Fertility journey of a patient with McCune-Albright syndrome associated with bilateral ovarian involvement

Joanna J. Kim M.D. , Stephanie Dufour M.D. , Sara Awad M.B.B.S., M.H.P.E. , Bryden Magee M.D.
{"title":"Fertility journey of a patient with McCune-Albright syndrome associated with bilateral ovarian involvement","authors":"Joanna J. Kim M.D. ,&nbsp;Stephanie Dufour M.D. ,&nbsp;Sara Awad M.B.B.S., M.H.P.E. ,&nbsp;Bryden Magee M.D.","doi":"10.1016/j.xfre.2024.08.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To report a patient with McCune-Albright syndrome (MAS) with bilateral ovarian involvement who had achieved a pregnancy through in vitro fertilization (IVF).</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Setting</h3><div>Academic fertility center.</div></div><div><h3>Patient(s)</h3><div>A 33-year-old female with McCune-Albright syndrome who presented with primary infertility because of ovulatory dysfunction secondary to excessive secretion of growth hormone in addition to autonomous estrogen secretion by her ovaries.</div></div><div><h3>Exposure</h3><div>In vitro fertilization and near-normalization of insulin-like growth factor-1 (IGF-1) using somatostatin analogue lanreotide.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Reproductive outcomes after medical treatment for MAS-associated anovulatory infertility involving bilateral MAS ovarian involvement and growth hormone excess.</div></div><div><h3>Result(s)</h3><div>Spontaneous ovulation was resumed in this patient using lanreotide which regulated IGF-1 levels after unsuccessful ovulation induction with letrozole. Despite documented ovulation, she failed to conceive and subsequently, underwent an IVF cycle using an antagonist cycle with recombinant follicular stimulating hormone and recombinant luteinizing hormone stimulation. A total of 13 oocytes were retrieved and three good quality blastocysts were cryopreserved. Two frozen embryo transfer cycles were completed and she achieved a pregnancy, which unfortunately ended in an incomplete miscarriage.</div></div><div><h3>Conclusion(s)</h3><div>Through IVF and near-normalization of IGF-1 using lanreotide, pregnancy was achieved in a patient with MAS who had achieved good ovarian stimulation despite a history of bilateral ovarian involvement and associated hyperfunctioning endocrinopathies.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 453-457"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705567/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"FS Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666334124000874","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective

To report a patient with McCune-Albright syndrome (MAS) with bilateral ovarian involvement who had achieved a pregnancy through in vitro fertilization (IVF).

Design

Case report.

Setting

Academic fertility center.

Patient(s)

A 33-year-old female with McCune-Albright syndrome who presented with primary infertility because of ovulatory dysfunction secondary to excessive secretion of growth hormone in addition to autonomous estrogen secretion by her ovaries.

Exposure

In vitro fertilization and near-normalization of insulin-like growth factor-1 (IGF-1) using somatostatin analogue lanreotide.

Main Outcome Measure(s)

Reproductive outcomes after medical treatment for MAS-associated anovulatory infertility involving bilateral MAS ovarian involvement and growth hormone excess.

Result(s)

Spontaneous ovulation was resumed in this patient using lanreotide which regulated IGF-1 levels after unsuccessful ovulation induction with letrozole. Despite documented ovulation, she failed to conceive and subsequently, underwent an IVF cycle using an antagonist cycle with recombinant follicular stimulating hormone and recombinant luteinizing hormone stimulation. A total of 13 oocytes were retrieved and three good quality blastocysts were cryopreserved. Two frozen embryo transfer cycles were completed and she achieved a pregnancy, which unfortunately ended in an incomplete miscarriage.

Conclusion(s)

Through IVF and near-normalization of IGF-1 using lanreotide, pregnancy was achieved in a patient with MAS who had achieved good ovarian stimulation despite a history of bilateral ovarian involvement and associated hyperfunctioning endocrinopathies.
一例伴有双侧卵巢受累的McCune-Albright综合征患者的生育之旅。
目的:报告一例双侧卵巢受累的McCune-Albright综合征(MAS)患者通过体外受精(IVF)获得妊娠。设计:病例报告。环境:学术生育中心。患者:一名患有mcune - albright综合征的33岁女性,因卵巢分泌过多生长激素和自主雌激素导致的排卵功能障碍而出现原发性不孕。暴露:体外受精和使用生长抑素类似物lanreotide使胰岛素样生长因子-1 (IGF-1)接近正常化。主要结局指标:双侧MAS相关无排卵性不孕症累及卵巢和生长激素过量治疗后的生殖结局。结果:在来曲唑诱导排卵失败后,该患者使用调节IGF-1水平的lanreotide恢复了自然排卵。尽管有排卵记录,但她未能怀孕,随后,使用重组促卵泡激素和重组黄体生成素刺激的拮抗剂周期进行了试管婴儿周期。共获得13个卵母细胞,并冷冻保存3个优质囊胚。两个冷冻胚胎移植周期完成后,她成功怀孕,但不幸的是不完全流产。结论:通过体外受精和使用lanreotide使IGF-1接近正常化,尽管有双侧卵巢受累史和相关的功能亢进内分泌病,但MAS患者获得了良好的卵巢刺激,最终实现了妊娠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
FS Reports
FS Reports Medicine-Embryology
CiteScore
3.50
自引率
0.00%
发文量
78
审稿时长
60 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信