Journal of Fluorine Chemistry最新文献_第10页

Iron-catalyzed sulfur alkylation of sulfenamides with in situ-generated 2,2,2-trifluorodiazoethane 铁催化磺胺类与原位生成的2,2,2-三氟重氮乙烷的硫烷基化反应

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-23 DOI: 10.1016/j.jfluchem.2023.110219

Xianda Wu , Minghong Chen , Shuiyun Zheng , Fu-Sheng He , Jie Wu

引用次数: 0

Regioselective synthesis of 3H-Pyrazoles bearing difluoromethyl phosphonate group 含膦酸二氟甲基3h -吡唑的区域选择性合成

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-21 DOI: 10.1016/j.jfluchem.2023.110218

Ita Hajdin , Romana Pajkert , Haibo Mei , Jianlin Han , Gerd-Volker Röschenthaler

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6,6-Difluorobicyclo[3.1.0]hexane as a Rigidified 4,4-Difluorocyclohexane Mimetic: Multigram Synthesis, Physicochemical Characterization, and Incorporation into Maraviroc Analogs 6,6-二氟双环[3.1.0]己烷作为刚性4,4-二氟环己烷的模拟物:多重图合成、物理化学表征和纳入马拉维洛克类似物

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-03 DOI: 10.1016/j.jfluchem.2023.110215

Bohdan Moroz , Kostiantyn P. Melnykov , Serhii Holovach , Andrey A. Filatov , Oleksii Raievskyi , Maksym Platonov , Oleksandr Liashuk , Dmytro M. Volochnyuk , Oleksandr O. Grygorenko

{"title":"6,6-Difluorobicyclo[3.1.0]hexane as a Rigidified 4,4-Difluorocyclohexane Mimetic: Multigram Synthesis, Physicochemical Characterization, and Incorporation into Maraviroc Analogs","authors":"Bohdan Moroz , Kostiantyn P. Melnykov , Serhii Holovach , Andrey A. Filatov , Oleksii Raievskyi , Maksym Platonov , Oleksandr Liashuk , Dmytro M. Volochnyuk , Oleksandr O. Grygorenko","doi":"10.1016/j.jfluchem.2023.110215","DOIUrl":"https://doi.org/10.1016/j.jfluchem.2023.110215","url":null,"abstract":"<div><p>Multigram synthesis of diastereomerically pure <em>cis</em>- and <em>trans</em>-6,6-difluorobicyclo[3.1.0]hexane building blocks starting from commercially available compounds is described. The diastereomeric mixture obtained by reaction of TMSCF<sub>3</sub> – NaI system with non-activated cyclopentene fragment using the slow addition protocol was effectively separated by flash column chromatography. Further simple chemical transformations produced diastereopure amines and carboxylic acids – promising building blocks for drug discovery. Physicochemical properties (i.e., p<em>K</em><sub>a</sub> and Log<em>P</em>) were measured for the title scaffold derivatives and compared with those with monocyclic and non-fluorinated counterparts. Two rigidified analogues of marketed anti-HIV drug Maraviroc were synthesized and evaluated by docking and molecular dynamics studies.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"272 ","pages":"Article 110215"},"PeriodicalIF":1.9,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022113923001306/pdfft?md5=6b209a7e966e9b87dc7824b606cbc60e&pid=1-s2.0-S0022113923001306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92023261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Continuous flow fluorination facilitated by KF assisted by water: From batch to continuous flow 水辅助下KF催化的连续流式氟化:从批量到连续流式

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110210

Tao Shen , Chenjun Jiang , Yifeng Lai , Linlin Wu , Liangquan Zhang , Chao Qian

引用次数: 0

Study of carbon-flax hybrid composites modified by fibre fluorination 氟化纤维改性碳-亚麻杂化复合材料的研究

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110213

Jean-Charles Agopian , Olivier Téraube , Samar Hajjar-Garreau , Karine Charlet , Marc Dubois

{"title":"Study of carbon-flax hybrid composites modified by fibre fluorination","authors":"Jean-Charles Agopian , Olivier Téraube , Samar Hajjar-Garreau , Karine Charlet , Marc Dubois","doi":"10.1016/j.jfluchem.2023.110213","DOIUrl":"https://doi.org/10.1016/j.jfluchem.2023.110213","url":null,"abstract":"<div><p>Knowing that fibre reinforced polymers are sensitive to moisture through their interphases, carbon and flax fibres sized with Bisphenol A diglycidyl ether were fluorinated under a N<sub>2</sub>/F<sub>2</sub> atmosphere. Because of differences in reactivity of gaseous F<sub>2</sub> between fibres and sizing, only the latter has been fluorinated, resulting in a covalent grafting of fluorine atoms onto the fibres, that has been evidenced by Infrared spectroscopy, and X-Ray Photoelectron Spectroscopy. Fluorinated fibres exhibit enhanced mechanical properties, as highlighted by tensile tests. Hybrid and non-hybrid composite materials were then fabricated with vacuum infusion process, using non-fluorinated and fluorinated carbon and flax fibres. Their hydrothermal behaviour and mechanical properties were investigated, in order to study the impact of both hybridisation and fibre fluorination on the composite properties. A better water resistance was observed for polymer materials reinforced with fluorinated fibres, whereas their mechanical properties were slightly lower than polymers reinforced with non-fluorinated fibres.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"272 ","pages":"Article 110213"},"PeriodicalIF":1.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92023259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Thiocarbonyl fluoride generated in situ from difluorocarbene for cyclization of vicinal X-H substituted amines (X = N, O or S) 由二氟化苯原位生成的硫代羰基氟，用于相邻X- h取代胺的环化(X = N, O或S)

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110212

Jia-Lu Hu , Mu-Xian Fu , Ji-Chang Xiao , Jin-Hong Lin

引用次数: 0

Influence of fluorine incorporation into waterborne acrylic coatings on resulting hydrophobic, thermal stability and drag- reduction properties 氟掺入水性丙烯酸涂料对疏水性、热稳定性和减阻性能的影响

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110217

Qingshan Wu , Tianyi Zhao , Mingjie Liu , Guanglong Zhang , Jinwei Zhang , Cunguo Lin , Yichi Chen

{"title":"Influence of fluorine incorporation into waterborne acrylic coatings on resulting hydrophobic, thermal stability and drag- reduction properties","authors":"Qingshan Wu , Tianyi Zhao , Mingjie Liu , Guanglong Zhang , Jinwei Zhang , Cunguo Lin , Yichi Chen","doi":"10.1016/j.jfluchem.2023.110217","DOIUrl":"https://doi.org/10.1016/j.jfluchem.2023.110217","url":null,"abstract":"<div><p>Fluorinated polyacrylate copolymers containing various amounts of 1H,1H,2H,2H-perfluorooctyl methacrylate (FA) were synthesized via a miniemulsion polymerization process. The characteristics of latex particles and films were investigated using transmission electron microscopy, dynamic light scattering, attenuated total reflectance Fourier transform infrared spectroscopy, <sup>1</sup>H and <sup>19</sup>F nuclear magnetic resonance spectroscopy, atomic force microscopy, energy dispersive spectroscopy, water contact angle measurements, and thermogravimetric analysis. The results showed that particle size increased almost linearly with FA content, and the surface hydrophobicity of the films increased with FA content up to 14.6 wt% and then plateaued. As the FA content increased, the surface roughness of the films initially increased and then decreased. The thermal stability of fluorinated polyacrylate was significantly enhanced when a high amount of FA was incorporated into the polymer chains. The fluorinated acrylic copolymer coating also exhibited a significant drag reduction effect, with the maximum drag reduction ratio reaching 12% at a water flow velocity of 0.8 m/s.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"272 ","pages":"Article 110217"},"PeriodicalIF":1.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92023258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth and luminescence characteristics of LiYF4: Yb,Er nanoparticles LiYF4: Yb,Er纳米颗粒的生长和发光特性

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110209

Shuang Wu, Yanhui Dong, Hao Cui, Daguang Li, Weiping Qin

{"title":"Growth and luminescence characteristics of LiYF4: Yb,Er nanoparticles","authors":"Shuang Wu, Yanhui Dong, Hao Cui, Daguang Li, Weiping Qin","doi":"10.1016/j.jfluchem.2023.110209","DOIUrl":"https://doi.org/10.1016/j.jfluchem.2023.110209","url":null,"abstract":"<div><p>The morphology and size of LiYF<sub>4</sub>:Yb,Er nanoparticles were controlled using an automatic nanomaterial synthesizer by changing the reaction time at high temperature. It was found that the nanoparticles underwent a growth and change process from small to large and then to small, and then remained at a basically stable size, reflecting the different growth stages of the nanoparticles, such as nucleation, growth, phase transition, and internal Ostwald ripening, etc. XRD analyses showed that LiF nanocrystals were first formed during the reaction process, and then all the products were converted into LiYF<sub>4</sub> nanocrystals. Under the excitation of a 980 nm laser, the LiYF<sub>4</sub>:Yb,Er nanoparticles showed regular downconversion and upconversion luminescence properties, which was basically consistent with the regularity of nanocrystal growth. The experimental results showed that the upconversion luminescence and downconversion luminescence intensities of nanocrystals increasd rapidly when the synthesis time was between 0 and 50 min, and they increased slowly after the synthesis time exceeded 50 min.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"272 ","pages":"Article 110209"},"PeriodicalIF":1.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92096297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemistry of new polyfluorinated oxiranyl anions and epoxy silanes 新型多氟氧基阴离子和环氧硅烷的化学性质

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110208

Viacheslav Petrov

{"title":"Chemistry of new polyfluorinated oxiranyl anions and epoxy silanes","authors":"Viacheslav Petrov","doi":"10.1016/j.jfluchem.2023.110208","DOIUrl":"https://doi.org/10.1016/j.jfluchem.2023.110208","url":null,"abstract":"<div><p>The reaction of partially fluorinated epoxides with strong, hindered bases in the presence of electrophiles resulted in functionalization of the epoxy ring. For example, the reaction of hexafluoroisobutene epoxide with LDA and trimethyl- or triethychlorosilanes at low temperature led to the formation of the corresponding epoxy silanes. In the case of the E- and Z-epoxides of 1,1,1,3,3,3-hexafluorobutene-2, the deprotonation step can be successfully carried out using i-PrMgCl<sup>.</sup>LiCl (Turbo Grignard reagent), and the reaction with chlorosilanes can be carried out at ambient temperature, which significantly simplifies the synthetic protocol. The process was found to be stereospecific, proceeding with complete retention of configuration of the epoxide ring and giving access to pure <em>E-</em> or <em>Z-</em>isomers of the corresponding epoxy silanes. Using this protocol, the corresponding epoxy silanes were also prepared from the epoxides of <em>E-</em>3,3,3,1-tetrafluoropropene-1 and 3,3,3-trifluoropropene-1.</p><p>The new silanes were demonstrated to be convenient reagents for the transfer of a fluorinated epoxy moiety to carbonyl compounds under fluoride anion catalysis. This process was shown to proceed with complete retention of the geometry of the epoxy ring.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"272 ","pages":"Article 110208"},"PeriodicalIF":1.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92023257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The CF⋅⋅⋅HCF2 interaction: A combination of hydrogen bonding and n → σ* stabilization CF⋅⋅HCF2相互作用:氢键和n→σ*稳定的结合

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI: 10.1016/j.jfluchem.2023.110191

Nathaniel G. Garrison , Stefan Andrew Harry , Maxime A. Siegler , Guilherme Cariello , Rodrigo A. Cormanich , Thomas Lectka

引用次数: 1