Japanese Journal of Cancer and Chemotherapy最新文献_第9页

[A Case of Pancreatic Acinar Cell Carcinoma with Invasive Ductal Carcinoma and Neuroendocrine Tumor]. 胰腺腺泡细胞癌合并浸润性导管癌及神经内分泌肿瘤1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Mitsuru Kinoshita, Yutaka Takeda, Yoshifumi Iwagami, Go Shinke, Yoshiaki Ohmura, Yoshiro Yukawa, Asami Arita, Kiminori Yanagisawa, Shinsuke Katsuyama, Ryo Ikeshima, Masayuki Hiraki, Keijiro Sugimura, Toru Masuzawa, Taishi Hata, Kohei Murata

{"title":"[A Case of Pancreatic Acinar Cell Carcinoma with Invasive Ductal Carcinoma and Neuroendocrine Tumor].","authors":"Mitsuru Kinoshita, Yutaka Takeda, Yoshifumi Iwagami, Go Shinke, Yoshiaki Ohmura, Yoshiro Yukawa, Asami Arita, Kiminori Yanagisawa, Shinsuke Katsuyama, Ryo Ikeshima, Masayuki Hiraki, Keijiro Sugimura, Toru Masuzawa, Taishi Hata, Kohei Murata","doi":"","DOIUrl":"","url":null,"abstract":"A 50-year-old female presented with abdominal pain. Upper gastrointestinal endoscopy revealed a 30 mm ulcerative lesion extending from the duodenal bulb to the descending portion, and biopsy confirmed poorly differentiated adenocarcinoma. Abdominal contrast-enhanced CT scan showed an hypovascular tumor in the pancreatic head with suspected invasion into the duodenum, along with enlarged #8 lymph node. PET-CT revealed abnormal uptake in the pancreatic head and #8 lymph node. She underwent robotic pancreaticoduodenectomy for a diagnosis of pancreatic head cancer with lymph node metastasis. Histopathological examination revealed proliferation of atypical cells in acinar, trabecular, ribbon-like anastomosing, and tubular structures. Immunohistochemistry showed positivity for Bcl10(60%), INSM1(20%), Ki-67 index of 45%, and coexistence of invasive ductal adenocarcinoma(20%). Based on these findings, the tumor was diagnosed as predominantly acinar cell carcinoma with invasive ductal adenocarcinoma and neuroendocrine tumor. Lymph node metastasis was positive showing Bcl10-positive acinar cell carcinoma. Four months postoperatively, recurrence was detected in the para-aortic lymph nodes, confirmed by biopsy to be acinar cell carcinoma. Chemotherapy was initiated but discontinued due to tumor progression leading to best supportive care.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"164-166"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cancer Care in a Super-Aged Society-Perspectives from a Medical Oncologist]. [一个超高龄社会的癌症护理——来自医学肿瘤学家的观点]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Tomonori Mizutani

{"title":"[Cancer Care in a Super-Aged Society-Perspectives from a Medical Oncologist].","authors":"Tomonori Mizutani","doi":"","DOIUrl":"","url":null,"abstract":"Aging is a risk factor for cancer, and the number of older adults with cancer is rising. When delivering cancer care for this population, it is essential to assess not only the cancer but also the individual as an older adult. Accurate evaluation requires understanding the biological, physiological, and social characteristics associated with aging. A comprehensive geriatric assessment is recommended to ensure proper evaluation. Additionally, when delivering evidence-based cancer care for older adults, it is important to acknowledge that randomized phase Ⅲ trials are not the only source of evidence. Community consensus and theoretical best practices, while sometimes considered weaker, still represent legitimate forms of scientific evidence. Therefore, the absence of strong evidence does not justify accepting approaches without supporting data. In treating older adults with cancer, it is crucial to tailor the treatment strategy to the patient's values and preferences. However, healthcare providers need to employ appropriate methods to accurately understand the preferences of older adults. To provide better cancer care for older adults, it is necessary to adopt an interdisciplinary approach, collaborating with not only medical oncologists but also nurses, pharmacists, dietitians, rehabilitation specialists, and medical social workers. Therefore, in Japan's super-aged society, medical oncologists need to serve as leaders in team-based cancer care, maintaining a broad perspective that addresses both'cancer'and'the older adult'.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"102-107"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of the Deodorizing Effect of an Electric Scalpels with a Smoke Evacuation System in Breast Surgery]. [乳房手术中带排烟系统的电刀除臭效果评价]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Chie Toshikawa, Eiko Sakata, Hitoshi Kameyama

引用次数: 0

[A Case of Robot-Assisted Total Pelvic Exenteration for Locally Advanced Rectal Cancer with Vaginal Invasion]. 【机器人辅助全盆腔切除术治疗局部晚期直肠癌伴阴道侵犯1例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Saori Nakano, Nobuyoshi Ohara, Mitsunobu Imasato, Shingo Noura, Akihiro Kitagawa, Yuki Ushimaru, Tomohira Takeoka, Hideo Tomihara, Sakae Maeda, Ryohei Kawabata, Atsushi Miyamoto

引用次数: 0

[Current Status and Future Perspectives of Cancer Rehabilitation]. [癌症康复的现状与未来展望]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Tetsuya Tsuji

{"title":"[Current Status and Future Perspectives of Cancer Rehabilitation].","authors":"Tetsuya Tsuji","doi":"","DOIUrl":"","url":null,"abstract":"As cancer becomes more of a chronic condition, cancer rehabilitation care aimed at maintaining and improving patients' quality of life(QOL)is becoming increasingly important. Cancer rehabilitation care addresses both disabilities caused by cancer itself and those that arise during the treatment process. Cancer rehabilitation is divided into four phases-preventive, restorative, supportive, and palliative. During the perioperative period, prehabilitation starting before surgery aims to prevent complications and promote recovery, while during chemotherapy and radiation therapy, the focus is on preventing inactivity and maintaining/improving physical and social functioning. For patients with advanced cancer, addressing cancer cachexia and bone metastases is crucial. Cachexia is managed through a multidisciplinary approach combining exercise therapy and nutritional management, while for bone metastases, early detection and appropriate use of orthoses help prevent pathological fractures. In the terminal phase, support focuses on maintaining QOL while prioritizing the wishes of patients and their families. Since the enactment of the\"Cancer Control Act\"in 2006, the infrastructure for cancer rehabilitation has been developing, and in 2010, \"Cancer Patient Rehabilitation Fee\"was newly established in the medical fee schedule. In terms of human resource development, professional training is being conducted through cancer rehabilitation training programs and cancer professional development plans. Going forward, there is a need for stage-specific treatment approaches, individualized care according to life stages, and strengthened multi-professional collaboration in advanced cancer care. With the increase in elderly cancer patients, cancer becoming a chronic condition, and more patients living with cancer, maintaining functional capacity and extending healthy life expectancy have become more important goals than just extending survival time. The provision of comprehensive, evidence-based rehabilitation care has become essential.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of Perioperative Anxiety and Depression in Gastric Cancer Patients]. 胃癌患者围手术期焦虑、抑郁的评价

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Shinichi Adachi, Atsushi Ueyama, Fumiaki Abe, Takuya Tokunaga, Yujiro Fujie, Naozumi Higaki, Shigeyuki Ueshima, Tadashi Ohnishi

{"title":"[Evaluation of Perioperative Anxiety and Depression in Gastric Cancer Patients].","authors":"Shinichi Adachi, Atsushi Ueyama, Fumiaki Abe, Takuya Tokunaga, Yujiro Fujie, Naozumi Higaki, Shigeyuki Ueshima, Tadashi Ohnishi","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: To evaluate the level of anxiety and depression of the patients, Hospital Anxiety and Depression Scale (HADS) is useful to evaluate symptoms such as dejection and uneasiness by asking patients to answer 14 questions. The aim of this study was to evaluate the changes of psychological characteristics such as anxiety and depression using HADS after gastrectomy in gastric cancer(GC)patients.Patients and methods: We retrospectively analyzed the clinical data of 79 patients with GC who underwent gastrectomy and answered HADS questions between January 2017 and August 2023. HADS is a tool to measure the feeling of anxiety(HADS-A)and depression(HADS-D). Total-HADS=(HADS-A)+(HADS-D). We examined the changes of total-HADS, HADS-A and HADS-D preoperatively, and at 3 and 6 months after operation.Result: There were no significant changes in HADS-D. However, there were significant changes in HADS-A and total-HADS preoperatively and postoperatively.Discussion and conclusion: Interestingly, anxiety points(HADS-A)tended to be improved after operation over time. Anxiety that the patients feel about operation might be resolved after undergoing it. Perioperative psychological evaluation and support therapy might lead to overall improvement in mental health in GC patients.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"143-145"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Duodenal Cancer with a History of Metachronous Multiple Colorectal Cancer Resections Achieving Endoscopic Complete Response following Pembrolizumab Treatment]. [1例伴有异时多发结直肠癌切除术的十二指肠癌患者经派姆单抗治疗后内镜下完全缓解]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Tatsushi Shingai, Satoshi Nagaoka, Rie Nakatsuka, Takashi Kusu, Masaki Hirota, Yoichi Makari, Takashi Matsumoto, Masanori Matsui, Satoshi Oshima

{"title":"[A Case of Duodenal Cancer with a History of Metachronous Multiple Colorectal Cancer Resections Achieving Endoscopic Complete Response following Pembrolizumab Treatment].","authors":"Tatsushi Shingai, Satoshi Nagaoka, Rie Nakatsuka, Takashi Kusu, Masaki Hirota, Yoichi Makari, Takashi Matsumoto, Masanori Matsui, Satoshi Oshima","doi":"","DOIUrl":"","url":null,"abstract":"A male in his 80s with a history of multiple colorectal cancer resections underwent an upper gastrointestinal endoscopy for anemia investigation, which revealed a non-ampullary duodenal carcinoma. Due to insufficient surgical tolerance for pancreaticoduodenectomy, pharmacotherapy was considered. With informed consent, an MSI test was conducted, showing MSI-high, leading to the initiation of pembrolizumab treatment. Four months after treatment began, the tumor reduced on upper gastrointestinal endoscopy and became difficult to identify after 1 year. Meanwhile, a CT scan performed during the tumor reduction process revealed a 15 mm nodule on the dorsal side of the pancreatic uncinate process, accompanied by a gradual increase in CA19-9 levels. At the time of complete response of the primary lesion, CA19-9 levels were abnormally high at 1,192 U/mL, and a CT scan showed a slight increase of the nodule to approximately 17 mm, with FDG-PET indicating an SUVmax of 4.17. The patient did not wish to undergo invasive procedures such as a needle biopsy. Therefore, radiation therapy(IMRT-VMAT 60 Gy/30 Fr)was administered to control the lesion, resulting in a significant reduction in CA19-9 levels and the avoidance of decreased ADL in this elderly patient due to treatment changes.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"146-148"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Challenges and Countermeasures in Cancer Surgery for Elderly Patients]. [老年肿瘤手术面临的挑战与对策]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Takayasu Azuma, Yasuhide Kofunato, Shigeru Marubashi

引用次数: 0

[National Cancer Control in a Super-Aged Society-Based on the Fourth Basic Plan to Promote Cancer Control]. [超老龄化社会下的国家癌症防治——基于第四次推进癌症防治基本规划]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Rika Kizawa, Genki Kanagawa, Aki Mukai, Daiki Hokkoku, Hajime Oi, Akira Toishi, Akira Chiba, Jun Masuda

{"title":"[National Cancer Control in a Super-Aged Society-Based on the Fourth Basic Plan to Promote Cancer Control].","authors":"Rika Kizawa, Genki Kanagawa, Aki Mukai, Daiki Hokkoku, Hajime Oi, Akira Toishi, Akira Chiba, Jun Masuda","doi":"","DOIUrl":"","url":null,"abstract":"In Japan, the ageing population is progressing rapidly, leading to an increase in the number of elderly cancer patients. These patients often have multiple chronic diseases, and cognitive decline can impact their physical symptoms, decision-making abilities, adherence to treatment, and management of adverse events. As dementia progresses, they require support in their daily lives. It is essential to consider their physical conditions and social backgrounds. In June 2006, the Cancer Control Act was enacted, followed by the formulation of the Basic Plan to Promote Cancer Control in June 2007. The Third Basic Plan, formulated in 2018, promoted comprehensive cancer control through the three pillars of\"cancer prevention\"\", improving cancer medical care\", and\"living with cancer\", addressing\"cancer in the elderly\"as a new focus in cancer control measures tailored to life stages. The Fourth Basic Plan, approved by the Cabinet in March 2023, aims to\"overcome cancer with all, ensuring that cancer control leaves no one behind\". It maintains the three-pillar structure of the Third Basic Plan to determine the current situation and challenges in\"cancer prevention\"\", cancer medical care\"and\"living with cancer\"alongside policies to tackle these issues. On this basis, we will continue to promote the development of a collaborative system with local medical institutions and nursing care facilities, and efforts to support the decision-making of elderly cancer patients and their families, so that they can receive appropriate cancer medical care according to their individual circumstances.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 2","pages":"115-123"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Robotic Gastrectomy Contributed to Safe Surgery in a Patient with Gastric Cancer with Severe Pulmonary Dysfunction Due to Myasthenia Gravis]. 【机器人胃切除术为一例重症肌无力所致胃癌合并严重肺功能障碍患者的安全手术做出贡献】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01

Hiroyuki Kanazawa, Shuhei Komatsu, Tomoki Konishi, Ryo Takeda, Hiroyuki Inoue, Koji Soga, Katsumi Shimomura, Jun Ikeda, Fumihiro Taniguchi, Yasuhiro Shioaki, Eigo Otsuji

引用次数: 0