Japanese Journal of Cancer and Chemotherapy最新文献_第9页

[A Case of Intussusception Due to Small Intestinal Cancer Diagnosed by Laparoscopy]. [腹腔镜诊断小肠肿瘤致肠套叠1例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Tsukasa Yoshida, Shun Miyanari, Tatsuro Ishikawa, Yasushi Takafuji, Kohei Fujinami, Takumi Hikawa, Takahiro Shimauchi, Yosuke Ueno, Michinori Murayama, Kazuo Hase

{"title":"[A Case of Intussusception Due to Small Intestinal Cancer Diagnosed by Laparoscopy].","authors":"Tsukasa Yoshida, Shun Miyanari, Tatsuro Ishikawa, Yasushi Takafuji, Kohei Fujinami, Takumi Hikawa, Takahiro Shimauchi, Yosuke Ueno, Michinori Murayama, Kazuo Hase","doi":"","DOIUrl":"","url":null,"abstract":"Most cases of primary small intestinal cancer are diagnosed at an advanced stage, and when accompanied by intussusception or obstruction, emergency surgery may be required. Preoperative evaluation of small intestinal cancer is challenging. The patient was a 52-year-old man who was referred to our hospital with abdominal pain and vomiting, and was diagnosed with small intestinal intussusception. Abdominal CT at our hospital revealed bowel wall thickening at the site where the intussusception had resolved, raising suspicion for small intestinal cancer. Based on the patient's clinical history and physical findings, delayed small intestinal perforation was suspected, and emergency surgery was performed. Laparoscopy-assisted surgery was carried out to resect the small intestinal tumor and peritoneal dissemination nodules. Pathological examination revealed moderately differentiated adenocarcinoma. The final diagnosis was pT3, pN1, pM1, and Stage Ⅳ. Laparoscopic surgery for small bowel cancer can be useful both for treatment and intraoperative diagnosis. In this case, the decision to perform non-curative resection based on the Stage Ⅳ diagnosis enabled early discharge and prompt initiation of additional treatments.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"210-211"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Mesenteric Desmoid Tumor Arising during Follow-Up of the Clinical Course of Ulcerative Colitis]. 溃疡性结肠炎临床病程随访中出现肠系膜硬纤维瘤1例

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Rika Ida, Jun Aoki, Michitoshi Goto, Hirotsugu Morioka, Masaaki Minagawa, Megumi Kawaguchi, Yuki Nakagawa, Michihiro Orihata, Shigetaka Yamasaki

引用次数: 0

[Microbiome and Colorectal Cancer]. [微生物组与结直肠癌]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Tatsuhiro Shibata

{"title":"[Microbiome and Colorectal Cancer].","authors":"Tatsuhiro Shibata","doi":"","DOIUrl":"","url":null,"abstract":"The number of colorectal cancer patients in Japan continues to rise, placing the country among the highest rates globally, surpassing even Western nations. Furthermore, the increase in colorectal cancer among younger individuals(under 50 years old)is a significant concern. This rapid rise in colorectal cancer patients cannot be explained solely by the adoption of Western lifestyles, suggesting the presence of unknown carcinogenic factors. Colibactin toxin, produced by certain gut bacteria (pks+ Escherichia coli), binds to AT-rich DNA and induces characteristic mutation patterns. An international collaborative study compared the differences in these mutation patterns across 981 colorectal cancer samples collected from 11 countries, including Japan. Surprisingly, it revealed that Japanese cases exhibited a significantly higher frequency of the colibactin toxin - induced mutation patterns(SBS88 and ID18)compared to other countries. Furthermore, SBS88 and ID18 were particularly prevalent in younger patients and notably prominent in the right colon, including the rectum. These findings suggest that interventions such as preventing infection with pks+ bacteria, eradicating them, or inhibiting the function of colibactin toxin could potentially reduce the incidence of colorectal cancer, particularly in younger patients. Such prevention is also considered likely to be effective in Japan, where infection is presumed to be highly prevalent.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"162-167"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Esophagogastric Junction Cancer Treated with Perioperative Nivolumab Therapy]. 围手术期纳武单抗治疗食管胃结癌1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Ryota Miura, Takeshi Toyozumi, Masaya Uesato, Koichi Hayano, Hisahiro Matsubara

引用次数: 0

[Curative Resection of Rectal Cancer with Simultaneous Pulmonary and Hepatic Metastasis by Multidisciplinary Approach]. 多学科联合治疗直肠癌伴肺、肝转移的疗效分析。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Takayuki Minoji, Ken Konishi, Yuko Fukumoto, Koutarou Muranishi, Takahiko Nishigaki, Hisanori Hatano, Isao Arai, Keishi Sugimoto, Kazuyuki Matsushita, Noriyoshi Sawabata, Kazunori Nakaguchi, Sadayuki Doi, Takashi Ito

{"title":"[Curative Resection of Rectal Cancer with Simultaneous Pulmonary and Hepatic Metastasis by Multidisciplinary Approach].","authors":"Takayuki Minoji, Ken Konishi, Yuko Fukumoto, Koutarou Muranishi, Takahiko Nishigaki, Hisanori Hatano, Isao Arai, Keishi Sugimoto, Kazuyuki Matsushita, Noriyoshi Sawabata, Kazunori Nakaguchi, Sadayuki Doi, Takashi Ito","doi":"","DOIUrl":"","url":null,"abstract":"Treatment for distant metastasis in Stage Ⅳ rectal cancer is complicated. We report a case in which a patient with concurrent lung and liver metastasis achieved R0 resection through a multidisciplinary treatment combining staged surgical resection and systemic chemotherapy. The patient was a 60-year-old woman who presented with rectal bleeding and abdominal pain during defecation. Further examination revealed a type 2 tumor in the rectal RS region and suspicious metastatic tumors in the left lung S1+2 and liver S6/7, S7, leading to a diagnosis of rectal cancer Stage Ⅳb. Due to the symptom, laparoscopic low anterior resection was performed. As a diagnostic treatment, S1+2 subregional resection was performed on the lung lesions, confirming the diagnosis of lung metastasis. Ten courses of FOLFOX plus panitumumab were administered, resulting in shrinkage of the liver tumors in segments S6/7 and S7. However, a new lesion was suspected in segment S5 and partial liver resection was performed for the 3 lesions. All resected lesions showed pathological findings consistent with complete response(CR), and R0 resection was achieved.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"218-220"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Postoperative Pancreatic Fistula Presenting as PET-Negative Lymph Node Swelling Following Gastrectomy for Gastric Cancer]. [1例胃癌胃切除术后胰瘘表现为pet阴性淋巴结肿大]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Kohei Hayashi, Kazuki Odagiri, Rei Suzuki, Ichiro Higuchi, Shigekazu Yokoyama, Hiroyoshi Takemoto, Takayuki Fukuzaki, Chikao Yutani

引用次数: 0

[Two Cases of Primary Hepatic PEComa Treated with Laparoscopic Liver Resection]. 腹腔镜肝切除术治疗原发性肝PEComa 2例

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Ryo Omote, Yuya Funatsu, Shinichiro Nakada, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Takanori Konishi, Hitoe Nishino, Kensuke Suzuki, Masayuki Ohtsuka

{"title":"[Two Cases of Primary Hepatic PEComa Treated with Laparoscopic Liver Resection].","authors":"Ryo Omote, Yuya Funatsu, Shinichiro Nakada, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Takanori Konishi, Hitoe Nishino, Kensuke Suzuki, Masayuki Ohtsuka","doi":"","DOIUrl":"","url":null,"abstract":"We report 2 cases of primary hepatic perivascular epithelioid cell tumor(PEComa), treated with laparoscopic partial liver resection. Case 1: A 44-year-old woman who presented with abdominal pain. Abdominal dynamic contrast-enhanced computed tomography(Dy-CT)revealed a low-enhancing liver tumor in both the arterial and venous phases. She underwent laparoscopic partial liver resection of segment 5 for diagnostic and therapeutic purposes. Histopathological examination confirmed the diagnosis of PEComa. Case 2: A 40-year-old woman was found to have a hepatic tumor was during an annual health checkup. Dy-CT demonstrated arterial-phase enhancement of the tumor with early visualization of the hepatic vein adjacent to the tumor. The tumor was preoperatively diagnosed as hepatocellular carcinoma, and laparoscopic partial liver resection of segment 3 was performed. Histopathological examination confirmed the diagnosis of PEComa. Preoperative diagnosis of hepatic PEComa remains challenging due to its rarity. However, early visualization of draining hepatic veins during the arterial-phase may aid in its diagnosis. Surgical resection is generally recommended, as PEComa may exhibit malignant potential in rare cases.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"227-229"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Local Gastrectomy for Gastric Cancer in a Patient with Post-Peritonitis Skin Grafting and Double Stoma Construction]. [腹膜炎后胃癌局部胃切除术1例植皮双造口]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Takeo Hara, Ryosuke Maki, Akinobu Yasuyama, Tomoki Hata, Miho Okano, Osamu Takayama, Hiroyoshi Takemoto, Yongkook Kim, Haruhiko Imamoto, Junichi Hasegawa

{"title":"[A Case of Local Gastrectomy for Gastric Cancer in a Patient with Post-Peritonitis Skin Grafting and Double Stoma Construction].","authors":"Takeo Hara, Ryosuke Maki, Akinobu Yasuyama, Tomoki Hata, Miho Okano, Osamu Takayama, Hiroyoshi Takemoto, Yongkook Kim, Haruhiko Imamoto, Junichi Hasegawa","doi":"","DOIUrl":"","url":null,"abstract":"A 77-year-old man was referred for treatment of a type 3 lesion located on the greater curvature of the gastric angle, which was detected by esophagogastroduodenoscopy. CT imaging showed no evidence of lymph node metastasis or distant metastases; and the clinical stage was cT2N0M0, cStage Ⅰ. The patient had a complex surgical history, including radical cystectomy with ileal conduit creation for invasive bladder cancer, followed by emergency surgeries for rectal perforation, which was managed with peritoneal lavage and drainage, and sigmoid colostomy. He also had another emergency surgery for perforation of sigmoid colon. Negative pressure wound therapy and subsequent skin grafting were performed for abdominal closure. Comorbidities included variant angina, asthma, and restrictive pulmonary dysfunction. Due to anticipated extensive adhesions, the limited access to the abdominal cavity, and the patient's poor ADL, a standard gastrectomy was not feasible. Local gastrectomy with limited lymphadenectomy was successfully performed. Pathology revealed adenocarcinoma, pT3N0M0, pStage ⅡA. The patient recovered without major complications. This case highlights the feasibility of performing local gastrectomy in high-risk patients with limited surgical access.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"201-203"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Gut Microbiota Transplantation for Esophageal and Gastric Cancer]. 肠道菌群移植治疗食管癌和胃癌。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Hirofumi Fukushima, Dai Ishikawa, Akihito Nagahara

引用次数: 0

[Esophageal Cancer and Gut Microbiome]. [食管癌和肠道微生物组]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-03-01

Yoshifumi Baba

{"title":"[Esophageal Cancer and Gut Microbiome].","authors":"Yoshifumi Baba","doi":"","DOIUrl":"","url":null,"abstract":"The gut microbiota has recently garnered considerable attention across the medical field, as its involvement has been reported in a broad spectrum of conditions including cancer, obesity, inflammatory bowel disease, and even neuropsychiatric disorders. The human body is composed of approximately 30 trillion human cells and an almost equal number of bacterial cells, forming a highly integrated symbiotic relationship. While the human genome encodes only about 20,000 genes, the gut microbiota harbors several million to tens of millions of genes, offering an overwhelmingly greater genetic repertoire. The composition of the microbiota is influenced by diet, lifestyle, medications, and aging, thereby shaping unique individual - specific patterns. Regional and temporal variations are also recognized, and functional redundancy among different bacterial taxa, known as\"functional mimicry,\"further underscores its flexibility. Thus, the gut microbiota should be regarded as a dynamic and modifiable ecosystem rather than a fixed entity, making it a promising target for disease prevention and therapeutic intervention. In the context of esophageal cancer, emerging evidence indicates that alterations in the microbiota may affect carcinogenesis, disease progression, and therapeutic responses. These insights highlight the potential of the microbiota as both a biomarker and a therapeutic target, and suggest that integrating microbiome research into clinical oncology could open new avenues for improving patient outcomes.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"158-161"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0