Beitrage zur Tabakforschung International/ Contributions to Tobacco Research最新文献

{"title":"Gas Chromatography-Tandem Mass Spectrometry Method for Selective Detection of 2-Nitropropane in Mainstream Cigarette Smoke.","authors":"Gala M Chapman,&nbsp;Juliana Giraldo Junco,&nbsp;Roberto Bravo Cardenas,&nbsp;Clifford H Watson,&nbsp;Liza Valentín-Blasini","doi":"10.2478/cttr-2019-0011","DOIUrl":"https://doi.org/10.2478/cttr-2019-0011","url":null,"abstract":"<p><p>Although 2-nitropropane is a potentially harmful compound present in cigarette smoke, there are few fully-validated, modern methods to quantitate it in mainstream cigarette smoke. We developed an isotope dilution gas chromatography-tandem mass spectrometry (ID-GC-MS/MS) method for the detection of 2-nitropropane in mainstream cigarette smoke. The vapor fraction of mainstream cigarette smoke was collected in inert polyvinyl fluoride gas sampling bags and extracted with hexanes containing isotopically labeled internal standard, then purified and concentrated via solid-phase extraction using a normal phase silica adsorbent and a 100% dichloromethane eluant. This method is sensitive enough to measure vapor phase 2-nitropropane concentrations in the nanogram range, with a 19 ng per cigarette method limit of detection. Product variability estimated from the analysis of 15 cigarette products yielded relative standard deviations ranging from 5.4% to 15.7%, and estimates of precision from two quality control products yielded relative standard deviations of 9.49% and 14.9%. Under the Health Canada Intense smoking regimen, 2-nitropropane in machine-generated mainstream smoke from 15 cigarette products ranged from 98.3 to 363 ng per cigarette.</p>","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190268/pdf/nihms-1672734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9496351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LC-MS/MS Analysis of Sugars, Alditols, and Humectants in Smokeless Tobacco Products.","authors":"Liqun Wang,&nbsp;Stephen Stanfill,&nbsp;Liza Valentin-Blasini,&nbsp;Clifford H Watson,&nbsp;Roberto Bravo Cardenas","doi":"10.2478/cttr-2019-0001","DOIUrl":"https://doi.org/10.2478/cttr-2019-0001","url":null,"abstract":"<p><p>Globally, smokeless tobacco (ST) includes a wide array of chemically diverse products generally used in the oral cavity. Although ST has been widely investigated, this study was undertaken to determine the levels of sugars (mono- and di-saccharides), alditols, and humectants present in major ST categories/subcategories by using high performance liquid chromatography coupled with a triple quadrupole mass spectrometer (HPLC-MS/MS). The products studied included chewing tobacco (loose leaf, plug, twist), US moist snuff, Swedish snus, creamy snuff, dry snuff, dissolvable tobacco products, and tobacco-coated toothpicks. The highest mean sugar level was detected in chewing tobacco (9.3-27.5%, <i>w/w</i>), followed by dissolvable tobacco (2.1%); all other products were lower than 1%. Creamy snuff had the highest mean alditol levels (22.6%), followed by dissolvable tobacco (15.4%); all others had levels lower than 1%. The detected mean humectant levels ranged from non-detectable to 5.9%. This study demonstrates the broad chemical diversity among ST. This research may aid researchers and public health advocates investigating the exposures and risks of ST. [Beitr. Tabakforsch. Int. 28 (2019) 203-213].</p>","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179048/pdf/nihms-1063829.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Within-Laboratory Variance Outlier Detection: An Alternative to Cochran’s Test","authors":"M. Morton","doi":"10.1515/cttr-2017-0014","DOIUrl":"https://doi.org/10.1515/cttr-2017-0014","url":null,"abstract":"Summary An important step in the full definition of an analytical method is the characterization of the within and between laboratory variability. This is typically done through collaborative studies involving multiple laboratories. The statistical analysis of the results of collaborative studies is generally carried out using standardized protocols such as those given in ISO 5725-2 or ASTM E691-14. One aspect of the evaluation of collaborative studies is the identification of outlying laboratories which are then excluded from the variance calculation associated with the analytical method. Whether particular laboratories are identified as outliers can have a dramatic effect on the calculated variances. The generally recommended approach to identify laboratories with excessive within-laboratory variation is Cochran’s Test or something similar. However, Cochran’s Test is very sensitive to non-normality of the underlying statistical distribution. When the assumption of normality is violated, Cochran’s Test can wrongly identify laboratories as outliers at much greater than the nominally stated error rate, even for deviations from normality that are very difficult to detect analytically. In this paper, an alternative to Cochran’s Test, adapted from Levene’s Test, is proposed and shown to approximately maintain the stated error rate when the underlying distribution is not normal. This newly adapted test is recommended for future collaborative study analysis in place of Cochran’s Test.","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66949873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of the Retention of Menthol in the Respiratory Tract of Menthol Cigarette Smokers: A Pilot Study","authors":"Melissa Hughes, Kyle F. Lott, J. Heck","doi":"10.2478/cttr-2014-0005","DOIUrl":"https://doi.org/10.2478/cttr-2014-0005","url":null,"abstract":"SUMMARY Menthol has been measured in cigarettes, in cigarette smoke preparations, and in smokers' blood and urine, but the efficiency of retention of smoke-delivered menthol by the smoker has not previously been reported. Thirteen smokers participated in a study designed to determine the deposition and retention efficiency of menthol in cigarette smoke in the respiratory tract when smoking mentholated cigarettes. This paper describes the results obtained during the measurement of analytes in exhaled cigarette smoke. Solanesol, nicotine, and menthol in exhaled smoke were collected using a vacuum-assisted pump during the smoking session in which each participant smoked three mentholated cigarettes within one hour. The analytes were quantified using a high-performance liquid chromatography (HPLC) method for solanesol and a gas chromatography- flame ionization detection (GC-FID) method for nicotine and menthol. Cigarette butts were collected after smoking and compared against those from machinesmoked cigarettes to provide an estimate of mouth-level exposures to the smoke constituents during normal smoking. An average of 93% of smoke-delivered menthol, 97% of nicotine and 64% of solanesol was retained by smokers of a mentholated cigarette. The results for solanesol and nicotine in this study were in agreement with prior published values for smokers of non-mentholated cigarettes. The findings of this study confirm the general utility of the mouth-level exposure technique to estimate smokers' exposures to mainstream smoke constituents, and are consistent with a considerable body of evidence from investigations of cigarette smoke exposure biomarkers indicating that exposures of smokers to major smoke constituents from menthol and non-menthol cigarettes are essentially identical. [Beitr. Tabakforsch. Int. 26 (2014) 26-33] ZUSAMMENFASSUNG Der Mentholgehalt ist bereits in Zigaretten, in Zigarettenrauchextrakten sowie im Blut und Urin von Rauchern bestimmt worden, zur Effizienz der Retention von über den Rauch abgegebenem Menthol beim Raucher wurden bisher jedoch noch keine Daten vorgelegt. Es nahmen dreizehn Raucher an einer Studie zur Ermittlung der Deposition und Retentionseffizienz in den Atemwegen von im Zigarettenrauch enthaltenen Menthol beim Rauchen mentholhaltiger Zigaretten teil. Dieser Artikel beschreibt die Ergebnisse der Messung der Analyten in exhaliertem Zigarettenrauch. Während der Rauchsitzung rauchte jeder Teilnehmer drei mentholhaltige Zigaretten innerhalb einer Stunde und es wurden Solanesol, Nikotin und Menthol im exhalierten Rauch mithilfe einer vakuumunterstützten Pumpe gesammelt. Zur Quantifizierung der Analyten wurde bei Solanesol die Methode der Hochleistungsflüssigchromatografie (HPLC) eingesetzt sowie bei Nikotin und Menthol die Methode der Gaschromatografie mit Flammenionisationsdetekor (GC-FID). Die Zigarettenstummel wurden nach dem Rauchen gesammelt und mit denen maschinell abgerauchter Zigaretten verglichen, um eine Schätzung ","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73439205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Full Bibliography of Alan Rodgman","authors":"Charles R. Green","doi":"10.2478/CTTR-2014-0006","DOIUrl":"https://doi.org/10.2478/CTTR-2014-0006","url":null,"abstract":"This chronological bibliography of Alan Rodgman’s lifetime publications covers 66 years reporting his research and analysis of scientific data. The entries span his academic research, company-sponsored investigation of tobacco and smoke chemistry, data analysis during his consulting years and personally motivated publications reflecting upon his knowledge base of tobacco and smoke research. It should be noted that the crowning achievement of his publications, i.e., the second edition of The Chemical Components of Tobacco and Tobacco Smoke, was published in the year of his death. He was active to the very end. We who collaborated with Dr. Rodgman were always confident that our research would be reported accurately, grammatically correct, even the most complex chemical structures properly named and pertinent literature fully cited. The basis for this bibliography principally comes from a list maintained by Alan Rodgman himself. I thank Drs. Tom Perfetti and Mike Ogden for assisting me in reviewing the information. [Beitr. Tabakforsch. Int. 26 (2014) 34–36].","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76846214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Cigarette Yields and Smoking Time Under Different Machine Smoking Regimes","authors":"S. Colard, T. Verron, Rémi Julien, X. Cahours, S. Purkis","doi":"10.2478/cttr-2014-0003","DOIUrl":"https://doi.org/10.2478/cttr-2014-0003","url":null,"abstract":"SUMMARY Many tobacco product regulations worldwide require the reporting of ?tar”, nicotine and carbon monoxide and set limits on their yields measured following the ISO smoking regime. Within the current regulatory framework, the introduction or recommendation for an additional more intense smoking regime with filter ventilation blocked has been made. The relationship was evaluated between measured yields and the difference between smouldering and smoking times with filter ventilation open or blocked under different smoking regimes. Development and evaluation of a cigarette burning model revealed a straight line relationship passing through the origin, showing that the \"tar\", nicotine and CO yields from one smoking regime can be used to predict the yields at any smoking time. Consequently, the rationale for conducting laboratory work under an additional specific regime is questionable and the additional data set adds no more value beyond adding a point to a known line. [Beitr. Tabakforsch. Int. 26 (2014) 4-18] ZUSAMMENFASSUNG In vielen der weltweiten Rechtsvorschriften für Tabakerzeugnisse wird die Angabe des Gehalts an Kondensat, Nikotin und Kohlenstoffmonoxid verlangt und es werden Grenzwerte für deren Ausbeuten auf der Grundlage der Verfahren zur Messung des Tabakkonsums gemäß ISO festgelegt. Es wurde nun vorgeschlagen, innerhalb des bestehenden Rechtsrahmens ein zusätzliches intensiveres Messverfahren, bei dem die Filterbelüftung blockiert ist, einzuführen bzw. zu empfehlen. Es wurde das Verhältnis zwischen den gemessenen Ausbeuten und die Differenz zwischen Glimm- und Rauchzeiten mit geöffneter bzw. blockierter Filterbelüftung entsprechend unterschiedlicher Messverfahren bestimmt. Die Ermittlung und Analyse eines Zigarettenverbrennungsmodells ergab eine durch den Nullpunkt verlaufende Gerade, mit der gezeigt werden konnte, dass die mit einem Messverfahren ermittelten Ausbeuten an Kondensat, Nikotin und CO verwendet werden können, um die Ausbeuten zu beliebigen Abrauchzeiten zu prognostizieren. Daher ist die Begründung für die Durchführung von Laboruntersuchungen gemäß einem weiteren Messverfahren fragwürdig. Die so gewonnenen zusätzlichen Daten brächten, abgesehen von der Ermittlung eines weiteren Punktes auf einer bereits bekannten Geraden, keinerlei zusätzlichen Nutzen. [Beitr. Tabakforsch. Int. 26 (2014) 4-18] RESUME De par le monde, de nombreuses réglementations sur les produits du tabac exigent la déclaration des valeurs de goudrons, de nicotine et de monoxyde de carbone, et imposent des limites sur leurs rendements selon le régime de fumage ISO. Dans le contexte réglementaire actuel, l’introduction ou la recommandation d’un régime de fumage plus intense avec la ventilation du filtre bouchée a été faite. La relation entre les rendements mesurés et la différence entre le temps de combustion libre et de fumage, ventilation filtre ouverte ou bouchée, a été évaluée avec l’application de différents régimes de fumage. Le développement et l’a","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89806481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Evaluation of the CReSSmicro™ Portable Topography Device: Implications for Clinical Research","authors":"M. Oldham, S. Plunkett, Michael T. Fisher, K. H. Shafer, M. Morton","doi":"10.2478/cttr-2014-0004","DOIUrl":"https://doi.org/10.2478/cttr-2014-0004","url":null,"abstract":"SUMMARY Performance of the CReSSmicro™ v.2.0.0 portable smoking topography device was evaluated in a controlled laboratory environment using a calibrated smoking machine to generate known, reproducible smoking topographies. Device performance was evaluated using unlit and lit cigarettes over a range of puff volumes (25 to 100 mL) at 2 s puff duration using a sine wave profile. The device missed 93% and 100% of the 25 mL/2 s puffs for unlit and lit cigarettes, respectively. The device underreported puff durations for the entire volume range, i.e., from 40 mL (0.9 ± 0.17 s) to 100 mL (1.6 ± 0.11 s) for both unlit and lit cigarettes. Puff volumes were under reported for lower volumes from 40 mL (25.6 ± 5.5 mL) to 70 mL (68.8 ± 3.7 mL) for both unlit and lit cigarettes and slightly over reported for higher volumes from 85 mL (89.4 ± 7.6 mL) to 100 mL (103.4 ± 9.8 mL) for lit cigarettes. Experimental results indicated that a 12.5-20mL/s (750-1,200 mL/min) flow threshold for puff recognition was responsible for the observed results. This study reinforces the importance of fully understanding device performance prior to performing clinical studies of human smoking topography. [Beitr. Tabakforsch. Int. 26 (2014) 19-25] ZUSAMMENFASSUNG Die Leistungsfähigkeit des mobilen Rauchtopographiegerätes CReSSmicro™ v.2.0.0 wurde in einer kontrollierten Laborumgebung untersucht. Dabei wurde eine kalibrierte Abrauchmaschine eingesetzt, um bekannte, reproduzierbare Rauchtopographien zu erzeugen. Die Maschinenleistung wurde mit Hilfe von angezündeten und nicht angezündeten Zigaretten mit unterschiedlichen Zugvolumina (25 bis 100 mL) mit einer Zugdauer von 2 s und einem Sinusprofil untersucht. Bei den nicht angezündeten bzw. angezündeten Zigaretten wurden jeweils 93 % bzw. 100 % der 25 mL/2 s- Züge vom Gerät nicht gezählt. Das Gerät wies in allen gewählten Volumina, d.h. von 40 mL (0,9 ± 0,17 s) bis 100 mL (1,6 ± 0,11 s), für sowohl nicht angezündete als auch angezündete Zigaretten eine zu geringe Zugdauer aus. Die Zugvolumina wurden bei den niedrigeren Volumina von 40 mL (25,6 ± 5,5 mL) bis 70 mL (68,8 ± 3,7 mL) für sowohl nicht angezündete als auch angezündete Zigaretten geringer als tatsächlich angegeben und bei den höheren Volumina von 85 mL (89,4 ± 7,6 mL) bis 100 mL (103,4 ± 9,8 mL) für angezündete Zigaretten etwas zu hoch angegeben. Die Versuchsergebnisse zeigten, dass ein Durchflussschwellenwert von 12,5-20 mL/s (750-1.200 mL/min) bei der Bestimmung der Züge für die beobachteten Ergebnisse verantwortlich war. Diese Studie unterstreicht, wie wichtig es ist, die Leistungsfähigkeit der Maschinen genau zu kennen, bevor klinische Studien zur Rauchtopographie beim Menschen durchgeführt werden können. [Beitr. Tabakforsch. Int. 26 (2014) 19-25] RESUME La performance de l’appareil portable de topographie du fumage CReSSmicro™ v.2.0.0 a été évaluée en milieu contrôlé dans un laboratoire, en utilisant une machine à fumer étalonnée pour générer des topographies du fumage re","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89812118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EDITORS’ NOTE","authors":"W. Heller, G. Scherer","doi":"10.2478/cttr-2014-0001","DOIUrl":"https://doi.org/10.2478/cttr-2014-0001","url":null,"abstract":"It was with great sadness that we heard that Dr Alan Rodgman passed away in December 2013 only a few months before his 90th birthday. For this issue, his friend, colleague, and collaborator, Dr Charles Green, has kindly consented to write a tribute to Dr Rodgman ́s life. As an author, Dr Rodgman published 15 full papers in our journal. As a member of our Advisory Board from 1976–1987, he was a most conscientious reviewer who took infinite care and trouble in order to improve the manuscripts he was asked to review. In an inofficial capacity, he was always willing to offer support even after his retirement from the board. In this issue, we would like to honour this eminent and distinguished scientist in tobacco research of many decades by publishing his impressive list of publications provided by Dr Green.","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81610513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco leaf protein. I : An evaluation of the use of putative chemical growth enhancers for tobacco leaf protein production","authors":"D. D. Jong","doi":"10.2478/CTTR-2013-0619","DOIUrl":"https://doi.org/10.2478/CTTR-2013-0619","url":null,"abstract":"","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/CTTR-2013-0619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69194590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarette Smoke Formation Studies: II. Smoke Distribution and Mainstream Pyrolytic Composition of Added 14C-Menthol (U)","authors":"R. W. Jenkins, R. H. Newman, M. Chavis","doi":"10.2478/cttr-2013-0254","DOIUrl":"https://doi.org/10.2478/cttr-2013-0254","url":null,"abstract":"Abstract The distribution of 14C-menthol (U) and its combustion and pyrolytic products in cigarette smoke is described. The mainstream smoke contains 28.9 percent of the total activity with 44.3 percent in the sidestream smoke and 26.9 percent in the butt. The major 14C-menthol smoke product in the mainstream smoke is unchanged menthol (98.9%). A puff-by-puff plot of menthol delivery is presented. The results obtained are explained hypothetically","PeriodicalId":35431,"journal":{"name":"Beitrage zur Tabakforschung International/ Contributions to Tobacco Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73671709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}