Phytomedicine Plus最新文献

{"title":"Comprehensive regulation of Danggui-Shaoyao-San and its active constituent PGG on puromycin aminonucleoside induced nephrotic syndrome in rats","authors":"Zaiping Xu ,&nbsp;Ye Feng ,&nbsp;Mo Yang ,&nbsp;Wenxin Zhang ,&nbsp;Kun Zhang ,&nbsp;Fan Xu ,&nbsp;Yunlai Wang","doi":"10.1016/j.phyplu.2025.100844","DOIUrl":"10.1016/j.phyplu.2025.100844","url":null,"abstract":"<div><div>Background: Danggui-Shaoyao-San (DSS) is a classic Chinese compound prescription that has been proven to be effective in treating nephrotic syndrome (NS) in both clinical trials and animal experiments. This study aimed to reveal the mechanism of action of DSS and one of its main constituents, 1,2,3,4,6-O-pentagalloylglucose (PGG), in protecting the kidney through multiple pathways. Methods: In vivo, we used TUNEL assay, western blotting, real-time quantitative PCR, and immunofluorescence to further confirm the regulatory effects of these interventions on apoptosis, podocyte structure and oedema-related proteins in renal tissue. Results: The results of animal experiments showed that DSS effectively alleviated NS. In different combinations, the blood-associated herbs group and PGG decreased the plasminogen related indicators. Molecular mechanism studies revealed that DSS improved the fusion of podocyte foot processes and inhibited renal cell apoptosis. Furthermore, DSS and PGG were confirmed to have improving effects on sodium transporter related proteins and aquaporin 2. Conclusions: These results demonstrate that DSS can alleviate NS by inhibiting apoptosis, ameliorating podocyte injury and possibly reducing sodium and water retention via plasminogen and that its active constituent PGG has a special effect on plasminogen-epithelial Na⁺ channel, which provides a potential candidate for the treatment of NS.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100844"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of coriander components linalool and geranyl acetate on stress-related neuroendocrine and behavioral measures in adult zebrafish (Danio rerio)","authors":"Maureen L. Petrunich-Rutherford","doi":"10.1016/j.phyplu.2025.100843","DOIUrl":"10.1016/j.phyplu.2025.100843","url":null,"abstract":"<div><div>Herbal medicines and their components represent an area rich for exploration, especially in the context of managing conditions like anxiety. Previous literature has indicated that extracts of the coriander (<em>Coriandrum sativum</em>) plant may have significant anxiolytic potential. However, it is currently unclear how the individual phytochemical components of coriander regulate anxiety-like behavior and stress axis activity. In the current study, coriander components linalool or geranyl acetate, or control (system water) were acutely administered to adult zebrafish for 1 h; subsequently, subjects were tested for anxiety-like behavior and motor activity in the novel tank test. To explore the potential impact of coriander components on stress axis regulation, baseline levels of cortisol were also determined from whole-body extracts. It was expected that linalool and geranyl acetate would reduce anxiety-like behavior and decrease levels of whole-body cortisol compared to control. Neither of the coriander components tested had a significant impact on exploratory and freezing behavior; however, linalool did significantly depress motor activity compared to control. There was no significant effect of either component on baseline levels of cortisol. Additional studies are needed to determine the contribution of specific coriander constituents to the regulation of anxiety-like behaviors. This information would provide support for clinical investigations into herbal medicines and their phytochemical constituents in the treatment of anxiety and other stress-related conditions.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100843"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacological survey of Rwandese medicinal plants used for respiratory infections. Effect of Senecio maranguensis extract against respiratory syncytial virus","authors":"Colores Uwamariya ,&nbsp;Jackson T. Mollel ,&nbsp;Farshid M. Rad ,&nbsp;Wouter A. Remmerswaal ,&nbsp;Joanna Said ,&nbsp;Charles Hannoun ,&nbsp;Masum Miah ,&nbsp;Ambjörn Kärmander ,&nbsp;Daniel Umereweneza ,&nbsp;Théoneste Muhizi ,&nbsp;Eric Seruyange ,&nbsp;Emile Bienvenu ,&nbsp;Tomas Bergström ,&nbsp;Edward Trybala","doi":"10.1016/j.phyplu.2025.100842","DOIUrl":"10.1016/j.phyplu.2025.100842","url":null,"abstract":"<div><h3>Background</h3><div>The knowledge of traditional health practitioners (THPs) on the use of medicinal plant remedies for treatment of human respiratory ailments provides a potential resource for identification of relevant plants and isolation of active ingredients.</div></div><div><h3>Purpose</h3><div>We aimed to identify medicinal plants used by THPs for treatment of respiratory ailments, then screen them in cultured cells for activity against respiratory syncytial virus (RSV), and assess the antiviral potential of identified screening hits.</div></div><div><h3>Methods</h3><div>Forty Rwandese THPs were interviewed to identify medicinal plants used for treatment of respiratory ailments. The indicated plant samples were collected and successively extracted using <em>n</em>-hexane, ethyl acetate, methanol, and water. Extracts were screened for anti-RSV activity and for cytotoxicity in HEp-2 cells.</div></div><div><h3>Results</h3><div>Based on ethnopharmacological survey of THPs, 48 plants used for treating respiratory ailments were identified. Of 203 plant extracts prepared for screening, ten methanolic and four aqueous extracts exhibited anti-RSV activity, manifested by EC₅₀ values ranging from 1.6 to 39.5 µg/ml and selectivity indices (SI, CC₅₀/EC₅₀) of 12–294. Extended studies of an anti-RSV potential of methanolic extract of <em>Senecio maranguensis</em> O. Hoffm. leaves revealed that this preparation targeted the virus fusion (F) protein because extract resistant virus variants carried the double nucleotide substitution at c1104t and a1105g resulting in the T335M amino acid change in the F protein trimer internal cavity.</div></div><div><h3>Conclusion</h3><div>We found that eleven plants, traditionally used against respiratory ailments, exhibited substantial anti-RSV activity in cultured cells, exemplified by the <em>S. maranguensis</em> methanolic extract that affected the activity of RSV F protein.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100842"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting mitochondrial biogenesis: Chandraprabha Vati in the management of metabolic syndrome","authors":"Prashant Dongre,&nbsp;Anuradha Majumdar","doi":"10.1016/j.phyplu.2025.100841","DOIUrl":"10.1016/j.phyplu.2025.100841","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic Syndrome (MetS) is an assortment of indications like obesity, dyslipidemia, and hyperglycemia, often linked to glucose intolerance, mitochondrial dysfunction, and low-grade inflammation. <em>Chandraprabha Vati</em> (CPV) is an Ayurvedic herbo-mineral formulation known for its antihyperglycemic and antilipidemic properties.</div></div><div><h3>Objectives</h3><div>To compare CPV's impacts alongside the hypoglycemic effects of metformin and the lipid-lowering effects of fenofibrate, in addition to evaluating CPV's capability to improve MetS-associated complications by promoting mitochondrial biogenesis.</div></div><div><h3>Materials and Methods</h3><div>After ten weeks of a high-fat diet with 10 % fructose (HFFD), Sprague-Dawley (SD) rats resembling the condition of MetS. Later, followed by CPV treatment (p.o.) for five weeks treatment with CPV. The study evaluated the effects of the interventions on anthropometric parameters, lipid profile, serum insulin, and levels of inflammatory markers such as TNF-α and IL-6. Furthermore, it evaluated the expression of genes related to inflammation and mitochondrial function, like NOD-like receptor protein 3 (NLRP3), caspase-1, mitochondrial transcription factor A (TFAM), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α).</div></div><div><h3>Result</h3><div><strong>:</strong> Compared to the disease control group, CPV at 100 mg/kg showed a significant reduction in body weight and improvements in anthropometric parameters, glucose tolerance, lipid profiles, and insulin sensitivity. The serum levels of inflammatory cytokines TNF-α and IL-6 were markedly decreased. CPV treatment upregulated the mRNA expression of mitochondrial biogenesis markers TFAM and PGC-1α while significantly downregulating inflammasomes such as caspase-1 and NLRP3 in cardiac, liver, and skeletal muscle tissues.</div></div><div><h3>Conclusion</h3><div>CPV could effectively combat mitochondrial dysfunction and chronic low-grade inflammation associated with MetS in rats.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100841"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The commercial availability of plant-based phytochemical components used in GLP-1 inhibition for the treatment of type-2 diabetes","authors":"Sharanjeet Kour ,&nbsp;Sanjeev Singh","doi":"10.1016/j.phyplu.2025.100825","DOIUrl":"10.1016/j.phyplu.2025.100825","url":null,"abstract":"<div><h3>Aim of the study</h3><div>The objective of this review is to evaluate the commercial availability and therapeutic potential of plant-based phytochemical components that enhance using GLP-1 reduction to treat type 2 diabetes. This work explores their conventional uses, pharmacological effects, and mechanisms of action in modulating GLP-1 inhibition, aiming to expand knowledge on their role in diabetes management.</div></div><div><h3>Materials and methods</h3><div>A literature review involving international and domestic databases was conducted to identify existing research on plant-based compounds that stimulate GLP-1 inhibition. Data on the availability of these formulations in the market, their ethnopharmacological applications, and their phytochemical composition were gathered and analyzed.</div></div><div><h3>Results</h3><div>The review identified several plant-derived compounds with GLP-1-stimulating properties, including berberine, curcumin, resveratrol, quercetin, and flavonoids, which have demonstrated the potential to enhance insulin secretion and improve glucose homeostasis. Many of these bioactive compounds are commercially available as herbal supplements or integrated into anti-diabetic formulations. Some formulations have shown greater efficacy and safety than others and have undergone clinical evaluations for diabetes management.</div></div><div><h3>Conclusion</h3><div>Plant-based GLP-1 inhibition offers promising alternatives for type 2 diabetes treatment. However, challenges such as phytochemical variability, extraction complexity, low bioavailability, and stability issues hinder their synthesis and large-scale production. Advanced techniques are required to enhance formulation, standardization, and commercialization. Addressing these challenges is essential to ensuring consistency, efficacy, and broader application, particularly in resource-limited settings.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100825"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent investigation of the medicinal plants’ effectiveness in the natural management of urinary and gallstones: a review","authors":"Youssef Miyah ,&nbsp;Mohammed Benjelloun ,&nbsp;Hajar El Omari ,&nbsp;Karima El-Mouhdi ,&nbsp;Mohammed El Feniche","doi":"10.1016/j.phyplu.2025.100839","DOIUrl":"10.1016/j.phyplu.2025.100839","url":null,"abstract":"<div><h3>Background</h3><div>The search for natural management techniques using medicinal plants is driven by the inescapable health problems of kidneys and gallstones, which can lead to serious complications and acute pain. These issues are often linked to an unbalanced diet, inadequate hydration, family history, and high doses of certain drugs. Conventional treatments for urinary and gallstones have limited efficacy and do not always guarantee a complete cure, which increases the risk of complications, particularly recurrence.</div></div><div><h3>Purpose</h3><div>This review paper thoroughly examines medicinal plants' potential to treat and prevent gallstones and urinary tract stones and envision a future when natural remedies integrate with conventional medical practices.</div></div><div><h3>Study design</h3><div>This study looks at kidney and biliary diseases, particularly stones, explores conventional treatments (drugs, lithotripsy, and surgery), and highlights medicinal plants used as natural remedies. Several medicinal traditions are examined for their historical use and preparations. By analyzing phytochemistry and prevention mechanisms, research focuses on medicinal plants' active principles and modes of action and their therapeutic and preventive effect against stones. It also examines how these plants can reduce the risk of stone formation, provide an alternative to conventional treatments, and reduce the need for surgery. The study also discusses the importance of a suitable diet and lifestyle to prevent stones. The advantages and disadvantages of herbal remedies are also explored in addition to recommendations for future clinical research into their efficacy.</div></div><div><h3>Conclusion</h3><div>Medicinal plants could be a viable alternative to traditional treatments, especially for biliary and kidney stones. Although this study shows promise in both prevention and treatment, more clinical trials are necessary to fully investigate the efficacy and safety of these natural remedies to confirm their value in a broader medical setting.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100839"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating bioinformatics with network pharmacology and experimental validation analysis to reveal the pharmacological mechanism of Ma-xing-shi-gan-tang in treating viral pneumonia","authors":"Li Huie ,&nbsp;Wang Qiong ,&nbsp;An Huijie,&nbsp;Zhang Qiang,&nbsp;Du Wei,&nbsp;Jiao Ying,&nbsp;Pan Siwei,&nbsp;Ding Huihui,&nbsp;Luo Aiwu","doi":"10.1016/j.phyplu.2025.100837","DOIUrl":"10.1016/j.phyplu.2025.100837","url":null,"abstract":"<div><div>Viral pneumonia is mainly caused by lung inflammation caused by viral infection, and respiratory syncytial virus pneumonia and adenovirus pneumonia are commonly seen in clinical practice. Ma-xing-shi-gan-tang (MXSGT) is a traditional Chinese herbal formula, and many researchers have confirmed its therapeutic effect on viral pneumonia. However, the mechanism of treating viral pneumonia still needs to be elucidated. In this study, network pharmacology has been used to explore the therapeutic effects and therapeutic targets of MXSGT and bioactive compounds. Initially, 143 active proteins and 689 ways of interaction between active proteins were identified through the MXSGT-compound-target and the target protein-protein interaction network. KEGG enrichment analysis revealed 27 signal pathways (<em>P</em> &lt; 0.05), covering the HIF-1α signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway, and Toll-like receptor signaling pathway. Through biological experiments, it has been confirmed that compared with the mice of viral pneumonia, the lung index of the MXSGT group is significantly reduced, and the content of inflammatory factors in lung tissue is reduced considerably. MXSGT may exert therapeutic effects on viral pneumonia by inhibiting the PI3K/Akt/HIF-1α pathway.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100837"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights of Terminalia citrina (Gaertn.) Roxb. Ex Fleming inhibiting multidrug resistant Acinetobacter baumannii","authors":"Nevia Longjam ,&nbsp;Romen Meitei Lourembam ,&nbsp;Jobina Rajkumari ,&nbsp;Sadokpam Shreekant ,&nbsp;Sushmita Bhattacharya ,&nbsp;Amit Kar ,&nbsp;Sushil Kumar Chaudhary ,&nbsp;Sulagna Basu ,&nbsp;Sarita Jena ,&nbsp;Shantibhusan Senapati ,&nbsp;Pulok Kumar Mukherjee ,&nbsp;Sarangthem Indira Devi","doi":"10.1016/j.phyplu.2025.100840","DOIUrl":"10.1016/j.phyplu.2025.100840","url":null,"abstract":"<div><h3>Background</h3><div>The Northeast region of India is renowned for its rich biodiversity and unique flora, including many plants with unstudied medicinal properties<em>. Terminalia citrina</em> is a medicinal plant traditionally used to treat chronic fever, loss of appetite, diarrhoea, asthma, boils, dizziness, haemorrhoids, anaemia, eye diseases, and infections. This study highlights potential bioactive compounds of <em>T. citrina</em> with antimicrobial activity against sepsis-causing pathogens, specifically <em>Acinetobacter baumannii</em> isolates, and presents the toxicity studies conducted on an animal model.</div></div><div><h3>Purpose</h3><div>The study focused on validating the traditional use of medicinal plants for treating microbial infections and assessing their toxicity in an animal model.</div></div><div><h3>Methods</h3><div><em>T. citrina</em> plant species were collected and evaluated for antimicrobial activity against sepsis causing MDR pathogens <em>Acinetobacter baumannii, Klebsiella pneumoniae</em>, and <em>Escherichia coli</em>. The bioactive metabolites were identified using liquid chromatography–mass spectrometry (LC-MS). The <em>in-vitro</em> cytotoxicity of the active fraction was assessed using the MTT assay on the Caco-2 cell line followed by <em>in-vivo</em> toxicity study in BALB/c mice.</div></div><div><h3>Results</h3><div>The crude extract of <em>T. citrina</em>, obtained using a hydroalcoholic solvent, inhibited the growth of <em>A. baumannii</em> isolates AB0014, AB0015, and AB0018. LC-MS analysis identified five metabolites in the EM2 subfraction of <em>T. citrina</em>. The MTT assay demonstrated no cytotoxic effects on the Caco-2 cell line. Treatment of <em>A. baumannii</em> isolate AB0014 with the EM2 subfraction of <em>T. citrina</em> at 2.82 mg/mL altered cellular morphology, causing cell shrinkage and growth inhibition. Acute and subacute oral toxicity studies of <em>T. citrina</em> (EM2) showed no signs of toxicity or behavioural changes.</div></div><div><h3>Conclusion</h3><div><em>T. citrina</em> found in Manipur, India, exhibited antimicrobial activity on MDR <em>A. baumannii</em> clinical isolates. The presence of phenolic compounds -in <em>T. citrina</em> (EM2) may be attributed to the antimicrobial activity. The <em>T. citrina</em> active fraction (EM2) may be an alternative candidate for developing a new drug for managing sepsis.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100840"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Documentation of folk-medicinal uses of fruit tree species by the indigenous communities of Sikkim Himalayas","authors":"Sudip Kumar Dutta ,&nbsp;Prakash Chettri ,&nbsp;VK Mishra","doi":"10.1016/j.phyplu.2025.100838","DOIUrl":"10.1016/j.phyplu.2025.100838","url":null,"abstract":"<div><h3>Background</h3><div>Sikkim is one of the Himalayan states in India and the only fully organic state in the country. Despite being a hotspot for biodiversity worldwide, it has received comparatively limited research. Indigenous people of the state place a great value on the edible wild fruit plants, which are also a significant source of ethnomedicine.</div></div><div><h3>Aim</h3><div>The aim of the current study, conducted from 2021 to 2024, was to document the wild edible fruits of the Indian state of Sikkim and their socioeconomic significance among rural communities, as well as their ethnomedical uses.</div></div><div><h3>Methods</h3><div>A total of 76 people from 23 villages, spanning a range of age groups (45–75 years), with both male and female respondents, were interviewed.</div></div><div><h3>Results</h3><div>There were a total of 59 fruit species found, representing 48 genera and 32 families. Numerous illnesses, including stomach issues (dysentery, diarrhea, ulcers, vomiting, and constipation), fever, bronchitis, diabetes, jaundice, toothaches, anemia, swellings, skin conditions, bone fractures, itching, conjunctivitis, viral diseases, urinary diseases, tuberculosis, heart conditions, and many more, can be cured by these wild edible fruits that grow locally. Numerous other researchers worldwide, and in the northeastern Himalayan region specifically, have reported similar findings. Among all the families, Rosaceae accounted for the maximum with a total of 14 % of total of genera, followed by Moraceae (12 %), Rutaceae (8 %), Anacardiaceae (7 %), Combretaceae (5 %) and Elaeagenaceae, Fabaceae, Lauraceae, Myrtaceae, Rubiaceae (3 % each). In terms of the fruits' socioeconomic value, the majority of wild fruits are used in rural areas for traditional medicine, firewood, house construction, animal feed, and charcoal. The majority of these fruits can be purchased in the neighborhood market for between Rs. 60 and Rs. 300 per kilogram.</div></div><div><h3>Conclusions</h3><div>It is recommended that the great variety of edible wild fruit plants be preserved for use in the future. Certain species can be cultivated on marginal soils with little agricultural value and in conventional agroforestry systems. Despite their many applications, these fruits have not yet received adequate documentation. Therefore, it is crucial to record these priceless species before they go extinct.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100838"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition and medicinal applications of Citrus essential oils: Current insights and future perspectives","authors":"Farah Aprisza Sheelmarevaa ,&nbsp;Pramesthi Reitza Navisya Vasall ,&nbsp;Nandang Permadi ,&nbsp;Asep Harja ,&nbsp;Sarifah Nurjanah ,&nbsp;Jamaludin Al-Anshori ,&nbsp;Euis Julaeha","doi":"10.1016/j.phyplu.2025.100836","DOIUrl":"10.1016/j.phyplu.2025.100836","url":null,"abstract":"<div><div><em>Citrus</em> essential oils (CEOs) are volatile aromatic compounds derived from various plant structures, such as peels, leaves, flowers, and seeds, with unique chemical compositions influenced by species, climate, and extraction methods. CEOs, rich in terpenes and terpenoids, exhibit diverse biological activities, including antimicrobial, antioxidant, and anti-inflammatory properties. These oils have shown significant potential in combating infectious diseases and preserving food, alongside applications in the pharmaceutical, cosmetic, and perfume industries. This review summarizes current knowledge on CEOs' using PRISMA methodology focusing in chemical composition and biological activities, emphasizing their medicinal applications, such as anticancer and antimicrobial activities, and the mechanisms underlying their effects. In addition, it evaluates the benefits and challenges of their use in modern medical settings, highlighting their potential as natural agents for enhancing public health.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100836"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}