Infection Epidemiology and Microbiology最新文献

{"title":"Fever without Focus in Children Aged 1 to 36 Months- Aetiological Profile and Predictors of Specific Aetiology- A Prospective Observational Study","authors":"Padmasani Venkat Ramanan, Thasma Santhanakrishnan Arunprasath","doi":"10.52547/iem.8.1.61","DOIUrl":"https://doi.org/10.52547/iem.8.1.61","url":null,"abstract":"This study aimed to describe the aetiological profile of fever without focus (FWF) in children aged one to thirty-six months and to identify clinical and laboratory predictors of specific aetiologies, especially serious bacterial infection (SBI). Methods: Children in the age range of one to thirty-six months, who were hospitalised due to FWF were included in this study. This prospective study was done over a period of 20 months in a medical college hospital in southern India. CBC (complete blood count) and CRP (c-reactive protein) tests, urine microscopic examination, blood and urine culture, Dengue antigen testing, and chest X-ray test were done for all feverish children. For those with fever beyond 5 days, additional tests including serological tests for Dengue, scrub typhus, and leptospirosis as well as Widal test were done. The final diagnosis was recorded, and clinical and laboratory parameters were analysed. Findings: Among 141 children with FWF, 41 (29%) had SBI, and 21(14.9%) had Dengue fever (DF). Leucocytosis, neutrophilia, and raised CRP levels were good predictors of SBI. Thrombocytopenia was an excellent predictor of DF. High fever was significantly associated with SBI and Dengue ( p =.004), and fever beyond 3 days at presentation was significantly associated with SBI ( p =<.001). Pyuria had a high specificity (94.5%) for identifying urinary tract infection (UTI). About 50% of UTIs were caused by extended spectrum beta lactamase (ESBL) producing organisms. Conclusion: SBI and DF were the most common causes of FWF. High fever, fever beyond 3 days at presentation, leucocytosis, neutrophilia, and a positive CRP test were predictors of SBI. Pyuria suggests UTI. Empirical antibiotic therapy should cover ESBL producing organisms. High fever and thrombocytopenia suggest Dengue fever.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72568581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the Relationship between COVID-19 and Clinical, Laboratory, and Demographic Data in Patients Referring to Shahid Rajaei Governmental Health Centers in Bandar Lengeh","authors":"Maryam Ghobahi, Behnosh Heidari, M. Arfaatabar, Enayat Aghel, F. Rahimi, Marziyeh Yazdanpanah, Sareh Bagheri-Josheghani, Zohreh Fakhrieh-Kashan","doi":"10.52547/iem.8.1.35","DOIUrl":"https://doi.org/10.52547/iem.8.1.35","url":null,"abstract":"Background: Many factors are involved in the development of SARS-CoV-2 infection in individuals in each region, such as physiological conditions, underlying diseases, and observance of personal protection and hygiene;therefore, this study aimed to investigate factors affecting the incidence of COVID-19 in Bandar Lengeh, Hormozgan province, southern Iran. Materials & Methods: Blood samples and demographic information were collected from suspected COVID-19 patients referring to Shahid Rajaei governmental health centers in Bandar Lengeh city. Hematological, biochemical, and serological tests were performed on the samples. PCR experiment was conducted to confirm SARS-CoV-2 infection. The thorax computed tomography (CT) was performed for all patients. Findings: According to the PCR test results, the prevalence rate of SARS-CoV-2 infection was 26.92% among 130 individuals enrolled in this study. SARS-CoV-2 infection was more prevalent among clerks than in other occupational groups (p=0.017). Increased ESR (erythrocyte sedimentation rate) and decreased WBC (white blood cell), lymphocyte, and platelet counts were evident in COVID-19 patients. Also, the prevalence of COVID-19 infection was higher in patients with blood group A (33.3%) than in patients with other blood groups. The CRP (C-reactive protein) test was positive for 31 patients whose PCR test was positive for SARS-CoV-2. In addition, LDH (lactate dehydrogenase) level was higher in infected individuals compared to other participants (p=0.018). Conclusion: In addition to the PCR test result, the most effective factors for diagnosing COVID-19 patients best on blood tests were as follows: increased CRP, ESR, and LDH levels and decreased WBC, lymphocyte, and platelet counts. © 2021, TMU Press.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89057967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Cryptococcaemia in HIV Infected Patients with CD4 Counts of ≤100 Cells/mm3-A Cross Sectional Study in a Tertiary Care Hospital","authors":"P. Kaur, Japsimran Kaur","doi":"10.52547/iem.8.1.53","DOIUrl":"https://doi.org/10.52547/iem.8.1.53","url":null,"abstract":"study aimed to investigate the of in patients of 51-100. Also, 55 patients (55%) received antiretroviral therapy (ART), and 45 (45%) cases were ART naï�ve. About 56% of patients had no opportunistic infections, and 37% had pulmonary tuberculosis. Three samples were positive in LFA, showing a prevalence of 3%, while only one of the culture samples was positive for Cryptococcus species. However, low CD4 count was found to be strongly correlated with positive serum cryptococcal antigenemia. Conclusion: The present study reveals that cryptococcal antigenemia is a health problem, and that cryptococcal antigen screening and treatment policy recommended by WHO should be performed routinely for HIV patients registered in ART centres in the current setting, especially for those who are ART naï�ve and have CD4 counts of ≤100 cells/mm","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83135182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection Rate and Clinical Symptoms of Trichomoniasis among Women Referring to the Hospital in Mahshahr City in Khuzestan Province, Southwest of Iran","authors":"A. Dalimi, E. Moradi, J. Sadraei, M. Pirestani","doi":"10.52547/iem.8.1.27","DOIUrl":"https://doi.org/10.52547/iem.8.1.27","url":null,"abstract":"the 18s rRNA gene were finally sequenced. Findings: The prevalence rate of this parasite was determined to be 1.54%. The highest prevalence rate of infection and clinical symptoms were observed in women aged 31-40 years. Totally, clinical symptoms were observed in 64.70% of infected women, including vaginal itching and irritation (64.70%) and abnormal discharge (26.47%). Conclusion: The prevalence rate of Trichomonas infection was relatively low in women living in Mahshahr. In addition, about 35.29% of infected women were found to be clinically asymptomatic.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84255532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria and Urinary Tract Infections among Children Under five Years with Malnutrition at a District Hospital in Ghana","authors":"E. Ameyaw, I. Okyere, Taiba Jibril Afaa, R. Ameyaw, Thomas O. Konney, Patience Tuah","doi":"10.52547/iem.8.1.43","DOIUrl":"https://doi.org/10.52547/iem.8.1.43","url":null,"abstract":"is a major cause of morbidity and mortality in children under five years. This study aimed to evaluate malaria and urinary tract infections among children under five years of age with malnutrition. This cross-sectional study was carried out on 189 children under five years with malnutrition. Their weight and height were measured using standard scales. Weight to height/length (wasting), weight to age (underweight), and height/length to age (stunting) ratios were computed using WHO growth charts. Clinical features were assessed. Blood smear, rapid diagnostic test for malaria, as well as urine dipstick test were done to detect those with malaria and urinary tract infections. Findings: About 80.95% of participants had marasmus, and 11.64% had marasmic kwashiorkor, while 7.41% had kwashiorkor. Also, 23.70 and 62.42% of participants had moderate and severe malnutrition, respectively; in addition, 21.69 and 2.12% were moderately and severely stunted, respectively. Regarding underweight (weight to age), 50.26 and 4.76% were moderately and severely underweight, respectively. Also, 15.87% of participants had a positive blood smear for malaria, and 19.58% had a positive rapid diagnostic test for malaria, while 20.11 and 20.63% had positive results for nitrite and leukocyte esterase activity in urine dipstick test, respectively. Conclusion: Malaria and infections are common among with malnutrition and could be diagnosed simple laboratory tests such as rapid diagnostic tests and urine dipstick tests in health facilities without laboratory support in resource-limited countries.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"359 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80216165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Vancomycin and Gentamycin Resistance among Enterococci spp. in Iran during 2007-2019: A Systematic Review","authors":"M. Arfaatabar, T. Shahbazi, Tahoora Ebrahimi","doi":"10.52547/iem.8.1.77","DOIUrl":"https://doi.org/10.52547/iem.8.1.77","url":null,"abstract":"Enterococci are Gram-positive bacteria that colonize the intestine of warm-blooded animals and humans as normal flora. Enterococci cause a variety of community-acquired and nosocomial infections. The emergence of vancomycin and gentamicin resistant enterococci has made a major challenge in the treatment of enterococcal infections worldwide. Therefore, the present study was conducted to evaluate the prevalence of vancomycin and gentamycin resistance among Enterococcus spp in Iran during 2007-2019. Materials & Methods: In this study, 26 studies were reviewed to collect data on the frequency of vancomycin and gentamicin resistant enterococci in Iran. To find studies published during January 2007 to January 2019, a search strategy was performed by searching different Iranian and international databases, including SID, Google Scholar, Scopus, Medline, Pub Med, and Web of Science. Findings:","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"29 19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85149806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for Vaccine Design for Coronavirus All Variants of Concern Using Immunoinformatics Techniques","authors":"Anamika Basu","doi":"10.52547/iem.8.3.259","DOIUrl":"https://doi.org/10.52547/iem.8.3.259","url":null,"abstract":"Aims: A short sequence of viral protein/ peptide could be used as a potential vaccine to treat coronavirus. Considering all variants of concern (VOC), designing a peptide vaccine for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is a challenging task for scientists. Materials & Methods: In this study, an epitope-containing vaccine peptide in nonstructural protein 4 (nsp4) of SARS-CoV-2 was predicted. Using a modified method for both B and T cell epitope prediction (verified by molecular docking studies), linear B and T cell epitopes of nsp4 protein were predicted. Predicted epitopes were analyzed with population coverage calculation and epitope conservancy analysis. Findings: The short peptide sequence74QRGGSYTNDKA84 was selected as B-cell epitope by considering the scores of surface accessibility, hydrophilicity, and beta turn for each amino acid residue. Similarly, the peptide sequences 359 FLAHIQWMV367 and359FLAHIQWVMFTPLV373 were predicted as T cell epitopes for MHC-I and MHC-II molecules. These two potential epitopes could favor HLA-A*02:01 and HLA-DRB*01:01 as MHC allelic proteins with the lowest IC50 values, respectively. No amino acid mutations were observed in GISAID (global initiative on sharing all influenza data) database for alpha, beta, gamma, and delta variants of concerns. Among seven amino acid point mutations in nsp4 protein of omicron variant, none were present in the peptide sequences of the predicted epitopes. Conclusion: Short peptide sequences could be predicted as vaccines to prevent infections caused by coronavirus variants of concerns. © 2022, TMU Press.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70686319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Presence of fimH and bfpA Genes in Escherichia coli Isolated from Pregnant Women","authors":"F. Keshavarzi, R. Rahmani, Farouq Karimpour","doi":"10.52547/iem.7.4.297","DOIUrl":"https://doi.org/10.52547/iem.7.4.297","url":null,"abstract":"Article Type Original Research Authors Fatemeh Keshavarzi, phD1* Rozhin Rahmani, MSc1 Farouq Karimpour, MSc2 How to cite this article Keshavarzi F., Rahmani R., Karimpour F. Evaluation of the Presence of fimH and bfpA Genes in Escherichia coli Isolated from Pregnant Women. Infection Epidemiology and Microbiology. 2021;7(4): 297-304 1Department of biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran 2Department of biology, Kurdistan Science & Research Branch, Islamic Azad University, Sanandaj, Iran * Correspondence Address: Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. F.keshavarzi@iausdj.ac.ir Article History Received: July 05 2021 Accepted: October 25 ,2021 Published: November 05 ,2021 Background: Escherichia coli (E. coli) is one of the most abundant bacteria in human and animal infections. Many virulence genes in E. coli intensify its infectivity. This study explored the presence of two pathogenic genes, including fimH and bfpA, in E. coli strains isolated from pregnant women. Materials & Methods: From autumn 2016 to spring 2017, a total of 100 E. coli isolates were collected from clinical samples (116) of pregnant women. The strains were identified using biochemical tests (catalase, Simmons citrate, indole, mobility, H2S, MR, VP, TSI, and urease). The presence of pathogenic genes in these isolates was examined using colony PCR method. Finally, the relationship between the gene and the site of infection was analyzed in SPSS-23 software. Findings: PCR results indicated that out of 100 E. coli samples, 15 were bfpA positive (15%), and 64 were fimH positive (64%). A significant relationship was found between the presence of bfpA gene and samples taken from blood (p=.049), and stool (p<.001). Conclusion: None of the urinary strains harbored the bfpA gene, while the strains isolated from stool had a significant relationship with the presence of bfpA gene (OR = 18.667), which confirms that this gene is of great importance for EPEC (enteropathogenic E. coli). There was also a significant relationship between blood-isolated strains and the presence of bfpA gene. A significant relationship was also found between the fimH gene and strains isolated from urine samples (OR=36.733), while no relationship was observed between the presence of fimH gene and blood-isolated strains. Copyright© 2021, TMU Press. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. 10.52547/iem.7.4.297","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81820400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Tuberculosis Treatment Failure among Tuberculosis Patients in Khuzestan Province: A Retrospective Cohort Study","authors":"S. Mousavi, M. Fararouei, H. Rashidi, S. Shojaei, Faeze Bahrami Astaraki","doi":"10.52547/iem.7.4.289","DOIUrl":"https://doi.org/10.52547/iem.7.4.289","url":null,"abstract":"Article Type Original Research Authors Sayed Ali Mousavi, MSc1* Mohammad Fararouei, PhD2 Hadi Rashidi, MSc3 Saeideh Shojaei, MSc4 Faeze Bahrami Astaraki, BSc5 How to cite this article Mousavi SA., Fararouei M., Tabatabyi H., Rashidi H., Shojae S., Bahrami Astaraki F. Risk Factors of Tuberculosis Treatment Failure among Tuberculosis Patients in Khuzestan Province: A Retrospective Cohort Study. Infection Epidemiology and Microbiology 2021;7(4): 289-296 1 Department of Public Health, Shoushtar Faculty of Medical Science, Shoushtar, Iran 2 HIV/AIDS Research Center, Shiraz University of Medical Science 3 Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran 4 Epidemiology, Department of Epidemiology, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5Undergraduate Student of Nutrition science, Shoushtar University of Medical * Correspondence Address: Department of Public Health, Shoushtar Faculty of Medical Science, Shoushtar, Iran mousavi_a@Shoushtarums.ac.ir Article History Received: July 05 2021 Accepted: September 25 ,2021 Published: November 25 ,2021 Background: Tuberculosis (TB) is an infectious and communicable disease and one of the top ten causes of death throughout the world. Monitoring and evaluating TB treatment outcomes provides the required data for taking the necessary measures to control TB. Thus, this study was carried out to find determinants of treatment failure among patients with smear-positive pulmonary TB in Khuzestan province during 2006-2014 Material and Methods: This retrospective cohort study was conducted over a 9-year period in Khuzestan province. Predictors of treatment failure were analyzed using multivariate logistic regression Findings: Among 5342 patients, the cumulative incidence of unsuccessful TB treatment was 1.85%. More than half of TB patients (59.2%) enrolled in this study were male, and most of them were living in urban areas (79.8%). Significant predictors of treatment failure were age (p=·001), weight (p= ·039), number of delayed days in diagnosis (p=·01), isoniazid resistance (p≤·001), and number of bacilli in patients` sputum at the beginning of treatment (p≤·001). Conclusion: In this study, the rate of successful treatment was quite high; nevertheless, new cases of treatment failure could be prevented with special efforts such as prompt diagnosis and precise follow-up under Direct Observation Treatment Short course (DOTS) strategy. Copyright© 2021, TMU Press. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. 10.52547/iem.7.4.289","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78630643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria","authors":"Hussain Yahaya Ungo-kore, Joseph Olorunmola Ehinmidu, Josiah Ademola Onaolapo, Olayeni Stephen Olonitola","doi":"10.52547/iem.7.4.347","DOIUrl":"https://doi.org/10.52547/iem.7.4.347","url":null,"abstract":"Article Type Original Research Authors Hussain Yahaya Ungo-kore, MSc1* Joseph Olorunmola Ehinmidu, MSc2 Josiah Ademola Onaolapo, MSc2 Olayeni Stephen Olonitola, MSc3 How to cite this article Yahaya Ungo-kore H., Olorunmola Ehinmidu J., Ademola Onaolapo J., Stephen Olonitola O. In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria. Infection Epidemiology and Microbiology. 2021;7(3): 347-356 1Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University. 2Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria 3Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna * Correspondence Address: Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna 1044, Nigeria hussaini.yahaya@udusok.edu.ng Article History Received: March 05 2021 Accepted: April 25 ,2021 Published: November 05 ,2021 Background: The fungal infection of tinea capitis is a common mycosis that affects the scalp superficially, especially in children. Oral treatment of this infection remains the preferred treatment process in clinical dermatology. Many antifungals available for dermatophyte treatment lead to treatment failure. Determination of antifungal susceptibility of dermatophytes in-vitro has been reported to be important to curb dermatophyte infections using effective antifungal drugs. The aim of this study was to investigate and determine in vitro minimum inhibitory concentration (MIC) of amphotericin B, ketoconazole, griseofulvin, terbinafine, and fluconazole against dermatophyte clinical isolates using agar dilution method. Materials and Methods: In this study, in vitro susceptibilities of 32 dermatophyte clinical isolates collected from primary school pupils in Sokoto metropolis were investigated to five antifungals (fluconazole, terbinafine, ketoconzole, amphotericin B, and griseofulvin) using the CLSI agar dilution method. Findings: The results obtained revealed that griseofulvin and terbinafine were the most potent antifungal agents among those tested. Conclusion: Agar dilution method could be an alternative method for MIC-determination of antifungal drugs against dermatophyte species, since it is cost effective and affordable with consistent results, especially in developing countries. Copyright© 2021, TMU Press. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. 10.52547/iem.7.4.347","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90088024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}