Bulletin of Pharmaceutical Sciences. Assiut最新文献

{"title":"Letrozole attenuates cardiometabolic risk in Plasmodium berghei-infected female mice","authors":"A. Abdulkareem, A. Babamale, Caleb Jesutomisin, Oluwabunmi Badmos-king, I. Dare, L. Olatunji, S. Ugbomoiko","doi":"10.21608/bfsa.2023.178428.1593","DOIUrl":"https://doi.org/10.21608/bfsa.2023.178428.1593","url":null,"abstract":"","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127337008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATING THE EFFECTS OF PERITONSILLAR INFILTRATION OF BUPIVACAINE AND DEXAMETHASONE ON POST-TONSILLECTOMY PAIN REDUCTION IN KIDS","authors":"Manijeh Yousefi Moghadam, Mohammad Shouride Yazdi, S. Foji, Kaveh Ghajari, P. Amiri","doi":"10.21608/bfsa.2023.175568.1583","DOIUrl":"https://doi.org/10.21608/bfsa.2023.175568.1583","url":null,"abstract":"This study aimed to investigate the effect of percutaneous injection of bupivacaine and dexamethasone on pain relief after pediatric tonsillectomy. This clinical trial study was performed on 68 children undergoing tonsillectomy surgery. The intervention group was given topical dexamethasone and topical bupivacaine to reduce postoperative pain but oral paracetamol was administered at a dose of 15 mg/kg when pain score was > 4 in the control group patient. Postoperative pain was recorded by VAS score at 6, 12 and 24 hrs. In the experiment 51.5% of the subjects were male and 48.5% were female and mean age was 7.5 ± 2.99 years. Mean pain at 6 and 12 hrs after surgery was not significantly different between the intervention and control groups, but at 24 hrs after surgery the mean pain in the intervention group was 1.85 ± 0.85 and in the control group was 2.38 ± 1.18 which was statistically significant. There was no significant correlation between mean age, sex, weight, and duration of surgery with mean pain scores in the intervention group and control group at 6, 12 and 24 hrs after surgery.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"2017 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114885470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Pentoxifylline effects on liver steatosis utilizing Dixon-based MRI technique; randomized controlled study.","authors":"Sahar H.Elhini, Asmaa A Elsayed, A. Elberry, Nadia F. El Ameen, Ahmed Abdelfadil Saedii, M. Ibrahim, Nadia Ismail, Haitham Saeed, H. Rabea","doi":"10.21608/bfsa.2023.177573.1591","DOIUrl":"https://doi.org/10.21608/bfsa.2023.177573.1591","url":null,"abstract":"Background: Pentoxifylline (PTX) has been proven to reduce hepatic steatosis in animal models; however, data regarding its safety and efficacy in type-2 diabetics (T2D) with nonalcoholic fatty liver disease (NAFLD) are rare. Aim: Determine the effects of PTX in reducing liver fat content (LFC; %) in T2D patients with NAFLD in various disease states. Methods: 187 T2D subjects with NAFLD were randomized to receive either Pentoxifylline 800 mg (PTX group) or standard T2D care only (control group) for 24 weeks. The primary outcomes included changes in LFC (%) as measured by magnetic resonance imaging-derived proton density fat-fraction technique (MRI-PDFF) and the calculation of a fibrosis score (NFS). Results: PTX significantly reduced LFC (%) more than the control group (-8.18 vs. -1.87; P< 0.0001). Only the PTX group significantly reduced the NFS score (-1.16; P<0.0001). The PTX group showed significant LFC changes in liver segments II (-9.77; P< 0.0001), IVb (-9.51; P< 0.0001), and VI (-9.13; P< 0.0001); however, the control group achieved significant LFC changes in liver segments III (-2.57; P= 0.02) and VI (-2.22; P= 0.04). In subgroup analysis, PTX showed comparable efficacy in decreasing LFC in different fibrosis scores, gender, and BMI categories. However, Patients with severe steatosis grade (LFC>22.1%) (-10.55%; P=0.001) and HbA1c levels > 7.5% (-8.75%; P= 0.015) achieved significantly higher LFC reductions than other steatosis grades and HbA1c categories. Conclusion: PTX presented a similar efficacy profile in reducing LFC in different fibrosis scores, genders, and BMI categories, while patients with severe steatosis grade and HbA1c > 7.5% achieved higher LFC reductions.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123741478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and prognostic significance of platelet to lymphocyte ratio in diffuse large B-cell lymphoma: A meta-analysis","authors":"M. Abdelrahim, Haitham Saeed, M. Shaaban","doi":"10.21608/bfsa.2023.174887.1578","DOIUrl":"https://doi.org/10.21608/bfsa.2023.174887.1578","url":null,"abstract":"Background: Nowadays, there is a significant but variable correlation between the diffuse large B-cell lymphoma (DLBL) and the platelet-lymphocyte ratio (PLR). This meta-analysis will assess this association. Methods : A thorough search was done up until June 2022","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125643551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Azathioprine and biological treatment genetic association with clinical response and toxicity in inflammatory bowel disease patients.","authors":"M. Abdelrahim, Nashwa Eltantawy, Amira B. Kassem, I. Elzayyadi, A. Elberry, Layla M. Salah","doi":"10.21608/bfsa.2023.175286.1580","DOIUrl":"https://doi.org/10.21608/bfsa.2023.175286.1580","url":null,"abstract":"Inflammatory Bowel Disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is characterized by a chronic inflammatory process of the patient’s gut. This review aims to summarize the pharmacogenetics of biologics approved for IBD and the correlation with azathioprine-metabolizing enzymes and adverse reactions, therefore highlighting a likely relationship between particular polymorphisms and therapeutic response. Therefore, we reviewed and discussed the activities of therapeutic drug monitoring (TDM) protocols that use monoclonal antibodies (mABs) with a particular attention to the integration of other actions aimed to exploit the most effective and safest medications for IBD cases. The pharmacotherapy of IBD (CD and UC) has experienced a great advancement with the advent of mABs which have peculiar pharmacokinetic properties differentiating them from chemical agents, like aminosalicylates, antimetabolites (e.g., azathioprine (AZA), 6-mercaptopurine (6MP)), and methotrexate), and immunosuppressant agents (steroids and cyclosporine). But clinical studies showed that biologicals might have pharmacokinetic variability which can affect the anticipated clinical outcomes, beyond primary resistance phenomena. Thus, TDM protocols are applied to the doses of medications according to the required serum mABs levels. This aims to maximize the favourable effects of mABs and minimize the toxicity. But, the presence of particular genetic polymorphisms in patients might determine a different outcome in response to treatment, indicating the heterogeneity of the effectiveness among IBD cases. Indeed, many reports demonstrated significant associations between polymorphisms and response to biologics. In conclusion, the improvement of TNF-, TNFR and IL-1 pharmacogenetics could be the best approach toward a targeted treatment for IBD.Pre-therapy genotyping has to be integrated with IBD therapeutic guidelines, as it is the most suitable approach to choose the most appropriate biologicals for each case. Also, the addition of pharmacodynamic markers (including serum, cellular, or tissue concentrations of TNF-alpha and IL-8) might boost the predictive performance of models and, eventually, control the disease with a significant improvement in quality of life (QOL).","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"53 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124322494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis, Characterization, and Antimicrobial Assessment of Metal Nanoparticles from Dryopteris manniana (HOOK.) C. Chr Leaf Extract","authors":"I. Ejidike","doi":"10.21608/bfsa.2022.163564.1512","DOIUrl":"https://doi.org/10.21608/bfsa.2022.163564.1512","url":null,"abstract":"Background: An integral part of nature is medicinal plants containing natural constituents which are vital to health. Dryopteris manniana (Hook.) C. Chr. leaves contain phytochemicals such as polyphenols and flavonoids which serve as an effective reducing agent. Methods: Metallic nanoparticles were synthesized by reducing salts of silver, nickel, manganese, and copper using Dryopteris manniana leaf extracts to form metal nanoparticles represented as AgNPs, NiNPs, MnNPs, and CuNPs respectively. The obtained nanoparticles were then characterized using UV-Visible Spectroscopy, Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDX). The antimicrobial activities of the nanoparticles were investigated against six microbial strains using the disk diffusion method. Results: The EDX result identified the metal atoms present in the metal nanoparticles formed. The SEM revealed that AgNPs have a diamond-like crystalline, CuNPs have a triangular-like structure, NiNPs have a teardrop-like structure, and MnNPs have a spherical crystalline structure. The results of the antimicrobial experiments showed that the nanoparticles have activity against all the tested bacteria but are less active against some isolated fungi. AgNPs showed zone of inhibitions: S. aureus (10 mm), α-H. streptococcus (8 mm), and E. coli (12 mm), while CuNPs exhibited 9 mm, 11 mm, and 11 mm against S. aureus, E. coli, and α-H. streptococcus respectively. Conclusion: This method for green metal nanoparticle synthesis may useful in nanomedicine, environmental, and industrial applications as they possess greater effectiveness and reduced toxicity, however, further investigation will be implemented.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"1 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132988196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity is associated with Autophagy dysregulation in Egyptian women","authors":"Abdel Rahman Abdel qawy, T. Saleem, R. Salama, Ghada Mohamed, E. Radwan","doi":"10.21608/bfsa.2022.175521.1582","DOIUrl":"https://doi.org/10.21608/bfsa.2022.175521.1582","url":null,"abstract":"Background: Obesity causes a reduced life quality and economic burden to Egyptians. Therefore","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127013733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Phytochemical Screening, Antioxidant and Wound Healing Activities of Pistacia palaestina Boiss. Extracts","authors":"Mohammed Alshlash, A. Kitaz, W. Abdelwahed","doi":"10.21608/bfsa.2022.170738.1559","DOIUrl":"https://doi.org/10.21608/bfsa.2022.170738.1559","url":null,"abstract":"The current work was designed to undertake a qualitative phytochemical screening of various plant parts of Pistacia palaestina, and estimate antioxidant and wound healing activities for therapeutic applications. The qualitative phytochemical screening of the leaf and the fruit of P. palaestina was performed using different chemical tests. The total phenolic content (TPC), total flavonoid content (TFC)","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126413691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Aspergillus oryzae ASU44 (OL314732) and their kojic acid as pesticides against cotton aphid, Aphis gossypii","authors":"G. Mahmoud, Abdel-Naser A. Zohri, Nahla Kamal-Eldin, N. Abdelhamid","doi":"10.21608/bfsa.2022.169505.1549","DOIUrl":"https://doi.org/10.21608/bfsa.2022.169505.1549","url":null,"abstract":"Because of their negative effects on the environment, humans, and other organisms, chemical pesticides have been prohibited in many countries. Alternative microbial management is easy-to-implement, effective, and safe for humans and the environment. Fungus-based bio-pesticide products like kojic acid could commercialize as effective alternative chemical pesticides. Aspergillus oryzae ASU44 (OL314732) was isolated from hollyhock rhizosphere and identified using 18S rRNA gene sequencing. The strain showed high ability of kojic acid production especially after optimizing the production using 41-run Box-Behnken statistical design. Maximum kojic acid production was 46.53 g/l (predicted values 46.62 g/l) obtained in run number (23) using Glucose (150, g/l), Yeast extract (5 g/l), KH 2 PO 4 (3 g/l), MgSO 4 .7H 2 O (0.5 g/l) and pH (3). The design was effective to applied with coefficient (R 2 ) 0.988, 0.986 (adjusted R 2 0.975, 0.972) for kojic acid (g/l) and dry fungal mass formation (g/l). The pathogenicity of the fungus and their kojic acid in addition to standard synthetic kojic acid was investigated to the cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae). All treatments had a considerable impact on aphid mortality. The mortality rate was relative to the duration of exposure and the quantities of bio-pesticides agents. However, data revealed that as concentrations increased, the lethal time values decreased . Aspergillus oryzae ASU44 and its extract containing kojic acid were found effective against A. gossypii. As a result, this research suggests that these agents could be effective in aphid cotton management.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129468077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UTİLİZATİON OF THE STABİLİTY-İNDİCATİNG RP-HPLC METHOD FOR DİETRY SUPPLEMENT CALCİUM OROTATE QUANTİFİCATİON İN CAPSULE DOSAGE FORM","authors":"T. Kumar, Koduru Swathi, M. Chaitanya, Kalepu Swathi, Bairam Ravindar","doi":"10.21608/bfsa.2022.161819.1516","DOIUrl":"https://doi.org/10.21608/bfsa.2022.161819.1516","url":null,"abstract":"A rapid, accurate, and precise HPLC approach for quantifying calcium orotate in capsule dosage form was developed and validated. As optimum conditions for analysis, a C 8 column (250 mm x 4.6 mm, 5μ) was used as the stationary phase, with a mobile phase of 65:35 v/v acetonitrile and 25 mM potassium dihydrogen phosphate buffer (pH 4.7) at a flow rate 1 ml/min and detected at 254 nm. The method showed a 0.999 correlation and an excellent linear response throughout a concentration range of 15–90 μg/ml. Retention lasted for 3.186 minutes. Validation of the method done as per the requiremnts of ICH and subjected to oxidation, photolysis, heat, acid, alkali hydrolysis, and water stress. Degradation byproducts did not affect the ability to detect calcium orotate, hence the approach is stability indicating. The approach may be used to determine calcium orotate in pharmaceutical capsule dose form since the findings of the research were within the parameters of ICH standards.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121203074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}