Indonesian Journal of Clinical Pharmacy最新文献

{"title":"Terapi Farmakologi Nyeri pada Amyotrophic Lateral Sclerosis","authors":"I. D. Mahdayana, H. B. Hidayati","doi":"10.15416/IJCP.2020.9.4.327","DOIUrl":"https://doi.org/10.15416/IJCP.2020.9.4.327","url":null,"abstract":"The cause of motor neurons is amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease with the potential to cause a frequently ignored sensory disorder called pain. Furthermore, pain therapy today is usually based on the clinician’s experience while standardized pain management for ALS patients is unused. Therefore, this literature review aimed to explore ALS clinical features and pain management. The database investigation was performed on PubMed and Google Scholar using the keywords “Amyotrophic Lateral Sclerosis”, “pain”, “pharmacology”, and “therapy”. The results showed the presence of several pain clinical features in ALS, including cramps, spasticity and musculoskeletal pain, and therefore the need for ALS pain supervision to be based on the major cause. However, there were limited evidence reported investigating the effectiveness of drug therapy for this pain, and further research is required to discover efficient and safe pain treatment agents.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131899052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Antiemetic Premedication Administration Timing on Nausea and Vomiting Incidence among Breast Cancer Patients Receiving Chemotherapy","authors":"M. Rahmadi, I. D. Kharismawati, H. Purwanto, Irvina Harini, S. Suharjono, C. Alderman","doi":"10.15416/IJCP.2020.9.4.298","DOIUrl":"https://doi.org/10.15416/IJCP.2020.9.4.298","url":null,"abstract":"The risk factors affecting chemotherapy-induced nausea and vomiting (CINV) includes antiemetic premedication time pattern, and this study investigates the capability of enhancing this in breast cancer patients receiving high emetogenic chemotherapy (HEC). Furthermore, this observational research was implemented at the oncology unit of Dr. Soetomo General Hospital Surabaya over a three-month period involving 69 female patients. The results showed unspecific antiemetic premedication timing in comparison to those with recommended timeframes, was connected with greater occurrence of both acute nausea in all cycles of chemotherapy (p<0.05), and acute vomiting in second and third cycles (p<0.05) but not in the first cycle (p=0.49). However, specific time administration of antiemetic treatment was linked with lower incidence of delayed nausea in all cycles (p<0.05), and less delayed vomiting in second and third cycles (p<0.05) but not in first cycle (p=0.10). These findings indicate specific time administration of antiemetic drugs causes significant advantages in mitigating CINV among breast cancer patients treated with emetogenic chemotherapy, and significantly lessened the occurrence of acute and delayed nausea and vomiting.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"272 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115900580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artikel Review: Interaksi Silang Pensinyalan Wnt dan TGF-β pada Kanker Prostat","authors":"Luthfi H. Siwi, I. A. Wicaksono, Riezki Amalia","doi":"10.15416/IJCP.2020.9.4.341","DOIUrl":"https://doi.org/10.15416/IJCP.2020.9.4.341","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125083904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan antara Penggunaan Antihipertensi pada Pasien Preeklamsia terhadap Insidensi Asfiksia Neonatal dan Berat Badan Lahir Rendah di RSUP Dr. Hasan Sadikin Bandung","authors":"M. F. Sitorus, Lia Amalia","doi":"10.15416/IJCP.2020.9.4.280","DOIUrl":"https://doi.org/10.15416/IJCP.2020.9.4.280","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129205279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginekomastia Terkait Efavirenz: Laporan Dua Kasus Pasien HIV","authors":"Nurfitri Bustamam, I. Setiawan, Laura Hotdiana","doi":"10.15416/ijcp.2020.9.3.229","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.229","url":null,"abstract":"Pada pasien human immunodeficiency virus (HIV) positif, terapi antiretroviral (ARV) dapat berkontribusi terhadap kejadian ginekomastia. Ditemukan dua kasus ginekomastia pada pasien HIV di RS Pengayoman Cipinang antara tahun 2017–2019. Pada penelitian ini digunakan data yang diambil secara retrospektif dari rekam medis dan dianalisis menggunakan algoritma Naranjo. Kasus pertama, Tn. X, 34 tahun, diterapi dengan fixed-dose combination (FDC) berisi Tenofovir+Lamivudine+Efavirenz (TDF+3TC+EFV). Setelah dua tahun, kedua payudaranya membesar tanpa disertai nyeri. Terapi dengan TDF+3TC+EFV dilanjutkan selama 11 bulan, tetapi ukuran payudaranya tidak bertambah besar. Kasus kedua Tn. Y, 36 tahun, diterapi dengan Duviral (AZT+3TC)+EFV. Setelah 36 bulan, payudara kanan mulai membesar, tetapi tidak nyeri. Terapi dengan Duviral +EFV dilanjutkan selama dua tahun. Namun, ukuran payudara semakin membesar hingga diameternya 5 cm, keras, nyeri, tidak keluar air susu, dan tidak ada pembesaran kelenjar di ketiak. Oleh karenanya, EFV disubstitusi dengan Neviral. Setelah 12 bulan diterapi dengan Duviral+Neviral, terjadi regresi ginekomastia. Total skor Naranjo menunjukkan Tn. Y mungkin ( probable ) mengalami ginekomastia akibat EFV, sedangkan Tn. X cukup mungkin ( possible ) mengalami ginekomastia akibat EFV. Oleh karenanya, perlu dipertimbangkan substitusi EFV bagi pasien untuk menghindari penurunan tingkat kepatuhan minum obat akibat distres karena ginekomastia. Kata kunci: Antiretroviral, efavirenz, ginekomastia yang diinduksi obat, pasien HIV Gynecomastia Associated with Efavirenz: Report of Two Cases of HIV Patients Abstract The antiretroviral (ARV) therapy administration is found to greatly contribute to gynecomastia incidence in human immunodeficiency virus (HIV) positive patients. Therefore, this study aims to determine the effects and characteristics of gynecomastia incidence among HIV patients receiving antiretroviral (ARV) therapy. Two gynecomastia cases were found among HIV patients at Cipinang Pengayoman Hospital in the year 2017–2019. In this study, data were collected retrospectively from medical records and analyzed using the Naranjo algorithm. The first case, Mr. X, 34 years old, was treated with a fixed-dose combination (FDC) containing Tenofovir+Lamivudine+Efavirenz (TDF+3TC+EFV). After two years of therapy, there was breasts enlargement without pain. Then, the TDF+3TC+EFV therapy continued for 11 months, however, no changes was observed. The second case, Mr. Y, 36 years old, was being treated with Duviral (AZT+3TC)+EFV. After 36 months, the right breast began to enlarge without pain, then, the Duviral+EFV therapy continued for two years. However, the breast size was getting bigger until it was 5 cm in diameter, hard, painful, without milk, and no enlargement of the glands in the armpit. Then, the EFV was substituted with Neviral, after 12 months of Duviral+Neviral therapy, gynecomastia regression occurred. The Naranjo total score indicated that Mr.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130483636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efek Toksik Merkuri dalam Krim Pencerah Wajah dari Perspektif Klinis","authors":"Retno Haryanti, Auliya A. Suwantika, M. A. Bratadiredja","doi":"10.15416/ijcp.2020.9.3.245","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.245","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123241626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laporan Kasus: Perbaikan Kadar Prolaktin pada Makroadenoma Hipofisis dengan Terapi Bromokriptin dan EETA","authors":"N. P. L. Gayatri, H. B. Hidayati","doi":"10.15416/ijcp.2020.9.3.237","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.237","url":null,"abstract":"Hiperprolaktinemia merupakan salah satu gejala klinis yang umum terjadi pada kasus makroadenoma hipofisis. Hiperprolaktinemia yang terjadi pada makroadenoma hipofisis dapat disebabkan oleh adanya penekanan massa tumor terhadap infundibulum ( pituitary stalk ) atau pun adanya sekresi hormon oleh tumor. Penelitian ini bertujuan untuk membahas pengaruh pemberian terapi bromokriptin dan operasi Endoscopic Endonasal Transsphenoidal Approach (EETA) terhadap perbaikan kadar hormon prolaktin dan kondisi klinis pada kasus makroadenoma hipofisis dengan hiperprolaktinemia. Dalam laporan kasus ini, dilaporkan bahwa seorang remaja pria usia 17 tahun datang dengan hilangnya penglihatan mata kanan, nyeri kepala, sulit menelan, dan ginekomasti. Pemeriksaan Magnetic Resonance Imaging (MRI) otak dengan kontras didapatkan adanya lesi ekstra aksial supratentorial di intrasellar yang meluas hingga suprasellar. Pada pemeriksaan laboratorium didapatkan adanya hiperprolaktinemia 198,10 ng/mL (nilai referensi 2,1–17,1 ng/mL). Hiperprolaktinemia yang terjadi pada kasus ini dapat disebabkan oleh tumor hipofisis yang mensekresi prolaktin (prolaktinoma) dan/atau akibat dari pendesakan massa tumor terhadap infundibulum. Berdasarkan hasil anamnesis, pemeriksaan fisik, pemeriksaan laboratorium dan penunjang, pasien didiagnosis mengalami makroadenoma hipofisis. Kami mempresentasikan kasus perbaikan kondisi klinis dan total penurunan kadar prolaktin sebesar 79,70% (pre pengobatan 198,10 ng/mL, post pengobatan 40,20 ng/mL) pada pasien dengan makroadenoma hipofisis yang disertai hiperprolaktinemia setelah dilakukan pemberian terapi bromokriptin 2,5 mg per hari selama 14 hari masa perawatan di rumah sakit dan tindakan operasi EETA. Kata kunci: Bromokriptin, ginekomasti, hiperprolaktinemia, makroadenoma hipofisis A Case Report: Prolactin Levels Improvement in Pituitary Macroadenoma with Bromocriptine Therapy and EETA Abstract Hyperprolactinemia is one of the common clinical symptoms of pituitary macroadenoma. Hyperprolactinemia that occurs in pituitary macroadenoma can be caused by the suppression of the tumor mass against the infundibulum (pituitary stalk) or due to hormone secretion by the tumor. This study aims to discuss the effect of bromocriptine therapy and Endoscopic Endonasal Transsphenoidal Approach (EETA) surgery on prolactin level and clinical conditions in pituitary macroadenoma with hyperprolactinemia. This case report presents a seventeen years old boy with loss of right eye vision, headache, swallowing difficulty, and gynecomastia. Brain Magnetic Resonance Imaging (MRI) scan with contrast media found an extra-axial supratentorial lesions extending to the suprasellar. Also, based on laboratory examination, hyperprolactinemia was found with prolactin level of 198.10 ng/mL (reference value 2.1–17.1 ng/mL). Hyperprolactinemia that occurred in this case was found to be caused by a prolactin-secreting pituitary tumor (prolactinoma) towards the infundibulum. Based on the ana","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134436972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengetahuan, Sikap, dan Praktik Tenaga Kesehatan terhadap Penyakit Tuberkulosis: Sebuah Review","authors":"Idzni R. E. Yahya, R. K. Sinuraya, I. M. Puspitasari","doi":"10.15416/ijcp.2020.9.3.255","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.255","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133533655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Kejadian Infeksi Carbapenem Resistant Acinetobacter baumannii dengan Penggunaan Antibiotika Golongan Karbapenem pada Pasien di Rumah Sakit St. Carolus","authors":"Y. E. Lestari, Retnosari Andrajati, Angela C. M. Nusatia","doi":"10.15416/ijcp.2020.9.3.189","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.189","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124781616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penggunaan Gen E6 Sebagai Target Deteksi Human Papillomavirus Tipe 11 dengan Metode Polymerase Chain Reaction","authors":"Mariana Wahjudi, Eko Setiawan, Elchemy N. Tofinastri","doi":"10.15416/ijcp.2020.9.3.205","DOIUrl":"https://doi.org/10.15416/ijcp.2020.9.3.205","url":null,"abstract":"","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131668973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}