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Japanese Journal of Cancer and Chemotherapy最新文献

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[Ⅲ. New Development in Chemotherapy for Unresectable Advanced or Recurrent Gastric Cancer]. [Ⅲ.不可切除的晚期或复发性胃癌化疗的新进展].
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Yohei Kubota, Yu Sunakawa
{"title":"[Ⅲ. New Development in Chemotherapy for Unresectable Advanced or Recurrent Gastric Cancer].","authors":"Yohei Kubota, Yu Sunakawa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"896-902"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Feasibility of FP Therapy in Outpatient Setting for Inoperable Recurrent Esophageal Cancer]. [FP疗法在门诊治疗无法手术的复发性食管癌的可行性]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Ryuichi Morita, Takeshi Ishikawa, Toshifumi Doi, Junichiro Itani, Daiki Sone, Naoto Iwai, Ryohei Hirose, Ken Inoue, Osamu Dohi, Akito Harusato, Naohisa Yoshida, Kazuhiko Uchiyama, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Tomohisa Takagi, Hideyuki Konishi, Yoshito Itoh
{"title":"[Feasibility of FP Therapy in Outpatient Setting for Inoperable Recurrent Esophageal Cancer].","authors":"Ryuichi Morita, Takeshi Ishikawa, Toshifumi Doi, Junichiro Itani, Daiki Sone, Naoto Iwai, Ryohei Hirose, Ken Inoue, Osamu Dohi, Akito Harusato, Naohisa Yoshida, Kazuhiko Uchiyama, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Tomohisa Takagi, Hideyuki Konishi, Yoshito Itoh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the emergence of immune checkpoint inhibitors(ICIs)in recent years, the treatment outcomes for unresectable recurrent esophageal cancer have improved markedly. In 5-FU+cisplatin(FP)first-line therapy, 5-FU administration takes 5 days and generally requires hospitalization. However, frequent hospitalization for treatment is a crucial issue that must be resolved in terms of time investment and optimal use of hospital resources. Here, we evaluated the safety and potential adverse effects of the administration of FP therapy in an outpatient setting. After central venous ports were placed in 5 patients, cisplatin was administered using a short hydration method and 5-FU was infused for 120 hours using an infusion pump. No crucial adverse events or major pump-related problems occurred, suggesting the feasibility of this treatment in an outpatient setting. However, the duration of 5-FU administration via the pump varied more than the expected deviation (10%, 12 hours), indicating that the issues require further consideration.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"907-911"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Upper G. I. Cancer]. [Upper G. I. Cancer].
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Masanori Terashima
{"title":"[Upper G. I. Cancer].","authors":"Masanori Terashima","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"885-886"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Low-Grade Appendiceal Mucinous Neoplasm-A Complex Preoperative Diagnosis]. [一例低级别阑尾黏液瘤--复杂的术前诊断]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Naoki Kinjo, Ryoji Kamei, Hiroki Nakatsu
{"title":"[A Case of Low-Grade Appendiceal Mucinous Neoplasm-A Complex Preoperative Diagnosis].","authors":"Naoki Kinjo, Ryoji Kamei, Hiroki Nakatsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 63-year-old woman was admitted to our hospital with suspected appendicitis. Abdominal CT revealed an enlarged appendix, and findings consistent with some small nodules. She was diagnosed with appendicitis and successfully treated with antibiotics. Contrast-enhanced CT performed 2 months after discharge revealed a reduction in small nodules, and tumor markers were not elevated. Therefore, we concluded that this case was unlikely to be an appendiceal tumor. Interval appendectomy was performed laparoscopically, and histopathological analysis revealed a low-grade appendiceal mucinous neoplasm(LAMN). Herein, we present this case and review the relevant literature.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"943-945"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Recurrent Esophageal Cancer Showing Good Response to Nivolumab in a Super-Elderly Patient-A Case Report]. [超高龄患者复发性食管癌对 Nivolumab 反应良好--病例报告】。］
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Hiromasa Komori, Nobutoshi Hagiwara, Tsutomu Nomura, Nobuyuki Sakurazawa, Hideki Kogo, Mikito Suzuki, Hirokazu Okamoto, Hiroshi Yoshida
{"title":"[Recurrent Esophageal Cancer Showing Good Response to Nivolumab in a Super-Elderly Patient-A Case Report].","authors":"Hiromasa Komori, Nobutoshi Hagiwara, Tsutomu Nomura, Nobuyuki Sakurazawa, Hideki Kogo, Mikito Suzuki, Hirokazu Okamoto, Hiroshi Yoshida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 91-year-old man with thoracic esophageal cancer(pT3N1M0, pStage Ⅲ)and gastric cancer(pT1b2N0M0, pStage ⅠA)underwent esophagectomy. Three years and 4 months postoperatively, chest computed tomography revealed a mass shadow near the aortic arch. Upper gastrointestinal endoscopy revealed a submucosal tumor-like lesion on the left wall of the gastric tube, which was identified as recurrent esophageal cancer. The patient and his family strongly requested nivolumab administration and initiated treatment. The tumor shrank remarkably after 6 months of nivolumab therapy. Although an immune-related adverse event(irAE)was observed, no other adverse events occurred. After 1 year of administration, the tumor did not increase, and remained under control. We suggest that nivolumab therapy is an effective regimen for older patients with recurrent or inoperable esophageal cancer that is difficult to treat with conventional anticancer drugs, provided that strong irAEs do not occur.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"939-941"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Real-World Data of Immunohistochemical Staining for DNA Mismatch Repair Proteins Highlight Candidates for Immune Checkpoint Inhibitor Treatment in Patients with Gastrointestinal Cancer]. [DNA错配修复蛋白免疫组化染色的真实世界数据凸显胃肠道癌症患者免疫检查点抑制剂治疗的候选者】。］
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Naoyuki Sakamoto
{"title":"[Real-World Data of Immunohistochemical Staining for DNA Mismatch Repair Proteins Highlight Candidates for Immune Checkpoint Inhibitor Treatment in Patients with Gastrointestinal Cancer].","authors":"Naoyuki Sakamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Overall assessment of KEYNOTE-164 study, KEYNOTE-158 study and CheckMate 142 study demonstrated the clinical benefits of immune checkpoint inhibitors(ICIs)among patients with mismatch repair deficient(dMMR)/high microsatellite instability(MSI-H)cancer. As a result, ICIs have been approved for treatment of MSI-H solid tumor regardless of the tumor type. However, the frequency of real-world diagnosed dMMR gastrointestinal cancer were rarely reported. Therefore, the results of immunohistochemical staining for DNA mismatch repair proteins was investigated. 175 samples of gastrointestinal cancers were examined between November 2019 and June 2023. Clinical and pathological characteristics were obtained from clinical and histopathological records. In real world populations with high proportion of elderly people, the frequency of diagnosed dMMR gastrointestinal cancer may be high compared with previous reports. Furthermore, based on the deficient pattern of mismatch repair protein and age, most cases classified as dMMR may be sporadic. Right side tumors and female may increase the likelihood of dMMR colorectal cancer. The current results justified immunohistochemical staining for DNA mismatch repair proteins, strongly involved in the appropriate patient selection for ICIs therapy, should be conducted for elderly patients newly diagnosed as gastrointestinal cancer. We believe that further clinical cancer immunology research, and then challenging insight targeting dMMR gastrointestinal cancer will result in future development of novel immunotherapy combination strategies well tolerated even in elderly patients.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"873-878"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Case of Acute Pancreatitis during Eribulin Mesilate Therapy for Metastasis of Breast Cancer]. [甲磺酸伊利布林治疗乳腺癌转移期间的急性胰腺炎病例]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Tsuyaka Koga, Kengo Shirahane, Shunya Nakashita, Noriko Oza, Koichiro Morita, Hitoshi Aibe
{"title":"[Case of Acute Pancreatitis during Eribulin Mesilate Therapy for Metastasis of Breast Cancer].","authors":"Tsuyaka Koga, Kengo Shirahane, Shunya Nakashita, Noriko Oza, Koichiro Morita, Hitoshi Aibe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a 46-year-old Japanese woman diagnosed with Stage Ⅳ right breast cancer, cT1cN1M1(ovarian and peritoneal metastases). We administered bevacizumab+paclitaxel as the first-line treatment. In the 13th course, the peritoneal dissemination progressed, and the regimen was changed to eribulin(1.4 mg/m2)as the second-line treatment. During the second course, abdominal distension developed and was resolved during follow-up. However, abdominal distension and pain were observed from day 9 of the fourth course. Based on the results of blood chemistry and CT scans, she was diagnosed with acute pancreatitis(CT Grade 1)and was admitted to the hospital. After fasting and fluid replacement therapy, her clinical symptoms and laboratory data improved, and was discharged from the hospital 8 days later. She had no history of excessive alcohol consumption and no evidence of biliary disease, and was considered having eribulin-induced pancreatitis.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"955-957"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Case of Testicular Seminoma in Which the Diagnosis Was Preceded by the Discovery of Atypically Shaped Metastatic Nodules in the Lung]. [睾丸精原细胞瘤病例，诊断前在肺部发现形状异常的转移结节]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Ryo Ichikawa, Akane Kato, Takuma Atagi, Takayuki Shiina, Shogo Ide, Sachie Koike, Keiichiro Takasuna, Maki Osada, Ryo Kitahara, Takayuki Kamigaito, Toshitsugu Nakamura
{"title":"[Case of Testicular Seminoma in Which the Diagnosis Was Preceded by the Discovery of Atypically Shaped Metastatic Nodules in the Lung].","authors":"Ryo Ichikawa, Akane Kato, Takuma Atagi, Takayuki Shiina, Shogo Ide, Sachie Koike, Keiichiro Takasuna, Maki Osada, Ryo Kitahara, Takayuki Kamigaito, Toshitsugu Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 57-year-old man visited our hospital due to abnormal chest X-ray findings. Chest computed tomography(CT)showed amalgamated beaded solid nodules in the right upper lobe of the lung. Lobectomy of the right upper lobe was performed and the nodule was histologically determined to be seminoma. Positron emission tomography(PET)-CT showed high 18F-fluorodeoxyglucose(FDG)uptake in the lung nodules and faint uptake in the left testicle. As ultrasound and palpation detected no tumor in the testes, consent to perform orchiectomy was not obtained. Considering the PET-CT findings, we diagnosed testicular seminoma with solitary pulmonary metastasis, which is extremely rare.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"951-953"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ⅰ. Minimally Invasive Esophagectomy for Esophageal Cancer]. [食管癌微创食管切除术]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Eisuke Booka, Yuki Sakai, Ryoma Haneda, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
{"title":"[Ⅰ. Minimally Invasive Esophagectomy for Esophageal Cancer].","authors":"Eisuke Booka, Yuki Sakai, Ryoma Haneda, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"887-890"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of the Tumor Microenvironment through HER2 Signaling-Insights from Gastric Cancer Cases with Heterogeneous HER2 Overexpression]. [通过 HER2 信号调控肿瘤微环境--来自异质性 HER2 过度表达胃癌病例的启示]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-09-01
Shotaro Nakajima, Satoshi Fukai, Akinao Kaneta, Hideaki Tsumuraya, Akira Matsuishi, Hirokazu Okayama, Motonobu Saito, Kosaku Mimura, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Koji Kono
{"title":"[Regulation of the Tumor Microenvironment through HER2 Signaling-Insights from Gastric Cancer Cases with Heterogeneous HER2 Overexpression].","authors":"Shotaro Nakajima, Satoshi Fukai, Akinao Kaneta, Hideaki Tsumuraya, Akira Matsuishi, Hirokazu Okayama, Motonobu Saito, Kosaku Mimura, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Koji Kono","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>HER2, a member of the human epidermal growth factor receptor(HER)family, exhibits gene amplification, protein overexpression, or both in 13-27% of gastric cancer(GC)cases. Through the activation of downstream Akt and ERK pathways, HER2 promotes the survival and proliferation of gastric cancer cells. The impact of HER2 signaling on the tumor microenvironment(TME)in GC remains unclear, and the heterogeneity of HER2 overexpression in GC tissues is considered a contributing factor. In this study, we focused on differences in the TME between HER2-positive and HER2-negative areas in HER2-positive GC and found that HER2 signaling, particularly the HER2-Akt cascade, may suppress stimulator of interferon genes (STING)expression and reduce CD8+ T cell infiltration in tumor cells. Overall, our findings suggest the potential for a novel therapeutic approach to activate the anti-tumor immune response in HER2-positive GC.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 9","pages":"903-905"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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