针刺研究最新文献

{"title":"[Application of transcutaneous electrical acupoint stimulation in preoperative analgesia for intertrochanteric fracture of femur in elderly patients].","authors":"Xin Zhou, Ming-Li Huang, Jin-Wei Zhao, Xiao-Ling Rong, Zhi-Yuan Han, Xiao-Tao Chen, Hong-Jiang Jiang, Chang-Jun Ju","doi":"10.13702/j.1000-0607.20241048","DOIUrl":"10.13702/j.1000-0607.20241048","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the clinical effect of transcutaneous electrical acupoint stimulation(TEAS) on preoperative analgesia for the elderly patients with intertrochanteric fracture of femur.</p><p><strong>Methods: </strong>A total of 126 elderly patients with intertrochanteric fracture of femur were randomized into an observation group(63 cases, one case dropped out) and a control group(63 cases, 2 cases dropped out ). In the observation group, TEAS was operated at Huantiao (GB30), Yanglingquan (GB34), Zusanli (ST36) and Kuanguxue (Extra) on the affected side. In the control group, the sham-TEAS was delivered with the electrode patches attached on the same points, without electric current exerted. The interventions of the two groups started in 1 h on the 1st day of hospital-stay, stimulated for 1 h, twice daily, for maximal 3 d. The numeric rating scale (NRS) was observed on the day of hospital administration (T0), at 1 h (T1), 12 h (T2), 24 h (T3) and 48 h (T4) after the 1^st intervention of the two groups, separately. The amount of additional analgesic drugs, the incidence of complications, and patient satisfaction for analgesia were recorded.</p><p><strong>Results: </strong>The NRS scores either resting or passive movement from T1 to T4 were reduced compared with the score at T0 in the two groups (<i>P</i><0.05). Compared with the control group, the NRS scores of observation group were lower from T1 to T4 when resting and from T2 to T4 during passive movement (<i>P</i><0.05). The analgesia satisfaction score of the observation group was higher than that of the control group (<i>P</i><0.05). The incidence of nausea and vomiting was lower in the observation group compared with the control group (<i>P</i><0.05). The amount of additional analgesic drugs was reduced in the observation group in comparison with the control group (<i>P<</i>0.05).</p><p><strong>Conclusions: </strong>TEAS exhibits the favorable preoperative analgesic effects in the elderly patients with intertrochanteric fracture of femur, and it reduces the dosage of analgesic drugs, and the occurrence of complications.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"689-693"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of acupuncture on intracerebral mitochondrial function in mice with cerebral hemorrhage].","authors":"Hao Liu, Chen Ruan, Pei-Pei Feng, Xin-Wei Li, Zhong-Wei Guo, Ke-Lang Lou, Xiao-Qing Yu, Jia DU","doi":"10.13702/j.1000-0607.20240186","DOIUrl":"https://doi.org/10.13702/j.1000-0607.20240186","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To observe the effect of acupuncture on the recovery of neurological function in mice with intracerebral hemorrhage (ICH), so as to explore its mechanism of regulating mitochondria in brain tissue of ICH mice through the utilization of RNA sequencing and m6A methylation sequencing technology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twenty-four male C57BL/6J mice were ramondly divided into sham operation, model, and acupuncture groups (&lt;i&gt;n&lt;/i&gt;=8 in each group). The ICH model was established by injection of the rat's auto-blood (10 μL) into the right caudatum region. Acupuncture group received manual acupuncture stimulation of \"Baihui\" (GV20) for 30 min, once every 12 h for 7 d. After the intervention, the behavioral scores of mice in each group were evaluated. The contents of glutathione peroxidase malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in brain tissue were detected by ELISA. The N6-methyladenosine (m6A) modification genes of ICH mice brain tissue were analyzed using RNA and m6A sequencing. The protein expression level of mitochondrial outer membrane translocase 20 (TOMM20) was detected by Western blot. The mRNA expression levels of Ndufb3、Ndufb6、Uqcr11、Cox7c、Ndufv1、Ndufb11 and Cytb were detected by PCR.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the sham operation group, the suspension test score, balance walking test score, GSH-Px and SOD contents in the brain tissue were decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.01), while the MDA content in the brain tissue was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01) in the model group. After the intervention and compared with the model group, the scores of the suspension test, the balance walking test and the contents of GSH-Px and SOD were increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01, &lt;i&gt;P&lt;/i&gt;&lt;0.05), while the content of MDA was decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.01) in the acupuncture group. RNA sequencing showed that a total of 780 differentially expressed genes were screened in the model group compared with the sham operation group, a total of 1 097 differentially expressed genes were screened in the acupuncture group compared with the model group, and the shared differential genes in the sham group vs model group and model group vs acupuncture group were 342;and 50 common differential genes were obtained after intersection with mitochondrial-related genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the screened differentially expressed genes revealed that the above differential genes were mainly enriched in the oxidative phosphorylation pathway. PCR and Western blot verification results showed that compared with the sham operation group, the expression levels of Ndufb3, Ndufb6, Uqcr11, Cox7c, Ndufv1, Ndufb11 and Cytb mRNA, and the expression level of TOMM20 protein were decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.01) in the model group. All the indexes mentioned above were reserved (&lt;i&gt;P&lt;/i&gt;&lt;0.01) in the acupuncture group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Acupuncture can impro","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"624-632"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exploration of the mechanism of electroacupuncture at \"Jiaji\" (EX-B2) in treating neuronal apoptosis in rats with spinal cord injury based on the JAK2/STAT3 pathway].","authors":"Huan-Ying Jiang, Dong-Xu Zhang, Zhong-Ren Sun, Xue-Feng Jiao, Ming-Yuan Zhou, Fei Huang, Zi-Ru Luo, Mei-Qi Sun, Xin Kai, Hong-Na Yin","doi":"10.13702/j.1000-0607.20240070","DOIUrl":"https://doi.org/10.13702/j.1000-0607.20240070","url":null,"abstract":"<p><strong>Objectives: </strong>To observe the effect of electroacupuncture (EA) at \"Jiaji\" (EX-B2) on inhibiting neuronal apoptosis in rats with spinal cord injury based on the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, so as to explore the underlying mechanism of EA in the treatment of spinal cord injury.</p><p><strong>Methods: </strong>A total of 36 SD rats were randomly divided into sham operation group, spinal cord injury group, and Jiaji EA group, with 12 rats in each group. The spinal cord injury model was established using Allen's method. The Jiaji EA group was treated with EA at EX-B2 (once a day, 30 min each time, for a total of 14 d). After the treatment, the Basso Beattie Bresnahan (BBB) score was used to evaluate the hindlimb motor function of rats in each group. HE staining was used to observe the morphological changes of spinal cord tissues. TUNEL staining was used to observe the pathological changes and neuronal apoptosis rate of the spinal cord. Western blot was used to detect the relative expression levels of phosphorylated (p)-JAK2, p-STAT3, B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), and Caspase-3 proteins in the spinal cord.</p><p><strong>Results: </strong>Compared with the sham operation group at the same time point, the BBB score decreased (<i>P</i><0.01), the spinal cord tissue structure in the injury area was disordered, the cell body shrank, and the neuronal apoptosis rate increased (<i>P</i><0.01), the expression levels of p-JAK2, p-STAT3, Bax, and caspase-3 proteins increased (<i>P</i><0.01) while the expression level of Bcl-2 protein decreased (<i>P</i><0.01) in rats of the spinal cord injury group. Compared with the spinal cord injury group, the BBB score increased on the 7^th and 14^th day of intervention (<i>P</i><0.01), the spinal cord tissue structure tended to be normal, the degree of neuronal damage was reduced, and the apoptosis rate decreased (<i>P</i><0.01), the expression levels of p-JAK2, p-STAT3, Bax, and caspase-3 proteins decreased (<i>P</i><0.01, <i>P</i><0.05), while the expression level of Bcl-2 protein increased (<i>P</i><0.05) in rats of the Jiaji EA group.</p><p><strong>Conclusions: </strong>EA at EX-B2 can improve the motor function of rats with spinal cord injury, up-regulate the expressions of anti-apoptotic factors, down-regulate the expressions of pro-apoptotic factors, and reduce neuronal apoptosis in spinal cord injury. The mechanism may be related to the inhibition of the activation of the JAK2/STAT3 signaling pathway.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"633-640"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis on acupoint compatibility regularity and application characteristics of moxibustion in the treatment of cognitive disorders].","authors":"Xiao-Xia Chen, Lu-Jun Tang, Di Ren, Li-Hua Zhao","doi":"10.13702/j.1000-0607.20241054","DOIUrl":"https://doi.org/10.13702/j.1000-0607.20241054","url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the acupoint compatibility regularity and application characteristics of moxibustion in the treatment of cognitive impairment disorders through data mining technology.</p><p><strong>Methods: </strong>Eligible clinical studies of moxibustion for treatment of cognitive disorders were searched from databases of PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and SinoMed from the inception of the databases to August 3^rd, 2024 and according to our inclusion and exclusion criteria. Then, a new database for moxibustion treatment of cognitive impairment disorders was established to conduct the standardized processing and frequency analysis using Microsoft Excel 2019. The association rule analysis was performed using the Apriori algorithm of IBM SPSS Modeler 18.0 software. A complex network diagram of high-frequency co-occurring acupoints (stronger compatibility connection between acupoints) was drawn using Cytoscape 3.10.2 software, and the cluster analysis was performed using Origin Lab version 2021 software.</p><p><strong>Results: </strong>A total of 121 articles were included, containing 139 prescriptions and 66 acupoints, with a total frequency of acupoints being 633. The top six acupoints in order are Baihui(GV20), Zusanli (ST36), Shenting (GV24), Dazhui(GV14), Sanyinjiao(SP6) and Shenshu (BL23), and the main meridian selected is the Governer Vessel. The frequently used acupoints mostly distributed in head, face and the lower limbs. Among the specific acupoints, the intersection acupoints are the most frequently used. Among the association rules, GV20-GV24 and ST36-SP6 had the highest support degree. Cluster analysis showed that the acupoints can be divided into 4 groups. The simple moxibustion method is mostly used, and the mild moxibustion is the first one. The mostly used number of moxa-cones is 3, moxibustion duration is 30 min each time, a single course of treatment is 6 times a week, and the total course of treatment is 8 weeks.</p><p><strong>Conclusions: </strong>In the treatment of cognitive impairment disorders, the main acupoints frequently employed are GV20, GV24, GV14, ST36, SP6 and BL23. With an appropriate moxibustion dosage, a good clinical effect can be achieved.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"694-702"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of electroacupuncture on expression in blood-brain barrier in rats with cerebral ischemia-reperfusion injury by regulating HIF-1α/VEGF/MMP-9 signaling pathway].","authors":"Teng-Wei Liao, Ying-Yan Wang, Shao-Wen Li, Xiao-Wen Xu, Yan-Zhen Zhu, Yu-Ting Tang, Lin Liu, Rui-Huan Pan, Hong-Xia Chen, Le-Chang Zhan","doi":"10.13702/j.1000-0607.20241047","DOIUrl":"https://doi.org/10.13702/j.1000-0607.20241047","url":null,"abstract":"<p><strong>Objectives: </strong>To observe the effect of electroacupuncture (EA) on the expression of hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF), matrix metalloproteinases 9 (MMP-9) and tight junction proteins in rats with cerebral ischemia-reperfusion injury (CI/RI) , so as to explore its potential mechanism in alleviating injury of neurological function and blood-brain barrier (BBB).</p><p><strong>Methods: </strong>A total of 84 male SD rats were used in the present study. The CIRI model was established by occlusion of the middle cerebral artery and reperfusion (MCAO/R), followed by dividing the CIRI rats into model group, EA group, and edaravone group (<i>n</i>=21 in each group). And another 21 normal rats were used as the sham operation group. For rats of the EA group, EA (2 Hz/15 Hz, 1 mA) was applied to \"Baihui\" (GV20) and \"Zusanli\" (ST36) on the affected limb for 20 min, once a day for 3 days. Rats of the edaravone group were intraperitoneally injected with edaravone injection (3 mg/kg), once a day for 3 days. The modified neurological severity score (mNSS) was used to evaluate the neurological behavior of rats. TTC staining was used to detect the percentage of cerebral infarction volume. HE staining was used to observe the pathological changes of cerebral cortex in ischemic area. Transmission electron microscopy was used to observe the changes of BBB ultrastructure in ischemic cortex. Evans blue (EB) staining was used to evaluate BBB permeability. Immunofluorescence was used to detect the expression of HIF-1α and VEGF protein in ischemic cortex. The protein and mRNA expressions of HIF-1α, VEGF, MMP-9, Zonula Occludens 1 (ZO-1), Occludin and Claudin-5 in the ischemic cortex were detected by Western blot or real-time PCR, respectively.</p><p><strong>Results: </strong>Compared with the sham operation group, the neurological deficit score, the percentage of cerebral infarction volume, EB leakage, the positive expressions of HIF-1α and VEGF, the protein and mRNA expressions of HIF-1α, VEGF and MMP-9 of ischemic cortex were increased (<i>P</i><0.01) in the model group , while the protein and mRNA expressions of ZO-1, Occludin and Claudin-5 were decreased (<i>P</i><0.01). After the intervention and compared with the model group, the neurological deficit score, the percentage of cerebral infarction volume, EB leakage, the positive expressions of HIF-1α and VEGF, the protein and mRNA expressions of HIF-1α, VEGF and MMP-9 of ischemic cortex were decreased (<i>P</i><0.01, <i>P</i><0.05) in the EA and edaravone groups;the protein and mRNA expression of ZO-1, Occludin and Claudin-5 were increased (<i>P</i><0.05, <i>P</i><0.01) in the EA group;the protein and mRNA expression of Occludin were increased (<i>P</i><0.01, <i>P</i><0.05) and the mRNA expression of ZO-1 and Claudin-5 were increased (<i>P</i><0.05, <i>P</i><0.01) in the edaravone group. The ultrastructure of BBB was damaged in the model group, which were re","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"613-623"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the effect of α-synuclein in acupuncture treatment for Parkinson's disease].","authors":"Yi-Wei Shen, Shun Wang, Yan Bai, Yu-Lin Wang, Cong He, Yu Zhang, Zheng-Nan Liu","doi":"10.13702/j.1000-0607.20240237","DOIUrl":"10.13702/j.1000-0607.20240237","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a chronic progressive neurological degenerative disease caused by the degeneration of dopaminergic neurons in the substantia nigra. α-synuclein (α-Syn) misfolding and aggregation is the crucial pathogenesis of PD, and is closely related to the other pathogenesis, such as brain-gut axis dysfunction, mitochondrial dysfunction, oxidative stress, neuroinflammation, iron and lipid metabolic disorders, and autophagy lysosomal dysfunction. Acupuncture plays a neuroprotective role by attenuating neuroinflammation, regulating brain-gut axis, repairing ubiquitin-proteasome system and autophagy lysosomal system, and modulating signaling pathways, so as to inhibit α-Syn abnormal folding and aggregation. This article reviews the effect of α-Syn in the pathogenesis of PD and acupuncture treatment, so as to provide the valuable guidance for clinical treatment.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"714-720"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances of researches on acupuncture treatment of Parkinson's disease by regulating mitochondrial function].","authors":"Ru-Qi Zhang, Bing-Xu Zhu, Xiao-Jie Dong, Lin Chen, Sheng-Chun Wang","doi":"10.13702/j.1000-0607.20240406","DOIUrl":"https://doi.org/10.13702/j.1000-0607.20240406","url":null,"abstract":"<p><p>The pathological mechanism of Parkinson's disease (PD) is complex and affected by multi-system and multi-level factors including mitochondrial dysfunction (MD). It has been demonstrated that all patients with PD have a marked loss of dopaminergic neurons in the substantial nigra pars compacta, and MD is an important initial factor causing dopaminergic neuron degeneration. Clinical practice has shown that acupuncture has a positive role in the treatment of PD. In the present article, we summed up recent research results about the mechanisms of acupuncture underlying improvement of PD from the standpoint of mitochondrial function. Acupuncture has been shown to be able in improving mitochondrial function, and restoring mitochondrial homeostasis, and protecting the normal morphological structure of mitochondria. It can also regulate the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α), adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), and Sirtuins (SIRT) to take part in mitochondrial biogenesis; decrease the levels of dynamin-related protein 1 (Drp1), mitochondrial fission factor (MFF), and mitochondrial fission protein 1 (Fis1) protein to preserve mitochondrial dynamic stability; and modulate the expression of PTEN-induced putative kinase 1 (PINK1), Parkin, P62, microtubule-associated protein light chain 3Ⅱ (LC3Ⅱ), and Beclin1 to promote autophagy. In addition, through controlling mitochondrial energy metabolism, preserving calcium homeostasis, reducing oxidative stress, and preventing neuronal apoptosis, acupuncture can also help improve mitochondrial dysfunction and prevent the onset and progression of PD. However, more researches are warranted to fully unravel the underlying mechanisms of acupuncture intervention before it can be popularized in clinical settings.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 6","pages":"721-727"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical observation of electroacupuncture at Erheliao (TE22) and Jianer (Extra) in treatment of subjective tinnitus in the acute phase].","authors":"Li-Wei Xu, Yu-Lan Liu, Yue Wang, Xing-Miao Quan, Ying Li, Yan-Hong Hao, Hong-Ling Bao","doi":"10.13702/j.1000-0607.20240191","DOIUrl":"10.13702/j.1000-0607.20240191","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the clinical effect of electroacupuncture (EA) at Erheliao (TE22) and Jianer (Extra) on subjective tinnitus in the acute phase.</p><p><strong>Methods: </strong>A total of 68 patients with subjective tinnitus were randomly divided into an observation group (34 cases, 1 case dropped out) and a control group (34 cases, 1 case dropped out). In the control group, the routine acupuncture was administrated. In the observation group, besides the regimen as the control group, EA was applied to TE22 and Jianer (Extra). In the two groups, the needles were retained for 30 min in each intervention, and the intervention was delivered once daily and 1 course of treatment was composed of 15 days;and two courses of treatment were required. Before and after intervention completion, the scores of tinnitus evaluation questionnaire (TEQ), visual analogue scale (VAS) for tinnitus and insomnia severity index (ISI) were observed. Using SF-36 quality of life assessment scale, the scores for physical health and mental health were evaluated. The clinical effect was calculated.</p><p><strong>Results: </strong>After treatment, the scores of TEQ, VAS and ISI were decreased in the two groups compared with those before treatment (<i>P<</i>0.05). The scores of TEQ, VAS and ISI in the observation group were lower than those in the control group (<i>P<</i>0.05). When compared with the scores before treatment, the scores of physical health and mental health were increased after treatment in both groups (<i>P<</i>0.05), and there was no significant difference in the score of physical health between the two groups, but the score of mental health in the observation group was higher than that in the control group (<i>P<</i>0.05). The total effective rate was 87.9% (29/33) in the observation group and 72.7% (24/33) in the control group. The total effective rate in the observation group was superior to that of the control group (<i>P<</i>0.05).</p><p><strong>Conclusions: </strong>EA at TE22 and Jianer (Extra) combined with routine acupuncure can better promote the recovery of tinnitus and improve the quality of lift and psychological health in the patients, presenting a satisfactory clinical effect.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 5","pages":"599-604"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of auricular acupuncture combined with intermittent catheterization on urethral sphincter overactivity in the patients with neurogenic bladder after spinal cord injury].","authors":"Zhi-Lan Zhang, Ya-Feng Ren, Xiao-Meng Huang, Hui-Lin Wei, Wen-Ya Shang, Jing Huang, Bing Li","doi":"10.13702/j.1000-0607.20240245","DOIUrl":"10.13702/j.1000-0607.20240245","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To observe the clinical efficacy of auricular acupuncture combined with intermittent catheterization on urethral sphincter overactivity in patients with neurogenic bladder (NB) after spinal cord injury (SCI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 90 patients with SCI were randomly divided into an auricular acupuncture group, an intermittent catheterization group and a combined treatment group, 30 cases in each group. All the patients in the three groups received the basic rehabilitation nursing and normal rehabilitation training. Additionally, in the auricular acupuncture group, auricular acupuncture was applied to \"Spleen\" (CO13), \"Kidney\" (CO10), \"Bladder\" (CO9) and \"Subcortex\" (AT4). In the intermittent catheterization group, the intermittent catheterization was operated. In the combined treatment group, the auricular acupuncture and the intermittent catheterization were delivered in combination. In the auricular acupuncture and the combined treatment group, the needles were retained for 1 h, once daily. One course of treatment was composed of 6 d and 4 courses were required. At the baseline and after interventions, the maximum urethral pressure (MUP), the residual urine volume (RU), the case number of urethral sphincter opening, the case number of vesicoureteral reflux, the number of white blood cells in urine, the case number of bladder function balance and traditional Chinese medicine (TCM) syndrome score were compared, with clinical efficacy evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the baseline, MUP, RU, the case number of urethral sphincter opening, the case number of vesicoureteral reflux, the number of white blood cells in urine, the case number of bladder function balance, and TCM symptom score were improved in the combined treatment group after 4 weeks of treatment (&lt;i&gt;P&lt;/i&gt;&lt;0.05);and the therapeutic effects of the above indicators except the number of white blood cells in urine and TCM symptom score were improved more significantly when compared with the auricular acupuncture group and the intermittent catheterization group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). In the auricular acupuncture group, MUP, RU, the case number of urethral sphincter opening, the case number of vesicoureteral reflux, the case number of bladder function balance and TCM symptom score were ameliorated in comparison with the baseline (&lt;i&gt;P&lt;/i&gt;&lt;0.05);while in the intermittent catheterization group, the improvements were obtained in the RU, the case number of urethral sphincter opening, the case number of vesicoureteral reflux, the case number of bladder function balance and the number of white blood cells in urine (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The total effective rate in combined treatment group was significantly higher than that in auricular acupuncture group and intermittent catheterization group (&lt;i&gt;P&lt;/i&gt;&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The combination of auricular acupuncture and intermittent catheterization is clearly effective ","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 5","pages":"584-591"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Acupuncture effects and neuro-immune regulation: a breakthrough in \"treating diseases at the root\"].","authors":"Jia-He Tian, Hong-Ye Wan, Shen-Bin Liu","doi":"10.13702/j.1000-0607.20250346","DOIUrl":"10.13702/j.1000-0607.20250346","url":null,"abstract":"<p><p>The holistic philosophy of traditional Chinese medicine (TCM) embodied in acupuncture therapy has gained novel insights within the neuroimmune regulatory framework. Its mechanistic framework encompasses 3 pivotal dimensions: 1) Acupuncture stimulation at acupoints transduces mechanical signals into neuroelectrical and biochemical signals, initiating localized immunomodulatory microenvironment remodeling; 2) The autonomic nervous system orchestrates systemic and organ-specific immune homeostasis through vagus nerve-mediated anti-inflammatory effects and sympathetic nerve-mediated bidirectional regulatory dynamics; 3) The enteric nervous system facilitates barrier restoration via neuropeptide-microbiota crosstalk, establishing bidirectional gut-brain axis immune communication. Emerging bioelectronic devices based on somatosensory-autonomic reflex circuits are driving the evolution of acupuncture from empirical practice to precision neuromodulation. Future research should integrate multi-omics profiling and artificial intelligence algorithms to construct a comprehensive \"mechanical stimulation-neural coding-immune response\" mapping paradigm. This will operationalize TCM's core principle of \"treating the root of disease\" into targeted neuromodulation strategies against inflammatory and immune-related disorders through defined neural circuit interventions.</p>","PeriodicalId":34919,"journal":{"name":"针刺研究","volume":"50 5","pages":"538-552"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}