Terapi Farmakologi Nyeri pada Amyotrophic Lateral Sclerosis

The cause of motor neurons is amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease with the potential to cause a frequently ignored sensory disorder called pain. Furthermore, pain therapy today is usually based on the clinician’s experience while standardized pain management for ALS patients is unused. Therefore, this literature review aimed to explore ALS clinical features and pain management. The database investigation was performed on PubMed and Google Scholar using the keywords “Amyotrophic Lateral Sclerosis”, “pain”, “pharmacology”, and “therapy”. The results showed the presence of several pain clinical features in ALS, including cramps, spasticity and musculoskeletal pain, and therefore the need for ALS pain supervision to be based on the major cause. However, there were limited evidence reported investigating the effectiveness of drug therapy for this pain, and further research is required to discover efficient and safe pain treatment agents.