range due to the restricted mobility of polymer chain with the addition of nanoparticles. PTPP also exhibited a piezoelectric effect with a coefficient of 26.4 pC/N, which was further enhanced by the incorporation of LiNbO₃, reaching a maximum increase of 6.4 %. These novel nanocomposites show great potential for energy-harvesting applications in electronic devices.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110404"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration towards the bromopentafluorosulfanylation reaction of terminal alkynes
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2024.110386
Marie-Rose Ouellet-Du Berger , Jean-Philippe Bouillon , Jean-François Paquin
{"title":"Exploration towards the bromopentafluorosulfanylation reaction of terminal alkynes","authors":"Marie-Rose Ouellet-Du Berger ,&nbsp;Jean-Philippe Bouillon ,&nbsp;Jean-François Paquin","doi":"10.1016/j.jfluchem.2024.110386","DOIUrl":"10.1016/j.jfluchem.2024.110386","url":null,"abstract":"<div><div>In this paper, we report our efforts toward the development of a bromopentafluorosulfanylation reaction of terminal alkynes. The use of tetrabromomethane (CBr<sub>4</sub>) as a bromine atom source allowed the formation of the bromopentafluorosulfanylated product. Practically, however, the desired products could not be separated from the minor chloropentafluorosulfanylated products as well as the dibromoalkene side-products generated under those reaction conditions.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110386"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the use of carbon and boron nitride nanotubes as sensors for ClF3: A density functional theory analysis
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110401
Fatemeh Biniaz, Mohammad Reza Zardoost, Mohammad Reza Toosi
{"title":"New insights into the use of carbon and boron nitride nanotubes as sensors for ClF3: A density functional theory analysis","authors":"Fatemeh Biniaz,&nbsp;Mohammad Reza Zardoost,&nbsp;Mohammad Reza Toosi","doi":"10.1016/j.jfluchem.2025.110401","DOIUrl":"10.1016/j.jfluchem.2025.110401","url":null,"abstract":"<div><div>The ability of born nitride and carbon nanotubes to adsorb ClF<sub>3</sub> was investigated by the density functional theory method. The electronic properties including HOMO and LUMO energies, density of states, chemical potential, electrophilicity index, softness, hardness, and natural bond orbital analysis were studied. Our findings indicate that among the studied tubes the (6,0) CNT is more suitable for adsorbing ClF<sub>3</sub> molecule. The adsorption of ClF<sub>3</sub> on the nanotubes significantly reduces the energy gap and hardness parameters of the tubes. This factor increases the conductivity of the system. The adsorption energies in the investigated models are negative, which confirm that the adsorption process is thermodynamically favorable and the complexes are stable. Also, among these compounds, (6,0) CNT- ClF<sub>3</sub> has the greatest adsorption energy. QTAIM calculations confirm the observed adsorption energies.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110401"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143354279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regio- and stereochemical behavior of cyclooctane and cyclodecane derivatives containing CF2 moieties
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110397
Matheus P. Freitas
{"title":"Regio- and stereochemical behavior of cyclooctane and cyclodecane derivatives containing CF2 moieties","authors":"Matheus P. Freitas","doi":"10.1016/j.jfluchem.2025.110397","DOIUrl":"10.1016/j.jfluchem.2025.110397","url":null,"abstract":"<div><div>Cyclooctane and cyclodecane are important medium-size rings in organic chemistry, and fluorination can significantly modulate the properties of organic molecules, such as polarity, viscosity, and acidity. In this quantum-chemical study, two CF<sub>2</sub> groups replaced the methylene moieties of the most stable conformations of cyclooctane (boat-chair) and cyclodecane (boat-chair-boat) to evaluate the effect of head, corner, and edge substitution on the energetics of the possible structures, including both constitutional and stereochemical-type isomers. It was found that CF<sub>2</sub> groups prefer to occupy head (at C5) and corner positions of the cyclooctane ring rather than head (at C1) and edge positions, as these latter positions orient the fluorines <em>endo</em>, causing transannular repulsion. However, the <strong>2,7</strong> isomer, which possesses an edge CF<sub>2</sub> group, is remarkably stable due to an unprecedented transannular hydrogen bond between hydrogen at C3 and the CF<sub>2</sub> at C7. Similar findings were obtained for the cyclodecane derivatives, indicating that fluorination is preferable in certain positions due to steric and strain relief, while the transannular hydrogen bond also plays a secondary role as a source of stabilization. Given the CF<sub>2</sub> groups' ability to order the conformation of these medium-size rings, fluorination may be utilized in systems where this property is required, such as in liquid crystals.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110397"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, purification and characterisation of novel PFAS following nontarget analysis
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110398
Ana R.L. Araujo , Anton Pavlov , Jon Eigil Johansen , Sicco Brandsma , Huiling Liu
{"title":"Synthesis, purification and characterisation of novel PFAS following nontarget analysis","authors":"Ana R.L. Araujo ,&nbsp;Anton Pavlov ,&nbsp;Jon Eigil Johansen ,&nbsp;Sicco Brandsma ,&nbsp;Huiling Liu","doi":"10.1016/j.jfluchem.2025.110398","DOIUrl":"10.1016/j.jfluchem.2025.110398","url":null,"abstract":"<div><div>PFAS, or per- and polyfluorinated alkyl substances, are among the most prevalent environmental contaminants. Because of their toxicity and widespread use, these substances must be regulated in order to reduce the associated hazards. Effective regulation requires accurate measurement of PFAS concentrations, but the lack of commercially available reference standards hinders the identification and quantification of novel PFAS discovered through nontarget analysis techniques. In this work, we aimed to fill this gap by synthetising new PFAS reference standards, based on findings reported in the literature through nontarget assays.</div><div>We performed the synthesis of 17 novel PFAS reference standards, including three fluorotelomer thioether amido sulfonic acid (FTSASs), three fluorotelomer sulfonyl amido sulfonic acid (FtSO2AoS), 6:2 Fluorotelomer sulfinyl amido sulfonic acid (6:2 FtSOAo), three perfluoroalkane sulfonamide diacetic acids (FASEE diacids), three perfluroalkyl amidoalkyl amine (PFAAAm), perfluoro (4-methyl-3,6-dioxaoct-7-ene) sodium sulfonate (PS acid sodium salt), perfluoro (4-methyl-3,6-dioxaoct-7-ene) sulfonic acid (PS acid), perfluoro-3-{ [1-(ethenyloxy)propan-2-yl]oxy}propanoic acid (EVE acid), and 6- (2,2,3,3,4,4,4-Heptafluorobutoxy)hexan-1-ol. Various chemical reactions were carried out to synthesise the chemicals, and the Dry Column Vacuum Chromatography (DCVC) was selected as the best purification technique. The linear isomer product was obtained by recrystallisation when branched isomers were present. The identity and purity of the synthesised reference standards were confirmed using a combination of NMR spectroscopy (¹H, ¹⁹F, ¹³C) and mass spectrometry (m<em>/z</em>, LC-MS, or GC–MS).</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110398"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the reaction of hexafluoro-1,4-naphthoquinone with substituted phenols
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110402
Ekaterina N. Kudryavtseva, Boris V. Lichitsky, Evgeny V. Tretyakov
{"title":"Investigation of the reaction of hexafluoro-1,4-naphthoquinone with substituted phenols","authors":"Ekaterina N. Kudryavtseva,&nbsp;Boris V. Lichitsky,&nbsp;Evgeny V. Tretyakov","doi":"10.1016/j.jfluchem.2025.110402","DOIUrl":"10.1016/j.jfluchem.2025.110402","url":null,"abstract":"<div><div>Reaction of hexafluoro-1,4-naphthoquinone with various phenols was studied for the first time. It was shown that sodium acetate is a convenient reagent for implementation of the process. The investigated condensation led exclusively to substitution of two fluorine atoms in the quinone core. Based on performed research the method for preparation of substituted 2,3-diaryloxy-5,6,7,8-tetrafluoronaphthalene-1,4-diones was elaborated. Using similar conditions pentafluorobenzo[<em>a</em>]phenoxazine derivatives were obtained from 2-aminophenols. In contrast to phenols cyclic 1,3-diketones in the reaction with perfluoronaphthoquinone act as C-nucleophiles resulting in fluorinated polycondensed furans. Structures of key obtained products were proved using X-ray analysis.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110402"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing CF3 group at alkenyl C=C bond. Recent developments
IF 1.7 4区 化学
Journal of Fluorine Chemistry Pub Date : 2025-02-01 DOI: 10.1016/j.jfluchem.2025.110403
Karolina Paszek, Henryk Koroniak, Katarzyna Koroniak–Szejn
{"title":"Introducing CF3 group at alkenyl C=C bond. Recent developments","authors":"Karolina Paszek,&nbsp;Henryk Koroniak,&nbsp;Katarzyna Koroniak–Szejn","doi":"10.1016/j.jfluchem.2025.110403","DOIUrl":"10.1016/j.jfluchem.2025.110403","url":null,"abstract":"<div><div>Recently, significant interest has been developed in pharmaceuticals containing fluorine The biological effects depend on the number and type of fluorine groups in the drug molecule. Much attention has been also paid to improve biological activity, <em>in vivo</em> stability, or bioavailability by studying the chemical modification of peptide structure. The most frequently studied fluorine-containing functional group is the trifluoromethyl group, which also occurs as a C(sp<sup>2</sup>)–CF<sub>3</sub> bond. The trifluoromethyl alkyl group structure helps the peptide maintain its original <em>β</em>-turn structure, effectively mimicking the natural peptide bond, which allows it to function as its isostere. Therefore, the development of methods for synthesizing the trifluoromethylalkene group is becoming increasingly popular due to the potential of the products as building blocks of bioactive molecules. This review describes various methods for the preparation of the compounds with a trifluoromethylalkene group using trifluorinating reagents via the transition metal-mediated and the transition metal-free trifluoromethylation reactions.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"282 ","pages":"Article 110403"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信