Phytomedicine Plus最新文献

{"title":"Scopoletin as a cardioprotective agent against cisplatin-induced oxidative stress and inflammation","authors":"Esam Qnais ,&nbsp;Omar Gammoh ,&nbsp;Yousra Bsieso ,&nbsp;Mohammad Alqudah ,&nbsp;Mohammad Wedyan ,&nbsp;Sara Altaber ,&nbsp;Alaa A.A. Aljabali ,&nbsp;Abdelrahim Alqudah ,&nbsp;Taher Hatahet","doi":"10.1016/j.phyplu.2025.100738","DOIUrl":"10.1016/j.phyplu.2025.100738","url":null,"abstract":"<div><h3>Background</h3><div>Cisplatin (CP) is a chemotherapeutic agent notorious for its cardiotoxic effects. Scopoletin, a natural coumarin, has shown potential due to its antioxidant, anti-inflammatory, and anti-apoptotic properties, which may counteract CP-induced cardiotoxicity.</div></div><div><h3>Purpose</h3><div>The study aimed to explore the cardioprotective effects of scopoletin against CP-induced damage in mice, focusing on histopathological changes, cardiac biomarkers, oxidative stress, inflammation, apoptosis, and the modulation of key signaling pathways.</div></div><div><h3>Study Design</h3><div>A controlled experimental design was employed to evaluate scopoletin's efficacy in alleviating CP-induced cardiotoxicity, with dosing variations to assess dose dependency.</div></div><div><h3>Methods</h3><div>Male mice were allocated into five groups: a control group, a cisplatin-only group, two groups treated with low (50 mg/kg/day) and high doses (150 mg/kg/day) of scopoletin in conjunction with cisplatin, and a scopoletin-only group. The interventions were administered over a period of one week, with cardiac damage assessed through histopathological examinations, serum cardiac biomarker measurements, and analyses of oxidative stress, inflammatory cytokines, and apoptosis-related proteins. The efficacy of scopoletin in modulating the p62/Keap1/Nrf2 pathway was also examined.</div></div><div><h3>Results</h3><div>Histopathological assessments showed less tissue damage in scopoletin-treated groups (<em>p</em> &lt; 0.01). Cardiac biomarkers were significantly lower in <span>l</span>- and H-scopoletin groups compared to the CP-only group (<em>p</em> &lt; 0.05, <em>p</em> &lt; 0.01). Scopoletin effectively reduced ROS and MDA levels while enhancing antioxidant enzymes like SOD, CAT, and GSH (<em>p</em> &lt; 0.01). With scopoletin treatment, inflammatory cytokines TNF-α and IL-6 were notably reduced (<em>p</em> &lt; 0.01). Apoptosis analysis revealed lower levels of pro-apoptotic proteins and higher levels of Bcl-2 in scopoletin groups (<em>p</em> &lt; 0.05, <em>p</em> &lt; 0.01). Significantly, scopoletin restored the function of the p62/Keap1/Nrf2 signaling pathway (<em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>The findings suggest scopoletin's potential as an adjunctive therapy in cancer treatment to mitigate CP's adverse effects, warranting further clinical investigation.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100738"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review","authors":"Sarthak Mishra,&nbsp;Payal Mittal","doi":"10.1016/j.phyplu.2025.100741","DOIUrl":"10.1016/j.phyplu.2025.100741","url":null,"abstract":"<div><h3>Background</h3><div>PCOS, a prevalent endocrine condition in reproductive years, exhibits irregular ovulation, polycystic ovaries, insulin resistance, and elevated androgen levels. <em>Desmostachya bipinnata (</em>L.<em>)</em>, Poaceae known as \"Kusha,\" is a sacred grass integral to Vedic rituals, serving as a rich source of bioactive elements.</div></div><div><h3>Purpose</h3><div>This review focused on the bioactive compounds of <em>D. Bipinnata</em> which have shown various pharmacological action. We also focus on the phytochemical and pharmacological studies of <em>D. Bipinnata</em>. The present review is an effort to gather and consolidate the most recent information available on <em>D. Bipinnata.</em></div></div><div><h3>Material and Methods</h3><div>Reference searches were achieved from various sources along with Google Scholar, Science Direct, Scopus, PubMed, and Springer with the keywords “PCOS”, “Hyperandrogenism”, “Therapeutic prospects”, “Herbal remedies”, “Bioactive compounds” in the text.</div></div><div><h3>Result</h3><div>The review compiles traditional and pharmacological uses of a plant rich in antioxidants, flavonoids, alkaloids, terpenoids, and sterols. Traditionally, the herb and root have treated various illnesses. Research highlights its broad pharmacological properties, such as antipyretic, analgesic, antidiarrheal, menorrhagia, and hepatoprotective.</div></div><div><h3>Conclusion</h3><div><em>Desmostachya bipinnata (</em>L.<em>)</em> shows promise for PCOS management due to its rich content of bioactive compounds, including quercetin, linoleic acid, stigmasterol, Camphene, coumarins, and terpenes known for PCOS treatment. Despite these findings, additional clinical studies are required to validate its efficacy. This review delves into PCOS epidemiology, pathophysiology, and therapeutic potential, spotlighting <em>D. bipinnata</em> as a potential herbal solution for PCOS, pending additional research.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100741"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer","authors":"Abhishek Chauhan ,&nbsp;Hemant Joshi ,&nbsp;Divya Kandari ,&nbsp;Diwakar Aggarwal ,&nbsp;Ritu Chauhan ,&nbsp;Hardeep Singh Tuli ,&nbsp;Arpit Mehrotra ,&nbsp;Abhilasha Sood ,&nbsp;Ujjawal Sharma ,&nbsp;Darin Mansor Mathkor ,&nbsp;Shafiul Haque ,&nbsp;Naveen Chandra Joshi ,&nbsp;Laurent Dufossé","doi":"10.1016/j.phyplu.2024.100721","DOIUrl":"10.1016/j.phyplu.2024.100721","url":null,"abstract":"<div><h3>Background</h3><div>Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn considerable attention due to its therapeutic potential, particularly its anticancer properties. It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conventional chemotherapeutics by modulating key signaling pathways like PI3K/AKT, MAPKs, and NF-κB.</div></div><div><h3>Purpose</h3><div>This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. Keywords such as \"Oridonin,\" \"Apoptosis,\" \"Cancer Cell Signaling Pathways,\" \"PI3K/AKT,\" \"ROS,\" and \"Nanotechnology\" were used, yielding 96 relevant studies.</div></div><div><h3>Results</h3><div>Oridonin induces apoptosis through intrinsic and extrinsic pathways, involving ROS amplification and mitochondrial membrane potential regulation. It modulates proteins like Bax, Bcl-2, cytochrome c, and caspases, leading to DNA fragmentation. Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential.</div></div><div><h3>Conclusion</h3><div>Oridonin demonstrates robust anticancer activity by modulating signaling pathways and inducing apoptosis. Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100721"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances","authors":"Mithila Debnath,&nbsp;Mahir Azmal,&nbsp;Rashid Taqui,&nbsp;Moshiul Alam Mishu,&nbsp;Ajit Ghosh","doi":"10.1016/j.phyplu.2025.100752","DOIUrl":"10.1016/j.phyplu.2025.100752","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) is a significant and prevalent threat in the current period, with a dearth of accessible treatment options. There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this regard.</div></div><div><h3>Purpose</h3><div>The study aimed to adopt a new strategy to identify and characterize potential biomarkers and therapeutic phytochemicals for AD by integrating gene expression data and computational analysis.</div></div><div><h3>Methods</h3><div>A differential expression analysis was conducted using GEO2R, where the significant differentially expressed genes (DEGs) were identified in brain areas that include the Entorhinal Cortex (EC) and Posterior Cingulate (PC), as well as in peripheral blood. The interactions between DEGs and phytochemicals were investigated using computational approaches that involve molecular docking and molecular dynamic simulations.</div></div><div><h3>Results</h3><div>A total of 17 potential biomarkers including BAD, CDK5, FN1, ITGA4, and MAPK9 were identified. Quercetin and Berberine have shown significant binding affinities to these biomarkers according to molecular docking studies, indicating their potential as effective treatment agents. The ADME profile has shown the presence of favorable properties, specifically blood-brain barrier permeability. These findings suggest that the biomarkers found are implicated in important pathways associated with the development of AD and they emphasize the potential of Quercetin and Berberine as therapeutic agents.</div></div><div><h3>Conclusions</h3><div>This study provides a thorough comprehension of the molecular basis of AD and proposes that Quercetin and Berberine have the potential as efficacious therapy options. This research provides a promising viewpoint on treatments for AD by focusing on proteins that are increased in certain parts of the brain, such as the EC and PC, which play a crucial role in the pathways leading to neurodegeneration.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100752"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community","authors":"Nancy Bonareri Mitaki ,&nbsp;Ilemobayo Victor Fasogbon ,&nbsp;Onyinye Vivian Ojiakor ,&nbsp;Wusa Makena ,&nbsp;Emmanuel O. Ikuomola ,&nbsp;Reuben Samson Dangana ,&nbsp;Ibe Micheal Usman ,&nbsp;Ekom Monday Etukudo ,&nbsp;Augustine Oviosun ,&nbsp;Swase Dominic Terkimbi ,&nbsp;Elizabeth Bessy Umoren ,&nbsp;Angela Mumbua Musyoka ,&nbsp;Solomon A Mbina ,&nbsp;Esther Ugo Alum ,&nbsp;Ibrahim Babangida Abubakar ,&nbsp;Godson Emeka Anyanwu ,&nbsp;Patrick Maduabuchi Aja","doi":"10.1016/j.phyplu.2024.100717","DOIUrl":"10.1016/j.phyplu.2024.100717","url":null,"abstract":"<div><h3>Background Information</h3><div>Diabetes is a serious global health issue that is particularly common in East Africa. Lifestyle factors influence the incidence, mortality, and morbidity of diabetes. Medicinal plants have phytochemicals with anti-diabetic properties.</div></div><div><h3>Purpose</h3><div>This systematic review assesses the efficacy, efficiency, safety, and feasibility of phytotherapy in the treatment of diabetes in the East African Community (EAC).</div></div><div><h3>Methods</h3><div>we conducted a comprehensive literature search using PubMed, Scopus, and Web of Science databases. We limited our search to peer-reviewed English articles, preclinical models, and intervention studies reporting the use of medicinal plants in the treatment of diabetes, particularly in EAC. This article follows the Guidelines for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Two reviewers independently performed data collection and quality assessment. We retrieved 465 articles from the database and reviewed eight articles that met the inclusion criteria for this study.</div></div><div><h3>Results</h3><div>we identified eight medicinal plants: <em>Maerua decumbens, Rotheca myricoides</em> (Hochst), <em>Piper capence, Berberis holstii, Polyscias fulva (Hiern) Harms, Lippia javanica, Caesalpina bonducella,</em> and <em>Securinega virosa</em>. We extracted and analyzed information from the literature and showed that seven medicinal plants reduce blood sugar levels and insulin sensitivity through their mechanism of action.</div></div><div><h3>Conclusion</h3><div>The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. <em>Caesalpinia bonducella</em> seed extract is less effective in controlling high blood sugar. More preclinical studies are needed to investigate the potential of phytotherapy in the management of diabetes in EAC.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100717"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmocology, phytochemistry and pharmacology of the genus Orthosiphon: A review","authors":"Rui Wang ,&nbsp;Ling Qiu ,&nbsp;Qing-wen Zhang,&nbsp;Ligen Lin","doi":"10.1016/j.phyplu.2025.100748","DOIUrl":"10.1016/j.phyplu.2025.100748","url":null,"abstract":"<div><h3>Background</h3><div>Plants of the genus <em>Orthosiphon</em> (Lamiaceae) have been widely employed in traditional and ethnic medicines for the treatment of various diseases, including diabetes, kidney stones, edema, rheumatism, hepatitis, hypertension, and urinary tract disorders.</div></div><div><h3>Purpose</h3><div>This review summarized the research progresses in botany, traditional uses, phytochemistry, and pharmacological activities on plants of the genus <em>Orthosiphon</em>. Additionally, this review described the shortcomings of studies on these species, thus serving as the basis of further researches and development of these traditional herbal medicines.</div></div><div><h3>Method</h3><div><em>Orthosiphon</em>-related information was collected from the online databases, such as Google Scholar, SciFinder, Web of Science, Elsevier, PubMed and China Knowledge Resource Integrated (CNKI).</div></div><div><h3>Results</h3><div>Plants of the genus <em>Orthosiphon</em> are widely distributed in African, Australia, South Asian, and Southeast Asian, and in China. Phytochemical investigations on <em>Orthosiphon</em> species have revealed the presence of various compounds, mainly including phenolic acids, flavonoids, diterpenoids, triterpenoids, sesquiterpenoids, and chromenes. Previous reports have demonstrated the diverse pharmacological properties of extracts and constituents derived from <em>Orthosiphon</em>, such as anti-cancer, anti-diabetic, anti-inflammatory, antioxidant, hepatoprotective, analgesic, and nephroprotective effects. However, previous researches on this genus were somewhat limited and skewed towards a few species, with a particular emphasis on <em>O. aristatus, O. wulfenioides, O. thymiflorus</em> and <em>O. rubicundus</em> (D. Don) Benth, which might be attributed to the ethnopharmacological background, geographical constraints, and the distribution of these species. In the future, more investigations on other species of the genus <em>Orthosiphon</em> are needed.</div></div><div><h3>Conclusion</h3><div>This study provided a comprehensive overview of the ethnopharmacological, phytochemical, and pharmacological progresses related to the genus of <em>Orthosiphon</em>. Despite substantial bias in attention among various species of the genus <em>Orthosiphon</em>, its potential as health food and therapeutic agents is evident. The genus is an underexplored source of bioactive compounds with potential in various therapeutic areas. This review laid the groundwork for further investigation and development of these traditional herbal remedies.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100748"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Garcinia livingstonei aqueous leaf extract on hyperglycaemic-induced human sperm cell: An in-vitro study","authors":"Murendeni Nethengwe ,&nbsp;Kunle Okaiyeto ,&nbsp;Chinyerum S. Opuwari ,&nbsp;Oluwafemi O. Oguntibeju","doi":"10.1016/j.phyplu.2025.100750","DOIUrl":"10.1016/j.phyplu.2025.100750","url":null,"abstract":"<div><div>Hyperglycaemia is the main instigator of the development of male infertility in men with diabetes mellitus (DM). The consequent production of excessive reactive oxidative species (ROS) and a compromised antioxidant defence system leads to testicular damage and a decline in sperm parameters. Supplementation with antioxidants sourced from medicinal plants is beneficial in the treatment of DM-related male infertility. However, a search for more efficacious and easily accessibly medicinal plants is paramount. <em>Garcinia livingstonei</em> is a well-known and accessible medicinal plant used in traditional practices for the treatment of diabetic complications. However, very scarce information on the plant extract's potential benefits exists in the literature. The current study investigated the effect of aqueous leaf extract of <em>G. livingstonei</em> on hyperglycaemic human male sperm cell parameters. Hyperglycaemia was induced using sperm media supplemented with 100 mM D-glucose over 24 h. Hyperglycaemia induction led to a significant (P&lt;0.05) decline in sperm motility, vitality, DNA integrity, mitochondrial membrane potential (MMP), and acrosome integrity. The effect of the plant extract on spermatozoa was concentration-dependent, with the lowest concentration demonstrating the highest protective effects. A significant (P&lt;0.05) improvement in all tested sperm parameters was observed after exposure of the hyperglycaemic spermatozoa to aqueous leaf extract of <em>G. livingstonei.</em> The effect of acarbose on all tested sperm parameters was comparable to that of the plant extract. The findings of this study suggest the potential therapeutic effect of <em>G. livingstonei</em> in the treatment of DM-related male infertility. However, the use of an appropriate dosage depending on the pathological target is paramount.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100750"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virgin coconut oil lessens trichloroacetic acid assault on the stomach and intestine of rats via enhancement of Nrf2 but inhibition of TNF-α, IL1β/NF-kB signalling pathway","authors":"OO Oladokun ,&nbsp;KO Ajeigbe ,&nbsp;MA Adelakun","doi":"10.1016/j.phyplu.2024.100725","DOIUrl":"10.1016/j.phyplu.2024.100725","url":null,"abstract":"<div><h3>Background</h3><div>Trichloroacetic acid (TCA), a known environmental toxicant, causes organ damage via oxidative stress and activation of pro-inflammatory cytokines. Virgin coconut oil (VCO) is known for many beneficial health effects associated with its phenolic acids and flavonoid contents. We, therefore, explore the mechanisms underlying the antioxidative and anti-inflammatory mechanisms of Virgin Coconut oil (VCO) alone, or combined with 5-fluorouracil (5FU) in the treatment of TCA-induced gastric and intestinal damage in rats.</div></div><div><h3>Materials and Methods</h3><div>Rats received TCA (250 mg/Kg b.wt, p.o) for ten days, followed by either 5 % or 10 % VCO per gram feed alone or in combination with 5FU (50 mg/kg, i.p) for another ten days. Stomach and intestinal tissue oxidative stress parameters and inflammatory markers were evaluated along with histological examination.</div></div><div><h3>Results</h3><div>TCA's intoxication which caused a decrease in the activity of SOD, CAT, GPx, and Nrf2 in the stomach and colon, and an increase in MDA, MPO, TNF-α, IL-1β, and NF-kB levels were all reversed by VCO, either alone or in combination with 5-FU. Further, histomorphometry data favored the anti-inflammatory potentials of VCO. Parietal cell mass and inflammatory cell infiltration elaborated by TCA were reduced significantly by VCO and 5-FU. Similarly, intestinal crypt depth assessment and inflammatory cell infiltration earlier increased in the TCA group was quashed by VCO. Still, both gastric mucous and goblet cells hitherto reduced were significantly enhanced by VCO alone or in combination with 5-FU. Focal disruption of the gastric pit, derangement of surface epithelium, and sloughing of the surface epithelial barrier of the intestinal villi occasioned by TCA were all assuaged by VCO.</div></div><div><h3>Conclusions</h3><div>Virgin coconut oil shows a promising adjunctive effect quashing trichloroacetic acid-induced injury in the stomach and intestine via suppression of lipid peroxidation, enhancement of Nrf2 but inhibition of TNF-α, IL-1β/NF-kB signaling.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100725"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of an herbal galactagogue decoction versus powdered formulation in lactating rats","authors":"Pruksa Chotitham ,&nbsp;Suksalin Booranasubkajorn ,&nbsp;Saracha Pattanapholkornsakul ,&nbsp;Pravit Akarasereenont ,&nbsp;Pinpat Tripatara","doi":"10.1016/j.phyplu.2025.100745","DOIUrl":"10.1016/j.phyplu.2025.100745","url":null,"abstract":"<div><h3>Background</h3><div>An herbal galactagogue formula in Thai traditional medicine, known as the Prasanamnom formula (PNF), has been utilized to increase maternal breast milk. The traditional method of administering PNF is via decoction, which has become inconvenient in modern times. Consequently, it has been newly produced in a powdered form for capsule prescription. However, the efficacy and safety of PNF in either form have not been studied.</div></div><div><h3>Purpose</h3><div>This study investigated the effects of PNF decoction and powder on milk production and their safety regarding organ functions.</div></div><div><h3>Methods</h3><div>Maternal rats were administered distilled water, PNF decoction (300, 600, 1000 mg/kg), or PNF powder from the capsule (100, 300, 1000 mg/kg), or given 10 mg/kg domperidone as a positive control, once daily on postnatal days (PND) 1 to 21. Milk yield was estimated by pup weight. Analyses were conducted on maternal blood samples collected on prenatal days, and PND 7, 14, and 21, and pup blood samples collected on PND 22.</div></div><div><h3>Results</h3><div>PNF decoction (600 mg/kg) and domperidone significantly increased the mean of milk production and serum prolactin level when compared with the vehicle control. The PNF powder had no such effects. Both PNF decoction and powder did not exhibit subacute toxicity to the liver and kidneys in maternal rats and pups.</div></div><div><h3>Conclusion</h3><div>The effectiveness of the PNF decoction in improving both milk production and prolactin levels was similar to that of domperidone. Additionally, the traditional decoction method was effective in increasing milk production and elevating serum prolactin levels in mother rats.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100745"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications","authors":"Carlos Andrés Coy-Barrera ,&nbsp;Laura Galvis ,&nbsp;Maria Juliana Rueda ,&nbsp;Sergio Alejandro Torres-Cortés","doi":"10.1016/j.phyplu.2025.100746","DOIUrl":"10.1016/j.phyplu.2025.100746","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;This review focuses on the various applications of species from the genus &lt;em&gt;Croton&lt;/em&gt;, which belongs to the family Euphorbiaceae. It aims to summarize information gathered worldwide from studies of &lt;em&gt;Croton&lt;/em&gt; species concerning ethnobotanical, pharmacological, and other uses over the past ten years and the respective discussion. An important aspect to consider is that the present review of herbal medicines provides an alternative for developing new therapeutic objectives supported by preclinical studies and promotes new treatment options against the diseases that affect us in the current situation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Within the framework of this review, bibliographical research was conducted based on literature published in specialized journals and by accessing crucial information from globally recognized scientific databases (Google Scholar, PubMed, Web of Science, Scopus, Science Direct, SciELO, and SpringerLink). After extraction from electronic databases, articles were selected based on eligibility criteria. In total, 268 published articles of plants of species of the genus Croton were reviewed for ethnobotanical uses, of which 172 were considered for final analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The increase in studies focusing on species of this genus worldwide can be attributed to their wide range of medicinal applications. Ethnobotanical studies reflect numerous uses in different communities, addressing issues such as intestinal disorders, general pain, cancer, hypertension, diabetes, hemorrhoids, sexual impotence, respiratory diseases, COVID -19, ulcers, and intestinal parasites. The information on traditional medicine has aroused the interest of the scientific community, which seeks to identify the chemical components responsible for its use . In this context, the main components of &lt;em&gt;Croton&lt;/em&gt; are primarily terpenoids, flavonoids, and phenolic compounds, to which various types of biological activities are attributed, such as antioxidants, antibacterial, anticoagulant, antimicrobial, cytotoxic, anti-inflammatory, and anticancer activities. Furthermore, &lt;em&gt;Croton&lt;/em&gt; has applications as an insecticide and as an alternative source of biodiesel. This demonstrates that species of this genus possess potential for various medicinal applications and serve as a source of chemical compounds that could become active principles of phytotherapeutics with significant results.&lt;/div&gt;&lt;div&gt;It is evident that this type of compound has variety concerning oxygen substituents, which may provide information of interest for future studies on structure-activity relationships and offer alternatives of natural origin that can be evaluated against related organisms to demonstrate the pharmacological potential found in the literature.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This revision has a novel and principal aim: to collect information on the biomedicinal, chemical, and industrial applicat","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100746"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}