Sodium alginate film incorporated with zinc oxide nanoparticles as antibacterial agent

Abstract

Alginate biopolymer has been used in the design and development of several wound dressing materials such as (foams, topical formulations, nanofibers, films) due to its favorable properties, such as biocompatibility and non-toxicity. It has been particularly attractive in wound healing applications to date. Additionally, it can be loaded by antibacterial materials such as antibiotics, antibacterial plant extracts and metal nano-oxides. The aim of this study was to design sodium alginate (SA) based zinc oxide (ZnO) nanoparticles as antibacterial film for wound healing applications. The ZnO nanoparticles, with an average particle size of about 16.75 nm, were synthesized by sol-gel method and characterized by scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR). They were then incorporated as antibacterial into sodium alginate with different concentration (0, 5, 7.5, 10%). Effectiveness of antibacterial activity was carried out against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus) to characterize the sample. The prepared ZnO/SA film presents a promising potential for applications as novel wound dressings