Journal of Fluorine Chemistry最新文献

Research on the synthesis of trifluoromethyl-substituted isoquinoline-1,3(2h,4h)-diones via decarboxylative radical addition/cyclization reaction 脱羧自由基加成/环化反应合成三氟甲基取代异喹啉-1,3(2h,4h)-二酮的研究

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110456

Yu Zhang , Bao Feng Du , Jinpeng Miao , Xian Jin Yang

引用次数: 0

Engineering perfluoroarene-arene interactions in coumarin-1,2,3-triazole-arene hybrid molecules 香豆素-1,2,3-三唑-芳烃杂化分子中的全氟芳烃-芳烃相互作用

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110453

Abraham Colin-Molina , Jannet Cruz-de la Cruz , David Corona-Becerril , Minerva Rentería-Ortega , Rigoberto Barrios-Francisco

{"title":"Engineering perfluoroarene-arene interactions in coumarin-1,2,3-triazole-arene hybrid molecules","authors":"Abraham Colin-Molina , Jannet Cruz-de la Cruz , David Corona-Becerril , Minerva Rentería-Ortega , Rigoberto Barrios-Francisco","doi":"10.1016/j.jfluchem.2025.110453","DOIUrl":"10.1016/j.jfluchem.2025.110453","url":null,"abstract":"<div><div>In this work, we describe the synthesis and characterization of five hybrid molecules combining coumarin, 1,2,3-triazole, and arene or perfluoroarene units (compounds 5a, 5b, 6a, 6b, and 7). Crystallization conditions of these compounds were explored, and single crystals of compounds 5b and 7 (as a dioxane solvate, 7.DIOX) were obtained. X-ray diffraction analysis revealed the presence of perfluoroarene–arene (ArF···Ar) interactions that govern the solid-state packing of both structures, leading to rod-like stacking in 5b and layered arrays in 7·DIOX. The ArF···Ar contacts were associated with centroid-to-centroid distances between 3.8 and 4.1 Å. Thermal analysis (TGA-DSC) confirmed that all compounds maintain structural integrity at high temperatures; 7·DIOX retained its crystallinity up to 150 °C before solvent loss. Powder X-ray diffraction confirmed the formation of pure crystalline phases under the employed recrystallization conditions. Additionally, preliminary solid-state fluorescence studies showed modest emission for all coumarin-containing compounds (5a, 5b, and 7·DIOX), with red-shifted maxima and variable quantum yields potentially influenced by non-covalent interactions in their molecular packing. These results underscore the utility of perfluoroarene–arene interactions in directing solid-state organization in fluorinated hybrid molecules.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110453"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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PFAS analytical methods – A practical guide PFAS分析方法。实用指南

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110444

Graham K. Ansell, Hassan Javed

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Base-mediated [3 + 2] cyclization/rearrangement of N-2,2,2-trifluoroethylisatin ketimines with diethyl azodicarboxylate for construction of spirooxindoles containing trifluoromethyl-1,2,4-triazoles n -2,2,2-三氟乙基化atin酮胺与二乙基偶氮二羧酸酯的碱介导[3 + 2]环化/重排以构建含三氟甲基-1,2,4-三唑的螺菌吲哚

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110452

Yabo Zhang , Liangjun Chen , Wenhe Shi , Panpan Guo , Yan Fu , Ran Guo

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Microwave-assisted sodium borohydride/lanthanide rare earth chlorides system for reduction of terminal carboxyl groups in liquid fluoroelastomer 微波辅助硼氢化钠/镧系稀土氯化物体系还原液态氟弹性体末端羧基

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110457

Qi Wang, Ranran Qi, Xiaojie Zhang, Mingyi Liao

{"title":"Microwave-assisted sodium borohydride/lanthanide rare earth chlorides system for reduction of terminal carboxyl groups in liquid fluoroelastomer","authors":"Qi Wang, Ranran Qi, Xiaojie Zhang, Mingyi Liao","doi":"10.1016/j.jfluchem.2025.110457","DOIUrl":"10.1016/j.jfluchem.2025.110457","url":null,"abstract":"<div><div>Liquid terminal carboxyl fluororubber (LTCFs) derived from poly(vinylidene fluoride-co-hexafluoropropylene) was efficiently converted to liquid terminal hydroxyl fluororubber (LTHFs) through a microwave-assisted reduction process employing NaBH4/lanthanide chloride (MCl3; M = La, Ce, Sm, Gd) catalytic systems. Comprehensive structural characterization via FTIR, UV–Vis, 1H NMR, GPC, and titration analyses confirmed the transformation of terminal carboxyl groups (-COOH) to hydroxyl groups (-OH) while simultaneously reducing backbone carbon-carbon double bonds (-C = C-) to single bonds (-C-C-). Systematic evaluation revealed NaBH4/CeCl3, NaBH4/SmCl3, and NaBH4/GdCl3 systems achieved exceptional reduction efficiencies exceeding 80 %. Process optimization using the NaBH4/SmCl3 system established optimal parameters: 4 min microwave irradiation at 320 W power, SmCl3/-COOH molar ratio of 2:1, and substrate/solvent ratio of 1:10 (g/mL), yielding 84.60 % conversion efficiency. The microwave methodology demonstrated remarkable temporal efficiency, achieving >80 % conversion within 4 min compared to conventional thermal methods requiring hours. This accelerated process significantly enhanced reaction kinetics while maintaining structural fidelity, as evidenced by comprehensive spectroscopic and chromatographic analyses. The work establishes a robust microwave-assisted platform for precise fluororubber functional group modification with potential applications in advanced fluoropolymer synthesis.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110457"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Electrophilic aromatic fluorination of N-Arylacetamides: A computational and efficacy study n -芳基乙酰胺的亲电芳氟化：计算和功效研究

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI: 10.1016/j.jfluchem.2025.110455

Meghan Betourney, Hannah Ashton, Gabrielle Costello, Jordan Hunter, Sang H. Park, Benjamin Shepler, Joseph C. Sloop, Matthew Stancea, Karla Wilmott

{"title":"Electrophilic aromatic fluorination of N-Arylacetamides: A computational and efficacy study","authors":"Meghan Betourney, Hannah Ashton, Gabrielle Costello, Jordan Hunter, Sang H. Park, Benjamin Shepler, Joseph C. Sloop, Matthew Stancea, Karla Wilmott","doi":"10.1016/j.jfluchem.2025.110455","DOIUrl":"10.1016/j.jfluchem.2025.110455","url":null,"abstract":"<div><div>Using selected N+-F and N-F fluorinating agents, a series of fluorinated N-arylacetamides have been prepared via electrophilic aromatic substitution. Reactant ratios and reaction conditions were varied to ascertain selectivity toward mono-fluorination and to provide optimum conversion to products, which ranged from 0–94 %. In addition, fluorinations of selected N-arylacetamides were undertaken using aqueous and ionic liquid media, sonication and microwave irradiative methods, and were compared with conventional fluorination conditions conducted in acetonitrile. Temperature, reaction time and solvent effects on fluorination as well as trends observed in fluorinating agent reactivity, fluorination selectivity and product distribution for these N-arylacetamides are discussed. A preference for fluorination ortho to the acetamido and trifluoroacetamido groups was observed for most N-arylacetamides investigated. An exception to this trend was found in the case of N-(4-methoxyphenyl)acetamide, where fluorination ortho to the methoxy group predominated. Computationally determined partial charge distribution results for the N-arylacetamides featured in this study were found to support the experimentally observed fluorination regiochemistry.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110455"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Physicochemical characterization of fluoride solid electrolyte PbSnF4 synthesized via sonochemical reaction 声化学合成氟固体电解质PbSnF4的理化性质

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-06-27 DOI: 10.1016/j.jfluchem.2025.110450

Meena M , Benson K Money , Amrtha Bhide

{"title":"Physicochemical characterization of fluoride solid electrolyte PbSnF4 synthesized via sonochemical reaction","authors":"Meena M , Benson K Money , Amrtha Bhide","doi":"10.1016/j.jfluchem.2025.110450","DOIUrl":"10.1016/j.jfluchem.2025.110450","url":null,"abstract":"<div><div>Demand for batteries with enhanced energy density and improved thermal safety is a key focus for researchers striving to build a sustainable environment. As fluoride ion batteries (FIB) are expected to exhibit high energy density and exceptional thermal stability, research activities are focused on identifying fluoride ion-conducting electrolytes. Among the various fluoride ion conductors, PbSnF4, renowned for its superior ionic conductivity, is typically synthesized via mechanochemical reaction. In the present work, PbSnF4 was synthesized via an acoustic cavitation-driven sonochemical reaction. This novel synthesis route has reduced the duration of the synthesis process to a few minutes compared with several hours for the mechanochemical reaction. The structural, morphological, and ionic transport properties are investigated. The ionic conductivity of the resulting orthorhombic PbSnF4 is evaluated to be 4.5 × 10⁻4 S/cm at RT. The contribution of fluoride ions to the total ionic conductivity is estimated via the DC polarization technique as 0.92. The electrochemical stability window (ESW) is measured through cyclic voltammetry (CV) as 0.7 V with PbF2/PbSnF4/SS cell configuration.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110450"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pentafluorinated thevinol scaffold for opioid ligands 阿片配体的五氟化醇支架

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-06-20 DOI: 10.1016/j.jfluchem.2025.110451

Sergey N. Gorlov , Irina V. Sandulenko , Alexander F. Smol'yakov , Аndrey А. Tyutyunov , Maria I. Godovikova , Sergey K. Moiseev

{"title":"Pentafluorinated thevinol scaffold for opioid ligands","authors":"Sergey N. Gorlov , Irina V. Sandulenko , Alexander F. Smol'yakov , Аndrey А. Tyutyunov , Maria I. Godovikova , Sergey K. Moiseev","doi":"10.1016/j.jfluchem.2025.110451","DOIUrl":"10.1016/j.jfluchem.2025.110451","url":null,"abstract":"<div><div>An addition reaction of Me3SiCF2CF3 to the carbonyl group of thevinal (10), a morphinan derivative, followed by an oxidation of the resulting mixture of the C(20)-epimeric secondary alcohols (20R)-11a and (20S)-11b (15:1) resulted in the first preparation of the pentafluorinated ketone 12. The latter is expected to serve as a starting compound for the preparation of thevinols and orvinols, putative opioid receptor ligands pentafluorinated within their C(20)-centered pharmacophore. It was shown that MeLi and MeMgI, indeed, add to the carbonyl group of ketone 12 to afford the mixture of C(20)-epimeric tertiary alcohols, pentafluoroethylthevinols, with the 20R-isomer predominating. The reduction of ketone 12 with LiAlH4 also results in the formation of a mixture of the C(20)-epimeric pentafluorothevinols (20R)-11a and (20S)-11b However, the ratio of the epimers (1:8) is opposite to that one obtained from the reaction of aldehyde 10 with Me3SiCF2CF3.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"285 ","pages":"Article 110451"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Purification of uranium tetrafluoride using ammonium bifluoride 用二氟化铵提纯四氟化铀

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-06-19 DOI: 10.1016/j.jfluchem.2025.110449

Kyle R. Foster , Juliano Schorne-Pinto , Ronald E. Booth , Annabelle Husek , Mina Aziziha , Hunter B. Tisdale , Bernie W.N. Fitzpatrick , Hans-Conrad zur Loye , Markus H.A. Piro , Theodore M. Besmann

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Cobalt-catalyzed C-H perfluoroalkylation of anilines 钴催化苯胺的C-H全氟烷基化

IF 1.7 4区化学

Journal of Fluorine Chemistry Pub Date : 2025-06-16 DOI: 10.1016/j.jfluchem.2025.110437

Shota Mizuno , Yoichi Obitsu , Munenori Inoue

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