Bulletin of Pharmaceutical Sciences. Assiut最新文献_第6页

Knowledge and Perceptions of Final Year Students Towards Pharmacovigilance and Adverse Drug Reaction Reporting at the College of Medical Sciences, Al-Razi University -Sana`a Yemen. 也门萨那Al-Razi大学医学院毕业班学生对药物警戒和药物不良反应报告的知识和看法。

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-08 DOI: 10.21608/bfsa.2023.194399.1671

Nabil Al-Baser

引用次数: 0

EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW 用包衣系统和脆性赋形剂提高片剂抗拉强度的研究进展

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-08 DOI: 10.21608/bfsa.2023.192140.1661

A. Ainurofiq, Chalimatussa’diyah Sholekah, Dzakiyyatul Hanifah, Eka Susanti, Meila Suryaningrum, Meyliana Kusumawardhani

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Therapeutical interventions for myalgic encephalomyelitis/chronic fatigue syndrome; A review of phase IV Clinical trials 肌痛性脑脊髓炎/慢性疲劳综合征的治疗干预IV期临床试验综述

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-06 DOI: 10.21608/bfsa.2023.199974.1690

Nasser M Alorfi

{"title":"Therapeutical interventions for myalgic encephalomyelitis/chronic fatigue syndrome; A review of phase IV Clinical trials","authors":"Nasser M Alorfi","doi":"10.21608/bfsa.2023.199974.1690","DOIUrl":"https://doi.org/10.21608/bfsa.2023.199974.1690","url":null,"abstract":"Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and complex illness with multifactorial etiology. Current clinical trials were examined to understand the characteristics of ME/CFS as well as possible therapeutical interventions. Aim: To identify features of clinical trials related to ME/CFS registered at ClinicalTrials.gov, specifically, the therapeutical interventions used to manage the syndrome in phase IV. Method: Analysis of all clinical trials registered at ClinicalTrials.gov for ME/CFS. Those clinical trials that employed a targeted therapy were included. The analysis identified a selection of clinical trials examining a targeted therapy for ME/CFS, providing a platform for further exploration of potential treatments. Results: By November 19th, 2022, 151 clinical trials related to ME/CFS had been found. Interventional studies were the most prevalent type. However, the trials were restricted to specific continents and were not extensively conducted in pediatric patients. Micronutrients were the most commonly used intervention. Phase IV studies had fewer clinical trials with limited interventional measures. Only three out of nine studies completed pharmacological interventional studies, and of these, sodium oxybate was being used most frequently. Conclusion: Among the clinical trials identified through this paper, there were few related to ME/CFS treatment. The interventions in the completed phase IV studies involved drugs that mainly interacted with the CNS, and more rarely that had an effect on blood vessels and blood perfusion. The limited number of phase IV clinical trials meant that the results were inconclusive.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114663435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacognostic, Phytochemical Evaluation, and Antioxidant Activity of the Leaves of Grewia bilamellata Gagnep. (Tiliaceae) 青叶的生药学、植物化学评价及抗氧化活性研究。(椴树科)

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-03 DOI: 10.21608/bfsa.2023.190720.1656

Poornima Gurivelli, S. K

{"title":"Pharmacognostic, Phytochemical Evaluation, and Antioxidant Activity of the Leaves of Grewia bilamellata Gagnep. (Tiliaceae)","authors":"Poornima Gurivelli, S. K","doi":"10.21608/bfsa.2023.190720.1656","DOIUrl":"https://doi.org/10.21608/bfsa.2023.190720.1656","url":null,"abstract":"This research seeks to analyze the Pharmacognostic, Phytochemical evaluation, Total Phenolic, Flavonoid Content, and Antioxidant activity of the leaves of Grewia bilamellata Gagnep. (G. bilamellata). This Pharmacognostic study comprises microscopic observation, leaf characteristics, phytochemical and physicochemical analyses, and total phenolic and flavonoid content. Antioxidant activity was examined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and H 2 O 2 assays. The leaf shows anomocytic stomata, covering, glandular and stellate type of trichomes, Total phenolic and flavonoid content turned greatest in ethanolic extract (EEGB) (90.69±2.86 mg GAE/g), and (26.21 ± 1.51 mg RE/g), respectively. EEGB showed the most intense 1,1-diphenyl-2-picrylhydrazyl (DPPH) and H 2 O 2 scavenging activity, with IC 50 59.96 and 59.24 µg/ml. Total phenolic and flavonoid contents - DPPH and H 2 O 2 scavenging assays were positively correlated. The Invitro Antioxidant results were also correlated with the Insilico method using xanthine oxidase (XOD) and superoxide dismutase (SOD) as targets. Microscopic and physicochemical parameters are valuable for authenticating drug identification and purity. G. bilamellata is a potential perspective source of antioxidants.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130498578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dispensing antibiotics without prescription in the Arab world: A narrative review of the prevalence, appropriateness, facilitators and preventive interventions. 在阿拉伯世界无处方分发抗生素:对流行、适当性、促进和预防性干预措施的叙述审查。

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-03 DOI: 10.21608/bfsa.2023.190095.1655

Hala Alagha

{"title":"Dispensing antibiotics without prescription in the Arab world: A narrative review of the prevalence, appropriateness, facilitators and preventive interventions.","authors":"Hala Alagha","doi":"10.21608/bfsa.2023.190095.1655","DOIUrl":"https://doi.org/10.21608/bfsa.2023.190095.1655","url":null,"abstract":"Inappropriate antibiotic-related practices are common worldwide but feature more strongly in developing countries. An example of such practices is dispensing antibiotics without prescription [DAwP] in community pharmacies, despite being illegal in most countries around the globe. The aim of this review is to discuss in-depth all aspects related to the practice of DAwP in Arab countries. We searched SCOPUS, PubMed and Google Scholar for articles involving studies addressing the practice of DAwP, conducted in any Arab country, and published from 2000 to 2022. We found that DAwP is very common with extremely high prevalence rates that differ according to methodologies used in those studies. Malpractices associated with DAwP include poor information-gathering before dispensing, poor counseling, inappropriate choice of the antibiotic, recommending antibiotics when they are not indicated, wrong duration and wrong dosing. Common factors shown to contribute to this practice include lax enforcement of regulations, misconceptions about antibiotics by the public, accessibility of community pharmacies, trustability of pharmacists, and the business orientation of pharmacies. Enforcement of regulations, increasing the competency of pharmacists by enhancing undergraduate pharmacy plans and establishing well-planned continuing education programs, reframing regulations to account for the expanding role of competent pharmacists, and increasing the awareness of the public towards antibiotics may limit DAwP and other antibiotic-related inappropriate practices.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122702755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of epithelial to mesenchymal transition in kidney fibrosis 肾纤维化中上皮向间质转化的影响

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-03 DOI: 10.21608/bfsa.2023.198221.1683

Olivia N. Beshay, Amany Bekhit, M. Fawzy, Mostafa Fathy

{"title":"The impact of epithelial to mesenchymal transition in kidney fibrosis","authors":"Olivia N. Beshay, Amany Bekhit, M. Fawzy, Mostafa Fathy","doi":"10.21608/bfsa.2023.198221.1683","DOIUrl":"https://doi.org/10.21608/bfsa.2023.198221.1683","url":null,"abstract":": Fibrosis is a pathological condition attributed to an inappropriate deposition of extracellular matrix that promotes scarring and dysfunction of the implicated organ or tissue. Moreover, fibrosis encompasses an enormous range of organs and tissues, each with a distinct molecular basis. Yet, two factors are discussed: the critical function of transforming growth factor-beta (TGF-β) and the participation of the inflammatory cascade, which is required to initiate fibrotic destruction. Epithelial to mesenchymal transition (EMT), the most prevalent cellular program underlying fibrosis, is regulated by TGF-β, as well as other cytokines. EMT has been widely investigated, although it has not yet been adequately examined as a potential treatment option for fibrosis. A better knowledge of the linkages between fibrosis and EMT may provide an option for the establishment of a highly useful anti-fibrotic treatment. Thus, we provide a general overview of EMT; summarize the significance of TGF-β/Smad signaling cascade in EMT induction, the correlation between both EMT and renal fibrosis and the promising treatment strategies targeting fibrosis induced by EMT.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126969653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the efficacy and toxicity of neo-adjuvant short course radiation therapy concurrently with continuous infusion 5-fluorouracil in the management of locally advanced rectal cancer patients. 新辅助短程放疗联合持续输注5-氟尿嘧啶治疗局部晚期直肠癌的疗效和毒性评价

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-03-30 DOI: 10.21608/bfsa.2023.186373.1639

Abeer F Amin, M. Khalil, T. Mohran, M. Abdel-Wanis, Maha Mohamed El-naggar, Radwan A. Torky

{"title":"Evaluation of the efficacy and toxicity of neo-adjuvant short course radiation therapy concurrently with continuous infusion 5-fluorouracil in the management of locally advanced rectal cancer patients.","authors":"Abeer F Amin, M. Khalil, T. Mohran, M. Abdel-Wanis, Maha Mohamed El-naggar, Radwan A. Torky","doi":"10.21608/bfsa.2023.186373.1639","DOIUrl":"https://doi.org/10.21608/bfsa.2023.186373.1639","url":null,"abstract":"Purpose: To assess the safety and efficacy of neo-adjuvant short-course radiation therapy (SCRT) concurrently with continuous infusion of 5-fluorouracil (5-FU) in the treatment of locally advanced rectal cancer. Method and material: Patients with cT3-4 or any T with N+ rectal cancer diagnosed by magnetic resonance imaging (MRI) and proved pathologically as adenocarcinoma were eligible to be enrolled in our study. Patients received continuous infusion of 5-FU with dose escalation from 100mg/m2/day up to 200mg/m2/day through 5 days concurrently with a SCRT (5 Gy x 5 fractions), followed by 2 months of neo-adjuvant mFOLFOX, radical surgery with total mesorectal excision (TME) was done for patients with complete clinical (cCR), partial response (PR) or stationary disease (SD) and was follow by 4 months of adjuvant mFOLFOX. Results: Twenty patients were included in the study. All patients completed a SCRT concurrently with 5-FU and the 5-FU dose was safely escalated to 200 mg/m2/d with no dose-limiting toxicity (DLT). Four patients (20%) out of 20 patients showed cCR, 14 patients (7o%) had PR, and 2 patients (10%) had disease progression (PD). Four patients (26.7) out of 15 patients had complete pathological response (pCR), and 11 patients (73.3%) had PR. The most common grade III and Ⅳ toxicities according to common terminology criteria of adverse events version 5.0 (CTCAE) were diarrhea and abdominal pain. The most common grade Ⅰ and Ⅱ toxicities were non-hematological toxicity mainly gastrointestinal.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130329591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing patterns and pharmacological knowledge of analgesics among community pharmacists in Jeddah, Saudi Arabia 吉达，沙特阿拉伯社区药师镇痛药的处方模式和药理知识

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-03-30 DOI: 10.21608/bfsa.2023.199161.1686

Nasser M Alorfi

{"title":"Prescribing patterns and pharmacological knowledge of analgesics among community pharmacists in Jeddah, Saudi Arabia","authors":"Nasser M Alorfi","doi":"10.21608/bfsa.2023.199161.1686","DOIUrl":"https://doi.org/10.21608/bfsa.2023.199161.1686","url":null,"abstract":"Background: Analgesics are frequently used to manage pain, and community pharmacists play a crucial role in prescribing these medications. However, inappropriate prescribing patterns and inadequate pharmacological knowledge of analgesics among pharmacists can lead to adverse health outcomes and increase healthcare costs. Aim: Eevaluating the prescribing patterns and pharmacological knowledge of analgesics among community pharmacists in Saudi Arabia. The study also seeks to identify any potential areas of deficiency in the knowledge or practices of community pharmacists regarding the safe and effective use of analgesics. Ultimately, to enhance the quality of care provided to patients who require analgesic therapy, by addressing any gaps in the knowledge or practices of community pharmacists. Method: In November 2022, a study was conducted in Jeddah to investigate the prescribing skills and level of pharmacological knowledge of analgesics among community pharmacists. The research design used for this study was cross-sectional. Results: One hundred thirty fours community pharmacists responded to the survey. Most participants were male, 31 years old or above, with a Bachelor’s Degree in Pharmacy. Most of the community pharmacists were aware of the correct use, side effects or complications, contraindications, safe dosage, and reaction mechanism of analgesics. The community pharmacists obtained a favorable mean knowledge score (> 50%) of analgesic drugs. Conclusion: Community pharmacists reported correct prescribing patterns and adequate pharmacological knowledge. However, when pharmacists have little community experience their analgesic drug knowledge tends to be weaker, but it becomes stronger after 5 years.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130061294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study the anti-inflammatory effects of tamsulosin by inflammatory cells analysis and lung histopathology in airway inflammation model in rats 通过大鼠气道炎症模型的炎症细胞分析和肺组织病理学研究坦索罗辛的抗炎作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-03-28 DOI: 10.21608/bfsa.2023.188807.1652

Hala Alabdali, M. Ibrahim

引用次数: 0

In-Silico study of Cassia tora Linn in the treatment of Gaucher disease: A Scientific Ethnomedical Study 决明子治疗戈谢病的计算机研究:一项科学的民族医学研究

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-03-28 DOI: 10.21608/bfsa.2023.184206.1620

Prasanth Dsnbk, Pamula Reddy Bhavanam, P. K. Pasala, Siva Prasad Panda, S. Achanti, Rajiv Jash, R. Jamullamudi, Siva Saikiran Badithala, Sandeep Katneni, Beebi Ayesha Md, Poojitha Mokkapati, Pavithra Chaganti

引用次数: 0