Journal of Fluorine Chemistry最新文献_第2页

Highly diversified fluorinated chromane-thiadiazol-saturated cyclic amine hybrids: Design, synthesis, single crystal XRD and MCF-7 Cell-line Study 高度多样化的氟化铬-噻二唑饱和环胺杂化物：设计、合成、单晶XRD和MCF-7细胞系研究

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-06-12 DOI: 10.1016/j.jfluchem.2025.110448

Bhavika Mohite , Bhadreshkumar K. Chabhadiya , Nishith Teraiya , Khushal Kapadiya , Ramavatar Meena , Aniruddhasinh Rana , Smita Jauhari

{"title":"Highly diversified fluorinated chromane-thiadiazol-saturated cyclic amine hybrids: Design, synthesis, single crystal XRD and MCF-7 Cell-line Study","authors":"Bhavika Mohite , Bhadreshkumar K. Chabhadiya , Nishith Teraiya , Khushal Kapadiya , Ramavatar Meena , Aniruddhasinh Rana , Smita Jauhari","doi":"10.1016/j.jfluchem.2025.110448","DOIUrl":"10.1016/j.jfluchem.2025.110448","url":null,"abstract":"<div><div>The current study focuses on the synthesis and characterization of novel fluorinated chromane derivatives, aiming to explore their structural and biological potential. The molecular framework integrates fluorine for enhanced physicochemical properties, employing nucleophilic substitution and cyclization strategies. The synthesized derivatives (4a–4j) were characterized using advanced spectroscopic methods (1H NMR, 19F NMR, 13C NMR, and mass spectrometry) and crystallographic analysis, confirming their structural core. Biological evaluations against MCF-7 breast cancer cells revealed significant cytotoxicity, with compounds 4 g and 4f demonstrating superior activity (IC50: 2.73 µM and 3.81 µM, respectively) compared to the standard sunitinib (IC50: 5.00 µM). SAR analysis highlights the role of specific cycloaliphatic and polar substituents in enhancing activity. Additionally, docking studies targeting VEGFR2 elucidated key binding interactions, corroborating the compounds' potential as anticancer agents. This work showed the incorporation of fluorine and the rational design of fluorinated scaffolds for drug development.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110448"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis and properties of energetic N-fluorodinitromethyl heterocyclic salts 含能n -氟二硝基甲基杂环盐的合成与性能研究

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-05-27 DOI: 10.1016/j.jfluchem.2025.110436

Andrei A. Gakh , Victor V. Semenov

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Synthesis of 1,1,2,2,3,3,4,4-octafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanesulfonyl fluoride 1,1,2,2,3,3,4,4-辛氟-4-[（1,2,2-三氟乙烯基）氧]丁烷磺酰氟的合成

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-05-24 DOI: 10.1016/j.jfluchem.2025.110432

Nobuyuki Uematsu , Hideo Saito , Masa-aki Sasayama , Sayuri Aoki , Mikihiko Nakamura , Nobuto Hoshi , Masanori Ikeda

{"title":"Synthesis of 1,1,2,2,3,3,4,4-octafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanesulfonyl fluoride","authors":"Nobuyuki Uematsu , Hideo Saito , Masa-aki Sasayama , Sayuri Aoki , Mikihiko Nakamura , Nobuto Hoshi , Masanori Ikeda","doi":"10.1016/j.jfluchem.2025.110432","DOIUrl":"10.1016/j.jfluchem.2025.110432","url":null,"abstract":"<div><div>We investigated two synthetic routes (Route A: first synthesis of the CF2<img>CFO group and then the SO2F group, Route B: first synthesis of the SO2F group and then the CF2<img>CFO group) to synthesize CF2<img>CFO(CF2)4SO2F (SSC monomer), the raw material for the short-side-chain perfluorinated polymer electrolyte membrane, from I(CF2)4I using the same commercially available reagents but in different order of use. In Route A, by-products [CF2<img>CFO(CF2)4I and the compound presumed to have the structure of CF2SO2F] were formed in the second half of the synthesis of SSC monomer, but they were difficult to remove from SSC monomer. On the other hand, in Route B, by-product I(CF2)4I formed in the first half of the synthesis of SSC monomer was easily removed by the conversion with oleum. In addition, the reaction of I(CF2)4I with Na2S2O4 produced I(CF2)4SO2Na and NaO2S(CF2)4SO2Na, which were separated by the extraction operation with ethyl acetate, and NaO2S(CF2)4SO2Na was converted to I(CF2)4I by chlorine gas in the presence of NaI. We chose Route B and obtained high-purity SSC monomer.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110432"},"PeriodicalIF":1.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives 氟化吡啶[4,3-b][1,4]噻嗪1,1-二衍生物的高效合成、结构及抗流感病毒活性

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110430

Larisa Politanskaya , Bulat Khasanov , Irina Bagryanskaya , Maria Niukalova , Sergey Aksakov , Irina Balashova , Vladimir Zarubaev

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Synthesis and characterization of 5-(trifluoromethyl)tetrazol-based energetic salts 5-（三氟甲基）四唑基含能盐的合成与表征

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110427

Jiawen Deng , Lukang Lin , Yahan Zhang , Xu Yao , Jun Zhang , Jin-Hong Lin , Wenbin Yi , Xing Zheng , Ji-Chang Xiao

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Fluorination of sulfonyl hydrazides with fluorine gas for the synthesis of sulfonyl fluorides 磺酰肼用氟气氟化合成磺酰氟

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110425

Zhou Yu , Sheng Wang , Wenbo Chen , Lele Wen , Long Lu

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One electron into the multilayer cyclic hexamer of hydrogen fluoride 一个电子进入多层环六聚体氟化氢

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110429

Hai-Han Liu, Zhong-Min Su, Hong-Liang Xu

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Difluoroamination of diaryl gem-dichlorides with difluorosulfamate tetramethylammonium salts 二芳基宝石二氯化物与二氟磺胺四甲基铵盐的二氟胺化

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110428

Sheng Wang , Zhou Yu , Wenbo Chen , Yaming Wu , Chun-Hui Xing , Long Lu

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Per- and polyfluoroalkyl substances (PFASs) in water-based environments: A systematic review of treatment technologies and research trends (2017–2024) 水基环境中的全氟和多氟烷基物质（PFASs）：处理技术和研究趋势的系统回顾（2017-2024）

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110435

Syed Muzzamil Hussain Shah , Ebrahim Al-Qadami , Ismail Abdulazeez , Mohamed A. Yassin , Sani I. Abba , Dahiru U. Lawal , Isam H. Aljundi

{"title":"Per- and polyfluoroalkyl substances (PFASs) in water-based environments: A systematic review of treatment technologies and research trends (2017–2024)","authors":"Syed Muzzamil Hussain Shah , Ebrahim Al-Qadami , Ismail Abdulazeez , Mohamed A. Yassin , Sani I. Abba , Dahiru U. Lawal , Isam H. Aljundi","doi":"10.1016/j.jfluchem.2025.110435","DOIUrl":"10.1016/j.jfluchem.2025.110435","url":null,"abstract":"<div><div>Emerging pollutants (EPs), a diverse group of organic contaminants including pharmaceuticals, personal care products, and industrial chemicals such as per- and polyfluoroalkyl substances (PFAS), pose a significant threat to global water quality, human health, and ecological systems. These persistent and often unregulated compounds necessitate effective removal strategies. To better understand the range of available PFAS treatment methods in water and their reported efficiency, a literature-based systematic review was conducted in multiple phases, ensuring a thorough and structured analysis. In the first phase, a comprehensive search of Scopus and Web of Science (WoS) was performed, employing specific keywords to identify the relevant research. As this study prioritized experimental research on PFAS degradation and removal, the selection process involved excluding duplicates, non-English publications, modeling studies, book chapters, PFAS monitoring and characterization studies, and the review articles. After a thorough screening, the technical papers specifically investigating the treatment methods were selected for an in-depth analysis, focusing on the several parameters, including the medium type, target PFAS, treatment type, treatment method and the treatment efficacy. This review critically synthesizes key information on effective treatment technologies and experimental procedures, presenting a year-wise analysis of advancements and trends. Therefore, the findings presented herein provide a comprehensive overview of the progress in PFAS degradation technologies, highlighting key advancements, challenges, and research gaps. Thus, this review serves as a valuable resource to guide future research and the development of more efficient and sustainable PFAS treatment strategies.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"283 ","pages":"Article 110435"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energetic insights into the fluorination of Cyclobutane: Mono- and Difluorocyclobutanes 对环丁烷氟化的高能洞察：单氟和二氟环丁烷

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-04-01 DOI: 10.1016/j.jfluchem.2025.110431

Matheus P. Freitas

{"title":"Energetic insights into the fluorination of Cyclobutane: Mono- and Difluorocyclobutanes","authors":"Matheus P. Freitas","doi":"10.1016/j.jfluchem.2025.110431","DOIUrl":"10.1016/j.jfluchem.2025.110431","url":null,"abstract":"<div><div>Cyclobutane, a key cycloalkane in various functional compounds, including pharmaceuticals, exhibits significant property modifications upon fluorination, such as altered conformation, polarity, and lipophilicity. This quantum-chemical study, performed at the G3MP2B3 level, investigates the effects of mono- and difluorination of cyclobutane. It examines the energetics of incorporating axial and equatorial fluorines at geminal, vicinal, and 1,3-relative positions. Isodesmic reaction analysis reveals that fluorination of cyclobutane is thermodynamically favorable overall. However, introducing axial fluorine is less energetically favorable, rendering diaxial trans-1,2- and cis-1,3-cyclobutanes unstable. Among the isomers, 1,1-difluorocyclobutane achieves notable stabilization via an anomeric-like interaction (nF → σ*CF), whereas other isomers experience greater destabilization due to Lewis-type interactions compared to electron delocalization. Axial and equatorial C − F bonds can be distinguished by their 1JCF coupling constants. These insights are valuable for the rational design of fluorinated cyclobutane derivatives with properties influenced by the stereochemical arrangement and relative positioning of fluorine atoms.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"283 ","pages":"Article 110431"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0