LC-MS/MS Analysis of Sugars, Alditols, and Humectants in Smokeless Tobacco Products.

Q3 Agricultural and Biological Sciences
Liqun Wang, Stephen Stanfill, Liza Valentin-Blasini, Clifford H Watson, Roberto Bravo Cardenas
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引用次数: 2

Abstract

Globally, smokeless tobacco (ST) includes a wide array of chemically diverse products generally used in the oral cavity. Although ST has been widely investigated, this study was undertaken to determine the levels of sugars (mono- and di-saccharides), alditols, and humectants present in major ST categories/subcategories by using high performance liquid chromatography coupled with a triple quadrupole mass spectrometer (HPLC-MS/MS). The products studied included chewing tobacco (loose leaf, plug, twist), US moist snuff, Swedish snus, creamy snuff, dry snuff, dissolvable tobacco products, and tobacco-coated toothpicks. The highest mean sugar level was detected in chewing tobacco (9.3-27.5%, w/w), followed by dissolvable tobacco (2.1%); all other products were lower than 1%. Creamy snuff had the highest mean alditol levels (22.6%), followed by dissolvable tobacco (15.4%); all others had levels lower than 1%. The detected mean humectant levels ranged from non-detectable to 5.9%. This study demonstrates the broad chemical diversity among ST. This research may aid researchers and public health advocates investigating the exposures and risks of ST. [Beitr. Tabakforsch. Int. 28 (2019) 203-213].

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无烟烟草制品中糖、糖醇和湿润剂的LC-MS/MS分析。
在全球范围内,无烟烟草(ST)包括一系列化学成分不同的产品,通常用于口腔。虽然ST已被广泛研究,但本研究采用高效液相色谱联用三重四极杆质谱仪(HPLC-MS/MS)来确定主要ST类别/亚类别中存在的糖(单糖和双糖)、糖醇和湿润剂的水平。研究的产品包括咀嚼烟草(散叶,塞,捻),美国湿鼻烟,瑞典鼻烟,奶油鼻烟,干鼻烟,可溶性烟草制品和烟草涂层牙签。平均糖含量最高的是咀嚼烟草(9.3 ~ 27.5%,w/w),其次是可溶性烟草(2.1%);所有其他产品都低于1%。奶油鼻烟的平均糖醇含量最高(22.6%),其次是可溶性烟草(15.4%);其他所有人的水平都低于1%。检测到的平均湿度水平从无法检测到5.9%不等。这项研究表明ST.中存在广泛的化学多样性。这项研究可以帮助研究人员和公共卫生倡导者调查ST. Beitr的暴露和风险。Tabakforsch。Int. 28(2019) 203-213]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Beitrage zur Tabakforschung International/ Contributions to Tobacco Research
Beitrage zur Tabakforschung International/ Contributions to Tobacco Research Agricultural and Biological Sciences-Agronomy and Crop Science
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