Journal of Colloid and Interface Science最新文献

{"title":"Crosslinking modification of starch improves the structural stability of hard carbon anodes for high-capacity sodium storage.","authors":"Yangkai Sun, Tianchi Shen, Zijian He, Shurong Wang","doi":"10.1016/j.jcis.2024.09.191","DOIUrl":"10.1016/j.jcis.2024.09.191","url":null,"abstract":"<p><p>Compared with the complex components of raw biomass, biomass derivatives with defined structures are more conducive to the controllable synthesis of hard carbon (HC) materials. Starch-based HC has garnered significant attention because of its cost-effectiveness; however, its practical applicability is limited by poor thermal stability. Herein, we propose a strategy for improving the stability of starch through self-assembly crosslinking modification, yielding high-performance HC. Starch and citric acid form a dense crosslinked structure through esterification between hydroxyl and carboxyl groups, effectively overcoming the poor thermal stability. The resulting HC exhibits a low specific surface area (SSA) and abundant closed pore structures, thereby enabling substantial sodium-ion storage. The optimized HC exhibits an improved reversible capacity of 378 mAh g^-1 and an initial Coulombic efficiency (ICE) of 90.9 %. After 100 cycles at 0.5 C, it retains 98 % initial capacity. The assembled full-cell shows a high energy density of 248 Wh kg^-1. Furthermore, the structure-performance relationship analysis reveals that the slope capacity is primarily affected by the defect concentration, while the plateau capacity is mainly determined by the closed pore structure. Galvanostatic intermittent titration technique (GITT) tests and in-situ Raman spectroscopy reveal that the sodium-ion storage mechanism in starch-based HC is \"adsorption-intercalation/filling.\"</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"678 Pt C","pages":"1142-1150"},"PeriodicalIF":9.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrite-free zinc metal anode for long-life zinc-ion batteries enabled by an artificial hydrophobic-zincophilic coating.","authors":"Hanning Zhang, Tao Shui, Nosipho Moloto, An Li, Ruogu Zhang, Jiacheng Liu, Song-Zhu Kure-Chu, Takehiko Hihara, Wei Zhang, ZhengMing Sun","doi":"10.1016/j.jcis.2024.09.092","DOIUrl":"10.1016/j.jcis.2024.09.092","url":null,"abstract":"<p><p>Considering the desired energy density, safety and cost-effectiveness, rechargeable zinc-ion batteries (ZIBs) are regarded as one of the most promising energy storage units in next-generation energy systems. Nonetheless, the service life of the current ZIBs is significantly limited by rampant dendrite growth and severe parasitic reactions occurring on the anode side. To overcome these issues caused by poor interfacial ionic conduction and water erosion, we have developed a facile strategy to fabricate a uniform zinc borate layer at the zinc anode/electrolyte interface (ZnBO). Such protective layer integrates superhydrophobic-zincopholic properties, which can effectively eliminate the direct contact of water molecules on the anode, and homogenize the interfacial ionic transfer, thereby enhancing the cyclic stability of the zinc plating/stripping. As a result, the as-prepared ZnBO-coated anode exhibits extended lifespan of 1200 h at 1 mA cm^-2 and demonstrates remarkable durability of 570 h at 20 mA cm^-2 in Zn||Zn symmetric cells. Additionally, when coupled to an NH₄V₄O₁₀ (NVO) cathode, it also delivers a superior cyclability (203.5 mAh/g after 2000 cycles at 5 A/g, 89.3 % capacity retention) in coin full cells and a feasible capacity of 2.5 mAh at 1 A/g after 200 cycles in pouch full cells. This work offers a unique perspective on integrating hydrophobicity and zincophilicity at the anode/electrolyte interface through an artificial layer, thereby enhancing the cycle lifespan of ZIBs.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"678 Pt B","pages":"1148-1157"},"PeriodicalIF":9.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial design of pyrene-based covalent organic framework for overall photocatalytic H₂O₂ synthesis in water.","authors":"Mengqi Zhang, Rongchen Liu, Fulin Zhang, Hongxiang Zhao, Xia Li, Xianjun Lang, Zhiguang Guo","doi":"10.1016/j.jcis.2024.09.189","DOIUrl":"10.1016/j.jcis.2024.09.189","url":null,"abstract":"<p><p>Covalent organic frameworks (COFs) have shown great potential in the photocatalytic production of hydrogen peroxide (H₂O₂) due to their precisely designed and customized ability. Nevertheless, the quest for efficient overall photosynthesis of H₂O₂ in pure water without sacrificial agents using COF photocatalysts remains a formidable challenge. Herein, three pyrene-based covalent organic frameworks are synthesized using an advanced interfacial design strategy. By incorporating functional groups of F, H, and OH into a COF skeleton, their wettability and charge-separation properties are fine-tuned. These COFs show great performances as photocatalysts for H₂O₂ production from water and air by utilizing both the oxygen reduction reaction and water oxidation reaction pathways. Compared to PyCOF-F and PyCOF-H, PyCOF-OH demonstrates superior H₂O₂ production efficiency due to its improved hydrophilicity and enhanced carrier separation, achieving a remarkable rate of 2961 µmol g^-1 h^-1 from 25 mL pure water and air. Further, the mechanism of H₂O₂ production over PyCOF-OH is clarified by combining a series of control experiments, in situ characterizations, and theoretical calculations. This study offers valuable insights into the interfacial design of high-performance photocatalysts for H₂O₂ synthesis.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"678 Pt C","pages":"1170-1180"},"PeriodicalIF":9.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioderived carbon aerogels loaded with g-C₃N₄ and their high Efficacy removing volatile organic compounds (VOCs).","authors":"Can Cheng, Hongyue Jing, Hongtian Ji, Yunpeng Li, Liying Ma, Jingcheng Hao","doi":"10.1016/j.jcis.2024.09.167","DOIUrl":"10.1016/j.jcis.2024.09.167","url":null,"abstract":"<p><p>Indoor air pollution, predominantly caused by volatile organic compounds (VOCs), poses significant health hazards when concentrations surpass critical thresholds. Using waste corn straw as carbon source and urea as nitrogen source, straw derived carbon aerogel (CAGH) loaded with g-C₃N₄_H₂_O-N₂_-450-3 h was successfully prepared by hydrothermal and water-assisted calcination. Following water-assisted regulation, g-C₃N₄_H₂_O-N₂_-450-3 h on CAGH exhibited a mixed structure comprising honeycomb and two-dimensional filaments, while the growth of g-C₃N₄_H₂_O-N₂_-450-3 h was uniformly distributed on carbon aerogel in a line-surface combination fashion. This innovative binding method not only enhanced the loading capacity of g-C₃N₄ and the mechanical elasticity of aerogel, but also exposed a large number of adsorption sites, resulting in a significant increase in its adsorption capacity for VOCs, exceeding that of commercial activated carbon (AC). In comparison to pure g-C₃N₄, CAGH exhibited an expanded photo-response range. Under the exposure of visible light, CAGH proved highly effective in eliminating 73.87 % of toluene. In addition, it has demonstrated efficient removal of formaldehyde and acetone VOCs with good cyclic stability. Therefore, this work aims to reduce the emission of pollutants at source and provide an effective and economical strategy for the preparation of clean building materials from renewable materials, with potential applications in the environmental field.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"678 Pt C","pages":"1112-1121"},"PeriodicalIF":9.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LaCo_0.95Mo_0.05O₃/CeO₂ composite can promote the effective activation of peroxymonosulfate via Co³⁺/Co²⁺ cycle and realize the efficient degradation of hydroxychloroquine sulfate.","authors":"Huiwen Ding, Tianqi Jiang, Haijiao Xie, Jianqiao Wang, Pengfei Xiao","doi":"10.1016/j.jcis.2024.09.174","DOIUrl":"10.1016/j.jcis.2024.09.174","url":null,"abstract":"<p><p>Hydroxychloroquine sulfate (HCQ) is extensively utilized due to its numerous therapeutic effects. Because of its properties of high solubility, persistence, bioaccumulation, and biotoxicity, HCQ can potentially affect water bodies and human health. In this study, the LaCo_0.95Mo_0.05O₃-CeO₂ material was successfully prepared by the sol-gel process, and it was applied to the experiment of degrading HCQ by activating peroxymonosulfate (PMS). The results of characterization analysis showed that LaCo_0.95Mo_0.05O₃-CeO₂ material had good stability, and the problem of particle agglomeration had been solved to some extent. Compared with LaCo_0.95Mo_0.05O₃ material, it had a larger specific surface area and more oxygen vacancies, which was helpful to improve the catalytic activity for PMS. Under optimal conditions, the LaCo_0.95Mo_0.05O₃-CeO₂/PMS system degraded 95.5 % of HCQ in 10 min. The singlet oxygen, superoxide radicals, and sulfate radicals were the main radicals for HCQ degradation. The addition of Mo⁶⁺/Mo⁴⁺ and Ce⁴⁺/Ce³⁺ promoted the redox cycle of Co³⁺/Co²⁺ and enhanced the degradation rate of HCQ. Based on density functional theory and experimental analysis, three HCQ degradation pathways were proposed. The analysis of T.E.S.T software showed that the toxicity of HCQ was obviously reduced after degradation. The LaCo_0.95Mo_0.05O₃-CeO₂/PMS system displayed excellent reusability and the ability to remove pollutants in a wide range of real-world aqueous environments, with the ability to treat a wide range of pharmaceutical wastewater. In summary, this study provides some ideas for developing heterogeneous catalysts for advanced oxidation systems and provide an efficient, simple, and low-cost method for treating pharmaceutical wastewater that has good practical application potential.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"678 Pt C","pages":"1151-1169"},"PeriodicalIF":9.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separator engineering: Assisting lithium salt dissociation and constructing LiF-rich solid electrolyte interphases for high-rate lithium metal batteries.","authors":"Changyong Zhao, Hanyan Wu, Xuejie Gao, Chen Cheng, Shuiping Cai, Xiaofei Yang, Runcang Sun","doi":"10.1016/j.jcis.2024.08.151","DOIUrl":"10.1016/j.jcis.2024.08.151","url":null,"abstract":"<p><p>Challenges associated with lithium dendrite growth and the formation of dead lithium significantly limit the achievable energy density of lithium metal batteries (LMBs), particularly under high operating current densities. Our innovative design employs a state-of-the-art 2500 separator featuring a meticulously engineered cellulose acetate (CA) coating (CA@2500) to suppress dendrite nucleation and propagation. The CO functional groups in CA enhances charge transfer kinetics and triggering the decomposition of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), which leads to the formation of a more robust solid electrolyte interphase (SEI) composed primarily of LiF. Moreover, the introduction of polar functional groups in the CA enhances the separator's hydrophilic properties, facilitating the uniform Li⁺ flux and creating a conductive pathway for efficient lithium migration. As a result, the CA@2500 separator exhibits a high lithium-ion transfer number (0.88) and conductivity. The lithium symmetric cell assembles with the CA@2500 separator displays a stable cycling performance over 5500 h at a current density and capacity of 10 mA cm^-2 and 10 mAh cm^-2, respectively. Additionally, LPF battery with CA@2500 separator shows an excellent capacity retention at 0.2 C with an average decay of 0.055 % per cycle. Moreover, a high capacity of 105 mAh g^-1 is maintained after 500 cycles at 5 C with an average decay of only 0.027 % per cycle. This work achieved high stability of LMBs through simplified engineering.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"677 Pt B","pages":"1084-1094"},"PeriodicalIF":9.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic engineering of heterostructure and oxygen vacancy in cobalt hydroxide/aluminum oxyhydroxide as bifunctional electrocatalysts for urea-assisted hydrogen production.","authors":"Minglei Yan, Junjie Zhang, Cong Wang, Lang Gao, Wengang Liu, Jiahao Zhang, Chunquan Liu, Zhiwei Lu, Lijun Yang, Chenglu Jiang, Yang Zhao","doi":"10.1016/j.jcis.2024.07.239","DOIUrl":"10.1016/j.jcis.2024.07.239","url":null,"abstract":"<p><p>Designing inexpensive, high-efficiency and durable bifunctional catalysts for urea oxidation reaction (UOR) and hydrogen evolution reaction (HER) is an encouraging tactic to produce hydrogen with reduced energy expenditure. Herein, oxygen vacancy-rich cobalt hydroxide/aluminum oxyhydroxide heterostructure on nickel foam (denoted as Co(OH)₂/AlOOH/NF-100) has been fabricated using one step hydrothermal process. Theoretical calculation and experimental results indicate the electrons transfer from Co(OH)₂ to highly active AlOOH results in the interfacial charge redistribution and optimization of electronic structure. Abundant oxygen vacancies in the heterostructure could improve the conductivity and simultaneously serve as the active sites for catalytic reaction. Consequently, the optimal Co(OH)₂/AlOOH/NF-100 demonstrates excellent electrocatalytic performance for HER (62.9 mV@10 mA cm^-2) and UOR (1.36 V@10 mA cm^-2) due to the synergy between heterointerface and oxygen vacancies. Additionally, the in situ electrochemical impedance spectrum (EIS) for UOR suggests that the heterostructured catalyst exhibits rapid reaction kinetics, mass transfer and current response. Importantly, the urea-assisted electrolysis composed of the Co(OH)₂/AlOOH/NF-100 manifests a low cell voltage (1.48 V @ 10 mA cm^-2) in 1 M KOH containing 0.5 M urea. This work presents a promising avenue to the development of HER/UOR bifunctional electrocatalysts.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"677 Pt A","pages":"1069-1079"},"PeriodicalIF":9.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering of peptide assemblies for adaptable protein delivery to achieve efficient intracellular biocatalysis.","authors":"Meiwen Cao, Rui Wang, Xiaomin Xu, Xinyue Hou, Wentao Wang, Xiaoming Zhang, Chen Ma, Yuxuan Zhang, Daikui Shi, Jianing Yang, Hongchao Ma","doi":"10.1016/j.jcis.2024.12.097","DOIUrl":"https://doi.org/10.1016/j.jcis.2024.12.097","url":null,"abstract":"<p><p>Efficient intracellular delivery of native proteins remains a big challenge, which greatly hinders the development of protein therapy. Here, we report a generalizable peptide vector that can encapsulate and deliver various proteins to achieve efficient intracellular biocatalysis. The peptide was rationally designed to be cationic amphiphilic peptide that consist of four functional fragments, that is, a hydrophobic domain to promote molecular assembly, an enzyme-cleavable fragment to introduce stimuli-responsibility, several cationic arginine (Arg) residues to enhance cell interaction and transmembrane efficiency, and the cystine (Cys) residues with redox sensitivity to adjust the stability of the peptide/protein complexes as needed. The peptide can co-assemble with proteins to form stable complexes in aqueous solution under mild condition. The complexes enter cell mainly through caveolae- and lipid raft-mediated endocytosis, giving a delivery efficiency of up to ∼97.2 %. They can then achieve efficient lysosomal escape and disassociation to release native proteins inside cells in response to intracellular stimuli. More strikingly, the delivered protein's bioactivity can be well maintained and the two model proteins of β-galactosidase (β-Gal) and horseradish peroxidase (HRP) both showed excellent intracellular biocatalytic activity. The study develops a versatile and adjustable peptide carrier platform for protein delivery and highlights impactful structure-function relationships, providing a new chemical guide for the design and optimization of functional protein nanocarriers.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"683 Pt 1","pages":"457-467"},"PeriodicalIF":9.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing cobalt-nickel dual-atoms on boron, nitrogen-codoped carbon nanotubes for carbon dioxide electroreduction to syngas.","authors":"Dan Ping, Yapeng Li, Shide Wu, Zhiqiang Zhang, Weitao Liu, Dingsheng Wang, Shuqing Liu, Shiwen Wang, Xuzhao Yang, Guanglu Han, Junfeng Tian, Dongjie Guo, Huajun Qiu, Shaoming Fang","doi":"10.1016/j.jcis.2024.12.096","DOIUrl":"https://doi.org/10.1016/j.jcis.2024.12.096","url":null,"abstract":"<p><p>Developing highly efficient electrocatalysts to produce syngas with a stable hydrogen/carbon monoxide (H₂/CO) ratio in a wide potential window via electrochemical carbon dioxide (CO₂) reduction is desperately required but still challenging. Herein, a dual-atomic site on boron, nitrogen-codoped carbon nanotubes (BCN) has been designed, containing both cobalt (CoN₅) and nickel (NiN₃B₂) sites. Benefiting from the structure advantage and the bifunctional Co/Ni sites, such designed catalyst (CoNi-BCN) demonstrates remarkable performance for syngas production, achieving a stable H₂/CO ratio of 1.5 over a broad potential window from -0.47 to -0.87 V vs. RHE. By tuning the Co/Ni molar ratio in CoNi-BCN, the H₂/CO ratio can be adjusted from 0.5 to 2. In addition, this electrocatalyst exhibits outstanding stability within a long-term 20 h electrolyzing. Both experimental and theoretical calculation results confirm the primary role of the Co sites in H₂ production and the Ni sites in CO production, as well as the preferred process for H₂ evolution. This work provides a strategy in the construction of dual-site catalysts for efficient syngas production, which is significant for practical applications.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"683 Pt 1","pages":"446-456"},"PeriodicalIF":9.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive boronate ester lipid nanoparticles for enhanced delivery of veliparib and platinum (IV) prodrug in chemotherapy.","authors":"Wanyue Xiao, Rui Geng, Duohang Bi, Yufeng Sun, Zhilang Li, Yijing Liu, Jintao Zhu","doi":"10.1016/j.jcis.2024.12.081","DOIUrl":"https://doi.org/10.1016/j.jcis.2024.12.081","url":null,"abstract":"<p><p>The chemotherapeutic effectiveness of breast cancer treatment is currently unsatisfactory due to inadequate drug delivery, suboptimal drug release, and drug inactivation. Herein, we present an innovative boronate ester lipid nanoformulation to improve the delivery of a platinum (IV) prodrug (Pt-C12) and veliparib (Veli), aiming to increase their therapeutic efficacy through a synergistic effect. We identify the optimal ratio of Pt-C12 to Veli for achieving synergy in vitro, followed by the encapsulation of Pt-C12 and Veli in lipid nanoparticles (NPs) incorporating responsive boronate ester lipids (LPC-PPE) to produce responsive lipid NPs (LPV NPs). These LPV NPs demonstrate high sensitivity to low levels of hydrogen peroxide (H₂O₂), enabling efficient drug release. In contrast, the nonresponsive lipid NP (DPV NP) control shows minimal responsiveness to H₂O₂. Furthermore, acidic tumor microenvironments trigger phenylboronic acid (PBA) generation from LPC-PPE in the LPV NPs. Compared with DPV NPs, the interaction between PBA on the LPV NPs and sugar components on tumor cells significantly improves LPV NP cellular uptake and lysosomal escape in vitro. Due to the enhanced cellular delivery and the synergistic drug combination, the LPV NPs induce an increase in apoptosis in 4 T1 cells compared with control groups. Moreover, the LPV NPs exhibit greater efficiency of drug delivery to tumors than the DPV NPs, and have a greater inhibitory effect on tumors than the controls. Overall, our findings highlight the potential of functional lipids and synergistic drug combinations in overcoming obstacles in breast cancer treatment and advancing the development of responsive delivery systems.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"683 Pt 1","pages":"375-386"},"PeriodicalIF":9.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}