Phytomedicine Plus最新文献

{"title":"Recent investigation of the medicinal plants’ effectiveness in the natural management of urinary and gallstones: a review","authors":"Youssef Miyah ,&nbsp;Mohammed Benjelloun ,&nbsp;Hajar El Omari ,&nbsp;Karima El-Mouhdi ,&nbsp;Mohammed El Feniche","doi":"10.1016/j.phyplu.2025.100839","DOIUrl":"10.1016/j.phyplu.2025.100839","url":null,"abstract":"<div><h3>Background</h3><div>The search for natural management techniques using medicinal plants is driven by the inescapable health problems of kidneys and gallstones, which can lead to serious complications and acute pain. These issues are often linked to an unbalanced diet, inadequate hydration, family history, and high doses of certain drugs. Conventional treatments for urinary and gallstones have limited efficacy and do not always guarantee a complete cure, which increases the risk of complications, particularly recurrence.</div></div><div><h3>Purpose</h3><div>This review paper thoroughly examines medicinal plants' potential to treat and prevent gallstones and urinary tract stones and envision a future when natural remedies integrate with conventional medical practices.</div></div><div><h3>Study design</h3><div>This study looks at kidney and biliary diseases, particularly stones, explores conventional treatments (drugs, lithotripsy, and surgery), and highlights medicinal plants used as natural remedies. Several medicinal traditions are examined for their historical use and preparations. By analyzing phytochemistry and prevention mechanisms, research focuses on medicinal plants' active principles and modes of action and their therapeutic and preventive effect against stones. It also examines how these plants can reduce the risk of stone formation, provide an alternative to conventional treatments, and reduce the need for surgery. The study also discusses the importance of a suitable diet and lifestyle to prevent stones. The advantages and disadvantages of herbal remedies are also explored in addition to recommendations for future clinical research into their efficacy.</div></div><div><h3>Conclusion</h3><div>Medicinal plants could be a viable alternative to traditional treatments, especially for biliary and kidney stones. Although this study shows promise in both prevention and treatment, more clinical trials are necessary to fully investigate the efficacy and safety of these natural remedies to confirm their value in a broader medical setting.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100839"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating bioinformatics with network pharmacology and experimental validation analysis to reveal the pharmacological mechanism of Ma-xing-shi-gan-tang in treating viral pneumonia","authors":"Li Huie ,&nbsp;Wang Qiong ,&nbsp;An Huijie,&nbsp;Zhang Qiang,&nbsp;Du Wei,&nbsp;Jiao Ying,&nbsp;Pan Siwei,&nbsp;Ding Huihui,&nbsp;Luo Aiwu","doi":"10.1016/j.phyplu.2025.100837","DOIUrl":"10.1016/j.phyplu.2025.100837","url":null,"abstract":"<div><div>Viral pneumonia is mainly caused by lung inflammation caused by viral infection, and respiratory syncytial virus pneumonia and adenovirus pneumonia are commonly seen in clinical practice. Ma-xing-shi-gan-tang (MXSGT) is a traditional Chinese herbal formula, and many researchers have confirmed its therapeutic effect on viral pneumonia. However, the mechanism of treating viral pneumonia still needs to be elucidated. In this study, network pharmacology has been used to explore the therapeutic effects and therapeutic targets of MXSGT and bioactive compounds. Initially, 143 active proteins and 689 ways of interaction between active proteins were identified through the MXSGT-compound-target and the target protein-protein interaction network. KEGG enrichment analysis revealed 27 signal pathways (<em>P</em> &lt; 0.05), covering the HIF-1α signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway, and Toll-like receptor signaling pathway. Through biological experiments, it has been confirmed that compared with the mice of viral pneumonia, the lung index of the MXSGT group is significantly reduced, and the content of inflammatory factors in lung tissue is reduced considerably. MXSGT may exert therapeutic effects on viral pneumonia by inhibiting the PI3K/Akt/HIF-1α pathway.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100837"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights of Terminalia citrina (Gaertn.) Roxb. Ex Fleming inhibiting multidrug resistant Acinetobacter baumannii","authors":"Nevia Longjam ,&nbsp;Romen Meitei Lourembam ,&nbsp;Jobina Rajkumari ,&nbsp;Sadokpam Shreekant ,&nbsp;Sushmita Bhattacharya ,&nbsp;Amit Kar ,&nbsp;Sushil Kumar Chaudhary ,&nbsp;Sulagna Basu ,&nbsp;Sarita Jena ,&nbsp;Shantibhusan Senapati ,&nbsp;Pulok Kumar Mukherjee ,&nbsp;Sarangthem Indira Devi","doi":"10.1016/j.phyplu.2025.100840","DOIUrl":"10.1016/j.phyplu.2025.100840","url":null,"abstract":"<div><h3>Background</h3><div>The Northeast region of India is renowned for its rich biodiversity and unique flora, including many plants with unstudied medicinal properties<em>. Terminalia citrina</em> is a medicinal plant traditionally used to treat chronic fever, loss of appetite, diarrhoea, asthma, boils, dizziness, haemorrhoids, anaemia, eye diseases, and infections. This study highlights potential bioactive compounds of <em>T. citrina</em> with antimicrobial activity against sepsis-causing pathogens, specifically <em>Acinetobacter baumannii</em> isolates, and presents the toxicity studies conducted on an animal model.</div></div><div><h3>Purpose</h3><div>The study focused on validating the traditional use of medicinal plants for treating microbial infections and assessing their toxicity in an animal model.</div></div><div><h3>Methods</h3><div><em>T. citrina</em> plant species were collected and evaluated for antimicrobial activity against sepsis causing MDR pathogens <em>Acinetobacter baumannii, Klebsiella pneumoniae</em>, and <em>Escherichia coli</em>. The bioactive metabolites were identified using liquid chromatography–mass spectrometry (LC-MS). The <em>in-vitro</em> cytotoxicity of the active fraction was assessed using the MTT assay on the Caco-2 cell line followed by <em>in-vivo</em> toxicity study in BALB/c mice.</div></div><div><h3>Results</h3><div>The crude extract of <em>T. citrina</em>, obtained using a hydroalcoholic solvent, inhibited the growth of <em>A. baumannii</em> isolates AB0014, AB0015, and AB0018. LC-MS analysis identified five metabolites in the EM2 subfraction of <em>T. citrina</em>. The MTT assay demonstrated no cytotoxic effects on the Caco-2 cell line. Treatment of <em>A. baumannii</em> isolate AB0014 with the EM2 subfraction of <em>T. citrina</em> at 2.82 mg/mL altered cellular morphology, causing cell shrinkage and growth inhibition. Acute and subacute oral toxicity studies of <em>T. citrina</em> (EM2) showed no signs of toxicity or behavioural changes.</div></div><div><h3>Conclusion</h3><div><em>T. citrina</em> found in Manipur, India, exhibited antimicrobial activity on MDR <em>A. baumannii</em> clinical isolates. The presence of phenolic compounds -in <em>T. citrina</em> (EM2) may be attributed to the antimicrobial activity. The <em>T. citrina</em> active fraction (EM2) may be an alternative candidate for developing a new drug for managing sepsis.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100840"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Documentation of folk-medicinal uses of fruit tree species by the indigenous communities of Sikkim Himalayas","authors":"Sudip Kumar Dutta ,&nbsp;Prakash Chettri ,&nbsp;VK Mishra","doi":"10.1016/j.phyplu.2025.100838","DOIUrl":"10.1016/j.phyplu.2025.100838","url":null,"abstract":"<div><h3>Background</h3><div>Sikkim is one of the Himalayan states in India and the only fully organic state in the country. Despite being a hotspot for biodiversity worldwide, it has received comparatively limited research. Indigenous people of the state place a great value on the edible wild fruit plants, which are also a significant source of ethnomedicine.</div></div><div><h3>Aim</h3><div>The aim of the current study, conducted from 2021 to 2024, was to document the wild edible fruits of the Indian state of Sikkim and their socioeconomic significance among rural communities, as well as their ethnomedical uses.</div></div><div><h3>Methods</h3><div>A total of 76 people from 23 villages, spanning a range of age groups (45–75 years), with both male and female respondents, were interviewed.</div></div><div><h3>Results</h3><div>There were a total of 59 fruit species found, representing 48 genera and 32 families. Numerous illnesses, including stomach issues (dysentery, diarrhea, ulcers, vomiting, and constipation), fever, bronchitis, diabetes, jaundice, toothaches, anemia, swellings, skin conditions, bone fractures, itching, conjunctivitis, viral diseases, urinary diseases, tuberculosis, heart conditions, and many more, can be cured by these wild edible fruits that grow locally. Numerous other researchers worldwide, and in the northeastern Himalayan region specifically, have reported similar findings. Among all the families, Rosaceae accounted for the maximum with a total of 14 % of total of genera, followed by Moraceae (12 %), Rutaceae (8 %), Anacardiaceae (7 %), Combretaceae (5 %) and Elaeagenaceae, Fabaceae, Lauraceae, Myrtaceae, Rubiaceae (3 % each). In terms of the fruits' socioeconomic value, the majority of wild fruits are used in rural areas for traditional medicine, firewood, house construction, animal feed, and charcoal. The majority of these fruits can be purchased in the neighborhood market for between Rs. 60 and Rs. 300 per kilogram.</div></div><div><h3>Conclusions</h3><div>It is recommended that the great variety of edible wild fruit plants be preserved for use in the future. Certain species can be cultivated on marginal soils with little agricultural value and in conventional agroforestry systems. Despite their many applications, these fruits have not yet received adequate documentation. Therefore, it is crucial to record these priceless species before they go extinct.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100838"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition and medicinal applications of Citrus essential oils: Current insights and future perspectives","authors":"Farah Aprisza Sheelmarevaa ,&nbsp;Pramesthi Reitza Navisya Vasall ,&nbsp;Nandang Permadi ,&nbsp;Asep Harja ,&nbsp;Sarifah Nurjanah ,&nbsp;Jamaludin Al-Anshori ,&nbsp;Euis Julaeha","doi":"10.1016/j.phyplu.2025.100836","DOIUrl":"10.1016/j.phyplu.2025.100836","url":null,"abstract":"<div><div><em>Citrus</em> essential oils (CEOs) are volatile aromatic compounds derived from various plant structures, such as peels, leaves, flowers, and seeds, with unique chemical compositions influenced by species, climate, and extraction methods. CEOs, rich in terpenes and terpenoids, exhibit diverse biological activities, including antimicrobial, antioxidant, and anti-inflammatory properties. These oils have shown significant potential in combating infectious diseases and preserving food, alongside applications in the pharmaceutical, cosmetic, and perfume industries. This review summarizes current knowledge on CEOs' using PRISMA methodology focusing in chemical composition and biological activities, emphasizing their medicinal applications, such as anticancer and antimicrobial activities, and the mechanisms underlying their effects. In addition, it evaluates the benefits and challenges of their use in modern medical settings, highlighting their potential as natural agents for enhancing public health.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100836"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the acute and subacute toxicity of Lepidium sativum L. seed extract on Wistar rats","authors":"Teshome Gebremeskel Aragie ,&nbsp;Kaleab Asres ,&nbsp;Wondwossen Ergete ,&nbsp;Samual Woldekidan ,&nbsp;Sileshi Degu ,&nbsp;Abiy Abebe ,&nbsp;Bihonegn Sisay ,&nbsp;Eyob Debebe ,&nbsp;Girma Seyoum","doi":"10.1016/j.phyplu.2025.100835","DOIUrl":"10.1016/j.phyplu.2025.100835","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Lepidium sativum L</em>., commonly known as garden cress, is a well-known medicinal plant used in many low- and middle-income communities for their primary healthcare. In Ethiopia, <em>L. sativum</em> seed is traditionally used to address various health issues; however, its safety profile has not yet been thoroughly investigated. Therefore, this study aimed to evaluate the acute and subacute toxicity of <em>Lepidium sativum</em> seed extract in Wistar rats.</div></div><div><h3>Methods</h3><div>An acute toxicity study was conducted in female Wistar albino rats that were administered in a single oral dose and followed for 14 days. Sub-acute oral toxicity study was conducted in rats of both sexes using a 28-day oral toxicity study model. Observations of the animals were performed regularly during the study period, and body weight was measured weekly. Finally, organ weight and histopathology, hematology, and clinical chemistry data were collected on the 29th day. One-way analysis of variance (ANOVA) was conducted, and the results are presented as mean ± standard deviation. Significance was declared at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Rats treated with 500 mg/kg and 1000 mg/kg of <em>L. sativum</em> seed extract showed significant signs of toxicity, such as diarrhea, decreased movement, and piloerection. The extract caused significant hepatic enlargement in both sexes in the 1000 mg/kg extract-treated groups. Elevation of liver enzymes with associated histopathological derangements of the liver was observed in both sexes in the 1000 mg/kg treatment groups.</div></div><div><h3>Conclusion</h3><div>The acute toxicity study of 70 % ethanol extract of <em>L. sativum</em> seeds did not result in mortality among rats at the administered doses. Therefore, the LD₅₀ value of the extract was estimated to exceed 5000 mg/kg, categorizing it as practically non-toxic (GHS Category 5). However, the subacute toxicity study revealed detrimental effects on liver histopathology, clinical chemistry, and hematologic parameters at the 500 mg/kg and 1000 mg/kg doses tested.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100835"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine (Shenqinlong Qingfei Peiyuan) alleviate pulmonary infection in immunodeficient mice by suppressing HMGB1 and reversing macrophage polarization","authors":"Meijun Liu ,&nbsp;Xiyuan Song ,&nbsp;Xiaoli Chen ,&nbsp;Pengfei Meng ,&nbsp;Qian Yu ,&nbsp;Liran Xu ,&nbsp;Aiping Lyu ,&nbsp;Kenneth CP Cheung","doi":"10.1016/j.phyplu.2025.100826","DOIUrl":"10.1016/j.phyplu.2025.100826","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary infections are a significant concern for HIV/AIDS patients, and the role of macrophage polarization is critical in this context. <em>Shenqinlong Qingfei Peiyuan Granules</em> (QFPY) have been reported to alleviate symptoms of these infections. This study aims to explore the mechanisms through which QFPY reduces lung infections by regulating macrophage polarization.</div></div><div><h3>Methods</h3><div>We developed an immunocompromised mouse model using Balb/c mice, simulating HIV infection by inoculating them with <em>Friend Leukemia Virus</em> (FLV, VR-245). Pulmonary infection was induced by nasal administration of <em>Streptococcus pneumoniae Type III</em> (ATCC 49619). The mice received QFPY treatment for 14 days. Post-treatment, we collected thymus, spleen, and lung tissue samples. T lymphocyte counts (CD3+, CD4+, and CD8+) were measured, and CD86 and CD163 expressions in bronchoalveolar lavage fluid (BALF) from lung tissue were assessed using flow cytometry. Cytokine levels, including IL-1β, TNF-α, TGF-β1, and IL-10, were evaluated using enzyme-linked immunosorbent assay (ELISA). Additionally, HMGB1 mRNA and protein levels were measured using quantitative PCR (qPCR) and Western blot techniques.</div></div><div><h3>Results</h3><div>QFPY treatment showed efficacy comparable to the current standard treatment for lung infections, <em>levofloxacin tablets</em> (LEV). In our immunocompromised mouse model, QFPY treatment reversed thymus shrinkage, reduced spleen swelling, increased T cell counts, and inhibited M1 macrophage polarization. These effects were achieved by suppressing the expression of HMGB1.</div></div><div><h3>Conclusions</h3><div>QFPY effectively restored immune homeostasis and reduced inflammation in HIV/AIDS-related pulmonary infections by modulating HMGB1 expression.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer","authors":"Meysam Hosseinzadeh ,&nbsp;Hassan Bazvand ,&nbsp;Ehsan Gravand ,&nbsp;Mohammad Hossein Pourhanifeh","doi":"10.1016/j.phyplu.2025.100827","DOIUrl":"10.1016/j.phyplu.2025.100827","url":null,"abstract":"<div><div>Periodontal disease and oral cancer are major global health issues, with periodontitis leading to tooth loss and linked to systemic diseases. Oral squamous cell carcinoma (OSCC), a leading cause of morbidity and mortality, is strongly associated with risk factors such as poor oral hygiene, smoking, and alcohol consumption. There is a connection between these conditions, as periodontal disease may elevate the risk of oral cancer through chronic inflammation and microbial dysbiosis. Ginsenosides, bioactive compounds found in ginseng, show promise for their therapeutic effects on both conditions. These saponins possess anti-inflammatory, antioxidant, and anticancer properties, and recent studies indicate they can modulate immune responses, inhibit tumor growth, and lower inflammatory markers in periodontitis by suppressing pro-inflammatory cytokines like IL-6 and TNF-α. This review discusses the therapeutic potential of ginsenosides in treating periodontitis and oral cancer, focusing on the underlying mechanisms.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100827"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of materia medica in the primary healthcare needs and managing livestock diseases among the Batswana in South Africa","authors":"John A. Asong ,&nbsp;Madeleen Struwig ,&nbsp;Morris M. Lebekwa ,&nbsp;Adeyemi O. Aremu","doi":"10.1016/j.phyplu.2025.100834","DOIUrl":"10.1016/j.phyplu.2025.100834","url":null,"abstract":"<div><h3>Background</h3><div>The Batswana descended mainly from Bantu-speaking tribes and regarded as an indigenous group in Southern Africa. Among this native group, medicinal plants play key roles for their primary healthcare needs and general well-being as well as managing livestock diseases.</div></div><div><h3>Purpose</h3><div>This study documented the ethnobotanical knowledge of medicinal plants used by the Batswana for managing their healthcare needs and livestock diseases in Mahikeng Local Municipality, South Africa.</div></div><div><h3>Methods</h3><div>A total of 128 participants comprising traditional healers and community members from 28 of the 35 wards in Mahikeng Local Municipality were interviewed, using semi-structured questionnaires. Ethnobotanical data including the local names, plant parts used, method of preparation and administration of the identified plants were documented. The data was analysed using relative frequency of citation (RFC) and use-value (UV).</div></div><div><h3>Results</h3><div>We recorded 100 plants representing 40 families used for alleviating 74 health problems affecting humans and livestock. The commonly treated health issues were dermatological (39 %), gastrointestinal (18 %) and respiratory (16 %) diseases. A total of 34 plants were used for treating diseases in humans and livestock. Based on the RFC values, the dominant plants were <em>Hypoxis hemerocallidea</em> Fisch.C. A Mey &amp; Ave (0.73), <em>Entada elephantina</em> (Burch.) S.A.O’Donell &amp; G.P. Lewis (0.66), <em>Helichrysum paronychioides</em> DC. Humbert (0.63) and <em>Drimia sanguinea</em> (Schinz) Jessop (0.63). In terms of UV, the top-ranked plants were <em>Hypoxis hemerocallidea</em> (0.18) and <em>Entada elephantina</em> (0.13). The dominant parts used for making herbal recipes were the leaves (27 %), roots (24 %) and whole plants (22 %).</div></div><div><h3>Conclusion</h3><div>The high number of plants recorded highlights the value and dependence on botanicals in folklore medicine among the Batswana. The current endeavour was vital towards preventing the erosion of important traditional knowledge and applications for the benefit of the present and future generations as well as potential downstream applications in the pharmaceutical and nutraceutical industries.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100834"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diosgenin mitigates oxidative stress and inflammation within the hepatorenal system associated with epilepsy and alcohol use disorders in murine models","authors":"Emmanuel O. Chidebe ,&nbsp;Benneth Ben-Azu ,&nbsp;Benjamin Oritsemuelebi ,&nbsp;Emuesiri G Moke ,&nbsp;Itivere A. Omogbiya ,&nbsp;Theresa Ezedom","doi":"10.1016/j.phyplu.2025.100833","DOIUrl":"10.1016/j.phyplu.2025.100833","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between alcohol consumption, multiorgan dysfunction and seizures is still largely unexplored. Diosgenin is a naturally occurring phytosteroid with diverse therapeutic benefits. This study aims to investigate the effects of diosgenin on liver and kidney (hepatorenal) oxidative stress following ethanol-exacerbated pentylenetetrazol-induced seizures.</div></div><div><h3>Methods</h3><div>Adult mice were randomly divided into groups, and administered diosgenin (25 and 50 mg/kg, p.o.) or diazepam (3 mg/kg, p.o.) concurrently with maximal and sub-convulsive pentylenetetrazol-induced seizures from days 8–14, after first 7 days of binge ethanol (2 g/kg, oral gavage) administration. The influence of ethanol on pentylenetetrazol-induced seizures was determined in the liver and kidney tissues, along with oxidative stress and inflammatory enzyme markers.</div></div><div><h3>Results</h3><div>Ethanol-exacerbated pentylenetetrazol-induced seizures mediate a significant increase in hepatic and kidney levels of oxidative stress, evidenced by a reduced antioxidant system (glutathione, catalase, superoxide dismutase, glutathione-transferase) and increased lipid peroxidation, marked by elevated malondialdehyde concentration compared to the control groups. This was also associated with increased myeloperoxidase activity, a marker of neutrophil infiltration, and increased weights of the liver, kidney, and adrenal. However, diosgenin increased the latency to seizures, as well as increased glutathione, catalase, superoxide dismutase, and glutathione transferase in the mice.</div></div><div><h3>Conclusion</h3><div>Diosgenin reduced liver and kidney oxidative stress and inflammation, suggesting protective effects in ethanol-exacerbated pentylenetetrazol-induced seizures.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100833"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}