NPG Neurologie - Psychiatrie - Geriatrie最新文献

{"title":"Facteurs de risque de la mortalité à long terme des patients survivant à un accident vasculaire cérébral au Burkina Faso","authors":"Pingdéwendé Victor Ouédraogo , Alassane Dravé , Julie Marie Adéline Wendlamita Kyélem , Abdoul Aziz Savadogo , Jeoffray Diendéré , Abaz Ouédraogo , Wendyam Amos Kagoné , Athanase Millogo , Léon Guéswendé Blaise Savadogo","doi":"10.1016/j.npg.2025.07.001","DOIUrl":"10.1016/j.npg.2025.07.001","url":null,"abstract":"<div><h3>Introduction</h3><div>La mortalité chez les survivants d’accidents vasculaires cérébraux (AVC) est 2 à 5 fois plus élevée par rapport à la population générale. L’objectif de ce travail était d’analyser la mortalité à long terme des survivants d’AVC au Centre Hospitalier Universitaire Sourô Sanou de Bobo-Dioulasso.</div></div><div><h3>Méthode</h3><div>Il s’est agi d’une étude rétrospective de type cohorte portant sur les patients hospitalisés du 1<sup>er</sup> janvier 2017 au 31 décembre 2019, sortis vivants du service de neurologie après un AVC.</div></div><div><h3>Résultats</h3><div>Au total, 144 patients ont été concernés par cette étude. L’âge moyen était de 60,1 ans (±<!--> <!-->13,3). Le sex-ratio était de 1,21. Les AVC ischémiques représentaient 60,4 % des cas et les AVC hémorragiques 39,6 %. L’hypertension artérielle était le principal facteur de risque cardiovasculaire (68,1 %). La conscience était normale chez 132 patients et les complications de décubitus ont été observées chez 23 patients au cours de l’hospitalisation. La durée moyenne d’hospitalisation était de 14<!--> <!-->jours. La durée moyenne de suivi était de 3,1 ans. La mortalité cumulée en post hospitalisation était de 32,6 % à 4 ans. Les facteurs prédictifs constants de la mortalité étaient l’âge (<em>p</em> <!-->=<!--> <!-->0,001 ; HR<!--> <!-->=<!--> <!-->1,04 ; IC95 % : 1,01–1,06) pour chaque augmentation d’une unité, le score de Glasgow ˃<!--> <!-->9 (<em>p</em> <!--><<!--> <!-->0,001 ; HR<!--> <!-->=<!--> <!-->0,12 ; IC95 % : 0,04–0,34), l’AVC hémorragique (<em>p</em> <!-->=<!--> <!-->0,01 ; HR<!--> <!-->=<!--> <!-->0,39 ; IC95 % : 0,18–0,80), l’absence de complication de décubitus (<em>p</em> <!-->=<!--> <!-->0,03 ; HR<!--> <!-->=<!--> <!-->0,45 ; IC95 % : 0,22–0,92) et le score de Rankin modifié à la sortie ≥<!--> <!-->3 (<em>p</em> <!-->=<!--> <!-->0,03 ; HR<!--> <!-->=<!--> <!-->2,44 ; IC95 % : 1,06–5,59).</div></div><div><h3>Conclusion</h3><div>La mortalité à long terme des AVC est élevée dans notre contexte. Le renforcement des soins vis-à-vis des groupes spécifiques pourrait contribuer à la réduction significative de cette mortalité à long terme.</div></div><div><h3>Introduction</h3><div>Mortality among stroke survivors is 2 to 5 times higher than in the general population. The objective of this work was to analyze the long-term survival of stroke survivors at Sourô Sanou University Hospital in Bobo-Dioulasso.</div></div><div><h3>Method</h3><div>This was a retrospective cohort study of patients hospitalised from 1 January 2017 to 31 December 2019. It concerned all patients over 15 years old who were discharged from the neurology department after a stroke.</div></div><div><h3>Results</h3><div>A total of 144 patients were involved in this study. The average age was 60.1 years (±<!--> <!-->13.3 years). The gender ratio was 1.21. Ischemic strokes accounted for 60.4% of cases and haemorrhagic strokes for 39.6%. The main cardiovascular risk factors were high","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 223-230"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le retentissement fonctionnel des maladies infectieuses chez les personnes âgées vulnérables","authors":"Joël Belmin","doi":"10.1016/j.npg.2025.10.002","DOIUrl":"10.1016/j.npg.2025.10.002","url":null,"abstract":"","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 221-222"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Déclin fonctionnel aigu chez une personne âgée atteinte d’une infection à chikungunya : un cas de décompensation gériatrique multifactorielle","authors":"Pauline Collin","doi":"10.1016/j.npg.2025.07.003","DOIUrl":"10.1016/j.npg.2025.07.003","url":null,"abstract":"<div><h3>Introduction</h3><div>L’infection à Chikungunya, bien que le plus souvent bénigne, peut entraîner des complications sévères et une perte d’indépendance marquée chez les sujets âgés.</div></div><div><h3>Observation</h3><div>Nous rapportons le cas d’un patient de 72 ans hospitalisé pour un déclin fonctionnel et une chute dans un contexte d’infection à Chikungunya. L’évolution clinique a été marquée par une désadaptation globale et une aggravation de la dépendance fonctionnelle.</div></div><div><h3>Conclusion</h3><div>Cette observation rappele l’importance de reconnaître les effets systémiques d’infections même modérées chez les sujets âgés et de mobiliser rapidement les ressources en gériatrie.</div></div><div><h3>Introduction</h3><div>Chikungunya infection, although most often benign, can lead to severe complications and significant loss of autonomy among older adults.</div></div><div><h3>Case report</h3><div>We report the case of a 72-year-old patient hospitalized for acute functional decline and a fall in the context of Chikungunya infection. The clinical course was marked by global decompensation and worsening functional dependence.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of recognizing the systemic impact of even moderate infections among older adults and the need for a rapid mobilization of geriatric care resources.</div></div>","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 266-269"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of chronic and infectious diseases on the mental health of older adults: A model-based study","authors":"Anjali Mishra ,&nbsp;Ashutosh Gaurav ,&nbsp;Sunit Kumar ,&nbsp;Dharmendra Kumar Singh","doi":"10.1016/j.npg.2025.08.005","DOIUrl":"10.1016/j.npg.2025.08.005","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Background: India is undergoing a demographic transition with an increasingly ageing population, triggering alarming concern for their mental health as they experience biological decline and related challenges. . Objectives: To compare disparities in mental health status between older adults with chronic or infectious diseases and those who are physically fit, and it examines outcomes among individuals with chronic and infectious diseases. Methods: This research used data from the &lt;em&gt;Longitudinal Ageing Study in India&lt;/em&gt; (LASI, 2020), focusing on 30,656 individuals aged 60&lt;!--&gt; &lt;!--&gt;years and above. Mental health was assessed through anxiety and depression scores, with structural equation modelling used to analyse the effects of these diseases on psychological wellbeing. Results: A one-standard-deviation increase in infectious diseases was associated with a 0.41-standard-deviation increase in anxiety and a 0.30-standard-deviation increase in depression. In addition, the rise in one standard deviation in chronic diseases a 0.23-standard-deviation increase in anxiety and a 0.13-standard-deviation increase in depression. Conclusion: Chronic and infectious diseases significantly affect the mental health of older adults, emphasizing the need for an integrated healthcare approach. Policymakers must prioritise mental health within the healthcare system, particularly in India, to enhance overall wellbeing and development, towards achieving &lt;em&gt;Sustainable Development Goal 3&lt;/em&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Contexte : L’Inde connaît une transition démographique avec une augmentation de la population âgée, ce qui suscite une préoccupation croissante pour leur santé mentale, car ils subissent un déclin biologique et les défis qui y sont liés. Objectifs: Examiner les disparités en matière de santé mentale entre les personnes âgées atteintes de maladies chroniques ou infectieuses et celles en bonne santé physique, tout en comparant les résultats entre les individus souffrant de maladies chroniques et ceux atteints de maladies infectieuses. Méthodes : Cette recherche utilise les données de l’étude &lt;em&gt;Étude longitudinale sur le vieillissement en Inde&lt;/em&gt; (LASI, 2020), portant sur 30 656 individus âgés de 60 ans et plus. La santé mentale a été évaluée à travers des scores d’anxiété et de dépression, et une modélisation par équations structurelles a été employée pour analyser les effets de ces maladies sur le bien-être psychologique. Résultats : Une augmentation d’un écart-type des maladies infectieuses était associée à une augmentation de 0,41 écart-type de l’anxiété et de 0,30 écart-type de la dépression. De plus, une augmentation d’un écart-type des maladies chroniques était associée à une augmentation de 0,23 écart-type de l’anxiété et de 0,13 écart-type de la dépression. Conclusion: Les maladies chroniques et infectieuses ont un impact significatif sur la santé mentale des personnes âgées, mettant en évidence la nécessité d’approches de soins intégr","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 244-256"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Développement et validation de l’échelle Évaluation Fonctionnelle pour les Ainés en Milieu Rural Africain: L’EFAMRA-UDS","authors":"Ibrahim Npochinto Moumeni ,&nbsp;Abdel-Nasser Njikam Moumeni ,&nbsp;Faustin Atemkeng Tsatedem ,&nbsp;Bristher Horlisther Tchuidjio Ketchogué ,&nbsp;Lamine Moumeni ,&nbsp;Rahoul Putou Moumeni ,&nbsp;Michael Temgoua ,&nbsp;Mourey France ,&nbsp;Oyene Kossi ,&nbsp;Sonia Sandra Jotsa ,&nbsp;Michel Noubom ,&nbsp;Amadou Njifou Njimah ,&nbsp;George Enow Orock Enonchong ,&nbsp;Pierre Watcho ,&nbsp;Siméon Pierre Choukem ,&nbsp;Roger Tsafack Nanfosso","doi":"10.1016/j.npg.2025.07.004","DOIUrl":"10.1016/j.npg.2025.07.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;Développer et valider une échelle d’évaluation fonctionnelle spécifiquement adaptée aux personnes âgées en milieu rural africain, afin de combler les lacunes des outils occidentaux inadéquats dans ce contexte culturel et environnemental.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthodes&lt;/h3&gt;&lt;div&gt;Étude prospective mixte menée en quatre phases méthodologiques entre juillet 2023 et mai 2024. Phase 1 : observation ethnographique de 45 personnes âgées dans quatre zones rurales de l’Ouest-Cameroun. Phase 2 : consultation participative auprès de 30 acteurs locaux (soignants et aidants familiaux). Phase 3 : conception multidisciplinaire collaborative des items et du système pictographique. Phase 4 : validation préliminaire auprès de 30 patients âgés (65–88 ans) à l’Hôpital Régional de Bafoussam et dispensaires ruraux affiliés.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;L’Échelle Fonctionnelle d’Évaluation des Personnes Âgées en Milieu Rural Africain (EFAMRA) comprend 20 items organisés en quatre domaines : mobilité contextuelle (7 items), activités domestiques adaptées (5 items), activités productives (4 items) et participation sociale (4 items). Elle évalue des tâches culturellement significatives : port de charges sur la tête, puisage d’eau, participation aux cérémonies communautaires. La validation préliminaire a démontré une excellente acceptabilité (96 %), un temps d’administration court (18&lt;!--&gt; &lt;!--&gt;minutes en moyenne), et une fiabilité inter-évaluateurs élevée (kappa&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,82). Les innovations majeures incluent un système pictographique accessible aux non-alphabétisés et une représentation en diagramme étoilé facilitant la communication thérapeutique.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;L’EFAMRA constitue une avancée pour l’évaluation gériatrique contextualisée, offrant un outil culturellement pertinent, biomécaniquement valide et applicable sans équipement spécialisé. Elle a montré une bonne sensibilité pour détecter les limitations fonctionnelles pertinentes et orienter des interventions de réadaptation adaptées aux réalités rurales africaines.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To develop and validate a functional assessment scale specifically designed for older adults in rural African settings, addressing the inadequacy of Western tools in this cultural and environmental context.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A mixed prospective study conducted in four rigorous methodological phases between July 2023 and May 2024. Phase 1: ethnographic observation of 45 old adults individuals in four rural areas of Western Cameroon. Phase 2: participatory consultation with 30 local stakeholders (healthcare providers and family caregivers). Phase 3: multidisciplinary collaborative design of items and a pictographic system. Phase 4: preliminary validation with 30 old patients (65–88&lt;!--&gt; &lt;!--&gt;years) at Bafoussam Regional Hospital and affiliated rural health centers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The Functional Assessmen","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 231-243"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chikungunya à La Réunion chez le sujet âgé : une présentation atypique au défi diagnostique","authors":"Elena Morello ,&nbsp;Céline Bougeois-Sarran","doi":"10.1016/j.npg.2025.06.005","DOIUrl":"10.1016/j.npg.2025.06.005","url":null,"abstract":"<div><div>Le chikungunya est une arbovirose émergente. Il existe une épidémie actuelle à La Réunion, département français d’outre-mer situé dans l’océan Indien. Les tableaux cliniques de chikungunya aigu comportent habituellement une fièvre, des arthralgies et une éruption cutanée. Chez le sujet âgé, ces tableaux sont atypiques et difficiles à identifier. Nous décrivons le cas d’un patient de 84 ans ayant contracté un chikungunya dont la présentation clinique était un tableau fébrile associant une récidive de chute et un syndrome confusionnel sans trouble neurocognitif sous-jacent connu. Le patient a présenté des complications en cascade, résolutives, sans altération de son statut fonctionnel. Une étude des signes cliniques spécifiques et syndromes gériatriques les plus souvent associés au chikungunya permettrait d’affiner les critères diagnostiques dans cette population.</div></div><div><div>Chikungunya fever is an emerging arbovirosis. Currently, there is an outbreak in Réunion island, a french overseas department in the Indian Ocean. The clinical symptoms of acute chikungunya typically comprise fever, arthralgia and skin rash. In elderly patients, these symptoms are atypical and difficult to identify. Here, we present the case of an 84-year-old patient who contracted a chikungunya fever. The patient's clinical presentation was a febrile illness associated with a fall and a delirium episod, without an underlying neurocognitive disorder. The patient experienced a series of complications which resolved without affecting his functional status. Studying the specific clinical signs and geriatric syndromes often associated with chikungunya would help to refine the diagnosis criteria for this population.</div></div>","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 262-265"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome coronarien aigu secondaire à une infection par le virus du chikungunya – à propos d’un cas","authors":"Laure Allan-Pattoglia ,&nbsp;Jean-Marc Eychène ,&nbsp;Céline Bougeois-Sarran","doi":"10.1016/j.npg.2025.06.001","DOIUrl":"10.1016/j.npg.2025.06.001","url":null,"abstract":"<div><div>Nous rapportons le cas d’une patiente de 92 ans, vivant à son domicile, ayant des comorbidités cardio-respiratoires. Elle a présenté un tableau inaugural d’œdème aigu pulmonaire sur un syndrome coronarien aigu associé à des douleurs diffuses non systématisées. Une infection par le virus du chikungunya est diagnostiquée dans le cadre d’une recherche de facteur précipitant, en pleine épidémie de cette arbovirose sur l’île de la Réunion. Une conjonction de facteurs explique la gravité du chikungunya, par ses répercussions ostéo-musculaires et globales, mais aussi par un surrisque cardiovasculaire. Bien qu’il n’existe pas de traitement spécifique de cette dernière, la prise en charge globale est essentielle afin de réduire la morbi-mortalité, notamment à travers la réhabilitation précoce.</div></div><div><div>This report concerns the case of a 92-year-old female patient, living at home, with cardio-respiratory comorbidities. Her inaugural presentation was an acute pulmonary oedema in association with an acute coronary syndrome with diffuse non-systematized pain. chikungunya infection was diagnosed in a search for a triggering factor, in the context of an arbovirus epidemic on the island of La Réunion. A combination of factors explains the severity of the chikungunya infection, with its osteo-muscular and global repercussions, as well as increased cardiovascular risk. There is however no specific treatment for it. Comprehensive management is essential to reduce morbidity and mortality, particularly through early rehabilitation.</div></div>","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 149","pages":"Pages 270-272"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes toward older adults among Arab healthcare professionals and students: A systematic review and recommendations for geriatric care","authors":"R.S. Younes ,&nbsp;F. Rajha","doi":"10.1016/j.npg.2024.11.002","DOIUrl":"10.1016/j.npg.2024.11.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;In the twenty-first century, the field of gerontology has experienced a shift toward the psychological well-being of older adults. Greater focus has been placed in recent years on the experiences of older adults and the questions of well-being and mental health in late adulthood. Attitudes toward older adults among healthcare professionals are an important factor that can influence the quality of geriatric care. In Arab countries, where high levels of prejudice against older adults have been observed in recent years and from which many healthcare professionals emigrate to practice worldwide, understanding the factors influencing these attitudes is crucial. This systematic review explores the attitudes of Arab healthcare professionals and students towards older adults and identifies factors linked to ageism, with the aim of proposing improvements in geriatric care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methodology&lt;/h3&gt;&lt;div&gt;Following a systematic literature search across six databases, relevant studies were selected using the PRISMA guidelines. Subsequently, ten studies were synthesized.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Knowledge of the processes of aging, levels of education, interpersonal relationships, and psychological factors such as self-esteem, empathy, and religiosity, were found to be significant predictors of attitudes towards older adults. Healthcare professionals and students with better education and knowledge of ageing, closer relationships with older adults, or high levels of empathy and self-esteem exhibited fewer negative attitudes towards older adults.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The findings highlight the need for educational reforms in healthcare training, including enhanced gerontology curricula, practical learning opportunities, and continuing education. Additionally, developing interpersonal skills and fostering personal development is crucial for improving geriatric care and reducing ageism in the healthcare sector.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Contexte&lt;/h3&gt;&lt;div&gt;Durant le XXI&lt;sup&gt;e&lt;/sup&gt; siècle, le domaine de la gérontologie s’oriente de plus en plus vers le bien-être psychologique des personnes âgées. Vu les expériences particulières des personnes âgées, une attention a récemment été accordée aux questions de bien-être et de santé mentale à la fin de la vie. Les attitudes des professionnels de santé envers les personnes âgées constituent un facteur important pouvant influencer la qualité des soins gériatriques. Dans les pays arabes, où des niveaux élevés de préjugés envers les personnes âgées ont été observés ces dernières années, et d’où de nombreux professionnels de santé émigrent pour exercer partout dans le monde, il est essentiel de comprendre les facteurs qui influencent ces attitudes. Cette revue systématique explore les attitudes des professionnels et étudiants arabes en santé envers les personnes âgées et identifie les facteurs liés à l’âgisme et les attitudes négatives, afin de contribuer à l’am","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 148","pages":"Pages 211-220"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson's disease between old drugs and new digital therapies: A pharmacological review","authors":"Francesco Ferrara","doi":"10.1016/j.npg.2025.04.002","DOIUrl":"10.1016/j.npg.2025.04.002","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates. Current pharmacological treatments, including levodopa and dopamine agonists, mainly offer symptomatic relief but do not modify disease progression. The heterogeneity of clinical manifestations and underlying molecular mechanisms has prompted a shift toward personalized medicine and innovative therapeutic strategies. Among emerging approaches, cell-based therapies — such as stem cell transplantation and induced pluripotent stem cells — aim to restore dopaminergic function and are under active investigation in preclinical and early clinical settings. In parallel, digital therapeutics and wearable technologies offer real-time, objective monitoring of motor and non-motor symptoms, enabling more accurate disease tracking and treatment optimization. These digital tools also facilitate remote patient management and adherence to therapy. Artificial intelligence (AI) has become increasingly integrated into PD research and care, with machine learning algorithms demonstrating high accuracy in early disease detection, symptom monitoring, and risk prediction. Notably, AI-based analyses of data from wearable sensors and digital biomarkers have identified prodromal signs of PD years before clinical diagnosis, offering promising avenues for preventive strategies. While no disease-modifying therapies are currently available, combining pharmacological treatments with advanced technologies and a deeper understanding of disease biology may pave the way for more effective and individualized interventions. The integration of AI, digital health, and cell-based therapies is a paradigm shift in the management and future treatment landscape of Parkinson's disease.</div></div>","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 148","pages":"Pages 179-186"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the molecular and neuropathological dimensions of dementia","authors":"Sumit Dutta ,&nbsp;Piyush Bhattacharjee ,&nbsp;Shaheen Noori ,&nbsp;Nilanjan Adhikari ,&nbsp;Samar Dule ,&nbsp;Mir Irfan Soyel ,&nbsp;Malay Besra ,&nbsp;Sudarshana Borah ,&nbsp;Priyanka Gupta","doi":"10.1016/j.npg.2025.05.002","DOIUrl":"10.1016/j.npg.2025.05.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Dementia covers a complex spectrum of cognitive disorders characterized by various pathological mechanisms, significantly impacting individuals and society. Currently, over 55 million people are affected worldwide with the economic burden predicted to increase from $2.8 trillion in 2019 to $4.7 trillion by 2030. This paper explores the four predominant dementia types. These are Alzheimer's disease, Vascular dementia, Lewy body dementia, and Frontotemporal dementia. Each exclusive type has discrete etiologies, symptoms, and progression patterns.</div></div><div><h3>Description</h3><div>Alzheimer's disease, responsible for about 70% of demenetias worldwide, is closely linked to amyloid plaques and tau tangles, while vascular dementia is defined by reduced blood circulation to the brain and cognitive decline. Lewy body dementia is defined by aberrant deposits of alpha-synuclein protein, leading to cognitive fluctuations and visual hallucinations. Frontotemporal dementia is usually seen in younger people and is identified by atrophy of the frontal, prefrontal, and temporal cortex. Recognizing these differences is important for creating targeted interventions and treatments.</div></div><div><h3>Conclusion</h3><div>This review aims to enhance comprehension of the underlying pathologies, diagnostic challenges, and therapeutic strategies associated with these dementias, ultimately contributing to improved care and management for affected individuals.</div></div>","PeriodicalId":35487,"journal":{"name":"NPG Neurologie - Psychiatrie - Geriatrie","volume":"25 148","pages":"Pages 187-201"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}