Analysis of Antiemetic Premedication Administration Timing on Nausea and Vomiting Incidence among Breast Cancer Patients Receiving Chemotherapy

M. Rahmadi, I. D. Kharismawati, H. Purwanto, Irvina Harini, S. Suharjono, C. Alderman
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Abstract

The risk factors affecting chemotherapy-induced nausea and vomiting (CINV) includes antiemetic premedication time pattern, and this study investigates the capability of enhancing this in breast cancer patients receiving high emetogenic chemotherapy (HEC). Furthermore, this observational research was implemented at the oncology unit of Dr. Soetomo General Hospital Surabaya over a three-month period involving 69 female patients. The results showed unspecific antiemetic premedication timing in comparison to those with recommended timeframes, was connected with greater occurrence of both acute nausea in all cycles of chemotherapy (p<0.05), and acute vomiting in second and third cycles (p<0.05) but not in the first cycle (p=0.49). However, specific time administration of antiemetic treatment was linked with lower incidence of delayed nausea in all cycles (p<0.05), and less delayed vomiting in second and third cycles (p<0.05) but not in first cycle (p=0.10). These findings indicate specific time administration of antiemetic drugs causes significant advantages in mitigating CINV among breast cancer patients treated with emetogenic chemotherapy, and significantly lessened the occurrence of acute and delayed nausea and vomiting.
止吐药前给药时间对乳腺癌化疗患者恶心呕吐发生率的影响分析
影响化疗引起的恶心呕吐(CINV)的危险因素包括止吐前用药时间模式,本研究探讨了在接受高致吐性化疗(HEC)的乳腺癌患者中增强这种情况的能力。此外,这项观察性研究是在泗水Soetomo综合医院肿瘤科进行的,为期三个月,涉及69名女性患者。结果显示,与推荐的时间框架相比,非特异性止吐药前时间与所有化疗周期中急性恶心(p<0.05)和第二和第三周期急性呕吐(p<0.05)的发生率增加有关,但与第一个周期无关(p=0.49)。然而,在所有周期中,特定时间给予止吐治疗与延迟性恶心发生率较低相关(p<0.05),并且在第二和第三周期中延迟性呕吐发生率较低(p<0.05),但在第一个周期中没有(p=0.10)。这些研究结果表明,在接受致吐性化疗的乳腺癌患者中,特定时间给药止吐药物在减轻CINV方面具有显著优势,并显著减少急性和延迟性恶心和呕吐的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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