Direct S-difluoromethylation of thiols: A facile synthetic route to difluoromethyl thioethers

IF 1.9 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2025-10-01 DOI:10.1016/j.jfluchem.2025.110475

Ahmed Aldulaimi , Shakir Mahmood Saeed , Soumya V Menon , Waam Mohammed Taher , Ruya yilmaz saber , Subhashree Ray , Karthikeyan Jayabalan , Aashna Sinha , Mariem Alwan , Renu Sharma

引用次数: 0

Abstract

This review gives an overview of the synthesis of difluoromethyl thioethers through the S-difluoromethylation of corresponding aromatic thiols. The review has been classified based on the type of difluoromethyling agents (i.e., organosulfur-based difluoromethylating agents, organosilicon-based difluoromethylating agents, organophosphorus-based difluoromethylating agents) and surveyed the literature up until the end of 2024.

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硫醇的直接s -二氟甲基化：二氟甲基硫醚的简便合成途径

本文综述了芳香族硫醇通过s -二氟甲基化合成二氟甲基硫醚的研究进展。本综述根据二氟甲基化剂的类型（即有机硫基二氟甲基化剂、有机硅基二氟甲基化剂、有机磷基二氟甲基化剂）进行了分类，并调查了截至2024年底的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.