FS Reports最新文献

{"title":"Successful pregnancy after preimplantation genetic testing for structural rearrangements in a couple with complex chromosome rearrangement and recurrent in vitro fertilization failures: a case report","authors":"Divyesh Upadhyay B.S. ,&nbsp;Rajia Al Halaby M.D. ,&nbsp;Sudha Anandt Ph.D. ,&nbsp;Firas Albuz Ph.D. ,&nbsp;Merlin Mary Varghese M.S. ,&nbsp;Braulio Peramo M.D.","doi":"10.1016/j.xfre.2024.10.006","DOIUrl":"10.1016/j.xfre.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>To present a case of a couple with 20 years of infertility and 10 recurrent in vitro fertilization (IVF) failures, identifying a paternal complex chromosome rearrangement using high-resolution karyotype together with preimplantation genetic testing for structural rearrangements (PGT-SR) and utilizing IVF-intracytoplasmic sperm injection to achieve a successful pregnancy.</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Setting</h3><div>Al Ain Fertility Center, Abu Dhabi, United Arab Emirates.</div></div><div><h3>Patients</h3><div>A 40-year-old male patient and a 37-year-old female patient with a history of infertility and recurrent IVF failures.</div></div><div><h3>Exposure</h3><div>In vitro fertilization-intracytoplasmic sperm injection with high-resolution karyotype and PGT-SR.</div></div><div><h3>Main Outcome Measures</h3><div>Identification of chromosomal abnormalities, successful embryo development, pregnancy outcome, and newborn karyotyping.</div></div><div><h3>Results</h3><div>Karyotyping revealed a paternal complex chromosome rearrangement, t(3;4;12) (q21;q33;q21), and a chromosomal polymorphism in the female (1qh+). In vitro fertilization-intracytoplasmic sperm injection with PGT-SR produced one euploid/balanced female embryo from 20 embryos across 8 cycles. The patient conceived after hormone replacement therapy and frozen embryo transfer, resulting in an uneventful, full-term pregnancy and delivery of a healthy baby via C-section. Newborn karyotyping was normal (46,XX).</div></div><div><h3>Conclusion</h3><div>High-resolution karyotype and PGT-SR should be offered to patients undergoing IVF, especially those with severe male factors, recurrent IVF failures, implantation failures, or recurrent pregnancy losses, to enhance the chances of a successful pregnancy.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 439-452"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incorrect conclusion about vaginally administered progesterone: when a randomized clinical trial gets it wrong","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2024.11.003","DOIUrl":"10.1016/j.xfre.2024.11.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 339-340"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is endometriosis typology a potentially better classification system for assessing risk of female infertility?","authors":"Karen C. Schliep Ph.D. ,&nbsp;Anna Z. Pollack Ph.D. ,&nbsp;Leslie V. Farland Sc.D. ,&nbsp;May Shaaban M.P.H. ,&nbsp;Bin Yan M.S.T.A.T. ,&nbsp;Jing Wang Ph.D. ,&nbsp;Lina Ghabayen M.D. ,&nbsp;Rachael B. Hemmert M.S.P.H. ,&nbsp;Joseph B. Stanford M.D. ,&nbsp;C. Matthew Peterson M.D.","doi":"10.1016/j.xfre.2024.08.009","DOIUrl":"10.1016/j.xfre.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether endometriosis typology, namely ovarian endometriomas (OE), deep infiltrating endometriosis (DIE), or superficial endometriosis (SE), correlates with fertility history.</div></div><div><h3>Design</h3><div>Prospective cohort.</div></div><div><h3>Setting</h3><div>One of fourteen surgical centers in Salt Lake City, Utah (n = 5) or San Francisco, California (n = 9).</div></div><div><h3>Patient(s)</h3><div>A total of 473 women (18–44 years) with no prior endometriosis diagnosis, undergoing laparoscopies/laparotomies, irrespective of indication, in Utah or California (2007–2009).</div></div><div><h3>Exposure</h3><div>Incident endometriosis.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Before surgery, we queried women about time to become pregnant for prior planned pregnancies. Generalized linear models were used to calculate adjusted prevalence ratios (aPR) for association between endometriosis typology and infertility, defined as having ever tried &gt;12 months (&gt;6 months for women ≥35 years) to get pregnant. We also generated fecundability odds ratios (aFOR) to capture time to pregnancy.</div></div><div><h3>Result(s)</h3><div>Twenty-five percent (n = 116) of women were diagnosed with SE only, 5% (n = 23) with OE, 6% (n = 29) with DIE, and 5% (n = 22) with OE + DIE, and 60% (n = 283) with no endometriosis. Compared with women with no endometriosis, women with SE had a 1.58 higher aPR (95% confidence interval [CI], 1.16–2.14), although women with OE and/or DIE had a 2.41 higher aPR for subfertility after adjusting for women’s age, body mass index, and site. Compared with women with no endometriosis, women with OE and/or DIE had a 53% lower historic fecundability (aFOR, 0.47; 95% CI, 0.24–0.95); however, no association was found among women with SE (aFOR, 0.81; 95% CI, 0.49–1.33).</div></div><div><h3>Conclusion(s)</h3><div>Specific endometriosis typologies may be associated with fecundability, with OE and/or DIE associated with nearly a 150% higher prevalence of subfertility and over a 50% lower historic fecundability.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 394-401"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking potential: advanced practice providers in reproductive endocrinology and infertility","authors":"Lauren Nervi M.S.N., R.N., N.P.-C.,&nbsp;Thomas A. Molinaro M.D., M.S.C.E.","doi":"10.1016/j.xfre.2024.11.002","DOIUrl":"10.1016/j.xfre.2024.11.002","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 352-353"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Envisioning a path from the Internet of Medical Things to improved fertility care access: a mini-review","authors":"Olutunmike Kuyoro M.D.,&nbsp;Randi Goldman M.D.","doi":"10.1016/j.xfre.2024.09.004","DOIUrl":"10.1016/j.xfre.2024.09.004","url":null,"abstract":"<div><div>Devices that function within a network of interconnected systems and are equipped with sensors, software, and tools designed to collect and exchange data are widely known as the Internet of Things (IoT). In recent years, the rapid growth of IoT technology has sparked significant interest in leveraging these systems to enhance healthcare delivery across various medical fields, including fertility care and assisted reproductive technology. The subset of IoT devices applied within the healthcare sector is referred to as the Internet of Medical Things (IoMT). Despite this growing technological potential, there has been little exploration into using IoMT to address a critical challenge in fertility care: the ongoing lack of access for many individuals in need of these services. In this article, we examine various applications of IoMT in healthcare, as well as how these may be extrapolated to the fertility field, and more importantly, assess how they may aid in bridging the access gap. We also explore potential challenges and pitfalls associated with implementing the IoMT, which underscores the need for careful oversight in its adoption and utilization.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 344-349"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of ovarian fibromas in young patients with Gorlin syndrome: a case series and review of the literature","authors":"Danielle T. Cipres M.D. ,&nbsp;Jessica Y. Shim M.D.","doi":"10.1016/j.xfre.2024.08.007","DOIUrl":"10.1016/j.xfre.2024.08.007","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the presentation and surgical management of ovarian fibromas among a case series of pediatric and adolescent patients with Gorlin syndrome.</div></div><div><h3>Design</h3><div>Retrospective case series.</div></div><div><h3>Setting</h3><div>Tertiary-care hospital.</div></div><div><h3>Patient(s)</h3><div>Patients aged 18 years and younger with a diagnosis of Gorlin syndrome who underwent surgical care of ovarian fibromas at a single tertiary children’s hospital from 1990 to 2022.</div></div><div><h3>Exposure</h3><div>Surgical management of ovarian fibromas.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Clinical characteristics, surgical treatment outcomes, ovarian conservation, surveillance imaging, and recurrence after surgical management of ovarian fibromas.</div></div><div><h3>Result(s)</h3><div>Four patients, aged between 5 and 18 years, underwent surgical resection of one or more ovarian fibromas. Dominant fibromas ranged in size from 4 to 9 cm, and most cases had multiple fibromas. Three patients underwent transverse laparotomies, and one patient had a laparoscopic approach. Unilateral oophorectomy was performed in three patients, two of whom presented with adnexal torsion. Among those with surveillance imaging, two patients with prior oophorectomy had a recurrence in the remaining contralateral ovary, one of whom underwent a second surgical procedure.</div></div><div><h3>Conclusion(s)</h3><div>Ovarian fibroma presentation and treatment varied widely among pediatric patients with Gorlin syndrome, and the presence of multiple and bilateral ovarian lesions raises important considerations regarding the optimal surgical approach and surveillance. Ovarian conservation should be prioritized in patients with Gorlin syndrome, because they are at risk of iatrogenic oophorectomy with their initial or repeat surgical management.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 430-438"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cohort study examining the outcomes of patients who present for fertility care and exceed a set body mass index threshold for treatment","authors":"Olutunmike Kuyoro M.D. ,&nbsp;Michal Mia Shalamov M.D. ,&nbsp;Cailey Brogan B.Sc. ,&nbsp;Randi Goldman M.D.","doi":"10.1016/j.xfre.2024.08.010","DOIUrl":"10.1016/j.xfre.2024.08.010","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the characteristics of patients who exceeded the body mass index (BMI) threshold for fertility treatment at their initial visit and identify those for whom treatment would be constrained.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Academic medical center.</div></div><div><h3>Patient(s)</h3><div>All new patients who presented for infertility treatment at an academic center between January 2020 and December 2022 and had BMI measured and recorded.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Likelihood of weight loss and treatment initiation for patients who exceed a set BMI threshold of 40 kg/m².</div></div><div><h3>Result(s)</h3><div>Of the 1,268 patients who had their BMI recorded at initial visit, 48% identified as non-Hispanic White, 15% as non-Hispanic Black, 13% as Asian, 11% as Hispanic, 0.2% as Native American, 4% as other; 9% were of unknown race/ethnicity. Overall, 6% of women exceeded the 40 kg/m² cutoff. Among Latino women, 7.5% exceeded the cutoff; among non-Hispanic Black women, 12% exceeded the cutoff. These percentages were greater than the percentage of non-Hispanic White women who exceeded the BMI cutoff (4.8%).</div></div><div><h3>Conclusion(s)</h3><div>Body mass index thresholds disproportionately affect the ability of ethnic minorities to use fertility treatment and could potentially be worsening barriers to care these population of patients already face.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 417-421"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial removal of the zona pellucida at the pronuclear stage: an exploratory study to improve embryo fragmentation","authors":"Keitaro Yumoto B.Sc. ,&nbsp;Toko Shimura B.Sc. ,&nbsp;Minori Kawamoto M.Sc. ,&nbsp;Minako Sugishima B.Sc. ,&nbsp;Yasuyuki Mio M.D., Ph.D.","doi":"10.1016/j.xfre.2024.08.011","DOIUrl":"10.1016/j.xfre.2024.08.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether artificial removal of zona pellucida (ZP) at the pronuclear stage improves good-quality embryos and blastocyst development in patients with difficulty conceiving because of severe fragmentation in early-cleavage stage.</div></div><div><h3>Design</h3><div>Exploratory investigation.</div></div><div><h3>Setting</h3><div>Reproductive center.</div></div><div><h3>Patient(s)</h3><div>Thirty-four patients scheduled for assisted reproductive technology (ART) treatment in our clinic between February 2020 and January 2021 were selected to undergo ZP removal according to their ART-related medical history. In total, 173 two pronuclei zygotes were obtained, with 101 allocated to the ZP-free group and 72 to the ZP-intact group. All patients had zygotes allocated in both ZP-free and ZP-intact groups.</div></div><div><h3>Intervention(s)</h3><div>Oocytes that were confirmed to be normally fertilized were placed in sucrose-containing HEPES medium for approximately 5 minutes and cultured under one of the following two conditions: ZP-free, in which the ZP was completely removed from the ooplasm by laser irradiation and a medium-blowing method with a biopsy pipette; and ZP-intact. Subsequently, embryos were either freshly transferred on day 2 (ZP-intact group only, according to patients’ wishes), or day 5/6, or they were cryopreserved on day 5/6/7 for future embryo transfer cycles for both groups.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Rates of good-quality embryos, blastocyst development, morphologically good-quality blastocyst development, and cryopreservation.</div></div><div><h3>Result(s)</h3><div>In ZP-free embryos, the inter-blastomere adhesion was not disturbed and the fragmentation was significantly decreased that resulted into significant improvement in all measured parameters compared with the ZP-intact group.</div></div><div><h3>Conclusion(s)</h3><div>Artificial ZP removal at the pronuclear stage may prevent excessive fragmentation leading to good-quality blastocysts. Moreover, patients with recurrent ART failure may achieve successful pregnancies.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 385-393"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do reproductive endocrinology and infertility fellowship websites reflect a commitment to diversity, equity, and inclusion?","authors":"Jasmine Eliwa M.D. ,&nbsp;Patricia J. Goedecke M.S. ,&nbsp;Jim Wan Ph.D. ,&nbsp;Rachel Weinerman M.D. ,&nbsp;Joseph Findley M.D. ,&nbsp;Rebecca Flyckt M.D.","doi":"10.1016/j.xfre.2024.08.005","DOIUrl":"10.1016/j.xfre.2024.08.005","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the frequency of diversity elements (DEs) in reproductive endocrinology and infertility (REI) fellowship websites and analyze these elements according to program characteristics.</div></div><div><h3>Design</h3><div>Forty-nine REI fellowship websites were assessed for 20 DEs that represent programmatic commitments to diversity, equity, and inclusion (DEI). Program websites were categorized by the number of discrete DEs featured: low (0–6); moderate (7–13); or high (14–20). Data were analyzed via R statistical software.</div></div><div><h3>Setting</h3><div>Not applicable.</div></div><div><h3>Patient(s)</h3><div>Not applicable.</div></div><div><h3>Exposure</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome was the level of DEs featured within REI fellowship websites. The secondary outcome was the association between DEs and program geographic region and accreditation status.</div></div><div><h3>Result(s)</h3><div>Program websites had a mean of 3 DEs. No program had a high number of DEs. Eighty-four percent of programs were low in DEs, with 16% exhibiting moderate DEs. Within the moderate group, most programs featured photographs of faculty (63%) and fellows (88%), commitment to DEI message (88%), diversity-specific language (88%), DEI webpage (88%), and DEI-related resources/opportunities (100%). In the low group, most programs presented photographs of faculty and fellows (71%). Programs did not feature active recruitment strategies (unconscious bias, holistic application review, DEI statistics, and implicit bias training). Diversity element category was not associated with program location. Programs with “initial accreditation” had the highest mean DEs.</div></div><div><h3>Conclusion(s)</h3><div>None of the REI fellowship websites demonstrated high levels of DEs. We speculate that by intentionally incorporating DEs into fellowship websites, programs can more effectively recruit underrepresented fellows and enhance the diversity of REI practitioners.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 411-416"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility journey of a patient with McCune-Albright syndrome associated with bilateral ovarian involvement","authors":"Joanna J. Kim M.D. ,&nbsp;Stephanie Dufour M.D. ,&nbsp;Sara Awad M.B.B.S., M.H.P.E. ,&nbsp;Bryden Magee M.D.","doi":"10.1016/j.xfre.2024.08.006","DOIUrl":"10.1016/j.xfre.2024.08.006","url":null,"abstract":"<div><h3>Objective</h3><div>To report a patient with McCune-Albright syndrome (MAS) with bilateral ovarian involvement who had achieved a pregnancy through in vitro fertilization (IVF).</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Setting</h3><div>Academic fertility center.</div></div><div><h3>Patient(s)</h3><div>A 33-year-old female with McCune-Albright syndrome who presented with primary infertility because of ovulatory dysfunction secondary to excessive secretion of growth hormone in addition to autonomous estrogen secretion by her ovaries.</div></div><div><h3>Exposure</h3><div>In vitro fertilization and near-normalization of insulin-like growth factor-1 (IGF-1) using somatostatin analogue lanreotide.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Reproductive outcomes after medical treatment for MAS-associated anovulatory infertility involving bilateral MAS ovarian involvement and growth hormone excess.</div></div><div><h3>Result(s)</h3><div>Spontaneous ovulation was resumed in this patient using lanreotide which regulated IGF-1 levels after unsuccessful ovulation induction with letrozole. Despite documented ovulation, she failed to conceive and subsequently, underwent an IVF cycle using an antagonist cycle with recombinant follicular stimulating hormone and recombinant luteinizing hormone stimulation. A total of 13 oocytes were retrieved and three good quality blastocysts were cryopreserved. Two frozen embryo transfer cycles were completed and she achieved a pregnancy, which unfortunately ended in an incomplete miscarriage.</div></div><div><h3>Conclusion(s)</h3><div>Through IVF and near-normalization of IGF-1 using lanreotide, pregnancy was achieved in a patient with MAS who had achieved good ovarian stimulation despite a history of bilateral ovarian involvement and associated hyperfunctioning endocrinopathies.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 453-457"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}