FS Reports最新文献

{"title":"Impact of an accessory cavitated uterine mass on fertility: case presentation and review of the literature","authors":"Michael Strug D.O., Ph.D. ,&nbsp;Abigail Christmas B.S. ,&nbsp;Amanda Schoonover M.P.H. ,&nbsp;Vivian C. Romero M.D. ,&nbsp;Marcos Cordoba M.D. ,&nbsp;Elizabeth Leary M.D. ,&nbsp;Mili Thakur M.D.","doi":"10.1016/j.xfre.2023.09.001","DOIUrl":"10.1016/j.xfre.2023.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>We report a case of an accessory cavitated uterine mass (ACUM) in a patient with infertility and chronic pelvic pain. In addition, we summarize the literature to better characterize ACUM diagnosis and management.</p></div><div><h3>Design</h3><p>A comprehensive literature search using the PubMed database was performed through April 2023. Historical ACUM diagnostic criteria were applied as inclusion criteria. Descriptive statistics and statistical evaluation were reported.</p></div><div><h3>Results</h3><p>A 31-year-old nulligravid woman presented with chronic pelvic pain, dysmenorrhea, primary infertility, and history of endometriosis. Three-dimensional ultrasonography identified an ACUM and laparoscopic excision provided complete resolution of symptoms. Subsequently, she conceived without assistance twice with uncomplicated vaginal deliveries. A total of 154 articles were identified, 34 papers met inclusion criteria and were individually reviewed, consisting of 70 reported cases. The most common presenting complaints were dysmenorrhea (81.4%), chronic pelvic/abdominal pain (54.1%), and refractory pain (34.3%). Diagnostic imaging included magnetic resonance imaging (62.9%) and transvaginal ultrasound (55.7%). Management included resection via laparoscopy (75.7%) or laparotomy (18.6%), or hysterectomy (5.7%). Of cases with reported outcomes, 90.7% had complete relief of symptoms after surgery.</p></div><div><h3>Conclusion</h3><p>ACUM often presents with dysmenorrhea, chronic pelvic pain, or abdominal pain and is identifiable on magnetic resonance imaging as a hyperenhancing mass. Three-dimensional transvaginal ultrasound can also accurately identify ACUM. A total of 90.7% of patients had complete relief of symptoms after intervention. It is important to identify ACUM early to relieve pain and reduce unnecessary interventions. Like our patient, other reports have demonstrated concomitant infertility and endometriosis. However, further investigation is needed to explore the association between infertility and ACUM.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 402-409"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001022/pdfft?md5=94a24e522f551c40128bc5c361d43f3c&pid=1-s2.0-S2666334123001022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes to reproductive endocrinology and infertility practice, research, and training as investor mergers increase","authors":"Farrah L. Saleh M.D. ,&nbsp;Eli Y. Adashi M.D., M.S. ,&nbsp;David B. Sable M.D. ,&nbsp;Vitaly A. Kushnir M.D. ,&nbsp;Hugh S. Taylor M.D.","doi":"10.1016/j.xfre.2023.08.001","DOIUrl":"10.1016/j.xfre.2023.08.001","url":null,"abstract":"<div><p>Private equity investment in fertility clinics has rapidly increased and is leading to unprecedented changes in the field of reproductive endocrinology and infertility (REI). The goal of this paper was to review private equity’s current integration in REI and discuss both benefits and challenges of investor involvement. We found that at least 25% of fellowship programs and medical schools were affiliated with private practice fertility clinics, not free-standing academic clinics. Approximately half of medical schools and nearly all REI fellowship programs that were affiliated with private practices were also backed by private investors. Research participation remains robust in private equity-affiliated REI clinics. With the changing infrastructure, we discuss the potential influence on trainee experience and research while also acknowledging the unique advantages that investor involvement may offer.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 332-336"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123000806/pdfft?md5=65737d9bd45e12e71e6de4721cde8d4a&pid=1-s2.0-S2666334123000806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123001928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges experienced by genetic counselors while they provided counseling about mosaic embryos","authors":"Olivia M. Moran M.Sc. ,&nbsp;Kayla Flamenbaum M.S. ,&nbsp;Diane Myles Reid M.S. ,&nbsp;Jeanna M. McCuaig Ph.D. ,&nbsp;Riyana Babul-Hirji M.Sc. ,&nbsp;David Chitayat M.D. ,&nbsp;Maian Roifman M.D.","doi":"10.1016/j.xfre.2023.08.006","DOIUrl":"10.1016/j.xfre.2023.08.006","url":null,"abstract":"<div><h3>Objective</h3><p>To survey genetic counselors (GCs) who have counseled about mosaic embryos regarding the challenges they faced in counseling this patient population and assess their need for more resources to support their practice.</p></div><div><h3>Design</h3><p>Self-administered online survey.</p></div><div><h3>Setting</h3><p>Academic university.</p></div><div><h3>Study Population</h3><p>Seventy-eight GCs primarily from the United States and Canada.</p></div><div><h3>Intervention(s)</h3><p>Genetic counselors completed a quantitative survey with an embedded qualitative component. Quantitative data were analyzed by descriptive statistics. An inductive thematic analysis was performed on open-text responses.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Genetic counselors were asked what clinical activities relating to mosaic embryos they performed. They were then asked to rate how challenging each activity was to perform using a 5-point scale; a rating of 4 or 5 was defined as highly challenging. Open-text questions enabled GCs to describe factors that they felt contributed to these challenges.</p></div><div><h3>Result(s)</h3><p>The challenges reported by GCs included the uncertainty of outcomes in offspring after mosaic embryo transfer, limited guidelines available to assist clinicians with counseling about mosaic embryos, and ranking mosaic embryos by suitability for transfer. The contributing factors suggested by participants included limited outcome data, limited GC involvement in pretest counseling for preimplantation genetic testing for aneuploidy (PGT-A), and perceived inconsistency in counseling practices across clinics. Genetic counselors differed in their genetic testing recommendations for pregnancies conceived after mosaic embryo transfer. Amniocentesis and postnatal assessment were recommended by 85% and 49% of GCs, respectively, and 15% recommended chorionic villus sampling and noninvasive prenatal testing. Almost all (92%) reported a need for more resources, such as standardized guidelines, more outcome data, and continuing education on PGT-A and mosaicism.</p></div><div><h3>Conclusion(s)</h3><p>This study describes challenges experienced by GCs while they counseled about mosaic embryos. Our findings demonstrate a need for more outcome data on mosaic embryo pregnancies and for evidence-based clinical guidelines. The differing recommendations for prenatal genetic testing among GCs in the study warrant further research into contributing factors. We strongly recommend that pretest counseling, including a discussion regarding mosaicism, is provided to all couples considering PGT-A to reduce counseling challenges and to promote patients’ informed decision-making.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 353-360"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123000855/pdfft?md5=a698a0898921ca52e93d9f087e864b1e&pid=1-s2.0-S2666334123000855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115124752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional follicular-phase ovarian stimulation vs. luteal-phase stimulation in suboptimal responders: a randomized controlled trial","authors":"Jorge Suñol M.D. ,&nbsp;Juan Carlos Castillo M.D., Ph.D. ,&nbsp;José Antonio Ortiz M.Sc., Ph.D. ,&nbsp;Jorge Ten M.Sc. Ph.D. ,&nbsp;Ana Fuentes M.D. ,&nbsp;Belén Moliner M.D., Ph.D. ,&nbsp;María Martínez M.D. ,&nbsp;Joaquín Llácer M.D., Ph.D. ,&nbsp;Jaime Guerrero M.Sc. Ph.D. ,&nbsp;Ana Pitas M.Sc. Ph.D. ,&nbsp;Andrea Bernabeu M.D., Ph.D. ,&nbsp;Rafael Bernabeu M.D., Ph.D.","doi":"10.1016/j.xfre.2023.07.003","DOIUrl":"10.1016/j.xfre.2023.07.003","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the oocyte yield between follicular-phase stimulation (FPS) and luteal-phase stimulation (LPS) in suboptimal responders.</p></div><div><h3>Design</h3><p>Prospective, randomized, crossover clinical trial.</p></div><div><h3>Patient(s)</h3><p>Forty-one patients with infertility according to the POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria (1b/2b).</p></div><div><h3>Intervention(s)</h3><p>Crossover study on 2 assigned ovarian stimulations that started randomly in the follicular or luteal phase. The in vitro fertilization cycles were not consecutive but separated in time (45 days to 6 months). The random crossover design ensured that all subjects received the first treatment by chance.</p></div><div><h3>Main Outcome Measure(s)</h3><p>The primary objective was the number of cumulus-oocyte complexes retrieved in each cycle. Secondary objectives were number of metaphase II and fertilized oocytes, additional doses of recombinant follicle-stimulating hormone, and the duration of ovarian stimulation (days).</p></div><div><h3>Result(s)</h3><p>The mean number of cumulus-oocyte complexes retrieved was similar between the FPS and LPS groups (7.5 ± 4.6 vs. 7.0 ± 4.1; 95% confidence interval [CI] for the mean, 5.8–8.7 vs. 5.6–8.3, respectively; the difference between means, −0.5; 95% CI, −1.8 to +1.5). Similarly, the mean number of metaphase II oocytes retrieved was not different between the FPS and LPS groups (5.4 ± 3.6 vs. 5.2 ± 2.8; 95% CI for the mean, 4.2–6.5 vs. 4.3–6.1, respectively; the difference between means, −0.2; 95% CI, −1.2 to +1.1). Moreover, the secondary objectives were similar between FPS and LPS groups.</p></div><div><h3>Conclusion(s)</h3><p>In this study, the oocyte yield in LPS did not increase in suboptimal responders compared with that in FPS when the onset of LPS was separated in time from FPS.</p></div><div><h3>Clinical Trial Registration Number</h3><p>NCT039393990 <span>https://beta.clinicaltrials.gov/study/NCT03939390</span><svg><path></path></svg>.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 344-352"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123000788/pdfft?md5=4ef145f3661c0a64877a4081b6a48fcb&pid=1-s2.0-S2666334123000788-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128836378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility treatment outcomes in transgender men with a history of testosterone therapy","authors":"Atoosa Ghofranian M.D. ,&nbsp;Samantha L. Estevez M.D. ,&nbsp;Caroline Gellman M.D. ,&nbsp;Dmitry Gounko B.S., M.A. ,&nbsp;Joseph A. Lee B.A. ,&nbsp;Kimberly Thornton M.D. ,&nbsp;Alan B. Copperman M.D.","doi":"10.1016/j.xfre.2023.10.006","DOIUrl":"10.1016/j.xfre.2023.10.006","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate fertility treatment outcomes among transgender (TG) men with a history of gender-affirming hormone therapy with exogenous testosterone.</p></div><div><h3>Design</h3><p>Descriptive, retrospective cohort study.</p></div><div><h3>Patients</h3><p>Transgender men with a history of gender-affirming hormone therapy with exogenous testosterone underwent fertility treatments, including embryo cryopreservation, in vitro fertilization (IVF), co-IVF, oocyte cryopreservation, and intrauterine insemination (IUI), between 2013 and 2021.</p></div><div><h3>Intervention</h3><p>Gender-affirming hormone therapy with testosterone.</p></div><div><h3>Main Outcome Measures</h3><p>Live births (LBs), number of frozen embryos, and number of frozen oocytes. Other outcome measures included total gonadotropin used, peak estradiol levels, oocytes retrieved, oocyte maturity rate, fertilization rate, and embryo grade.</p></div><div><h3>Results</h3><p>A total of 77 TG men self-presented or were referred to care at a single academic fertility center, of which 46 (59.7%) TG men underwent fertility preservation and/or family-building counseling, with 16 (20.8%) patients proceeding to fertility treatment. Of those patients who underwent treatment, 11 (68.8%) had a history of gender-affirming hormone therapy with exogenous testosterone use. Cohort 1 included IVF (n = 1), co-IVF (n = 1), embryo cryopreservation (n = 2), cohort 2 included oocyte cryopreservation (n = 4), and cohort 3 included IUI (n = 3). In cohort 1, both the patients who underwent IVF and the patients who underwent co-IVF achieved LBs. All embryo cryopreservation cycles froze three or more embryos. In cohort 2, the average number of frozen mature oocytes was 19.3 ± 16.2 (range 6–43). All patients who underwent IUI cycles achieved LB.</p></div><div><h3>Conclusion</h3><p>In this study, no correlation existed between patient age, time on or off gender-affirming hormone therapy with exogenous testosterone, total gonadotropin used, and number of oocytes retrieved. All patients who completed IVF or embryo cryopreservation produced high-quality blastocytes, and this is the first study to show successful IUI cycles in patients with a history of gender-affirming hormone therapy with exogenous testosterone. This study demonstrates that TG men who have used gender-affirming hormone therapy previously can successfully undergo fertility treatments to attain oocyte and embryo cryopreservation, pregnancy, and LBs.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 367-374"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001083/pdfft?md5=0dcd46162a9673aac6c65085fd20dbdd&pid=1-s2.0-S2666334123001083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consistency of endometrial receptivity array and histologic dating of spatially distinct endometrial samplings: a prospective, blinded study","authors":"Trenton L. Place D.O., Ph.D. ,&nbsp;Ravi Agarwal M.D. ,&nbsp;Parisa Najafzadeh M.D. ,&nbsp;Saloni Walia M.D. ,&nbsp;Lynda K. McGinnis Ph.D. ,&nbsp;Priya Kohli B.S. ,&nbsp;Juan C. Felix M.D. ,&nbsp;Richard J. Paulson M.D.","doi":"10.1016/j.xfre.2023.08.008","DOIUrl":"10.1016/j.xfre.2023.08.008","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the consistency of endometrial receptivity array (ERA) and histologic dating among 3 spatially distinct endometrial samples obtained during a cycle of exogenous estrogen and progesterone.</p></div><div><h3>Design</h3><p>Prospective blinded study.</p></div><div><h3>Setting</h3><p>University practice.</p></div><div><h3>Patients</h3><p>Twelve patients undergoing a mock frozen embryo transfer cycle.</p></div><div><h3>Intervention</h3><p>Endometrial biopsy was performed in a manner that provided a spatially organized endometrial specimen, corresponding to the fundus, middle, and lower segment. Each of these 3 sections was further divided into immediately adjacent specimens for ERA and histology.</p></div><div><h3>Main Outcome Measure</h3><p>Consistency of the ERA and histology results among fundal, mid, and lower endometrial biopsy specimens.</p></div><div><h3>Results</h3><p>The ERA showed variability in outcome among different patients but dated all specimens originating from the same patient identically. Histologic dating showed variability between patients as well as between different locations within the uterus. When comparing average dating results for each patient, we saw a positive correlation between histologic and ERA dating (Spearman Rho = 0.45); however, this did not reach statistical significance. The ERA results from upper, mid, and lower uterine biopsy specimens were identical for each autologous biopsy, whereas histologic dating showed variability with an average standard deviation of 0.71 days.</p></div><div><h3>Conclusions</h3><p>The increased heterogeneity of histologic dating is likely to be attributed to the subjectivity of the test. Furthermore, we did not observe a consistent lag or advancement in histologic or ERA dating between the fundal or lower uterine biopsies. Overall, clinicians should be reassured that endometrial tissue will return consistent ERA results independent of the location within the uterus in which it was obtained.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 375-379"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001009/pdfft?md5=f5456840cedf729a7b137f78cfd1b489&pid=1-s2.0-S2666334123001009-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115135029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment","authors":"Amy Kaing M.D. ,&nbsp;Amanda Adeleye M.D. ,&nbsp;Bani Tamraz Pharm.D., Ph.D. ,&nbsp;Victor Y. Fujimoto M.D.","doi":"10.1016/j.xfre.2023.10.002","DOIUrl":"10.1016/j.xfre.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>Explore whether racial differences in prevalence of CYP1A2∗1F polymorphism underlies estrogen metabolism differences among Asians and Caucasians.</p></div><div><h3>Design</h3><p>Prospective cohort study.</p></div><div><h3>Setting</h3><p>University-based fertility practice.</p></div><div><h3>Patient(s)</h3><p>Asian or Caucasian patients who underwent ovarian stimulation (OS) or programmed cycle frozen embryo transfer (FET) between October 2019 and April 2021.</p></div><div><h3>Intervention(s)</h3><p>None.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Trigger-day serum E2 per oocyte retrieved in OS cycles, and E2 on day of lining check in FET cycles.</p></div><div><h3>Result(s)</h3><p>Seventy-one participants were enrolled, 55 in OS group (29 Caucasian and 26 Asian) and 16 in FET group (10 Caucasian and 6 Asian). Peak E2 per oocyte retrieved in the OS group (n = 48) differed by race, with significantly lower levels in Caucasians compared with Asians (177.5 ± 64.2 vs. 261.1 ± 139.5 pg/mL). Prevalence of CYP1A2∗1F polymorphism did not significantly differ by race. Compared using Kruskal–Wallis test, peak E2 per oocyte retrieved did not differ by CYP1A2∗1F genotype. In multivariate linear regression model, adjusting for body mass index, caffeine intake, and self-reported race, there remained no significant correlation. In FET group, serum E2 on day of lining check was also not significantly different by CYP1A2∗1F genotype.</p></div><div><h3>Conclusion(s)</h3><p>Although a consistent difference in serum E2 between Asians and Caucasians undergoing OS was noted, the CYP1A2∗1F polymorphism is unlikely the primary driver of this difference.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 396-401"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001046/pdfft?md5=9b0ab43a7e6d97c38ca417f79bfa939d&pid=1-s2.0-S2666334123001046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135760580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office of Public Affairs update: a quarterly update from the American Society for Reproductive Medicine OffiTce of Public Affairs on key developments in reproductive health policy","authors":"Rebecca W. O’Connor J.D.","doi":"10.1016/j.xfre.2023.11.001","DOIUrl":"10.1016/j.xfre.2023.11.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Page 331"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001095/pdfft?md5=d294ebd907ea93f90d59cf535f91e552&pid=1-s2.0-S2666334123001095-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular phase length is not related to live birth outcome in women with unexplained infertility undergoing ovarian stimulation with intrauterine insemination cycles in a multicenter trial","authors":"Pardis Hosseinzadeh M.D. ,&nbsp;Jennifer D. Peck Ph.D. ,&nbsp;Heather R. Burks M.D. ,&nbsp;Irene Souter M.D. ,&nbsp;Angela Xing B.S. ,&nbsp;LaTasha B. Craig M.D. ,&nbsp;Michael P. Diamond M.D. ,&nbsp;Karl R. Hansen M.D. Ph.D.","doi":"10.1016/j.xfre.2023.08.003","DOIUrl":"10.1016/j.xfre.2023.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effect of follicular phase length (FPL) on pregnancy outcomes and endometrial thickness (ET) among women with unexplained infertility undergoing ovarian stimulation with intrauterine insemination (OS-IUI) with clomiphene citrate, letrozole, or gonadotropins.</p></div><div><h3>Design</h3><p>Cohort analysis of the Reproductive Medicine Network's Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation randomized controlled trial.</p></div><div><h3>Setting</h3><p>Multicenter randomized controlled trial.</p></div><div><h3>Patient(s)</h3><p>A total of 869 couples with unexplained infertility who underwent OS-IUI treatment cycles as part of the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation study.</p></div><div><h3>Intervention(s)</h3><p>FPL was evaluated as a categorical variable defined by quintiles (q1: ≤11 days, q2: 12 days, q3: 13 days, q4: 14–15 days, and q5: ≥16 days).</p></div><div><h3>Main outcome measure(s)</h3><p>Clinical pregnancy, live birth rates, and ET.</p></div><div><h3>Result(s)</h3><p>Decreasing FPL quintiles did not reduce clinical pregnancy or live birth rates in unadjusted or adjusted models with all treatment groups combined or when stratified by the ovarian stimulation medication. All FPL categories had significantly thinner ET compared with the 5th quintile (≥16 days) among women treated with clomiphene citrate or letrozole. Similar but diminished associations were observed among women who underwent ovarian stimulation with gonadotropins, but the observed differences were limited to those with FPL of 12 days or shorter when compared with FPL ≥16 days.</p></div><div><h3>Conclusion(s)</h3><p>Although shorter FPL was associated with reduced ET, it was not associated with the outcomes of clinical pregnancy or live birth in women with unexplained infertility undergoing OS-IUI in all treatment groups combined. Similar patterns existed when analyses of clinical pregnancy and live birth rates were stratified by treatment.</p></div><div><h3>Clinical trial registration</h3><p>NCT01044862.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 361-366"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266633412300082X/pdfft?md5=233fed796ce8042af9d0acb3deb5accc&pid=1-s2.0-S266633412300082X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121406465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive endocrinology and infertility nurse online orientation program evaluation: a quality improvement initiative","authors":"Jamie Vlasic D.N.P. ,&nbsp;Eleanor Stevenson Ph.D. ,&nbsp;Michelle Landrum Ed.D. ,&nbsp;Stephanie Gedzyk-Nieman D.N.P. ,&nbsp;Jennifer Wood B.S.N.","doi":"10.1016/j.xfre.2023.07.002","DOIUrl":"10.1016/j.xfre.2023.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effectiveness of a novel online orientation program (Nurses in REI Communication, Knowledge, and Skills [NRCKS]) among new and early-career reproductive endocrinology nurses to make recommendations for program quality improvement.</p></div><div><h3>Design</h3><p>Quality improvement.</p></div><div><h3>Subject(s)</h3><p>Reproductive endocrinology nurses.</p></div><div><h3>Exposure</h3><p>Online orientation program featuring 8 micromodules.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Knowledge acquisition, confidence, user experience, skills, and abilities</p></div><div><h3>Result(s)</h3><p>Nurses demonstrated a statistically significant increase in reproductive knowledge after completion of NRCKS. Most nurse users felt confident applying knowledge in the clinical settings after program completion. Nurse users had an overall positive experience with interactive components and quality of visuals. Most nurse users gained skills and abilities that they will implement into professional practice. Nurses suggested improving navigation, adding more visuals in content expert presentations, and teaching soft skills necessary for the role of reproductive endocrinology nurses.</p></div><div><h3>Conclusion(s)</h3><p>Nurses in REI Communication, Knowledge, and Skills was well received by nurse participants and emphasized the receptivity and desire for reproductive health and fertility training among novice reproductive endocrinology nurses. Nurses in REI Communication, Knowledge, and Skills increased nursing knowledge, and nurses felt confident applying newly gained knowledge in the clinical setting on completion. Nurse participants provided invaluable feedback for quality improvement to inform the hard launch. The results emphasize the online orientation’s strong potential to close the theory-practice gap.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"4 4","pages":"Pages 390-395"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266633412300079X/pdfft?md5=fd1f290fbf38e46c926ec24f58286d06&pid=1-s2.0-S266633412300079X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121465640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}