Phytomedicine Plus最新文献

{"title":"Variability in bioactive compounds, antioxidant activity, and cytotoxicity assessment of diverse organs of Iranian oak (Quercus brantii Lindl.)","authors":"Farzaneh Shakuri ,&nbsp;Ghasem Eghlima ,&nbsp;Hossein Behboudi","doi":"10.1016/j.phyplu.2025.100859","DOIUrl":"10.1016/j.phyplu.2025.100859","url":null,"abstract":"<div><div>The genus <em>Quercus</em> with over 1000 species is extensively dispersed throughout the temperate woodlands of the Northern Hemisphere and tropical climate zones. Numerous physiological functions, such as antibacterial, anti-inflammatory, liver-protective, gastroprotective, anticancer, antidiabetic, and antioxidant activities, have been documented and associated with the occurrence of bioactive compounds like phenolic acids, triterpenoids, and plant-based polyphenolic compounds. Given that different plant organs differ in terms of secondary metabolite production, this aim was to investigate the diversity of phytochemical compounds, antioxidant activity, and cytotoxicity of different parts of oak and its by-products. Total phenolic content varied between 50.4 to 125.3 mg GAE/g DW, with the maximum and minimum being in the gall and leaf. Fruit had the highest (68.3 mg RE/g DW) and the lowest (13.5) total flavonoid content in the gaz alafi. The highest (74.9 mg GAE/g DW) and minimum (8.9 mg GAE/g DW) total tannin were observed in the gall and gaz alafi, respectively. Gallic acid, salicylic acid, rosmarinic acid, 2,5-dihydroxybenzoic acid, chlorogenic acid, rutin, quercetin, caffeic acid, <em>p</em>-coumaric acid, and kaempferol were identified as the main phenolic compounds by HPLC-PDA analysis. Based on the results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, no significant cytotoxicity was observed on normal cell line (HDF) and gastric cancer cells (MKN45). This study shows that different parts of oak and its by-products can be valuable sources of bioactive compounds and can be used in various therapeutic and industrial applications.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100859"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coumarins in traditional medicine: Bridging ancient wisdom and scientific progress","authors":"Yasser Fakri Mustafa","doi":"10.1016/j.phyplu.2025.100857","DOIUrl":"10.1016/j.phyplu.2025.100857","url":null,"abstract":"<div><div>Coumarins are a diverse group of naturally occurring compounds long recognized in traditional medicine for their broad therapeutic potential. This narrative review explores their journey from ancient healing traditions—such as Ayurveda, Traditional Chinese Medicine, and various indigenous systems—to their contemporary biomedical relevance. Widely distributed in medicinal plants, coumarins have historically been used to treat inflammation, microbial infections, and oxidative stress-related conditions. These traditional applications are increasingly supported by modern pharmacological evidence. Structurally, coumarins exhibit significant chemical diversity, enabling a wide range of bioactivities, including anti-inflammatory, antioxidant, antimicrobial, and anticoagulant effects. Moreover, this review highlights how ancient practices effectively utilized these bioactive properties, many of which are now validated through experimental and clinical studies. On the other hand, advances in extraction methods, synthetic modifications, and drug delivery systems have improved the pharmacokinetic profiles and expanded the potential uses of coumarins. Despite their promise, safety concerns, particularly hepatotoxicity and dose-dependent effects, must be addressed to ensure clinical relevance. While natural coumarins generally display a favorable therapeutic index, synthetic derivatives require careful evaluation. Finally, this review aims to systematically explore the historical applications, pharmacological relevance, and therapeutic integration of coumarins in traditional medicine, while addressing their potential translational value in modern pharmacology. Bridging ethnopharmacological wisdom with contemporary science, coumarins emerge as promising candidates for integrative drug development. Their potential roles in treating neglected diseases and interacting synergistically with other agents warrant further exploration.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100857"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of Cyperus rotundus L. as a natural hair removal agent: A review of traditional and modern applications","authors":"Ghada Farouk Mohammed ,&nbsp;Mohammed Saleh Al-Dhubaibi ,&nbsp;Saleh Salem Bahaj ,&nbsp;Ahmed Ibrahim AbdElneam ,&nbsp;Ahmed Mohammed Al-Dhubaibi ,&nbsp;Lina Mohammed Atef","doi":"10.1016/j.phyplu.2025.100854","DOIUrl":"10.1016/j.phyplu.2025.100854","url":null,"abstract":"<div><h3>Introduction</h3><div>Hair removal is a fundamental aspect of daily life, with various hair removal methods evolving throughout hair removal history to meet cultural, aesthetic, and spiritual needs. Traditional hair removal practices have long sought effective hair removal products that not only remove hair but also promote skin health. <em>Cyperus</em> rotundus L<em>.</em> (<em>C</em>r L.), known as nut grass or purple nut sedge, has long been used in traditional medicinal systems like Ayurveda and Traditional Chinese Medicine (TCM) for treating various ailments, including skin conditions and depilation.</div></div><div><h3>Aim</h3><div>to understand the role of <em>C</em>r L. in decreasing hair growth.</div></div><div><h3>Results</h3><div><em>C</em>r L. contains essential oils (EOs) and phytochemicals such as flavonoids, alkaloids, and saponins, which contribute to its hair-removal properties. These compounds target hair follicles, dissolve keratin, and inhibit hair regrowth by modulating biological pathways. γ-curcumene, a key component, has been shown to suppress hair growth. Recent clinical trials have demonstrated the efficacy of <em>Cyperus</em> rotundus essential oil (CREO) in reducing hair growth, with minimal side effects. CREO has been found as effective as Alexandrite laser treatments in some cases, particularly in reducing white hair. This positions <em>C</em>r L. as a promising natural alternative to chemical depilatories, which often cause skin irritation.</div></div><div><h3>Conclusion</h3><div><em>C</em>r L. shows significant potential as a natural hair removal agent. With its strong safety profile and growing consumer demand for natural, sustainable beauty products, <em>C</em>r L. could serve as a viable alternative to synthetic depilatories, pending further clinical validation.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100854"},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and biochemical responses in Wistar rats treated with extracts from a hyperglycemia and diabetes-associated therapeutic Hensia crinita","authors":"Iwara A. Iwara ,&nbsp;Oju R. Ibor ,&nbsp;Eve Mboso ,&nbsp;Eyong Ubana Eyong ,&nbsp;Augustine Arukwe","doi":"10.1016/j.phyplu.2025.100849","DOIUrl":"10.1016/j.phyplu.2025.100849","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes, marked by insulin resistance, disrupts metabolic processes and causes significant complications. Herbal remedies are increasingly recognized for their potential in diabetes management, particularly in developing countries.</div></div><div><h3>Purpose</h3><div>To study the effects of <em>Hensia crinita</em> (<em>H. crinita</em>) extract on hyperglycemia and related therapeutic responses in Wistar rats.</div></div><div><h3>Methods</h3><div>Type 2 diabetes was induced with 10% fructose diet and 40 mg/kg streptozotocin (STZ). Thereafter, diabetic rats were treated with <em>H. crinita</em> leaf extracts at 200 and 400 mg/kg body weight, twice daily for 21 days. We used metformin (MET: 500 mg/kg body weight) treated rats as a positive control group.</div></div><div><h3>Results</h3><div>Our results showed that <em>H. crinita</em> extract significantly lowered fasting blood glucose (FBG) levels and increased body weight in diabetic rats. Molecular analysis revealed reductions in mRNA expression for insulin-responsive glucose transporter (<em>ir-glut</em>), <em>leptin</em>, proprotein convertase subtilisin/kexin type 9 (<em>pcsk9</em>), cardiac troponin (<em>crt</em>), estrogen receptor 1 (<em>esr-1</em>), fatty acid synthase (<em>fasn</em>) and melatonin (mt) in treated rats, compared to controls. Furthermore, hepatic biochemical analysis showed that AST, ALT, ALP and γ-GGT increased in diabetic control animal and <em>H. crinita</em> produced decreases that paralleled melatonin effects. Additionally, <em>H. crinita</em> treatment increased plasma estradiol (E2) and testosterone (T) levels and significantly reduced inflammatory markers, and these responses were comparable to MET effects.</div></div><div><h3>Conclusion</h3><div>These findings suggest that <em>H. crinita</em> exerts anti-hyperglycemic effects by modulating inflammation, hormonal balance, and key glucose metabolic enzymes, representing a potential therapeutic agent for diabetes treatment.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100849"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of traditional medicinal plants in cancer therapy: present efficacy and future directions","authors":"Adfar Reyaz,&nbsp;Syed Sanober Qadri,&nbsp;Darakhshan Javaid,&nbsp;Shahid Yousuf Ganie,&nbsp;Mohd Salim Reshi","doi":"10.1016/j.phyplu.2025.100845","DOIUrl":"10.1016/j.phyplu.2025.100845","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the advancements in modern medicine, phytotherapy remains popular due to their cultural significance, effectiveness, and lower costs. This review focuses on the potential of medicinal plants and plant metabolites in treating cancer, examining their mechanisms of action and therapeutic uses. Key findings reveal that phytochemicals such as quercetin, curcumin, and sanguinarine exhibit anticancer properties by targeting signalling pathways like JAK/STAT, ERK/MAPK, and p53, as well as inducing apoptosis and inhibiting metastasis. Furthermore, emerging evidence underscores their potential to enhance the efficacy of conventional treatments and reduce associated side effects.</div></div><div><h3>Methodology</h3><div>A detailed search on Scopus, PubMed, Medline, PubChem, Google Scholar, and Academic Search Premier was conducted for this review, using a strategy with keywords such as traditional plants, herbal medicine, and herbs in varying combinations</div></div><div><h3>Conclusion</h3><div>Phytotherapy in cancer treatment shows promise by enhancing therapy effectiveness and reducing side effects. Integrating traditional medicinal plants into modern care could offer personalized, safer treatment options. This review stands out by not only classifying the anticancer properties of phytochemicals but also by delving into their molecular mechanisms, and the challenges of standardization and regulatory oversight. By addressing these gaps, it provides a comprehensive framework for advancing phytotherapy in cancer treatment.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100845"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive regulation of Danggui-Shaoyao-San and its active constituent PGG on puromycin aminonucleoside induced nephrotic syndrome in rats","authors":"Zaiping Xu ,&nbsp;Ye Feng ,&nbsp;Mo Yang ,&nbsp;Wenxin Zhang ,&nbsp;Kun Zhang ,&nbsp;Fan Xu ,&nbsp;Yunlai Wang","doi":"10.1016/j.phyplu.2025.100844","DOIUrl":"10.1016/j.phyplu.2025.100844","url":null,"abstract":"<div><div>Background: Danggui-Shaoyao-San (DSS) is a classic Chinese compound prescription that has been proven to be effective in treating nephrotic syndrome (NS) in both clinical trials and animal experiments. This study aimed to reveal the mechanism of action of DSS and one of its main constituents, 1,2,3,4,6-O-pentagalloylglucose (PGG), in protecting the kidney through multiple pathways. Methods: In vivo, we used TUNEL assay, western blotting, real-time quantitative PCR, and immunofluorescence to further confirm the regulatory effects of these interventions on apoptosis, podocyte structure and oedema-related proteins in renal tissue. Results: The results of animal experiments showed that DSS effectively alleviated NS. In different combinations, the blood-associated herbs group and PGG decreased the plasminogen related indicators. Molecular mechanism studies revealed that DSS improved the fusion of podocyte foot processes and inhibited renal cell apoptosis. Furthermore, DSS and PGG were confirmed to have improving effects on sodium transporter related proteins and aquaporin 2. Conclusions: These results demonstrate that DSS can alleviate NS by inhibiting apoptosis, ameliorating podocyte injury and possibly reducing sodium and water retention via plasminogen and that its active constituent PGG has a special effect on plasminogen-epithelial Na⁺ channel, which provides a potential candidate for the treatment of NS.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100844"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of coriander components linalool and geranyl acetate on stress-related neuroendocrine and behavioral measures in adult zebrafish (Danio rerio)","authors":"Maureen L. Petrunich-Rutherford","doi":"10.1016/j.phyplu.2025.100843","DOIUrl":"10.1016/j.phyplu.2025.100843","url":null,"abstract":"<div><div>Herbal medicines and their components represent an area rich for exploration, especially in the context of managing conditions like anxiety. Previous literature has indicated that extracts of the coriander (<em>Coriandrum sativum</em>) plant may have significant anxiolytic potential. However, it is currently unclear how the individual phytochemical components of coriander regulate anxiety-like behavior and stress axis activity. In the current study, coriander components linalool or geranyl acetate, or control (system water) were acutely administered to adult zebrafish for 1 h; subsequently, subjects were tested for anxiety-like behavior and motor activity in the novel tank test. To explore the potential impact of coriander components on stress axis regulation, baseline levels of cortisol were also determined from whole-body extracts. It was expected that linalool and geranyl acetate would reduce anxiety-like behavior and decrease levels of whole-body cortisol compared to control. Neither of the coriander components tested had a significant impact on exploratory and freezing behavior; however, linalool did significantly depress motor activity compared to control. There was no significant effect of either component on baseline levels of cortisol. Additional studies are needed to determine the contribution of specific coriander constituents to the regulation of anxiety-like behaviors. This information would provide support for clinical investigations into herbal medicines and their phytochemical constituents in the treatment of anxiety and other stress-related conditions.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100843"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacological survey of Rwandese medicinal plants used for respiratory infections. Effect of Senecio maranguensis extract against respiratory syncytial virus","authors":"Colores Uwamariya ,&nbsp;Jackson T. Mollel ,&nbsp;Farshid M. Rad ,&nbsp;Wouter A. Remmerswaal ,&nbsp;Joanna Said ,&nbsp;Charles Hannoun ,&nbsp;Masum Miah ,&nbsp;Ambjörn Kärmander ,&nbsp;Daniel Umereweneza ,&nbsp;Théoneste Muhizi ,&nbsp;Eric Seruyange ,&nbsp;Emile Bienvenu ,&nbsp;Tomas Bergström ,&nbsp;Edward Trybala","doi":"10.1016/j.phyplu.2025.100842","DOIUrl":"10.1016/j.phyplu.2025.100842","url":null,"abstract":"<div><h3>Background</h3><div>The knowledge of traditional health practitioners (THPs) on the use of medicinal plant remedies for treatment of human respiratory ailments provides a potential resource for identification of relevant plants and isolation of active ingredients.</div></div><div><h3>Purpose</h3><div>We aimed to identify medicinal plants used by THPs for treatment of respiratory ailments, then screen them in cultured cells for activity against respiratory syncytial virus (RSV), and assess the antiviral potential of identified screening hits.</div></div><div><h3>Methods</h3><div>Forty Rwandese THPs were interviewed to identify medicinal plants used for treatment of respiratory ailments. The indicated plant samples were collected and successively extracted using <em>n</em>-hexane, ethyl acetate, methanol, and water. Extracts were screened for anti-RSV activity and for cytotoxicity in HEp-2 cells.</div></div><div><h3>Results</h3><div>Based on ethnopharmacological survey of THPs, 48 plants used for treating respiratory ailments were identified. Of 203 plant extracts prepared for screening, ten methanolic and four aqueous extracts exhibited anti-RSV activity, manifested by EC₅₀ values ranging from 1.6 to 39.5 µg/ml and selectivity indices (SI, CC₅₀/EC₅₀) of 12–294. Extended studies of an anti-RSV potential of methanolic extract of <em>Senecio maranguensis</em> O. Hoffm. leaves revealed that this preparation targeted the virus fusion (F) protein because extract resistant virus variants carried the double nucleotide substitution at c1104t and a1105g resulting in the T335M amino acid change in the F protein trimer internal cavity.</div></div><div><h3>Conclusion</h3><div>We found that eleven plants, traditionally used against respiratory ailments, exhibited substantial anti-RSV activity in cultured cells, exemplified by the <em>S. maranguensis</em> methanolic extract that affected the activity of RSV F protein.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100842"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting mitochondrial biogenesis: Chandraprabha Vati in the management of metabolic syndrome","authors":"Prashant Dongre,&nbsp;Anuradha Majumdar","doi":"10.1016/j.phyplu.2025.100841","DOIUrl":"10.1016/j.phyplu.2025.100841","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic Syndrome (MetS) is an assortment of indications like obesity, dyslipidemia, and hyperglycemia, often linked to glucose intolerance, mitochondrial dysfunction, and low-grade inflammation. <em>Chandraprabha Vati</em> (CPV) is an Ayurvedic herbo-mineral formulation known for its antihyperglycemic and antilipidemic properties.</div></div><div><h3>Objectives</h3><div>To compare CPV's impacts alongside the hypoglycemic effects of metformin and the lipid-lowering effects of fenofibrate, in addition to evaluating CPV's capability to improve MetS-associated complications by promoting mitochondrial biogenesis.</div></div><div><h3>Materials and Methods</h3><div>After ten weeks of a high-fat diet with 10 % fructose (HFFD), Sprague-Dawley (SD) rats resembling the condition of MetS. Later, followed by CPV treatment (p.o.) for five weeks treatment with CPV. The study evaluated the effects of the interventions on anthropometric parameters, lipid profile, serum insulin, and levels of inflammatory markers such as TNF-α and IL-6. Furthermore, it evaluated the expression of genes related to inflammation and mitochondrial function, like NOD-like receptor protein 3 (NLRP3), caspase-1, mitochondrial transcription factor A (TFAM), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α).</div></div><div><h3>Result</h3><div><strong>:</strong> Compared to the disease control group, CPV at 100 mg/kg showed a significant reduction in body weight and improvements in anthropometric parameters, glucose tolerance, lipid profiles, and insulin sensitivity. The serum levels of inflammatory cytokines TNF-α and IL-6 were markedly decreased. CPV treatment upregulated the mRNA expression of mitochondrial biogenesis markers TFAM and PGC-1α while significantly downregulating inflammasomes such as caspase-1 and NLRP3 in cardiac, liver, and skeletal muscle tissues.</div></div><div><h3>Conclusion</h3><div>CPV could effectively combat mitochondrial dysfunction and chronic low-grade inflammation associated with MetS in rats.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100841"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The commercial availability of plant-based phytochemical components used in GLP-1 inhibition for the treatment of type-2 diabetes","authors":"Sharanjeet Kour ,&nbsp;Sanjeev Singh","doi":"10.1016/j.phyplu.2025.100825","DOIUrl":"10.1016/j.phyplu.2025.100825","url":null,"abstract":"<div><h3>Aim of the study</h3><div>The objective of this review is to evaluate the commercial availability and therapeutic potential of plant-based phytochemical components that enhance using GLP-1 reduction to treat type 2 diabetes. This work explores their conventional uses, pharmacological effects, and mechanisms of action in modulating GLP-1 inhibition, aiming to expand knowledge on their role in diabetes management.</div></div><div><h3>Materials and methods</h3><div>A literature review involving international and domestic databases was conducted to identify existing research on plant-based compounds that stimulate GLP-1 inhibition. Data on the availability of these formulations in the market, their ethnopharmacological applications, and their phytochemical composition were gathered and analyzed.</div></div><div><h3>Results</h3><div>The review identified several plant-derived compounds with GLP-1-stimulating properties, including berberine, curcumin, resveratrol, quercetin, and flavonoids, which have demonstrated the potential to enhance insulin secretion and improve glucose homeostasis. Many of these bioactive compounds are commercially available as herbal supplements or integrated into anti-diabetic formulations. Some formulations have shown greater efficacy and safety than others and have undergone clinical evaluations for diabetes management.</div></div><div><h3>Conclusion</h3><div>Plant-based GLP-1 inhibition offers promising alternatives for type 2 diabetes treatment. However, challenges such as phytochemical variability, extraction complexity, low bioavailability, and stability issues hinder their synthesis and large-scale production. Advanced techniques are required to enhance formulation, standardization, and commercialization. Addressing these challenges is essential to ensuring consistency, efficacy, and broader application, particularly in resource-limited settings.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100825"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}