Riccardo Rinnovati, Socrate Xenos, Andrea Beltrame, Andrea Marigo, Giulia Forni, Maria Morini
{"title":"Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse.","authors":"Riccardo Rinnovati, Socrate Xenos, Andrea Beltrame, Andrea Marigo, Giulia Forni, Maria Morini","doi":"10.1294/jes.31.45","DOIUrl":"https://doi.org/10.1294/jes.31.45","url":null,"abstract":"<p><p>A neurofibroma was excised from the subcutis on the medial side of the left thigh of a 15-year-old Warmblood gelding, which had shown lameness of the left hind limb. No other source of lameness was found. Two weeks after surgery, the horse was sound at a lameness examination.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 3","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/4b/jes-31-045.PMC7538260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38492619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Equine Sarcoid","authors":"Beatrice Funiciello, P. Roccabianca","doi":"10.5772/intechopen.91013","DOIUrl":"https://doi.org/10.5772/intechopen.91013","url":null,"abstract":"","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78856350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Equine Reproduction: Seasonality, Endometritis, and Twinning in the Mare","authors":"D. Trundell","doi":"10.5772/intechopen.92999","DOIUrl":"https://doi.org/10.5772/intechopen.92999","url":null,"abstract":"This chapter reviews the seasonality and effect of photoperiod in mares and how, as clinicians, we can shorten the vernal transition period and improve our efficiency in getting mares in foal. Different protocols have been utilized to shorten the vernal transition, and each will be discussed. We will also examine endometritis in the mare. The role of biofilms in causing endometritis in our equine patients, and potential treatment plans, in particular breeding the dirty mare, will be reviewed. Finally, we will examine the effect of twin pregnancies in the mare, the most common cause of noninfectious abortion, and offer two management therapies for dealing with twinning in the mare.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83858699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ADAMTS Proteases: Potential Biomarkers and Novel Therapeutic Targets for Cartilage Health","authors":"S. Kandir","doi":"10.5772/intechopen.93046","DOIUrl":"https://doi.org/10.5772/intechopen.93046","url":null,"abstract":"The equine locomotor system’s health plays a key role on athletic performance. Bone and joint diseases are the major causes of lameness. Poor performance and diseases lead to great economic loss to equestrian sports and horse breeders. Therefore, prevention, early diagnosis, and therapy of joint diseases are important. A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) proteinase family plays an important role in many physiological processes such as tissue reorganization, coagulation, and angiogenesis. Aggrecan proteinases ADAMTS-4 and ADAMTS-5 are physiologically responsible for the restructuring with enzymatic cleavage of the cartilage, specific biomarkers in the synovium or body fluids for early diagnosis, and potential specific therapeutic targets in order to their role on degenerative joint diseases physiopathology in humans and various animals.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74080195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Zakirova, Kovac Milomir, M. Zhuravleva, Catrin Rutland, A. Rizvanov
{"title":"Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses","authors":"E. Zakirova, Kovac Milomir, M. Zhuravleva, Catrin Rutland, A. Rizvanov","doi":"10.5772/intechopen.92352","DOIUrl":"https://doi.org/10.5772/intechopen.92352","url":null,"abstract":"Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that have been made in equine therapy. It looks at the process from plasmid construction, in vitro testing through to trialing the equine-specific plasmid construct in horses with superficial digital flexor tendon (tendinitis) and suspensory ligament branch injuries. It also looks at the rationale for utilizing vascular endothelial growth factor (VEGF164) and a basic fibroblast growth factor (FGF2) for these trials and the cellular effects and potential mechanisms of actions.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77103271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani
{"title":"Gene Therapy for the Treatment of Equine Osteoarthritis","authors":"R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani","doi":"10.5772/intechopen.93000","DOIUrl":"https://doi.org/10.5772/intechopen.93000","url":null,"abstract":"Osteoarthritis (OA) is the predominant cause of lameness in horses. As in humans, the clinical symptoms of equine OA are persistent pain and dysfunction of the affected joint. Its pathology is similarly marked by progressive deterioration of the articular cartilage, subchondral bone sclerosis, marginal osteophytes, soft tissue inflammation and joint effusion. Disease pathogenesis is mediated by elevated levels of inflammatory cytokines and proteolytic enzymes in the articular tissues and synovial fluid. Existing pharmacologic agents can alleviate OA joint pain; none are able to inhibit erosive disease progression. As several gene-based treatments for human disease have received approval by the Food and Drug Administration (FDA), the transition to veterinary medicine will almost certainly follow. Several viral vector systems have demonstrated highly efficient gene transfer to the equine joint, enabling expression of therapeutic transgenes at efficacious levels for well over a year. Because of its large size, the equine joint is well suited to studies of gene-based therapies for arthritic disease. The forelimb joints are vulnerable to OA onset, and treatment and diagnostic modalities are the same in humans and horses. Here, we discuss the various gene-transfer approaches under investigation and the current progress toward the development an effective gene therapy for equine OA.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89820153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan.","authors":"Takahiro Aoki, Akiko Chiba, Megumi Itoh, Yasuo Nambo, Norio Yamagishi, Ken-Ichi Shibano, Soon Hon Cheong","doi":"10.1294/jes.31.29","DOIUrl":"https://doi.org/10.1294/jes.31.29","url":null,"abstract":"<p><p>The purpose of this study was to elucidate the colostral and foal serum immunoglobulin G (IgG) concentration values in heavy draft horses in Japan and to examine the effects of peripartum mare condition on colostral immunity. Colostrum was obtained 1 hr after foaling (pre-suckling; n=178). Blood was collected from the jugular vein of the foals (n=147) at 24 to 48 hr after birth. The foaling statuses of 73 mares were recorded. The average colostral IgG concentration was 10,540 ± 3,190 mg/dl (median=10,928; range 1,434-17,514 mg/dl). The average serum IgG concentration obtained from neonatal foals 24 to 48 hr after birth was 1,750 ± 919 mg/dl (median=1,890; range 0-3,510 mg/dl). Although colostral IgG did not differ between the normal foaling mare (n=59) and dystocial mare (n=14), foal serum IgG was lower in foals born in dystocia than in foals in normal foaling (P<0.05). This study demonstrates reference values for colostral and foal serum IgG specific to heavy draft horses in Japan and suggests that dystocia may interfere with the acquisition of colostral immunity in neonatal foals.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/e4/jes-31-029.PMC7316699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationships between morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses.","authors":"Mohamed B Mostafa, Yahya M Elemmawy","doi":"10.1294/jes.31.23","DOIUrl":"https://doi.org/10.1294/jes.31.23","url":null,"abstract":"<p><p>There is limited knowledge about causes of musculoskeletal injury in jumping Thoroughbred horses. The objective of this study was to describe the relationships between musculoskeletal disorders and linear and angular limb measurements acquired from photographs of horses with markers at specific reference points. The diagnosed musculoskeletal disorders in either fore or hind limbs were flexor tendonitis, suspensory ligaments desmitis, and osteoarthritis of the distal intertarsal and tarso-metatarsal and carpometacarpal joints. Lengths and angles in 17 clinically normal jumping Thoroughbred horses and 34 horses with musculoskeletal problems were measured. Horses with musculoskeletal disorders had significantly shorter neck, shoulder, and pelvis lengths (P<0.05), significantly longer arm and forearm front lengths (P<0.05), and significantly lower front shoulder, elbow, and hind fetlock joint angles (P<0.05). In conclusion, this study describes significant relationships between linear and angular morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. These data could possibly provide indicators for better selection of jumpers with less risk of developing orthopedic disorders.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/b4/jes-31-023.PMC7316700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed B Mostafa, Ahmed I Abdelgalil, Shaaban F Farhat, Zoe Raw, Laura M Kubasiewicz
{"title":"Morphometric measurements of the feet of working donkeys <i>Equus asinus</i> in Egypt.","authors":"Mohamed B Mostafa, Ahmed I Abdelgalil, Shaaban F Farhat, Zoe Raw, Laura M Kubasiewicz","doi":"10.1294/jes.31.17","DOIUrl":"https://doi.org/10.1294/jes.31.17","url":null,"abstract":"<p><p>Working equids rely on sound, balanced hooves, but data describing the typical morphology of the legs and feet of working donkeys are currently lacking. To address this gap in knowledge, the front and hind feet of twenty healthy working donkeys were measured and compared. Hoof width, weight-bearing lengths, heel width, dorsal hoof wall length and lateral and medial heel length of the hoof wall were determined, as well as toe angle, heel angle, hoof pastern axis, coronary band angle and a measure of 'ground surface size'. Viewed from the ground surface of the foot, front feet were more rounded and significantly larger than hind feet. Measures of medial-lateral balance and toe-heel angle ratio were within the recommended healthy guidelines for horses. Hoof pastern axis was broken forward for the studied animals, which supports previous research suggesting that a broken forward hoof pastern axis is normal for donkeys, although further study would be required to confirm whether this conformation is natural. Significant correlations were found between estimated body mass and hoof width in both the front and hind feet. These measurements provide valuable insight into the relationship between hoof and body characteristics, which may aid the development of guidelines for the trimming and management of working donkey hooves. Further study is, however, advised to confirm natural hoof conformation.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/43/jes-31-017.PMC7316701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Skivington, M. Kovač, E. Zakirova, A. Rizvanov, Catrin Rutland
{"title":"Investigation into Whether Proximal Suspensory Desmitis of the Hindlimb Could Predispose Horses to Sacroiliac Disease","authors":"Anne Skivington, M. Kovač, E. Zakirova, A. Rizvanov, Catrin Rutland","doi":"10.5772/intechopen.92353","DOIUrl":"https://doi.org/10.5772/intechopen.92353","url":null,"abstract":"Proximal suspensory desmopathy/desmitis (PSD) of the hindlimb is a well understood condition with widely accepted treatment protocols; however, there is little research demonstrating understanding or potential correlation between hindlimb PSD and sacroiliac disease (SID). Several studies have examined the co-existence of hindlimb PSD and SID each investigating unique predisposing factors. This has led to little direct correlation of cause and effect with no definitive conclusions drawn. The need to be objective is highlighted by the limited number of studies and that two studies used anecdotal evidence to support their hypothesis and thus creating the question does hindlimb proximal suspensory desmopathy predispose horses to sacroiliac disease? This review looks at the two conditions and compares the literature for each, including the incidence, biomechanics, anatomy, and treatment. The review further discusses whether one disorder predisposes horses/equids to the other.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73682431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}