Bulletin of Pharmaceutical Sciences. Assiut最新文献_第10页

LETROZOLE SUPPRESSES HEPATIC OXIDATIVE STRESS AND AMELIORATES LIPID ACCUMULATION IN FRUCTOSE-EXPOSED WISTER RATS 来曲唑抑制果糖暴露大鼠肝脏氧化应激和改善脂质积累

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-12-01 DOI: 10.21608/bfsa.2022.271777

A. Abdulkareem, Emmanuel Abe, Oluwafemi Omilana, L. Olatunji

{"title":"LETROZOLE SUPPRESSES HEPATIC OXIDATIVE STRESS AND AMELIORATES LIPID ACCUMULATION IN FRUCTOSE-EXPOSED WISTER RATS","authors":"A. Abdulkareem, Emmanuel Abe, Oluwafemi Omilana, L. Olatunji","doi":"10.21608/bfsa.2022.271777","DOIUrl":"https://doi.org/10.21608/bfsa.2022.271777","url":null,"abstract":"An increase in sugar intake, especially fructose or fructose-containing sweeteners, poses a serious public health challenge globally. Unlike glucose, fructose metabolism results in generation of oxidative stress, which promotes hepatic lipid accumulation and consequently increases the risk of non-alcoholic fatty liver disease (NAFLD). Chronic administration of letrozole has been previously reported to decrease lipid peroxidation and increase antioxidants but its effect on fructose-induced lipid accumulation has not been investigated. Thus, the present study sought to investigate the ameliorative effect of letrozole on hepatic oxidative stress and lipid accumulation in high fructose-taking Wister rats. After 3-week of exposure, our results reveal that fructose intake increased hepatic total cholesterol (p< 0.01), triglycerides (p< 0.001) and free fatty acid (p< 0.001). Similarly, fructose increased hepatic malondialdehyde (MDA) (p< 0.001 vs. control) and decreased catalase and superoxide dismutase activities (p< 0.001 and p < 0.05 vs. control, respectively). Furthermore, our data show that high fructose intake elevated levels of uric acid and xanthine oxidase activity in the liver (p< 0.001 vs. control). However, letrozole treatment attenuated the hepatic lipid accumulation, reduced MDA level, and suppressed uric acid biosynthesis in high fructose-taking rats. Conclusively, this study has demonstrated that high fructose intake induces hepatic uric acid synthesis, generating oxidative stress and promoting hepatic lipid accumulation in male Wister rats, while administration of letrozole attenuates the fructose effects. Our findings, therefore, suggest the efficacy of letrozole in attenuating hepatic lipid accumulation, hence, lowering the risk of NAFLD associated with excessive fructose intake.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134008002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY THE PROPHYLACTIC EFFECTS OF MELATONIN AND CYANOCOBALAMIN AGAINST CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY 研究褪黑素和氰钴胺对环磷酰胺所致心脏毒性的预防作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-12-01 DOI: 10.21608/bfsa.2022.271771

Waleed K. Ghanim, Muhsin S. G. Al-Moziel, Karamallah Al-Yousof

引用次数: 0

3D Printing Technology implementation for Personalized Medication 个性化医疗的3D打印技术实现

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-29 DOI: 10.21608/bfsa.2022.161199.1498

S. Kushwaha, Neelottama Kushwaha, Vishal Kumar

{"title":"3D Printing Technology implementation for Personalized Medication","authors":"S. Kushwaha, Neelottama Kushwaha, Vishal Kumar","doi":"10.21608/bfsa.2022.161199.1498","DOIUrl":"https://doi.org/10.21608/bfsa.2022.161199.1498","url":null,"abstract":"The unique properties of 3D printing technology, such as additive manufacturing, have been attributed to its growing demands in the pharmaceutical and medical device industries. In recent years, these technical approaches have gained in popularity as a cost-effective way to develop custom dose forms for tissue engineering and molecular diagnostics. A multimodal drug delivery system with faster release characteristics is being developed, which is useful in the case of personalized dose forms, according to an assessment of the existing situation. A review of 3D printing technology used throughout pharmaceutical applications was carried out. There are several kinds of 3D printers, and each one employs a unique technique to interact with different materials in diverse ways. In terms of material and application, the most crucial thing to keep in mind with 3D printing is that there is no one-size-fits-all solution. A light and heat source are sometimes used in 3D printers that employ powder materials to melt or fuse the layers of powder to create the desired shape. When using a 3D CAD (Computer Aided Design) file to make a 3D model or scanning a 3D object with a 3D scanner, the filament is heated by the extruder to form the layer and produce the desired shape","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127563965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemia Modified Albumin (IMA): a Novel Biomarker for the Diagnosis of Acute Coronary Syndrome 缺血修饰白蛋白(IMA):一种诊断急性冠脉综合征的新生物标志物

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-27 DOI: 10.21608/bfsa.2022.165375.1521

Aula Abo Saleh, Bassem Marouf, Afraa Zrieki

引用次数: 0

DEPRESSION-LIKE EFFECTS OF LEVETIRACETAM WAS HALTED BY PRETREATMENT WITH N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) BLOCKERS IN MICE 用n -甲基- d -天冬氨酸受体(nmdar)阻滞剂预处理小鼠左乙拉西坦可阻断抑郁样作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-24 DOI: 10.21608/bfsa.2022.157544.1482

A. Mesripour, T. Ahmadi

引用次数: 1

Need and satisfaction of healthcare specialists toward the performance of clinical pharmacists: A cross-sectional study in Palestine 医疗保健专家对临床药师表现的需求和满意度:巴勒斯坦的一项横断面研究

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-24 DOI: 10.21608/bfsa.2022.161880.1501

Mohammed Elhabil, M. Yousif, Kannan O. Ahmed, Mohamed Abunada, Khaled Almghari, A. Eldalo

{"title":"Need and satisfaction of healthcare specialists toward the performance of clinical pharmacists: A cross-sectional study in Palestine","authors":"Mohammed Elhabil, M. Yousif, Kannan O. Ahmed, Mohamed Abunada, Khaled Almghari, A. Eldalo","doi":"10.21608/bfsa.2022.161880.1501","DOIUrl":"https://doi.org/10.21608/bfsa.2022.161880.1501","url":null,"abstract":"Background: Although the willingness of healthcare specialists is a determining factor in the successful implementation of clinical pharmacy services, there is little information on specialists’ needs and satisfaction with incorporating such a new discipline into Palestinian clinical practice. Hence, this study aimed to determine the need and satisfaction of healthcare specialists toward the performance of clinical pharmacists in Palestine. Methods: A cross-sectional study using a self-administered questionnaire was undertaken between March and May 2022 at a tertiary care pediatric hospital. A total of 175 healthcare specialists (physicians, pharmacists, and nurses) working alongside clinical pharmacists were asked to participate in this survey. T-test and one-way ANOVA were used to examine the association between need and satisfaction with the different variables. Results: Of the total; 167 specialists completed the questionnaire with a response rate of 95.4%. The majority 95.8% of specialists expressed a need to work with clinical pharmacists and 94% of them were satisfied with their positive contribution to healthcare delivery. Significant differences were found between the practitioners' need and their country of education (p= 0.009) and profession (p= 0. 026). Moreover, male participants (p = 0.001) and those holding a master's degree (p = 0.002) were significantly satisfied with the performance of clinical pharmacists in the healthcare team. Conclusion: Most healthcare specialists had a positive belief in adopting the performance of clinical pharmacists in direct patient care. Consequently, Palestinian stakeholders should be in place to extrapolate clinical pharmacy workers within various healthcare centers and promote their professional collaboration with other specialists.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121009999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of RP-HPLC Method for Simultaneous Determination of Nebivolol Hydrochloride, Valsartan and Hydrochlorothiazide in co-administrated Antihypertensive Agents and Human Plasma 反相高效液相色谱法同时测定盐酸奈比洛尔、缬沙坦和氢氯噻嗪在抗高血压药物和血浆中的含量

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-23 DOI: 10.21608/bfsa.2022.167660.1537

M. Rizk, Maha Abou El- alamin, S. Mowaka, Mariam Mohamed

{"title":"Development of RP-HPLC Method for Simultaneous Determination of Nebivolol Hydrochloride, Valsartan and Hydrochlorothiazide in co-administrated Antihypertensive Agents and Human Plasma","authors":"M. Rizk, Maha Abou El- alamin, S. Mowaka, Mariam Mohamed","doi":"10.21608/bfsa.2022.167660.1537","DOIUrl":"https://doi.org/10.21608/bfsa.2022.167660.1537","url":null,"abstract":"Reversed phase high performance liquid chromatography combined with photodiode array (HPLC-PDA) detector method was developed for simultaneous determination of two binary antihypertensive combinations; either Nebivolol (NEB) with Hydrochlorothiazide (HCZ) or with Valsartan (VAL) in pharmaceutical formulation and spiked human plasma. The method was successfully applied to separate the three drugs on one chromatogram under the same chromatographic conditions that used for two binary combinations. The separation was established on Xterra C 18 column using gradient mobile phase which composed of acidified water of pH = 3.0 (adjusted with 0.1% orthophosphoric acid) and acetonitrile with flow rate of 1.0 mL/min. The drugs were determined at 280 nm. Concentration range of each analyte was shown linearity at 5.0–70.0 μg/mL for NEB, 8.0–60.0 μg/mL for HCZ and 5.0-80.0 μg/mL for VAL. The results of method validation were displayed according to ICH guidelines. The green assessment of the proposed has been carried out using two different tools.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116874632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between antibiotic resistance, biofilm formation and lasB gene in Pseudomonas aeruginosa isolated from different clinical specimens. 不同临床标本铜绿假单胞菌抗生素耐药性、生物膜形成与lasB基因的关系

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-13 DOI: 10.21608/bfsa.2022.166060.1527

Shimaa M Ghanem, G. Fadl, Rehab Abd El-Bak, Nancy Fawy

{"title":"Association between antibiotic resistance, biofilm formation and lasB gene in Pseudomonas aeruginosa isolated from different clinical specimens.","authors":"Shimaa M Ghanem, G. Fadl, Rehab Abd El-Bak, Nancy Fawy","doi":"10.21608/bfsa.2022.166060.1527","DOIUrl":"https://doi.org/10.21608/bfsa.2022.166060.1527","url":null,"abstract":"A microorganism's capacity to form a biofilm is seen as a sign of a clinically significant infection. Pseudomonas aeruginosa infections are challenging to treat since the majority of isolates have high levels of innate resistance to numerous antibiotics and a propensity to develop biofilms. A total of 350 specimens were collected from patients. 125 isolates of P. aeruginosa were recovered from different clinical samples. The antibiotic susceptibility of these isolates against Ciprofloxacin, Amikacin, cefepime, Norfloxacin, imipenem, Genamicin, Tobramycin, Aztreonam, Piperacillin-tazobactam and Colistin was determined using disk diffusion method. The TCP technique assay was chosen to identify the development of biofilm. Elastase gene detection was carried out using polymerase chain reaction (PCR) (lasB). The antibiotics against which there was the greatest resistance were cefepime (92.8%) and ciprofloxacin (67.2%). TCP technique identified 15 as weak or non-biofilm producers, 32 as moderate, and 78 as robust producers of biofilm. In 89.6% of P. aeruginosa isolates, LasB was found. P. aeruginosa's pattern of antibiotic resistance was more prevalent in biofilm producers than in non-producers. We come to the conclusion that P. aeruginosa biofilm development and drug resistance have a positive associatio n.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121680556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic-Assisted Extraction and Microencapsulation of Bioactive Compound From Pigeon Pea Seed 鸽豌豆种子中生物活性成分的超声辅助提取及微胶囊化研究

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-13 DOI: 10.21608/bfsa.2022.162608.1511

Muh. Irsal, M. Yusuf, Muhammad Tholhah Al Hayah, Andi Ma"ruf, M. Mahmud, S. N

引用次数: 0

Neuroprotective Effects of Phyllantus debilis on Rat's Hippocampus 叶菖蒲对大鼠海马的神经保护作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2022-11-11 DOI: 10.21608/bfsa.2022.156836.1473

L. Dwita, M. Iwo, E. Elfahmi, R. Mauludin

引用次数: 0