Journal of Equine Science最新文献_第8页

Gene Therapy for the Treatment of Equine Osteoarthritis 马骨关节炎的基因治疗

Journal of Equine Science Pub Date : 2020-06-19 DOI: 10.5772/intechopen.93000

R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani

{"title":"Gene Therapy for the Treatment of Equine Osteoarthritis","authors":"R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani","doi":"10.5772/intechopen.93000","DOIUrl":"https://doi.org/10.5772/intechopen.93000","url":null,"abstract":"Osteoarthritis (OA) is the predominant cause of lameness in horses. As in humans, the clinical symptoms of equine OA are persistent pain and dysfunction of the affected joint. Its pathology is similarly marked by progressive deterioration of the articular cartilage, subchondral bone sclerosis, marginal osteophytes, soft tissue inflammation and joint effusion. Disease pathogenesis is mediated by elevated levels of inflammatory cytokines and proteolytic enzymes in the articular tissues and synovial fluid. Existing pharmacologic agents can alleviate OA joint pain; none are able to inhibit erosive disease progression. As several gene-based treatments for human disease have received approval by the Food and Drug Administration (FDA), the transition to veterinary medicine will almost certainly follow. Several viral vector systems have demonstrated highly efficient gene transfer to the equine joint, enabling expression of therapeutic transgenes at efficacious levels for well over a year. Because of its large size, the equine joint is well suited to studies of gene-based therapies for arthritic disease. The forelimb joints are vulnerable to OA onset, and treatment and diagnostic modalities are the same in humans and horses. Here, we discuss the various gene-transfer approaches under investigation and the current progress toward the development an effective gene therapy for equine OA.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89820153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan. 初马和马驹血清免疫球蛋白G水平与日本重牵拉马围产期异常的关系。

Journal of Equine Science Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.29

Takahiro Aoki, Akiko Chiba, Megumi Itoh, Yasuo Nambo, Norio Yamagishi, Ken-Ichi Shibano, Soon Hon Cheong

{"title":"Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan.","authors":"Takahiro Aoki, Akiko Chiba, Megumi Itoh, Yasuo Nambo, Norio Yamagishi, Ken-Ichi Shibano, Soon Hon Cheong","doi":"10.1294/jes.31.29","DOIUrl":"https://doi.org/10.1294/jes.31.29","url":null,"abstract":"The purpose of this study was to elucidate the colostral and foal serum immunoglobulin G (IgG) concentration values in heavy draft horses in Japan and to examine the effects of peripartum mare condition on colostral immunity. Colostrum was obtained 1 hr after foaling (pre-suckling; n=178). Blood was collected from the jugular vein of the foals (n=147) at 24 to 48 hr after birth. The foaling statuses of 73 mares were recorded. The average colostral IgG concentration was 10,540 ± 3,190 mg/dl (median=10,928; range 1,434-17,514 mg/dl). The average serum IgG concentration obtained from neonatal foals 24 to 48 hr after birth was 1,750 ± 919 mg/dl (median=1,890; range 0-3,510 mg/dl). Although colostral IgG did not differ between the normal foaling mare (n=59) and dystocial mare (n=14), foal serum IgG was lower in foals born in dystocia than in foals in normal foaling (P<0.05). This study demonstrates reference values for colostral and foal serum IgG specific to heavy draft horses in Japan and suggests that dystocia may interfere with the acquisition of colostral immunity in neonatal foals.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/e4/jes-31-029.PMC7316699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Relationships between morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. 形态测量与跳跃纯种马肌肉骨骼疾病的关系。

Journal of Equine Science Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.23

Mohamed B Mostafa, Yahya M Elemmawy

{"title":"Relationships between morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses.","authors":"Mohamed B Mostafa, Yahya M Elemmawy","doi":"10.1294/jes.31.23","DOIUrl":"https://doi.org/10.1294/jes.31.23","url":null,"abstract":"There is limited knowledge about causes of musculoskeletal injury in jumping Thoroughbred horses. The objective of this study was to describe the relationships between musculoskeletal disorders and linear and angular limb measurements acquired from photographs of horses with markers at specific reference points. The diagnosed musculoskeletal disorders in either fore or hind limbs were flexor tendonitis, suspensory ligaments desmitis, and osteoarthritis of the distal intertarsal and tarso-metatarsal and carpometacarpal joints. Lengths and angles in 17 clinically normal jumping Thoroughbred horses and 34 horses with musculoskeletal problems were measured. Horses with musculoskeletal disorders had significantly shorter neck, shoulder, and pelvis lengths (P<0.05), significantly longer arm and forearm front lengths (P<0.05), and significantly lower front shoulder, elbow, and hind fetlock joint angles (P<0.05). In conclusion, this study describes significant relationships between linear and angular morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. These data could possibly provide indicators for better selection of jumpers with less risk of developing orthopedic disorders.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/b4/jes-31-023.PMC7316700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Morphometric measurements of the feet of working donkeys Equus asinus in Egypt. 埃及驴脚的形态计量学测量。

Journal of Equine Science Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.17

Mohamed B Mostafa, Ahmed I Abdelgalil, Shaaban F Farhat, Zoe Raw, Laura M Kubasiewicz

{"title":"Morphometric measurements of the feet of working donkeys Equus asinus in Egypt.","authors":"Mohamed B Mostafa, Ahmed I Abdelgalil, Shaaban F Farhat, Zoe Raw, Laura M Kubasiewicz","doi":"10.1294/jes.31.17","DOIUrl":"https://doi.org/10.1294/jes.31.17","url":null,"abstract":"Working equids rely on sound, balanced hooves, but data describing the typical morphology of the legs and feet of working donkeys are currently lacking. To address this gap in knowledge, the front and hind feet of twenty healthy working donkeys were measured and compared. Hoof width, weight-bearing lengths, heel width, dorsal hoof wall length and lateral and medial heel length of the hoof wall were determined, as well as toe angle, heel angle, hoof pastern axis, coronary band angle and a measure of 'ground surface size'. Viewed from the ground surface of the foot, front feet were more rounded and significantly larger than hind feet. Measures of medial-lateral balance and toe-heel angle ratio were within the recommended healthy guidelines for horses. Hoof pastern axis was broken forward for the studied animals, which supports previous research suggesting that a broken forward hoof pastern axis is normal for donkeys, although further study would be required to confirm whether this conformation is natural. Significant correlations were found between estimated body mass and hoof width in both the front and hind feet. These measurements provide valuable insight into the relationship between hoof and body characteristics, which may aid the development of guidelines for the trimming and management of working donkey hooves. Further study is, however, advised to confirm natural hoof conformation.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/43/jes-31-017.PMC7316701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Investigation into Whether Proximal Suspensory Desmitis of the Hindlimb Could Predispose Horses to Sacroiliac Disease 马后肢近端悬吊炎是否易患骶髂疾病的研究

Journal of Equine Science Pub Date : 2020-05-07 DOI: 10.5772/intechopen.92353

Anne Skivington, M. Kovač, E. Zakirova, A. Rizvanov, Catrin Rutland

引用次数: 0

Medieval Equine Medicine from Armenia 来自亚美尼亚的中世纪马医学

Journal of Equine Science Pub Date : 2020-03-12 DOI: 10.5772/INTECHOPEN.91379

Jasmine Dum-Tragut

引用次数: 0

Current Strategies for Prevention and Treatment of Equine Postoperative Ileus: A Multimodal Approach 目前预防和治疗马术后肠梗阻的策略:一种多模式的方法

Journal of Equine Science Pub Date : 2020-03-02 DOI: 10.5772/intechopen.91290

M. Kovač, R. Aliev, S. Pozyabin, Nevena Drakuĺ, A. Rizvanov

{"title":"Current Strategies for Prevention and Treatment of Equine Postoperative Ileus: A Multimodal Approach","authors":"M. Kovač, R. Aliev, S. Pozyabin, Nevena Drakuĺ, A. Rizvanov","doi":"10.5772/intechopen.91290","DOIUrl":"https://doi.org/10.5772/intechopen.91290","url":null,"abstract":"Equine paralytic (postoperative) ileus generally refers to an acute condition of impaired gastrointestinal motility. Paralytic ileus is most frequently seen following abdominal surgery on the small intestine in horses. Three main mechanisms are involved separately or simultaneously in its causation, namely neurogenicendocrinic, inflammatory-endotoxic and pharmacological mechanisms. Regardless of the cause, equine paralytic ileus can be fatal, if not properly diagnosed and treated. Over the past 22 years (1997–2019), we have diagnosed and treated more than 180 horses with postoperative ileus using differing methods. Based on our results and experience, and that of others, we have developed a multimodal strategy to reduce the incidence of postoperative ileus. This has resulted in effective treatment of ileus-diagnosed patients in 94% of cases, a significant improvement in survival rates over the last 20 years. In this review, we described pre-, intra-, and postoperative multiple supplementary preventative and treatment procedures that cure this condition. These methods are dependent on individual cases but include the control of endotoxemia and inflammation, as well as using the least traumatic surgical techniques, carrying out the pelvic flexure colotomy, improved anesthesia techniques, treating with continuous postoperative peritoneal lavage, the use of fluid, antibiotic and NSAIDs therapy, according to a scheme the use of different prokinetic agents (including metoclopramide, neostigmine methylsulfate and domperidone), nasogastric decompression, management to minimize the surgical and postoperative stress reaction and judicious timing of postoperative feeding of horses.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80006584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Seroprevalence of Brucella antibodies in Donkeys (Equus asinus) in Yobe south senatorial zone, Northeastern Nigeria. 尼日利亚东北部约贝南参议院区驴(马)布鲁氏菌抗体的血清阳性率

Journal of Equine Science Pub Date : 2020-03-01 Epub Date: 2020-03-19 DOI: 10.1294/jes.31.5

Shuaibu G Adamu, Musa Hassan, Mohammed B Ardo

{"title":"Seroprevalence of Brucella antibodies in Donkeys (Equus asinus) in Yobe south senatorial zone, Northeastern Nigeria.","authors":"Shuaibu G Adamu, Musa Hassan, Mohammed B Ardo","doi":"10.1294/jes.31.5","DOIUrl":"https://doi.org/10.1294/jes.31.5","url":null,"abstract":"A cross-sectional survey was conducted to determine the seroprevalence and risk factors influencing the presence of Brucella spp. antibodies in donkeys in Yobe south senatorial zone, Nigeria. The study was aimed at determining the importance of Brucella spp. infection in donkeys (Equus asinus). A total of 200 sera samples from of 105 males and 95 female donkeys were collected and screened for brucellosis using the rose bengal plate test (RBPT) and the indirect enzyme-linked immunosorbent assay (iELISA). Data obtained were analyzed to determine associations and risk factors. The analysis revealed that 21.5% and 18.5% were seropositive by RBPT and iELISA respectively, with 22.0% and 20.0% of the male and female donkeys being seropositive by RBPT, and 19.0% and 17.9% of the male and female donkeys being seropositive by iELISA, respectively. There was a statistically significant association between donkey age and positive rate of iELISA for detecting Brucella infection. Though the positive rate was higher for males than females, there was no statistically significant association between sex and location of donkeys and the sensitivities of RBPT and iELISA for detecting Brucella infection. In conclusion, this study indicates that brucellosis exists with high seroprevalence particularly among male and adult donkeys and is of public health significance and economic importance because it can lead to infertility and abortion in the stock.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/22/jes-31-005.PMC7078490.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37765629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Evaluation of acquired passive immunity in mule foals up to 60 days of age. 60日龄骡马驹获得性被动免疫的评价。

Journal of Equine Science Pub Date : 2020-03-01 Epub Date: 2020-03-19 DOI: 10.1294/jes.31.1

Vivian Dos Santos Baptista, Paula de Mattos Guttmann, Ana Carolina Rusca, Kátia Moreira da Silva, Daniel de Barros Macieira, Nayro Xavier de Alencar, Daniel Augusto Barroso Lessa

{"title":"Evaluation of acquired passive immunity in mule foals up to 60 days of age.","authors":"Vivian Dos Santos Baptista, Paula de Mattos Guttmann, Ana Carolina Rusca, Kátia Moreira da Silva, Daniel de Barros Macieira, Nayro Xavier de Alencar, Daniel Augusto Barroso Lessa","doi":"10.1294/jes.31.1","DOIUrl":"https://doi.org/10.1294/jes.31.1","url":null,"abstract":"Ten mule foals were used to investigate serum IgG concentration. Blood was collected from mares and foals on the day following parturition (D1), at 48 and 72 hr after birth (D2 and D3), and on D7, D14, D21, D28, D35, D42, and D60. Serum IgG concentration was determined by zinc sulfate turbidity test and was above 400 mg/dl at all time points, except for one foal on D2. Mean values were above 800 mg/dl from D1 to D7 and at D60. The difference between mares and foals at each collection time was significant, except at D1. For all other days, foal IgG values were lower than the mare IgG values. Mean IgG concentrations were lower from D14 to D42 compared with D1 and D60. The results show that the critical period for the mule foal is at D28, which can be a vulnerable window for infections. The variation pattern in IgG values is similar to that in data published for horse and donkey foals. There are no published studies to date on the subject, and the present contribution enables further understanding of the newborn mule foal.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/2a/jes-31-001.PMC7078489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37765686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The effects of a nutritional supplement containing salacinol in neonatal Thoroughbred foals. 含有salacinol的营养补充剂对新生纯种马驹的影响。

Journal of Equine Science Pub Date : 2020-03-01 Epub Date: 2020-03-19 DOI: 10.1294/jes.31.11

Atsushi Iida, Hitomi Saito, Akihito Amao, Takuya Fujita, Atsushi Kato, Fumitaka Ueda

引用次数: 1