FS Reports最新文献

{"title":"Bilateral ovarian abscesses following platelet-rich plasma injection for “ovarian rejuvenation”: a case report","authors":"Vanessa Kalinowska M.D. ,&nbsp;Haaris Mobin B.S. ,&nbsp;Elnur Babayev M.D., M.Sc.","doi":"10.1016/j.xfre.2025.12.009","DOIUrl":"10.1016/j.xfre.2025.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a case of severe infectious complications following ovarian platelet-rich plasma (PRP) injections for ovarian rejuvenation.</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Subjects</h3><div>A 45-year-old nulligravid woman with a history of uterine fibroids and ovarian cysts presenting to an academic medical center.</div></div><div><h3>Exposure</h3><div>Ovarian PRP injections were performed at an outside facility. Following presentation, the patient was treated with intravenous antibiotics. Because of persistent symptoms and clinical deterioration, she subsequently underwent image-guided aspiration of bilateral tubo-ovarian abscesses.</div></div><div><h3>Main Outcome Measures</h3><div>Resolution of infection and resumption of baseline activity and menstrual cycles.</div></div><div><h3>Results</h3><div>The patient presented with persistent lower abdominal pain, leukocytosis, and complex bilateral adnexal masses on imaging several days after intraovarian PRP injection. Cultures from aspirated abscesses grew <em>Streptococcus anginosus</em>. After treatment, she achieved full clinical recovery, resuming normal menses and activity within four months.</div></div><div><h3>Conclusion</h3><div>Ovarian PRP injections, although increasingly marketed for “rejuvenation,” carry risks of severe complications, including infection, such as tubo-ovarian abscess formation. This case underscores the need for caution and further investigation into the safety and efficacy of PRP for reproductive indications.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 112-115"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plan for the next step after a failed transfer cycle: “Doctor, what are we going to do differently?”","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2026.02.003","DOIUrl":"10.1016/j.xfre.2026.02.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 97-98"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Evaluation of severe male infertility”. Perspectives of exome sequencing as the first-line genetic test in severe spermatogenic failure","authors":"Stanislav Tjagur M.D., Ph.D. ,&nbsp;Margus Punab M.D., Ph.D. ,&nbsp;Avirup Dutta Ph.D. ,&nbsp;Maris Laan Ph.D.","doi":"10.1016/j.xfre.2026.01.002","DOIUrl":"10.1016/j.xfre.2026.01.002","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 168-169"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complexity of uncertainty: lessons from chimerism in in vitro fertilization","authors":"Greysha Rivera-Cruz M.D. ,&nbsp;Eduardo Hariton M.D., M.B.A.","doi":"10.1016/j.xfre.2026.02.004","DOIUrl":"10.1016/j.xfre.2026.02.004","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 105-106"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian hyperstimulation syndrome with pleural effusion after unassisted pregnancy during a luteal-phase stimulation cycle","authors":"Alice Emole B.S. ,&nbsp;Navyaa Sinha B.S. ,&nbsp;Dana Aboukhalil B.S. ,&nbsp;Sahil Gupta M.D. ,&nbsp;Aimee Eyvazzadeh M.D., M.P.H.","doi":"10.1016/j.xfre.2026.01.003","DOIUrl":"10.1016/j.xfre.2026.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a rare case of ovarian hyperstimulation syndrome (OHSS) presenting as an isolated right-sided pleural effusion because of endogenous human chorionic gonadotropin (hCG) production from a naturally conceived pregnancy during a luteal-phase ovarian stimulation cycle.</div></div><div><h3>Design</h3><div>Single-patient case report with longitudinal follow up.</div></div><div><h3>Subject</h3><div>A healthy 36-year-old woman with a 15-month history of primary infertility who was undergoing her second luteal-phase ovarian stimulation cycle.</div></div><div><h3>Exposure</h3><div>Controlled ovarian stimulation with menotropins, recombinant follicle-stimulating hormone, letrozole and somatropin, followed by endogenous hCG production from an unexpected naturally conceived pregnancy; no exogenous hCG trigger was administered.</div></div><div><h3>Main Outcome Measures</h3><div>Onset and clinical course of OHSS; volume and recurrence of pleural effusion; need for thoracentesis or an indwelling pleural catheter; maternal and neonatal outcome.</div></div><div><h3>Results</h3><div>A total of 17 ovarian follicles developed by stimulation day 11 with a modest peak estradiol concentration of 279 pg/mL, underscoring the unexpected nature of the subsequent severe presentation. Serum hCG measured 53 mIU/mL on day 11 and rose to 231 mIU/mL 2 days later, confirming conception and prompting cancelation of the stimulation cycle. After 6 days, the patient developed worsening dyspnea; imaging revealed a large right pleural effusion. Three thoracenteses over 10 days removed 4,700 mL of fluid before placement of a 12-French indwelling pleural catheter, which promptly relieved symptoms. Bilateral ovarian enlargement was present with no evidence of ascites. The pregnancy then progressed uneventfully until preterm delivery of a healthy infant at 32 weeks of gestation; both mother and child were discharged in good condition.</div></div><div><h3>Conclusion</h3><div>Ovarian hyperstimulation syndrome can occur despite low estradiol concentrations and the absence of an exogenous hCG trigger. Endogenous hCG from an unrecognized early pregnancy can independently provoke severe vascular hyperpermeability even in canceled cycles with low estradiol and no trigger shot. Clinicians should maintain vigilance for respiratory complications and perform routine pregnancy testing during luteal-phase stimulation to avert delayed diagnosis and morbidity.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 162-167"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the Authors: Safety and pharmacology of AMY109, a long-acting anti-interleukin-8 antibody, for endometriosis: a double-blind, randomized phase 1 trial","authors":"Peng-Hui Wang M.D., Ph.D. ,&nbsp;Chun-An Chen M.Sc. ,&nbsp;Mayuko Sekiya D.V.M. ,&nbsp;Kiyohiko Nakai M.Sc. ,&nbsp;Junnosuke Matsushima M.S.E. ,&nbsp;Ayako Nishimoto-Kakiuchi Ph.D.","doi":"10.1016/j.xfre.2025.12.008","DOIUrl":"10.1016/j.xfre.2025.12.008","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 1","pages":"Pages 95-96"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146175430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-trimester pregnancy loss after in vitro fertilization: risk factors and risk reduction","authors":"Sarah Rubin M.D. ,&nbsp;Olivia Nussbaum B.A. ,&nbsp;Kaleb Noruzi M.D. ,&nbsp;Autumn Brewer M.D. ,&nbsp;Shmuel Sashitzky M.D. ,&nbsp;Alexis Greene M.D. ,&nbsp;Martin Keltz M.D.","doi":"10.1016/j.xfre.2025.12.003","DOIUrl":"10.1016/j.xfre.2025.12.003","url":null,"abstract":"<div><h3>Objective</h3><div>To study changes in the rate and potential causes of second-trimester loss (STL) after in vitro fertilization (IVF) after 2 decades marked by the gradual adoption of elective single embryo transfer.</div></div><div><h3>Design</h3><div>Retrospective cohort study</div></div><div><h3>Subjects</h3><div>All patients who conceived via IVF between 2015 and 2023 at an academic fertility center. Patients who underwent therapeutic termination were excluded.</div></div><div><h3>Exposure</h3><div>In vitro fertilization.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was the rate of STL after IVF. Secondary associated factors assessed included multiple pregnancy, race, uterine defects and tubal factor infertility. Secondary factors were compared with all live births (n = 853), uterine factors were compared with a subset with equivalent uterine structural evaluation. (n = 595). Outcomes were compared with our prior data from 1999–2002.</div></div><div><h3>Results</h3><div>A total of 971 patients with clinical pregnancies were included; 10.2% resulted in a first-trimester loss and a total of 14 patients in our group had a STL. These patients were compared with a control group of 853 patients. Adenomyosis was found to be associated with an increased risk of STL, 35.7% (5/14), compared with 6.4% (38/595) of patients in our control group. Additionally, intrauterine scarring was associated with a higher rate of STL at 35.7% (5/14) vs. 12.6% (75/595). Tuboperitoneal disease was positively associated with STL with 42.9% (6/14), compared with 13.6% (116/853) among the control group. Additionally, patients who identified as Black were associated with an 8.0% (6/75) risk of STL and patients who identified as Hispanic were associated with increased risk of STL at 4.1% (5/122). In univariate analysis, a significant association was found between patients who identified as Black and STL, with 20 times higher odds of STL than patients who identified as White. A significant association was also found between patients who identified as Hispanic or Latino and STL, with 7.90 times higher odds of STL than patients who identified as White. When adjusting for race and ethnicity, parity, and preimplantation genetic testing for aneuploidy (PGT-A) usage in the multivariate model, uterine factor was found to have a significant association with STL, with 32.95 times higher odds of STL in patients with uterine factor.</div></div><div><h3>Conclusion</h3><div>Factors associated with STL include Black race, Hispanic ethnicity, adenomyosis, tubal factor infertility, and intrauterine scarring, with the racial and ethnic disparities in STL largely unchanged over 2 decades. Further study is needed to tailor risk prevention for reducing STL after IVF in at-risk groups.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 1","pages":"Pages 25-30"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146175363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of laparoscopic oophorectomy in a Dutch national pediatric cancer cohort","authors":"Nikita H.Z. Clasen M.Sc. ,&nbsp;M.E. Madeleine van der Perk M.D., Ph.D. ,&nbsp;Marianne D. van de Wetering M.D., Ph.D. ,&nbsp;Annelies M.E. Bos M.D., Ph.D. ,&nbsp;Anne-Lotte L.F. van der Kooi M.D., Ph.D. ,&nbsp;Kim van Loon M.D., Ph.D. ,&nbsp;Margreet A. Veening M.D. Ph.D. ,&nbsp;Irene M. IJgosse M.Sc. ,&nbsp;Sebastian J.C.M.M. Neggers M.D., Ph.D. ,&nbsp;Martine van Grotel M.D., Ph.D. ,&nbsp;Dorine Bresters M.D., Ph.D. ,&nbsp;Hanneke M. van Santen M.D., Ph.D. ,&nbsp;Willem M.J.A. Verpoest M.D. Ph.D. ,&nbsp;Leendert H.J. Looijenga Ph.D. ,&nbsp;Brigitte Arends Ph.D. ,&nbsp;Jeanette van Leeuwen M.D. ,&nbsp;Simone L. Broer M.D., Ph.D. ,&nbsp;Alida F.W. van der Steeg M.D., Ph.D. ,&nbsp;Marry M. van den Heuvel-Eibrink M.D., Ph.D.","doi":"10.1016/j.xfre.2025.11.008","DOIUrl":"10.1016/j.xfre.2025.11.008","url":null,"abstract":"<div><h3>Objective</h3><div>To report our experiences on the safety of laparoscopic oophorectomy (LO) for ovarian tissue cryopreservation in childhood cancer (CC) patients.</div></div><div><h3>Design</h3><div>Descriptive study of a prospectively registered cohort.</div></div><div><h3>Subjects</h3><div>All CC patients undergoing LO in the Netherlands from November 2020 until April 2024.</div></div><div><h3>Exposure</h3><div>Laparoscopic oophorectomy for means of fertility preservation before or during gonadotoxic treatment.</div></div><div><h3>Main Outcome Measures</h3><div>Safety, including procedure-related complications, such as critical events (desaturation, bradycardia), need for mechanical ventilation in a pediatric intensive care unit (PICU), site infections, hemorrhage, and survival, scored according to Clavien Dindo (CD) classification.</div></div><div><h3>Results</h3><div>Eighty-eight patients, median age 6.5 years (range 1–18 years) underwent LO, of which 2/88 patients developed CD grade 4, 1/88 CD grade 3, and 8/88 CD grade 2 complications, with the most common being port site infection (6%) and bleeding (6%). No clear determinant could be identified as a risk factor for complications. All patients recovered from procedure-related complications and no patient died as a consequence of oophorectomy.</div></div><div><h3>Conclusion</h3><div>Laparoscopic oophorectomy is a relatively safe procedure to preserve future fertility for girls with cancer with a high risk of gonadal failure and consequent infertility. However, LO can be accompanied by complications in children with cancer. Therefore, safety monitoring and identification of risk factors for complications based on larger cohorts in future studies are needed. Prevention of complications of LO is an important obligation to balance the future benefits against the risks of LO to enhance the future chance of pregnancy for girls with cancer.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 1","pages":"Pages 69-80"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of severe male infertility","authors":"Peter N. Schlegel M.D","doi":"10.1016/j.xfre.2025.12.005","DOIUrl":"10.1016/j.xfre.2025.12.005","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 1","pages":"Page 3"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current reproductive endocrinology and infertility practices regarding Rh-immune globulin administration in early pregnancy","authors":"Nimerta K. Sandhu M.D. ,&nbsp;Adriana J. Wong M.D. ,&nbsp;Richard J. Paulson M.D. ,&nbsp;Mitchell D. Creinin M.D.","doi":"10.1016/j.xfre.2025.10.009","DOIUrl":"10.1016/j.xfre.2025.10.009","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 1","pages":"Pages 86-89"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}