{"title":"A 10V neuron stimulator in 0.18µm CMOS process with voltage clothing and folding voltage techniques","authors":"Lee Lin, Chien-Chih Chen, K. Tang","doi":"10.1109/ISBB.2011.6107633","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107633","url":null,"abstract":"Biomedical implantable devices have drawn more and more attention in recent years. Extensive studies in neuroscience prove that neural stimulation techniques may cure or at least improve some diseases caused by neural abnormal discharge or disability. Two of the major challenges of implantable devices are combining a high-voltage driver and low-voltage digital control in a single chip, and accommodating large voltages in smaller feature size technology. This paper presents a new stimulator circuit structure to address these problems, using a novel folded voltage design to reduce the voltage supply from 20V to 10V, and a new floating voltage technique to solve the reliability issue. The proposed design has been fabricated and tested with TSMC 0.18µm 1P6M CMOS technology. 8000µA output current was delivered.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117200063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The study of signal transmission in toads' forelimbs","authors":"Yue-Lin Chen, Xiaoying Lu, Zhigong Wang, Cenyu Huang, Suyang Wang, Yifu Wang, Yihui Li","doi":"10.1109/ISBB.2011.6107690","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107690","url":null,"abstract":"The tests of meridians and acupoints have been studied for rabbits, goats, pigs and other animals by domestic and foreign meridian researchers. This paper describes a series of experiments in toads to study meridian phenomenon in vivo. The method based on electrical network theories using a high amplitude pulse tests dynamically the voltage signal transmission characteristics of different ports in the forelimbs of toads by three-dimensional scanning. We have preliminarily tracked out three “meridian channels” in the forelimb according to tracks of maximum transmission coefficient.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123702935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The state of field of high-throughput SNP genotyping system","authors":"Zheng Liu, Bin Liu, Yan Deng, N. He","doi":"10.1109/ISBB.2011.6107674","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107674","url":null,"abstract":"High-speed and low-cost high-throughput nucleic acid detection technology has become the mainstream of nucleic acid detection, and gradually developed to the super high-throughput. Application of high-throughput nucleic acid analysis technique has provided new technical platform for many research fields. Currently a lot of countries combine gene chip with corresponding technique to form a new generation of high-throughput analytical platforms, which are widely used in various fields. This particle discusses one main aspect, high-throughput analytical technique and detecting platforms of SNP genotyping analysis in detail. In addition to the current aspect on high-throughput analytical technique and commercial system, such as high-throughput SNP detecting chip and so on, the particle focuses on the newest research results in the field of China. And the particle introduces other high-throughput analytical system briefly, and then look ahead the development of this field.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"20 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114033966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liang-Hung Wang, Tsung-Yen Chen, Huan Chen, Y. Chen, Q. Fang, Shuenn-Yuh Lee
{"title":"An IEEE 802.15.4 RF transmitter for 2.4 GHz ISM band healthcare applications","authors":"Liang-Hung Wang, Tsung-Yen Chen, Huan Chen, Y. Chen, Q. Fang, Shuenn-Yuh Lee","doi":"10.1109/ISBB.2011.6107644","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107644","url":null,"abstract":"This paper presents a low-power RF-transmitter for intelligent healthcare systems. With attention to power-efficient communication in the local sensor network, the required low-power integrated circuits (ICs) are developed for a healthcare system with miniaturization and system integration. A quadrature CMOS voltage-controlled oscillator and a direct-conversion transmitter with PA and up-conversion mixer have been implemented to fit the specification of the IEEE 802.15.4 2.4 GHz standard. The low-power ICs of the transmitter have been applied in the TSMC 0.18-μm CMOS standard process. The measurement results reveal that the transmitter IC can fit in with the link budget of the UHF ZigBee system for healthcare applications.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114216687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and implementation of a wireless ECG acquisition and communication system with health-care services","authors":"Hui-Yang Hsiao, Liang-Hung Wang, Feng-Ching Liu, Chien-Chou Chen, Shuenn-Yuh Lee, Huan Chen","doi":"10.1109/ISBB.2011.6107636","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107636","url":null,"abstract":"In this paper, we present a system that can provide a better caring service to the remote patients. The system we developed mainly focuses on the cardiac signal acquisition (i.e., ECG) and its communication. A prototype using the ZigBee wireless technology was built to verify the designed functions and required system performance. Results show the hardware and firmware on the end-user device can work together very well to perform reliable ECG signal acquisition as well as communication task via the ZigBee wireless technology. In addition, a PC-based GUI interface is also developed to provide ECG signal processing task and health care video tracking and management functions.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"344-346 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116242348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An new method for frontier port pathogenic microorganism detection gene chip probe design","authors":"Lu Lin, C. Zhijun, Liu Guochuan, Wang Fei","doi":"10.1109/ISBB.2011.6107693","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107693","url":null,"abstract":"In process of genechip probe design for Pathogenic microorganism detection, the selection of SNP combination is of great importance. At present, no automatic design method is reported. This work is not easy and the result is not always satisfactory. A new approach of selecting SNP combination is proposed in this paper. Genetic algorithm is used to search optimal solution on the basis of classification ability of SNP combination, which is evaluated by the rough set theory. Other related experimental parameters are also been incorporated. Experiment results show that the method can get the best SNP combination pattern efficiently and accurately, which promises it a reliable approach for the genechip probe design.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124154616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FPGA-implementation of LMS adaptive noise canceller for ECG signal using model based design","authors":"Zhiguo Zhou, Jing He, Zhiwen Liu","doi":"10.1109/ISBB.2011.6107662","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107662","url":null,"abstract":"This paper introduces a new development flow named Model Based Design for biologic signal processing system designing on FPGA. An adaptive noise canceller based on LMS (Least Mean Square) algorithm is implemented on FPGA using this flow. The canceller removes the power-line interference from electrocardiogram (ECG) signal successfully. Finally, a performance evaluation and hardware resource utilization of this design for different system parameters are presented in this paper.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"64 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132463413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain activity during walking in patient with spinal cord injury","authors":"Li Wei, Huang Yue, Xu Jiang, Jiping He","doi":"10.1109/ISBB.2011.6107654","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107654","url":null,"abstract":"The capacity for walking is an important assessment to reflect the ability about how the patients who have movement disorders to control their lower limbs. Electroencephalography (EEG), which can describe brain activities, has been widely used in the field of neural engineering. The present study investigates 2D scalp topography mapping while the subjects perform gait-like movements with the assistance of a dynamic tilt table. Based on the result, we concluded that the motor function and the most nerve circuit of lower limbs in spinal cord injury (SCI) patients in level D are as normal as healthy human.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130207893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and evaluation of ultrasound-based surgical navigation system for percutaneous renal interventions","authors":"Hao Chen, Zhicheng Li, Chuan-shu Liao, Qing-song Zhu, Jia Gu","doi":"10.1109/ISBB.2011.6107651","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107651","url":null,"abstract":"This paper develops an ultrasound-based surgical navigation system for percutaneous renal intervention. The system integrates preoperative magnetic resonance (MR) planning with intraoperative ultrasonography (US) slices, where the MR imagery is registered to the calibrated US data. The interventional punctures can then be performed under a visualized guidance interface. We describe the navigation system in details and evaluate the navigated intervention via a phantom model.","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132808671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 2D analysis of oxygen transportation in a novel bioreactor based on oxygen carrier for bio-artificial liver support system","authors":"Meirong Duan, Chang-Zhe Wu, Xiao-Lin Huo, Ming Li","doi":"10.1109/ISBB.2011.6107661","DOIUrl":"https://doi.org/10.1109/ISBB.2011.6107661","url":null,"abstract":"Bioreactor (BR) is the key component of bio-artificial liver support system (BALSS). Sufficient mass transfer in BR is of great importance for hepatocytes and is essential to BALSS' fine quality. In this paper, a mathematical model describing oxygen distribution in a suspension BR with perfluorocarbons (PFC) called oxygen carrier was developed to obtain the most efficient BR operating parameters. The 2D model is based on the geometry of BR operated under unsteady-state conditions, and the BR which rotates periodically has two inlets and outlets working alternatively. The model equations are solved using the finite element software (Fluent). The calculated results of oxygen distribution showed that 200 ml/min to 400 ml/min inlet velocity with 0.3 min to 0.5 min BR","PeriodicalId":345164,"journal":{"name":"International Symposium on Bioelectronics and Bioinformations 2011","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116495523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}