Bulletin of Pharmaceutical Sciences. Assiut最新文献_第5页

CAPECITABINE EFFICACY WITH ADJUVANT RADIOTHERAPY IN THE TREATMENT OF EARLY STAGE BREAST CANCER (RETROSPECTIVE STUDY) 卡培他滨辅助放疗治疗早期乳腺癌的疗效(回顾性研究)

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-05-21 DOI: 10.21608/bfsa.2023.205370.1714

R. Mohamed, Seham A. Ali, S. Eid

{"title":"CAPECITABINE EFFICACY WITH ADJUVANT RADIOTHERAPY IN THE TREATMENT OF EARLY STAGE BREAST CANCER (RETROSPECTIVE STUDY)","authors":"R. Mohamed, Seham A. Ali, S. Eid","doi":"10.21608/bfsa.2023.205370.1714","DOIUrl":"https://doi.org/10.21608/bfsa.2023.205370.1714","url":null,"abstract":"Objectives: Our goal is to assess the effectiveness and toxicity of capecitabine as radio-sensatizer with adjuvant radiotherapy in breast cancer (BC) patients. Methods: On the radiation days, the patients got capecitabine 825 mg/m 2 every 12 hours with a 25% dosage reduction if creatinine clearance was lower than 30 ml/min with radiation therapy of dose of 4240 cGy administered in 16 fractions at a rate of 2.65 Gy each over the course of three weeks. In addition, a boost dose of 14 Gy administered in 7 fractions was added to the lumpectomy bed. Results: Study group were evaluated at 3, 12, 24, 36, 48, and 60 months. At 3 and 12 months, 29 patients (61.7%) exhibited G1 skin hyperpigmentation. At 60-month, 3 patients (7.5%) had G2 lymphedema (p = 0.226). At 24th month, 4 patients (9.3%) had G1 telangiectasia, 5 patients (11.6%) developed G1 skin fibrosis (p = 0.001). Moreover, one patient (2.3%) experienced a G1 cardiac event (p = 0.416). At 3 month radiation pneumonitis G1 was identified in 3 patients (6.4%) (p = 0.416). Despite the fact that 6 patients (15%) developed distant metastases, there were no instances of local recurrence. the OS rate was 85.1%. Conclusion: Adjuvant radiation combined with capecitabine is well tolerated and effective","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132120588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyme and cumin nanoemulsion as a promising antimicrobial agent against multidrug-resistant Staphylococcus aureus 百里香孜然纳米乳作为抗多重耐药金黄色葡萄球菌的一种有前景的抗菌剂

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-05-16 DOI: 10.21608/bfsa.2023.192901.1662

W. Ahmed, S. AL-Siraj, A. A. Abd El-Tawab, Fatma Elhofy, Dalia M. A. Elmasry

引用次数: 0

Portulaca oleracea leaves extract attenuates cyclophosphamide toxicity in mice 马齿苋叶提取物对小鼠的环磷酰胺毒性有减弱作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-05-16 DOI: 10.21608/bfsa.2023.172083.1565

A. Saleh, F. Sarhan, sabry el naggar, K. El-Said

引用次数: 0

Ameliorative Effect of Combined Treatment of Blueberry Fruit Extract and Voglibose on Streptozotocin-Induced Diabetes Mellitus in Rats 蓝莓果提取物与伏糖糖联合治疗链脲佐菌素所致大鼠糖尿病的改善作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-05-07 DOI: 10.21608/bfsa.2023.203205.1701

Omnia Elsayed Ahmed, M. Aboutabl, • Nesrine Salah El-Dine El-Sayed, Y. Maklad, S. Kenawy

引用次数: 0

Antimicrobial and in vitro cytotoxicity effect of green synthesized silver nanoparticles using aqueous leaf extract of Senna hirsuta 毛蕨叶水提物合成绿色纳米银的抗菌及体外细胞毒作用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-17 DOI: 10.21608/bfsa.2023.197850.1681

N. Palei, Bhuvana Mp, J. Rajangam, A. Dhar

{"title":"Antimicrobial and in vitro cytotoxicity effect of green synthesized silver nanoparticles using aqueous leaf extract of Senna hirsuta","authors":"N. Palei, Bhuvana Mp, J. Rajangam, A. Dhar","doi":"10.21608/bfsa.2023.197850.1681","DOIUrl":"https://doi.org/10.21608/bfsa.2023.197850.1681","url":null,"abstract":"In this study, we prepared silver nanoparticles (AgNPs) using an aqueous Senna hirsuta leaf extract. The AgNPs were characterized using UV visible spectrophotometer, particle size, zeta potential, energy diffraction X-ray (EDAX), Fourier transform infrared (FTIR), transmission electron microscopy (TEM) and determined antibacterial and cytotoxicity impact of the AgNPs. UV-Visible spectroscopy of Senna hirsuta leaf extract synthesized into AgNPs was carried out at various time intervals. The peak (λ max) was observed at 436–446 nm and it was broad. The particle size of the synthesized AgNPs was found 28.3 nm. The Zeta potential of AgNPs was found -4.4 mV. TEM analysis demonstrated that nanoparticles have a spherical form. According to the EDAX analysis, the extract effectively capped the AgNPs. Zone of inhibition of AgNPs were observed more than those of the extract. Silver nanoparticles demonstrated effective antimicrobial activity due to their large surface area, which allows for stronger contact with cell wall of bacteria. In vitro cytotoxicity showed that synthesized AgNPs a prominent cytotoxicity activity against MCF7 cell lines.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124774610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium alginate film incorporated with zinc oxide nanoparticles as antibacterial agent 海藻酸钠薄膜掺入氧化锌纳米颗粒作为抗菌剂

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-17 DOI: 10.21608/bfsa.2023.194715.1673

Bashar Alshami, W. Zam, Walid Khaddam

{"title":"Sodium alginate film incorporated with zinc oxide nanoparticles as antibacterial agent","authors":"Bashar Alshami, W. Zam, Walid Khaddam","doi":"10.21608/bfsa.2023.194715.1673","DOIUrl":"https://doi.org/10.21608/bfsa.2023.194715.1673","url":null,"abstract":"Alginate biopolymer has been used in the design and development of several wound dressing materials such as (foams, topical formulations, nanofibers, films) due to its favorable properties, such as biocompatibility and non-toxicity. It has been particularly attractive in wound healing applications to date. Additionally, it can be loaded by antibacterial materials such as antibiotics, antibacterial plant extracts and metal nano-oxides. The aim of this study was to design sodium alginate (SA) based zinc oxide (ZnO) nanoparticles as antibacterial film for wound healing applications. The ZnO nanoparticles, with an average particle size of about 16.75 nm, were synthesized by sol-gel method and characterized by scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR). They were then incorporated as antibacterial into sodium alginate with different concentration (0, 5, 7.5, 10%). Effectiveness of antibacterial activity was carried out against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus) to characterize the sample. The prepared ZnO/SA film presents a promising potential for applications as novel wound dressings","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117201504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating exposure to SARS-CoV-2 at the Arab International University, Syria: a snapshot after a year of pandemic 估计在叙利亚阿拉伯国际大学接触SARS-CoV-2:大流行一年后的快照

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-15 DOI: 10.21608/bfsa.2023.189767.1659

Wafika Zarzour, W. Habbal, Alaa Oraige, A. Ganama, Raghad Serri

{"title":"Estimating exposure to SARS-CoV-2 at the Arab International University, Syria: a snapshot after a year of pandemic","authors":"Wafika Zarzour, W. Habbal, Alaa Oraige, A. Ganama, Raghad Serri","doi":"10.21608/bfsa.2023.189767.1659","DOIUrl":"https://doi.org/10.21608/bfsa.2023.189767.1659","url":null,"abstract":"Background: After a year of pandemic in Syria, how prevalent the seropositivity is, and how far we are from herd immunity is a raised question. Aim: Our study aimed to estimate the overall exposure to SARS-COV-2 depending on the COVID-19-specific symptoms as well as the seroprevalence of anti-SARS-CoV-2 IgG antibodies among students and staff at the Arab International University (AIU) in Syria. Methods: All AIU students and staff were invited to voluntarily participate in the study by filling out and submitting an anonymous web-based survey. Responses were evaluated then asymptomatic and pauci-symptomatic respondents were notified of a phlebotomy appointment. Anti-SARS-CoV-2 IgG antibodies were analyzed by ELISA. Results: One third (122 of 381; 32%) of respondents were asymptomatic. The remaining respondents reported COVID-19-specific symptoms (177 of 381; 46.5%), mainly anosmia and/or ageusia (132 of 177; 74.5%), or nonspecific symptoms (82 of 381; 21.5%). Frequencies of symptoms onset showed a strong, positive correlation with the incidence of confirmed SARS-CoV-2 RNA-positive cases reported by the Ministry of Health in Syria. Anti-SARS-CoV-2 IgG antibodies were similarly detected in both symptomatic (21 of 33; 63.6%) and asymptomatic (39 of 61; 63.9%) individuals (P=.97). Conclusions: After a year of pandemic, a 69% exposure to SARS-CoV-2 is roughly estimated amongst asymptomatic and pauci-symptomatic individuals. Further post-vaccination assessment of seroprevalence against SARS-CoV-2 in future large-scale studies might provide a more complete picture of the SARS-CoV-2 epidemic in Syria.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"355 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124487280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between High Sensitivity C-Reactive Protein and Lipid Profile in Young Patients with Diabetes Mellitus Type 1 in Homs-Syria 叙利亚霍姆斯地区1型糖尿病年轻患者高敏c反应蛋白与血脂的相关性

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-15 DOI: 10.21608/bfsa.2023.188555.1648

Reham Deeban, S. Alwassouf

引用次数: 0

Review of serine protease inhibitors: Development and applications 丝氨酸蛋白酶抑制剂的研究进展及应用

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-15 DOI: 10.21608/bfsa.2023.194320.1669

M. Ramadan

引用次数: 0

Black fungus what do we know about it? Knowledge, attitude and practice of health care professionals in Iraq 黑木耳我们对它了解多少?伊拉克保健专业人员的知识、态度和做法

Bulletin of Pharmaceutical Sciences. Assiut Pub Date : 2023-04-11 DOI: 10.21608/bfsa.2023.170851.1560

Zainab M Al-Shammaa, Luma M Al-Obaidy

{"title":"Black fungus what do we know about it? Knowledge, attitude and practice of health care professionals in Iraq","authors":"Zainab M Al-Shammaa, Luma M Al-Obaidy","doi":"10.21608/bfsa.2023.170851.1560","DOIUrl":"https://doi.org/10.21608/bfsa.2023.170851.1560","url":null,"abstract":"Background: Black fungus is a serious infectious disease caused by mucoromycetes. The first cases of black fungus among patients with COVID-19 were reported in India in December 2020, followed by new cases in other countries like Iraq. This study aimed to assess the knowledge, attitude, and practice of healthcare professionals (HCPs) toward black fungus. Methods: This was a cross-sectional study, in which HCPs who are members of the Iraqi syndicate of physicians, dentists, and pharmacists from different Iraqi cities participated in this online survey between the 11 th of September and the 11 th of November 2021. Results: In total 340 HCPs participated in this study. 55% of participating HCPs had a poor level of knowledge. 52% of participating HCPs thought that COVID-19 vaccination could protect the person from black fungus disease. 44% of the participating HCPs thought that black fungus can be prevented in COVID-19 patients through the wise use of steroids and good glycemic control in diabetic patients. 96% of HCPs thought that the best management plan for black fungus includes antifungal therapy plus surgery. Conclusions: Although the majority of HCPs have general information about black fungus, the level of knowledge regarding different aspects of the disease is poor. Iraqi HCPs required more comprehensive educational programs to increase their knowledge of black fungus and other infectious diseases.","PeriodicalId":345040,"journal":{"name":"Bulletin of Pharmaceutical Sciences. Assiut","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116014067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0