FS Reports最新文献

{"title":"In vitro gametogenesis in the ongoing quest to vanquish infertility: the role of epigenetics","authors":"Eli Y. Adashi M.D., M.S. , Gary M. Wessel Ph.D.","doi":"10.1016/j.xfre.2024.10.001","DOIUrl":"10.1016/j.xfre.2024.10.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 342-343"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-neutral approach and later sleep midpoint in adolescents with “emerging polycystic ovary syndrome phenotype” as vehicles for sustainable weight loss","authors":"Josephine Z. Kasa-Vubu M.D. ,&nbsp;Alexandra Waisanen R.D.N. ,&nbsp;Julie Sturza M.P.H. ,&nbsp;Vasantha Padmanabhan Ph.D. ,&nbsp;Louise M. O’Brien M.S., Ph.D.","doi":"10.1016/j.xfre.2024.09.001","DOIUrl":"10.1016/j.xfre.2024.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>Incorporate sleep into a novel lifestyle intervention strategy in adolescents with Emerging symptoms of polycystic ovary syndrome (E-PCOS).</div></div><div><h3>Design</h3><div>A single-center cohort study.</div></div><div><h3>Setting</h3><div>University hospital-based clinic for adolescents with PCOS.</div></div><div><h3>Patients</h3><div>Forty-three girls at an age between 10 and 18 years presenting with E-PCOS between March 2015 and September 2017 with clinical signs of androgen excess and/or accelerated weight gain, acanthosis nigricans, irregular periods, or delayed menarche and followed every 6 months for a minimum of 4 visits, to October 2020.</div></div><div><h3>Interventions</h3><div>All patients received nutritional counseling, with a goal of “zero weight gain,” daily moderate physical activity goals of 45 minutes per day, and education regarding age-appropriate sleep duration. Three treatment strategies for E-PCOS symptoms were applied depending on the chief clinical complaint: anti-insulin approach with metformin; antiandrogen approach with oral contraceptive and spironolactone; and surveillance.</div></div><div><h3>Main Outcome Measures</h3><div>Body mass index (BMI) Z-score over time. Alanine Transaminase (ALT) levels as a risk factor for nonalcoholic fatty liver.</div></div><div><h3>Results</h3><div>Average number of return visits was 4 with 58% having &gt;4 return visits. Testosterone levels were correlated with ALT (<em>r</em> = 0.68). Weeknight sleep duration was less than age-appropriate recommendations for 63% of participants. Sleep midpoint correlated with ALT levels (<em>r</em> = 0.48). Despite the weight-neutral approach, regression models all demonstrated significant weight loss regardless of menarche status, metformin use, number of visits, and high vs. low ALT groups. Those with the latest sleep midpoint at baseline benefited the most, with BMI Z-score dropping significantly (interaction of time and baseline sleep midpoint from the first visit on school night).</div></div><div><h3>Conclusion</h3><div>A novel approach for adolescent girls with E-PCOS that focuses on metabolic endpoints and includes sleep duration and timing as specific targets, led to significant weight loss irrespective of treatment group.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 402-410"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No need to freeze everything: Are we striking the right balance in fertility treatments?","authors":"Lusine Aghajanova M.D., Ph.D.","doi":"10.1016/j.xfre.2024.10.003","DOIUrl":"10.1016/j.xfre.2024.10.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 354-355"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh vs. frozen: pregnancy outcomes and treatment efficacy between fresh embryo transfer vs. untested freeze-all cycles","authors":"Zoran J. Pavlovic M.D. ,&nbsp;Gabrielle E. Smotrich B.A. ,&nbsp;Erika P. New M.D. ,&nbsp;Samad Jahandideh Ph.D. ,&nbsp;Kate Devine M.D. ,&nbsp;Anthony N. Imudia M.D. ,&nbsp;Shayne Plosker M.D.","doi":"10.1016/j.xfre.2024.09.003","DOIUrl":"10.1016/j.xfre.2024.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>To compare pregnancy outcomes after single blastocyst embryo transfer among patients whose first autologous embryo transfer was either a fresh embryo transfer or a frozen embryo transfer (FET) after a freeze-all, in the absence of preimplantation genetic testing for aneuploidy (PGT-A).</div></div><div><h3>Design</h3><div>A multicenter retrospective cohort analysis.</div></div><div><h3>Setting</h3><div>National multicenter fertility practice.</div></div><div><h3>Patient(s)</h3><div>A total of 8,319 autologous first blastocyst embryo transfers in the absence of PGT-A were analyzed. Of them, 6,755 transfers were fresh embryo transfer (ET) and 1,564 transfers were FET after freeze-all.</div></div><div><h3>Exposure</h3><div>Patients underwent either a fresh or a frozen initial autologous, single blastocyst transfer in the absence of PGT-A.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Primary outcome measure was live birth rate. Secondary outcome measures included positive pregnancy test, clinical pregnancy rate, and miscarriage rate.</div></div><div><h3>Result(s)</h3><div>Live birth rate was comparable between the fresh ET and FET groups in the absence of PGT-A, after performing generalized estimating equation modeling to account for age, body mass index, antral follicle count, basal follicle-stimulating hormone, progesterone on day of trigger/day of final lining check, peak estradiol during in vitro fertilization stimulation cycle, number of oocytes retrieved during ovarian stimulation cycle, and primary diagnosis. Similarly, the secondary outcome variables of positive pregnancy test, clinical pregnancy rate, and miscarriage rates were comparable between the cohorts. These findings were observed in the entire study group, within each age category of &lt;35, 35–37, 38–40, and &gt;40 and among each stratified peak estradiol group.</div></div><div><h3>Conclusion(s)</h3><div>In the absence of PGT-A, patients and fertility providers can elect to pursue either fresh ET or embryo freeze-all with subsequent FET during the first autologous in vitro fertilization cycle.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 369-377"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office of Public Affairs update: a quarterly update from the American Society for Reproductive Medicine Office of Public Affairs on key developments in reproductive health policy","authors":"Rebecca O’Connor J.D.","doi":"10.1016/j.xfre.2024.10.004","DOIUrl":"10.1016/j.xfre.2024.10.004","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Page 341"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful pregnancy after preimplantation genetic testing for structural rearrangements in a couple with complex chromosome rearrangement and recurrent in vitro fertilization failures: a case report","authors":"Divyesh Upadhyay B.S. ,&nbsp;Rajia Al Halaby M.D. ,&nbsp;Sudha Anandt Ph.D. ,&nbsp;Firas Albuz Ph.D. ,&nbsp;Merlin Mary Varghese M.S. ,&nbsp;Braulio Peramo M.D.","doi":"10.1016/j.xfre.2024.10.006","DOIUrl":"10.1016/j.xfre.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>To present a case of a couple with 20 years of infertility and 10 recurrent in vitro fertilization (IVF) failures, identifying a paternal complex chromosome rearrangement using high-resolution karyotype together with preimplantation genetic testing for structural rearrangements (PGT-SR) and utilizing IVF-intracytoplasmic sperm injection to achieve a successful pregnancy.</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Setting</h3><div>Al Ain Fertility Center, Abu Dhabi, United Arab Emirates.</div></div><div><h3>Patients</h3><div>A 40-year-old male patient and a 37-year-old female patient with a history of infertility and recurrent IVF failures.</div></div><div><h3>Exposure</h3><div>In vitro fertilization-intracytoplasmic sperm injection with high-resolution karyotype and PGT-SR.</div></div><div><h3>Main Outcome Measures</h3><div>Identification of chromosomal abnormalities, successful embryo development, pregnancy outcome, and newborn karyotyping.</div></div><div><h3>Results</h3><div>Karyotyping revealed a paternal complex chromosome rearrangement, t(3;4;12) (q21;q33;q21), and a chromosomal polymorphism in the female (1qh+). In vitro fertilization-intracytoplasmic sperm injection with PGT-SR produced one euploid/balanced female embryo from 20 embryos across 8 cycles. The patient conceived after hormone replacement therapy and frozen embryo transfer, resulting in an uneventful, full-term pregnancy and delivery of a healthy baby via C-section. Newborn karyotyping was normal (46,XX).</div></div><div><h3>Conclusion</h3><div>High-resolution karyotype and PGT-SR should be offered to patients undergoing IVF, especially those with severe male factors, recurrent IVF failures, implantation failures, or recurrent pregnancy losses, to enhance the chances of a successful pregnancy.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 439-452"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incorrect conclusion about vaginally administered progesterone: when a randomized clinical trial gets it wrong","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2024.11.003","DOIUrl":"10.1016/j.xfre.2024.11.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 339-340"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is endometriosis typology a potentially better classification system for assessing risk of female infertility?","authors":"Karen C. Schliep Ph.D. ,&nbsp;Anna Z. Pollack Ph.D. ,&nbsp;Leslie V. Farland Sc.D. ,&nbsp;May Shaaban M.P.H. ,&nbsp;Bin Yan M.S.T.A.T. ,&nbsp;Jing Wang Ph.D. ,&nbsp;Lina Ghabayen M.D. ,&nbsp;Rachael B. Hemmert M.S.P.H. ,&nbsp;Joseph B. Stanford M.D. ,&nbsp;C. Matthew Peterson M.D.","doi":"10.1016/j.xfre.2024.08.009","DOIUrl":"10.1016/j.xfre.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether endometriosis typology, namely ovarian endometriomas (OE), deep infiltrating endometriosis (DIE), or superficial endometriosis (SE), correlates with fertility history.</div></div><div><h3>Design</h3><div>Prospective cohort.</div></div><div><h3>Setting</h3><div>One of fourteen surgical centers in Salt Lake City, Utah (n = 5) or San Francisco, California (n = 9).</div></div><div><h3>Patient(s)</h3><div>A total of 473 women (18–44 years) with no prior endometriosis diagnosis, undergoing laparoscopies/laparotomies, irrespective of indication, in Utah or California (2007–2009).</div></div><div><h3>Exposure</h3><div>Incident endometriosis.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Before surgery, we queried women about time to become pregnant for prior planned pregnancies. Generalized linear models were used to calculate adjusted prevalence ratios (aPR) for association between endometriosis typology and infertility, defined as having ever tried &gt;12 months (&gt;6 months for women ≥35 years) to get pregnant. We also generated fecundability odds ratios (aFOR) to capture time to pregnancy.</div></div><div><h3>Result(s)</h3><div>Twenty-five percent (n = 116) of women were diagnosed with SE only, 5% (n = 23) with OE, 6% (n = 29) with DIE, and 5% (n = 22) with OE + DIE, and 60% (n = 283) with no endometriosis. Compared with women with no endometriosis, women with SE had a 1.58 higher aPR (95% confidence interval [CI], 1.16–2.14), although women with OE and/or DIE had a 2.41 higher aPR for subfertility after adjusting for women’s age, body mass index, and site. Compared with women with no endometriosis, women with OE and/or DIE had a 53% lower historic fecundability (aFOR, 0.47; 95% CI, 0.24–0.95); however, no association was found among women with SE (aFOR, 0.81; 95% CI, 0.49–1.33).</div></div><div><h3>Conclusion(s)</h3><div>Specific endometriosis typologies may be associated with fecundability, with OE and/or DIE associated with nearly a 150% higher prevalence of subfertility and over a 50% lower historic fecundability.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 394-401"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking potential: advanced practice providers in reproductive endocrinology and infertility","authors":"Lauren Nervi M.S.N., R.N., N.P.-C.,&nbsp;Thomas A. Molinaro M.D., M.S.C.E.","doi":"10.1016/j.xfre.2024.11.002","DOIUrl":"10.1016/j.xfre.2024.11.002","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 352-353"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Envisioning a path from the Internet of Medical Things to improved fertility care access: a mini-review","authors":"Olutunmike Kuyoro M.D.,&nbsp;Randi Goldman M.D.","doi":"10.1016/j.xfre.2024.09.004","DOIUrl":"10.1016/j.xfre.2024.09.004","url":null,"abstract":"<div><div>Devices that function within a network of interconnected systems and are equipped with sensors, software, and tools designed to collect and exchange data are widely known as the Internet of Things (IoT). In recent years, the rapid growth of IoT technology has sparked significant interest in leveraging these systems to enhance healthcare delivery across various medical fields, including fertility care and assisted reproductive technology. The subset of IoT devices applied within the healthcare sector is referred to as the Internet of Medical Things (IoMT). Despite this growing technological potential, there has been little exploration into using IoMT to address a critical challenge in fertility care: the ongoing lack of access for many individuals in need of these services. In this article, we examine various applications of IoMT in healthcare, as well as how these may be extrapolated to the fertility field, and more importantly, assess how they may aid in bridging the access gap. We also explore potential challenges and pitfalls associated with implementing the IoMT, which underscores the need for careful oversight in its adoption and utilization.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 4","pages":"Pages 344-349"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}