Bulletin of Pharmaceutical Sciences. Assiut最新文献

Optimization of kojic acid production by Aspergillus coculture and it’s application as anti-browning agent 曲霉共培养生产曲酸的优化及其抗褐变剂的应用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-18 DOI: 10.21608/bfsa.2023.216073.1766

G. Mahmoud, Abdel-Naser A. Zohri, Nahla Kamal-Eldin

{"title":"Optimization of kojic acid production by Aspergillus coculture and it’s application as anti-browning agent","authors":"G. Mahmoud, Abdel-Naser A. Zohri, Nahla Kamal-Eldin","doi":"10.21608/bfsa.2023.216073.1766","DOIUrl":"https://doi.org/10.21608/bfsa.2023.216073.1766","url":null,"abstract":"Kojic acid has applications in many fields so it is important to increase the amount of kojic acid. In this study production of kojic acid increased using coculture of Aspergillus oryzae ASU44 (OL314732) and A. flavus ASU45 (OL314748) than single culture, after optimizing by Box-Behnken statistical design, the production enhanced to 114.28 g/l using Glucose (150, g/l) (A), Yeast extract (5 g/l) (B), KH 2 PO 4 (3 g/l) (C), MgSO 4 .7H 2 O (0.5 g/l) (D) and pH (3) (E). The design was effective and applicable with coefficient (R 2 ) 99.1% and adjusted R 2 value 98.1%. Ethyl acetate was the best extraction solvent with ratio 1:1 and the crystals of kojic acid appeared in needle shape after evaporation of ethyl acetate using rotatory evaporator. The crystalized kojic acid has the ability to inhibit the fungal pigment of A. niger ASU311. By increasing the KA concentration, the black color decreased, especially at 10 µg/ml comparing with the control samples. On the other hand, crystalized KA preserved the color of apple juice from the conversion to brown color and the activity increased by increasing the concentration until 50 µg/ml for 6 hrs comparing with the control. Application of kojic acid produced naturally using Aspergillus coculture considered safe and environmentally friendly for increasing the freshness of the fruit juice.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128736528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disturbances in plasma aliphatic and aromatic amino acids metabolomic profiles in Egyptian obese women 埃及肥胖妇女血浆脂肪和芳香氨基酸代谢组学特征的紊乱

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-13 DOI: 10.21608/bfsa.2023.209184.1741

Abdel Rahman Abdel qawy, T. Saleem, R. Salama, Ghada Mohamed, E. Radwan

{"title":"Disturbances in plasma aliphatic and aromatic amino acids metabolomic profiles in Egyptian obese women","authors":"Abdel Rahman Abdel qawy, T. Saleem, R. Salama, Ghada Mohamed, E. Radwan","doi":"10.21608/bfsa.2023.209184.1741","DOIUrl":"https://doi.org/10.21608/bfsa.2023.209184.1741","url":null,"abstract":"Background: According to the World Health Organization (WHO), Egypt ranks 18th with the highest prevalence of obesity worldwide. The impact of obesity is a result of its comorbidities rather than a direct effect. Therefore, it is of utmost importance to investigate its risk factors to establish its potential preventive strategies for future complications. This study aimed at investigating the disturbances in aliphatic and aromatic amino acids profiles in Egyptian obese women. Methods: The study comprised 85 women that were classified into 5 groups (17 each):1-healthy, 2-overweights, 3-moderate obese, 4-severe obese, 5-morbid obese. Plasma metabolomic profile of the previous amino acids was evaluated using an amino acid analyzer. Results: Compared with controls, obese subgroups had significantly stepwise higher levels in the mean plasma levels of tyrosine, total aromatic amino acids (AAA) and alanine together with significantly lower levels of leucine, isoleucine, total branched chain amino acids (BCAA), BCAA/AAA ratio and glycine. Conclusion: Multivariate regression analysis indicated that the significantly elevated circulating alanine levels were good independent predictors for identifying obese patients at risk of associated metabolic disorders. Moreover, the study suggested that AA metabolomic profile can be used as useful tools for early prediction of overweight women. Amino acids-directed regimens intervention could serve as a specific potential targeting strategy for management of obesity.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"274 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133831789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Propagation of Algerian Lavandula stoechas and Assessment of Biochemical Composition and Their Antioxidant Activity 阿尔及利亚薰衣草的体外繁殖及其生化成分和抗氧化活性评价

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-10 DOI: 10.21608/bfsa.2023.206977.1726

Roukia Benyammi, S. Krimat, Malika Alili, M. Bekhouche, Oumaima Touari, Nawel Belalia, Amina Missoum, L. Khelifi, Abdelkader Morsli

引用次数: 0

LAVENDER ESSENTIAL OIL IMPROVED DEPRESSIVE BEHAVIOR IN MICE AFTER IINTERFERON-α ADMINISTRATION BUT NOT AFTER CYCLOSPORINE A ADMINISTRATION 薰衣草精油改善干扰素-α后小鼠的抑郁行为，但环孢素a后没有改善

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-07 DOI: 10.21608/bfsa.2023.218646.1785

Samin Eghtedari Naeini, A. Mesripour, V. Hajhashemi

{"title":"LAVENDER ESSENTIAL OIL IMPROVED DEPRESSIVE BEHAVIOR IN MICE AFTER IINTERFERON-α ADMINISTRATION BUT NOT AFTER CYCLOSPORINE A ADMINISTRATION","authors":"Samin Eghtedari Naeini, A. Mesripour, V. Hajhashemi","doi":"10.21608/bfsa.2023.218646.1785","DOIUrl":"https://doi.org/10.21608/bfsa.2023.218646.1785","url":null,"abstract":"The purpose of this study was to assess whether Lavender essential oil (Lav) could alleviate depressive symptoms induced by Interferon-α (IFN-α) therapy, which reduces tryptophan levels, or Cyclosporine A (Cyc) treatment that leads to psychological issues by inhibiting the mammalian target of rapamycin (mTOR) receptor. The study focused on mice as the subjects for evaluation. Lav 50,100,200 mcL/kg, and Cyc 40 mg/kg (all IP) and IFN-α 1600000 IU/kg SC were administered. The tests were performed after 6 days of consecutive injections on day 7. First total activity was evaluated by the locomotor test, following the splash test and then immobility time during the forced swimming test (FST) was measured. Sucrose preference was measured in order to test anhedonia. The selected treatments did not cause noticeable changes on the locomotor activity. IFN-α increased the immobility time during FST (178.6±10.4 s vs. control 125.8±17.7 s; P < 0.05) indicating depressive-like effect, and IFN-α-lav200 decreased it to (83.3±22.2 s, vs. IFN-α; P<0.01). The grooming time during splash test increased from 36.8±6.1s in IFN-α group to 106.3±9.6 in IFN-α-lav200 group (P<0.05). Sucrose preference increased to 82% following IFN-α-Lav200 administration. However, Lav did not cause a significant change on Cyc-induced depression. Conclusion: While Lav demonstrated a beneficial effect in mitigating IFN-α-induced depression in mice, it was not able to fully reverse Cyc-induced depression. This suggests that Lav exerts its antidepressant effects through distinct mechanisms that may not involve modifications to the mTOR pathways.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129211594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the pharmacists knowledge, awareness, and practices towards pharmacovigilance in Syria 评估叙利亚药剂师对药物警戒的知识、意识和实践

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-05 DOI: 10.21608/bfsa.2023.220596.1801

Daniella Lahdo, Taldah Ahdali, Muaaz Alajlani

{"title":"Evaluation of the pharmacists knowledge, awareness, and practices towards pharmacovigilance in Syria","authors":"Daniella Lahdo, Taldah Ahdali, Muaaz Alajlani","doi":"10.21608/bfsa.2023.220596.1801","DOIUrl":"https://doi.org/10.21608/bfsa.2023.220596.1801","url":null,"abstract":"Background: The system of pharmacovigilance in Syria is administered by the Syrian Ministry Of Health (MOH), it is responsible for receiving reports from the patient all over the country for possible Adverse Drug Reactions (ADRs). Pharmacists are members of this system and play a very important role in its implementation. Until now, Few pharmacists know about this system in Syria, how to deal with it, or even how important it is. Aims: To discover Syrian pharmacists' knowledge, awareness, proceedings, and possible obstacles encountered while reporting the (ADRs). and to estimate the sociodemographic data from Damascus and rural Damascus. Methods: We used a self-administered, cross-sectional, questionnaire-based survey conducted on a random sample of 235 registered pharmacists in 2 Syrian governorates. Results: 84% was the rate of response, 45% had a familiarity with the PV system in Syria but the rest didn’t. Some of them have received complaints from patients about unknown side effects, and their percentage was 60%, only 22% reported it. The most significant percentage of notifications was through the company’s representative (10%), and 6% used the Ministry of Health (MOH) form. Conclusions: Pharmacists who participated in the survey showed limited knowledge about pharmacovigilance (PV), also about its importance and extent of application in Syria. They had overlapping attitudes toward the reports, although they emphasized the importance of it. However, the current level of participation is rather low.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126339871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antioxidant and Free Radical Scavenging Activities of Some Abundant Marine Macroalgae, Egypt. 埃及一些丰富的海洋大型藻类抗氧化和自由基清除能力的评价。

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-02 DOI: 10.21608/bfsa.2023.214520.1758

Hager Kamal, S. Heneidak, Gihan El Shoubaky, Abdel-hamied Rasmey

引用次数: 0

An Investigating the Genetic Effect of VKORC1 Gene Polymorphism on Warfarin Response in Egyptian Heart Patients VKORC1基因多态性对埃及心脏病患者华法林反应的遗传影响研究

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-02 DOI: 10.21608/bfsa.2023.215545.1763

Hassan Donkol, H. Ali, H. Hamed, M. Abdel-Rahman, Mohamed Abdel-Latif

引用次数: 0

The Potential of Ethanol Extract of Guava (Psidium guajava L.) Leaves as Adjuvant-Antibiotic on Salmonella typhi Characterized 番石榴醇提物的开发潜力叶片作为佐剂-抗生素治疗伤寒沙门菌的研究

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-08-01 DOI: 10.21608/bfsa.2023.211034.1747

Wahyu Hendrarti, Syamsu Nur, Astuti Amin, Michrun Nisa, H. Abidin

引用次数: 0

TM6SF2 rs58542926 is linked to thrombocytopenia-related advanced hepatic fibrosis in Egyptian patients with chronic hepatitis C TM6SF2 rs58542926与埃及慢性丙型肝炎患者血小板减少相关的晚期肝纤维化有关

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-07-27 DOI: 10.21608/bfsa.2023.215691.1764

M. Abdul, H. Elbadawy, A. Vitiello, Hanieh Ghassabian, Heba Altahir, E. Hassan, Abeer Sharaf, Amany Bekhit, Abobakr Abozeed, Hany Ahmed, Meky Abouzied, A. Calistri, G. Alvisi, M. Sabry, K. Thabet

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Influences of environmental factors on the active metabolites and certain bioactivities of Desert Date leaf and fruit (Balanites aegyptiaca L. Delile) grown in Egypt 环境因子对埃及沙漠枣叶和果实活性代谢产物及某些生物活性的影响

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-07-24 DOI: 10.21608/bfsa.2023.214909.1761

A. Zaher, F. Salama, N. El-Tayeh, Sara El-Nagar, Raoof Sultan, A. Gaafar

{"title":"Influences of environmental factors on the active metabolites and certain bioactivities of Desert Date leaf and fruit (Balanites aegyptiaca L. Delile) grown in Egypt","authors":"A. Zaher, F. Salama, N. El-Tayeh, Sara El-Nagar, Raoof Sultan, A. Gaafar","doi":"10.21608/bfsa.2023.214909.1761","DOIUrl":"https://doi.org/10.21608/bfsa.2023.214909.1761","url":null,"abstract":"Balanites aegyptiaca (L.) Delile is a medicinal wild tree, naturally distributed in wide regions of Africa and South Asia. The fruits are commercially available in Egypt as antidiabetic natural products. The current study aimed to determine the effects of environmental factors on the metabolites and the bioactivities of fruit and leaf extracts. The main ecological differences between the sites of collection, Wadi El−Gemal and Baris Oasis, are temperature, aridity, humidity, and location. The fruit extract of Baris Oasis showed higher saponin content and saponin metabolites (LC−MS analysis) than the fruit extract of Wadi El−Gemal. Baris Oasis fruit extract showed twice the inhibition of α−Glucosidase than Wadi El−Gemal fruit extract. Twelve phenolics and flavonoids were detected in Baris Oasis leaf extract, while ten compounds were detected in Wadi El−Gemal leaf extract using HPLC. The higher quality and quantity of flavonoids and phenolics of Baris Oasis leaf extract than Wadi El−Gemal leaf extract, have significant effects on the antioxidant and acetylcholinesterase inhibitory activities. In conclusion, elevation of temperature and aridity have significant positive effects on the synthesis and accumulation of B. aegyptiaca saponins, phenolics and flavonoids. The bioactivities of the fruit and leaf extracts are directly proportional to the variation in metabolites due to abiotic stresses.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127075699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0