Journal of Chromatography A最新文献_第9页

A green and practical strategy for therapeutic drug monitoring of teicoplanin A2 components in human plasma using functionalized liquid film solvent bar microextraction coupled with high-performance liquid chromatography–ultraviolet detection 功能化液膜溶剂棒微萃取-高效液相色谱-紫外检测技术用于人血浆中替柯planin A2成分的绿色实用监测策略

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-03 DOI: 10.1016/j.chroma.2026.466673

Jie Tian , Yi-fang Zhang , Yu-feng Sun , Dou Yan , Shuang Hu , Rong-rong Xing , Run-qin Wang , Li Yang , Xuan Chen

{"title":"A green and practical strategy for therapeutic drug monitoring of teicoplanin A2 components in human plasma using functionalized liquid film solvent bar microextraction coupled with high-performance liquid chromatography–ultraviolet detection","authors":"Jie Tian , Yi-fang Zhang , Yu-feng Sun , Dou Yan , Shuang Hu , Rong-rong Xing , Run-qin Wang , Li Yang , Xuan Chen","doi":"10.1016/j.chroma.2026.466673","DOIUrl":"10.1016/j.chroma.2026.466673","url":null,"abstract":"<div><div>A novel functionalized liquid film solvent bar microextraction (FLF-SBME) method coupled with high-performance liquid chromatography–ultraviolet detection (HPLC/UV) was developed for the extraction and subsequent determination of five A<sub>2</sub>-components of teicoplanin, TA<sub>2-1</sub>, TA<sub>2-2</sub>, TA<sub>2-3</sub>, TA<sub>2-4</sub> and TA<sub>2-5</sub>, simultaneously in human plasma. The microextraction mechanism of FLF-SBME was systematically elucidated, in which tri-<em>n</em>-octyl methyl ammonium chloride (TOMAC) was employed to modify polypropylene hollow fibers (PP-HFs), enabling efficient enrichment and separation of the target analytes from plasma. The key extraction parameters influencing efficiency were thoroughly optimized. Under optimal conditions, the method provided high enrichment factors (36–59) for all five A<sub>2</sub> components, along with good linearity (1.0–110 µg/mL; <em>r</em> > 0.99), limits of detection of 0.5–3.0 µg/mL, and lower limits of quantification of 1.0–5.0 µg/mL. The intra- and inter-day precision (RSD < 12.2 %) and accuracy (recoveries: 91.5–110.3 %) were satisfactory. With its notable enrichment capability, high selectivity, sensitivity, and reliability, the proposed FLF-SBME–HPLC/UV method is well-suited for the monitoring of teicoplanin in human plasma.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466673"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening terpene-based eutectic solvents for bisphenol A extraction from plastic-packed dairy products and water storage tanks: COSMO-RS and quantum chemistry calculations 从塑料包装乳制品和储水罐中提取双酚A的萜烯基共晶溶剂的筛选：cosmos - rs和量子化学计算

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-15 DOI: 10.1016/j.chroma.2026.466709

Nazir Fattahi , Parvin Zohrabi , Pouya Karimi , Filipe Hobi Bordón Sosa , Beshare Hashemi , Fereshteh Shiri

{"title":"Screening terpene-based eutectic solvents for bisphenol A extraction from plastic-packed dairy products and water storage tanks: COSMO-RS and quantum chemistry calculations","authors":"Nazir Fattahi , Parvin Zohrabi , Pouya Karimi , Filipe Hobi Bordón Sosa , Beshare Hashemi , Fereshteh Shiri","doi":"10.1016/j.chroma.2026.466709","DOIUrl":"10.1016/j.chroma.2026.466709","url":null,"abstract":"<div><div>Bisphenol A (BPA) is globally used in the plastic and polymer industries. Regarding its toxicity, it raises health and environmental concerns due to its potential leaching into water, soil, and food chains. This work aims to screen the most efficient terpene-based hydrophobic eutectic solvents (HESs) for the extraction of BPA using COSMO-RS, an in-silico predictive approach, thereby minimizing the need for extensive trial-and-error experimentation. We also evaluated the extraction efficiency of HESs by assessing the stability of hydrogen bonding using quantum chemistry calculations. A HES composed of menthol: octanoic acid (2:1) was found to be the most efficient solvent after experimental validations. Experimental design showed the optimal extraction conditions to be 95 µL of menthol: octanoic acid (2:1), 100 µL of KOH 4.5 M, and 100 µL of HCl 5.0 M. A maximum extraction recovery of 75% with a limit of detection of 0.05 µg/L was achieved under the optimal extraction conditions in a pH-switchable extraction process. The environmental impact and applicability of the method were subsequently evaluated using AGREE, AGREEprep, and the blue applicability grade index, scoring 0.61, 0.66, and 65.0, respectively.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466709"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered hydrophobic porous Fe3O4 microparticles for solvent-confined dispersive liquid-phase microextraction 用于溶剂约束分散液相微萃取的工程疏水多孔Fe3O4微粒。

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2025-12-20 DOI: 10.1016/j.chroma.2025.466641

Meiijian Wang , Hao Wang , Shiyun Lou , Dexi Tao , Yaolin Tang , Bingfang Zou , Yongqiang Wang

{"title":"Engineered hydrophobic porous Fe3O4 microparticles for solvent-confined dispersive liquid-phase microextraction","authors":"Meiijian Wang , Hao Wang , Shiyun Lou , Dexi Tao , Yaolin Tang , Bingfang Zou , Yongqiang Wang","doi":"10.1016/j.chroma.2025.466641","DOIUrl":"10.1016/j.chroma.2025.466641","url":null,"abstract":"<div><div>Liquid-phase microextraction (LPME) relies critically on precise solvent control to achieve efficient extractant recovery. To address this, we developed a magnetic microparticle-based dispersive liquid-phase microextraction (MP-DLPME) strategy, employing hydrophobic porous Fe<sub>3</sub>O<sub>4</sub> microparticles (∼1 μm) as solvent-stabilizing microcarriers. These microparticles were functionalized via covalent grafting of 3-chloropropyltriethoxysilane (CPS) and optimized porosity, enabling rigid confinement of organic solvents (e.g., 1-octanol) through dual mechanisms: (I) hydrophobic solvent anchoring to modified surfaces and (II) capillary trapping within mesopores. When applied to hydrophobic polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides (OPPs), the system generates solvent-encapsulated magnetic aggregates that dynamically fragment into microdroplets under vortex-induced shear forces, facilitating efficient analyte extraction via magnetic collection. By integrating the high efficiency of dispersive extraction with the rapid recovery of magnetic separation, the MP-DLPME method provides a robust sample pretreatment solution for environmental water analysis.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466641"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced metabolite profiling of herbal products using an integrated 4-in-1 analysis system and the MetaboTarget algorithm 使用集成的4合1分析系统和MetaboTarget算法增强草药产品的代谢物分析。

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-05 DOI: 10.1016/j.chroma.2026.466671

Mengyuan Wang, Yunuo Fan, Ye Zhang, Ling Chen, Bin Li, Ping Li

{"title":"Enhanced metabolite profiling of herbal products using an integrated 4-in-1 analysis system and the MetaboTarget algorithm","authors":"Mengyuan Wang, Yunuo Fan, Ye Zhang, Ling Chen, Bin Li, Ping Li","doi":"10.1016/j.chroma.2026.466671","DOIUrl":"10.1016/j.chroma.2026.466671","url":null,"abstract":"<div><div>The inherent chemodiversity and complexity of herbal products make their quality control extremely challenging. In this work, a comprehensive analysis strategy through combining a polarity-extended liquid chromatography-mass spectrometry system (4-in-1 analysis system) and a metabolite-oriented targeted screening algorithm (MetaboTarget) for herbal products was proposed. The 4-in-1 analytical technique significantly expanded detection coverage of analytes through polarity extension. The Python-based MetaboTarget algorithm constructs a predictive database of potential metabolites by integrating Phase I/II metabolic reaction rules with parent drug components absorbed into the blood. Using precursor ions for targeted DDA scanning of plasma samples enables comprehensive metabolite characterization through integration with feature-based molecular networking (FBMN). The developed strategy was successfully applied to the deep <em>in vitro</em> and <em>in vivo</em> analysis of chemical components of Gegen Qinlian Decoction (GQD). As a result, 303 components in GQD and 181 metabolites in plasma were annotated. This integrated strategy enables simultaneous detection of compounds across the full polarity spectrum (high/medium/low) while overcoming key challenges in metabolite identification through the MetaboTarget algorithm, which effectively addresses issues arising from strong endogenous interference and low target abundance, thereby providing a powerful tool for comprehensive characterization of complex herbal products.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466671"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an LC–ESI-MS/MS method for the determination of contaminants of emerging concern – towards extending quality surveillance of water resources 建立一种LC-ESI-MS /MS方法，用于确定新兴关注的污染物-对扩大水资源质量监测

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-20 DOI: 10.1016/j.chroma.2026.466717

Nataliia Leonova , Olga Konovalova , Peter Tarábek

{"title":"Development of an LC–ESI-MS/MS method for the determination of contaminants of emerging concern – towards extending quality surveillance of water resources","authors":"Nataliia Leonova , Olga Konovalova , Peter Tarábek","doi":"10.1016/j.chroma.2026.466717","DOIUrl":"10.1016/j.chroma.2026.466717","url":null,"abstract":"<div><div>Inclusion of emerging contaminants into water quality monitoring programs can serve as an additional layer for protecting water resources against deterioration. Based on prior non-target screening using LC–QTOF, a direct injection liquid chromatography–electrospray ionization-tandem mass spectrometry with multiple reaction monitoring method was developed for the determination of 23 micropollutants in natural waters. The combination of methodological simplicity, flexibility, environmental compatibility, and demonstrated performance under real-world monitoring conditions represents a significant advancement over existing chromatographic strategies for the determination of relevant and emerging pollutants. The method provides high sensitivity and reliability, enabling the simultaneous quantification of target analytes (pesticides, pharmaceuticals and products of their transformation) spanning a wide polarity range (XLogP3 0.3–6.1) and extending the applicability of multianalytes chromatographic analysis to complex environmental matrices. The limits of detection and quantification and linearity were evaluated in deionized water, groundwater, and surface water, while accuracy in terms of recovery and precision were determined in surface water. Pesticides provided satisfactory recoveries ranging from 83 to 120%, with quantification limits between 0.02 µg L<sup>−1</sup> and 0.18 µg L<sup>−1</sup>, whereas pharmaceuticals displayed recoveries of 83–119%, with quantification limits of 0.03–0.20 µg L<sup>−1</sup> in different types of water. Using the developed method, 599 water samples were analyzed between 2023 and 2025. The most frequently detected compounds at concentrations above the limit of quantification were terbumeton-desethyl, prometon and benzenesulfonamide in groundwater; fluconazole and sulfamethoxazole in surface water; and propazine-2‑hydroxy, terbuthylazine-2‑hydroxy and carbamazepine in both types of water samples.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466717"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid detection of perfluorinated compounds in tap water using confined methanol 使用密闭甲醇快速检测自来水中的全氟化合物

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-19 DOI: 10.1016/j.chroma.2026.466718

Xinyang Zhang, Huilan Piao, Mengqing Cui, Xiangzi Jin, Meihui Tong, Donghao Li, Yilin Zou

{"title":"Rapid detection of perfluorinated compounds in tap water using confined methanol","authors":"Xinyang Zhang, Huilan Piao, Mengqing Cui, Xiangzi Jin, Meihui Tong, Donghao Li, Yilin Zou","doi":"10.1016/j.chroma.2026.466718","DOIUrl":"10.1016/j.chroma.2026.466718","url":null,"abstract":"<div><div>Perfluorinated compounds (PFCs), characterized by their persistence and bioaccumulative properties, have been extensively detected across diverse environmental compartments, including aquatic systems, sediments, and organisms. These contaminants enter human bodies via food chain transfer, subsequently undergoing internal transport and metabolic transformation. Meanwhile, the detection of samples is also difficult to achieve sensitivity analysis due to the low content of the analytes and the complex matrix. Based on this, we propose a novel approach for analyzing the derivatives of 9 PFCs (derivatization reaction conditions: 1 min, room temperature) in tap water using carbon nanofibers/carbon fibers (CNFs/CFs) nanoconfined solvent extraction method, termed nanoconfined liquid phase nanoextraction (NLPNE), coupled with gas chromatography-mass spectrometry (GC–MS). The effect of various experimental parameters on extraction efficiency was investigated using a Box-Behnken design (BBD), such as volume of nanoconfined solvent, extraction time and desorption time, which method requires a less solvent-consumption (20 μL) and time ≤ 1 min, meeting the requirements for green environmental and sustainable development. Under optimal conditions, the developed method shown good linearity within the studied concentration range. Accuracy was evaluated by analyzing the extraction recovery of spiked tap water sample, the satisfactory recoveries (71.31%-126.15%) with RSD ≤ 17.45%. In addition, the limits of detection (LODs) for the analytes were in the range of 0.2–3 μg L<sup>−1</sup>, which the sensitivity has been significantly improved. Considering the versatility of nanoconfined solvent extraction method, indicated that the NLPNE is a promising pretreatment technique for detecting PFCs in real samples.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466718"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of protein digestion and solid-phase extraction strategies for oligonucleotide quantification in plasma using LC-MS/MS LC-MS/MS法测定血浆中寡核苷酸的蛋白质消化和固相萃取方法的比较评价。

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-14 DOI: 10.1016/j.chroma.2026.466707

Vidya Annavarapu, Michael G. Bartlett

{"title":"Comparative evaluation of protein digestion and solid-phase extraction strategies for oligonucleotide quantification in plasma using LC-MS/MS","authors":"Vidya Annavarapu, Michael G. Bartlett","doi":"10.1016/j.chroma.2026.466707","DOIUrl":"10.1016/j.chroma.2026.466707","url":null,"abstract":"<div><div>Oligonucleotide therapeutics are an emerging class of drugs, but their development is challenged by difficulties in efficient extraction and quantification, primarily due to their polarity and susceptibility to degradation by nucleases. Solid phase extraction (SPE) is one of the methods used for oligonucleotide extraction, offering sensitivity along with selectivity. Surfactant-based buffer has traditionally been used in SPE extraction of oligonucleotides, but there is now a growing focus on exploring alternatives to this method. In this study, we investigated the use of a non-surfactant buffer pretreatment module for SPE extraction of oligonucleotides using both WAX-based and mixed-mode microplates. The methods for both mixed-mode and WAX-based SPE microplates were validated and applied in an in-vitro stability study. Our study showed good recovery and easy sample preparation when using the non-surfactant buffer pretreatment module, across both microplate types. The surfactant-based buffer (SB) used with proteinase K also gave a better recovery when applied to the WAX-based SPE microplate.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466707"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkyl glucamine-based mixed-mode stationary phase for reversed-phase and hydrophilic interaction liquid chromatography 以烷基氨基葡萄糖为基础的混合模式固定相用于反相和亲水相互作用液相色谱

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-15 DOI: 10.1016/j.chroma.2026.466712

Shuo Wang , Yiming Gu , Jin Zhou , Shudong Wang

{"title":"Alkyl glucamine-based mixed-mode stationary phase for reversed-phase and hydrophilic interaction liquid chromatography","authors":"Shuo Wang , Yiming Gu , Jin Zhou , Shudong Wang","doi":"10.1016/j.chroma.2026.466712","DOIUrl":"10.1016/j.chroma.2026.466712","url":null,"abstract":"<div><div>In modern liquid chromatography, versatile mixed-mode stationary phases have emerged as a practical choice for complex separations. Glucamine is promising in this field due to its distinctive amino-substituted glucose structure. This work presents a novel alkyl glucamine-based stationary phase (SIL–GNOGA) prepared <em>via</em> an epoxide-amine ring-opening reaction and immobilized onto silica surfaces. The morphology and composition of the stationary phase were characterized by multiple analytical techniques. Its retention mechanism was systematically investigated using analytes with diverse properties under varied chromatographic conditions. Furthermore, the separation performance of SIL–GNOGA was assessed and compared against its alkylamine- and glucamine-based counterparts. The stationary phase demonstrated excellent versatility, enabling efficient separation of hydrophilic, hydrophobic, as well as amphiphilic analytes in hydrophilic interaction or reversed-phase mode, depending on their molecular characteristics. Notably, complex mixtures were successfully resolved in both modes through the synergistic effects of hydrophilic, hydrophobic, hydrogen-bonding, and electrostatic interactions. This mixed-mode capability highlights SIL–GNOGA’s broad selectivity and potential across diverse chromatographic applications.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466712"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasensitive detection of triazine herbicides in food via dispersive solid-phase extraction with nanoconfined task-specific ionic liquids in tunable hollow porous carbon spheres 在可调中空多孔碳球中，纳米限定任务特异性离子液体分散固相萃取超灵敏检测食品中三嗪类除草剂。

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2026-01-03 DOI: 10.1016/j.chroma.2026.466672

Xu Xu, Yuanjun Liao, Yuhan Guo, Yi Jiang, Lei Zhang

{"title":"Ultrasensitive detection of triazine herbicides in food via dispersive solid-phase extraction with nanoconfined task-specific ionic liquids in tunable hollow porous carbon spheres","authors":"Xu Xu, Yuanjun Liao, Yuhan Guo, Yi Jiang, Lei Zhang","doi":"10.1016/j.chroma.2026.466672","DOIUrl":"10.1016/j.chroma.2026.466672","url":null,"abstract":"<div><div>Triazine herbicides are widely detected in food and pose significant hazards to ecosystems and human health. In this study, a nanoconfined composite of task-specific ionic liquids (TSILs) within hollow porous carbon spheres (HPCS), denoted TSILs@HPCS, was synthesized via post-impregnation for selective enrichment and efficient extraction of triazine herbicides. Hydrophobic TSILs incorporating [NTf<sub>2</sub><sup>-</sup>] anion were systematically prepared. Confinement within HPCS tunable pores yielded a 6.0-fold increase in triazine herbicide adsorption capacity relative to pristine HPCS. The TSILs@HPCS composite serves as a multifunctional adsorbent, enabling the simultaneous sorptive removal, highly sensitive detection, and sieving of analytes. A dispersive solid-phase extraction method coupled with high-performance liquid chromatography was developed to quantify trace triazine herbicides in complex food matrices. This approach demonstrated low detection limits (0.06–0.12 μg kg<sup>-1</sup>) and high enrichment factors (124–192), confirming its suitability for residue analysis. These results establish TSILs@HPCS as a promising adsorbent for preconcentrating triazine herbicides in food samples.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466672"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confined silica particles in dually directional 1,2,3-triazolyl phthalonitrile based network: A robust nitrogen-rich Sorbent for the enrichment of nitroaromatics from water using HPLC-UV 双向1,2,3-三唑基邻苯二腈网络中的受限二氧化硅颗粒：一种高效液相色谱-紫外富集水中硝基芳烃的富氮吸附剂

IF 4 2区化学

Journal of Chromatography A Pub Date : 2026-02-08 Epub Date: 2025-12-20 DOI: 10.1016/j.chroma.2025.466640

Mohamed Rashad , AbdullahAlhendal , Laila Alshatti , Ali Husain

{"title":"Confined silica particles in dually directional 1,2,3-triazolyl phthalonitrile based network: A robust nitrogen-rich Sorbent for the enrichment of nitroaromatics from water using HPLC-UV","authors":"Mohamed Rashad , AbdullahAlhendal , Laila Alshatti , Ali Husain","doi":"10.1016/j.chroma.2025.466640","DOIUrl":"10.1016/j.chroma.2025.466640","url":null,"abstract":"<div><div>Owing to their extreme energetic properties, nitroaromatics (NACs) are well-recognized as explosive materials as well as toxic contaminations and source of environmental pollution. Thus, the development of accurate and extremely sensitive technologies for detecting NACs is critically necessary. In this study, the synthesis of a nitrogen-rich cross-linked polymer confining silica particles within its network structure (TPN-SiO<sub>2</sub>) is being described. The TPN-SiO<sub>2</sub> material was successfully prepared, in situ, via the Cu(I)-mediated azide-alkyne cycloaddition (CuAAC) polymerization of dually directional alkyne-terminated phthalonitrile monomers with 1,4-bis(azidomethyl)benzenes in the presence of silica particles. The resulting encapsulated silica network was fully characterized using its respective XPS, SEM, TEM, and FT-IR spectroscopic data, along with TGA analysis. TPN-SiO<sub>2</sub> was applied as an effective sorbent in solid phase extraction (SPE) for the enrichment of nitrobenzene compounds (NBs) before quantification by HPLC-UV. Three NBs (nitrobenzene, 4-nitrotoluene, and 2-nitrobenzaldehyde) were used to evaluate the effectiveness of the prepared SPE sorbent. Accordingly, and under optimal analytical extraction conditions, the results revealed a good linearity from 0.1-50 μgmL<sup>-1</sup> with correlation coefficients (R<sup>2</sup>) higher than 0.990. As well to this, the limits of detection and quantification were determined to be 2.4-33.9 μgL<sup>-1</sup> and 7.17–102.88 μgL<sup>-1</sup>, respectively, making this hybrid silica triazolyl-rich cross-linked sorbent appropriate for NBs enrichment and detection.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1768 ","pages":"Article 466640"},"PeriodicalIF":4.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0