FS Reports最新文献

{"title":"App-assisted in vitro fertilization: the way of the future?","authors":"Benjamin J. Peipert M.D., Iris T. Lee M.D., M.S.C.E.","doi":"10.1016/j.xfre.2025.05.004","DOIUrl":"10.1016/j.xfre.2025.05.004","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 166-167"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight loss before conception: effects on atherogenic apolipoprotein lipid particles and endothelial function during pregnancy","authors":"Robert A. Wild M.D., Ph.D. ,&nbsp;Daniel Zhao Ph.D. ,&nbsp;Michael J. McPhaul M.D. ,&nbsp;Rodney K. Edwards M.D. ,&nbsp;Karl R. Hansen M.D., Ph.D. ,&nbsp;Elizabeth L. Wolfe M.D. ,&nbsp;David S. Wrenn Ph.D.","doi":"10.1016/j.xfre.2025.02.009","DOIUrl":"10.1016/j.xfre.2025.02.009","url":null,"abstract":"<div><h3>Objective</h3><div>To assess atherogenic apolipoprotein lipids and markers of vascular function in pregnancy after prepregnancy weight loss.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Subjects</h3><div>The weight loss cohort included pregnant women who achieved prepregnancy weight loss, and the weight gain cohort consisted of those who gained weight before pregnancy. All patients became pregnant after enrolling in the randomized clinical trial “Improving Reproductive Fitness Through Pretreatment with Lifestyle Modification in Obese Women with Unexplained Infertility” and delivered a single live birth at ≥36 weeks of gestation.</div></div><div><h3>Exposure</h3><div>Prepregnancy weight loss.</div></div><div><h3>Main Outcome Measures</h3><div>Apolipoprotein lipid levels.</div></div><div><h3>Results</h3><div>Prepregnancy weight loss was associated with lower atherogenic apolipoprotein lipid levels during pregnancy and better indicators of vascular function.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that encouraging prepregnancy weight loss in obese women leads to improved vascular function during pregnancy. Prepregnancy weight loss has significant implications for healthcare professionals because it underscores the potential benefits of weight loss interventions in reducing the risk of cardiovascular disease for women who become pregnant.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 185-192"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol considerations for multigenerational blinding of preimplantation genetic testing for a monogenic condition for Huntington disease: a case report","authors":"Samuel Raine M.D. ,&nbsp;Dana R. Siegel M.D. ,&nbsp;Liya Rabkina M.S. ,&nbsp;Paulina Nassab M.S. ,&nbsp;Ana Cervero Ph.D. ,&nbsp;Jose Antonio Martinez-Conejero Ph.D. ,&nbsp;Hannah Elfman M.S. ,&nbsp;Alex J. Polotsky M.D.","doi":"10.1016/j.xfre.2025.03.007","DOIUrl":"10.1016/j.xfre.2025.03.007","url":null,"abstract":"<div><h3>Objective</h3><div>To report a unique case of preimplantation genetic testing for a monogenic condition (PGT-M) for Huntington disease (HD) using both exclusion-based testing and direct nondisclosure testing across multiple generations and to highlight the strategies used to protect reproductive autonomy and privacy.</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Subjects</h3><div>A reproductive-aged nulliparous couple with the male partner's family history significant for HD who desired to conceive a child with PGT-M to build a family without the risk of HD inheritance while simultaneously maintaining the anonymity of carrier results to the partner and all living family members.</div></div><div><h3>Exposure</h3><div>Two in vitro fertilization (IVF) cycles with exclusion-based PGT-M in the first cycle and direct nondisclosure PGT-M in the second cycle, followed by 2 frozen embryo transfers (FETs).</div></div><div><h3>Main Outcome Measures</h3><div>Number of low-risk euploid blastocysts suitable for embryo transfer.</div></div><div><h3>Results</h3><div>The first IVF cycle using exclusion-based PGT-M resulted in 14 good-quality blastocysts with only 1 blastocyst deemed at low risk of inheriting the at-risk HD haplotype. The first FET was unsuccessful. The male partner’s mother was tested and was found to be an HD carrier. The second IVF cycle used direct nondisclosure PGT-M, which resulted in 12 blastocysts suitable for transfer (both euploid and negative for HD). After the second failed FET, the male partner ultimately decided to undergo genetic testing for HD for himself and was negative for HD mutation. The couple then chose to attempt spontaneous conception and had a live birth of a healthy male infant without complications.</div></div><div><h3>Conclusion</h3><div>Multigenerational blinding of PGT-M for trinucleotide repeat disorders has great utility in preserving patient autonomy while limiting the risk of future progeny inheriting a life-limiting genetic condition. Careful, comprehensive counseling and multilevel strategies should be developed to enact these blinding measures to best serve patients and their families whose genetic information is being used for testing.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 201-205"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eggs-panding possibilities: feasibility of ex vivo oocyte retrieval in ovarian cancer","authors":"Maia Hare M.D. ,&nbsp;Lusine Aghajanova M.D., Ph.D.","doi":"10.1016/j.xfre.2025.03.009","DOIUrl":"10.1016/j.xfre.2025.03.009","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 216-217"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing time-lapse for flexible embryo assessment in in vitro fertilization: implications for grading confidence and workflow efficiency","authors":"Alicia Picou M.S. ,&nbsp;Kelly Athayde Wirka D.H.Sc. ,&nbsp;Allison Baxter Catherino Ph.D. ,&nbsp;Brooke Hayward S.M. ,&nbsp;Matthew David VerMilyea Ph.D.","doi":"10.1016/j.xfre.2025.03.006","DOIUrl":"10.1016/j.xfre.2025.03.006","url":null,"abstract":"<div><h3>Objective</h3><div>To compare embryologists’ confidence levels and grading concordance when assessing embryo morphology using time-lapse images vs. traditional direct observation under a microscope.</div></div><div><h3>Design</h3><div>Prospective study.</div></div><div><h3>Subjects</h3><div>Six embryologists on staff at the laboratory who ranged from junior to senior skillset levels.</div></div><div><h3>Exposure</h3><div>None.</div></div><div><h3>Main Outcome Measures</h3><div>Embryologists’ confidence levels in morphology assessments, intraobserver agreement for embryo grading, and assessment duration when using time-lapse images compared with direct observation under microscopes.</div></div><div><h3>Results</h3><div>From 6,435 morphology assessments across 714 embryos (62 cohorts), high-confidence levels were observed on day 5 for gradings using either direct observation (97.7%) or time-lapse images (94.6%), with no statistically significant difference. Confidence was consistently high (&gt;85%) across days 1, 3, 6, and 7, with direct observation having higher confidence rate than time-lapse-based assessment on days 1 and 3. Intraobserver agreement between direct observation vs. time-lapse-based assessment showed good-to-excellent concordance (κ ≥ 0.60) except for blastocyst morphology grade (κ = 0.58). The highest agreement was observed for day 5–7 embryo disposition decisions, with 94.1% concordance (κ = 0.89). Assessment durations were comparable between the two grading methods.</div></div><div><h3>Conclusion</h3><div>Embryologists maintained high confidence in morphology assessments using time-lapse systems, even under time constraints. Intraobserver agreement for embryo grading, assessed by comparing the same embryologist’s gradings using time-lapse images vs. direct observation, was comparable to previously reported levels of agreement for traditional morphology gradings. These findings highlight the feasibility of flexible or remote assessments without disrupting embryo culture, enhancing workflow adaptability, and paving the way for advancements with artificial intelligence integration.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 149-157"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic uterine fixation and ovarian pexy for fertility and ovarian preservation in a 40-year-old with anal cancer","authors":"Victoria Dillard M.D. ,&nbsp;Ameek Bindra B.A. ,&nbsp;Jeitzel Torres-Rodriguez B.S. ,&nbsp;Amy M. Vallerie M.D. ,&nbsp;Marc Fields M.D. ,&nbsp;Sara Ann B. Gilbert M.D. ,&nbsp;Eve Zaritsky M.D.","doi":"10.1016/j.xfre.2025.01.020","DOIUrl":"10.1016/j.xfre.2025.01.020","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a novel multidisciplinary approach to preserve ovarian function and fertility in a 40-year-old woman with newly diagnosed anal cancer.</div></div><div><h3>Design</h3><div>Case study of a multidisciplinary ovarian and fertility preservation strategy.</div></div><div><h3>Patient</h3><div>A 40-year-old nulliparous woman with a newly diagnosed stage IIA squamous cell carcinoma (SCC) of the anal canal and a history of cervical intraepithelial neoplasia (CIN 3, status post LEEP).</div></div><div><h3>Exposure</h3><div>The patient underwent an oocyte retrieval, followed by laparoscopic ovarian and uterine pexy to minimize radiation dose to the ovaries and uterus. She subsequently received external beam radiation therapy (EBRT).</div></div><div><h3>Main Outcome Measures</h3><div>Radiation dose to the ovaries and uterus; preservation of ovarian function and reproductive potential.</div></div><div><h3>Results</h3><div>The estimated mean radiation doses to the ovaries were limited to &lt;500 cGy, cumulatively, potentially preserving ovarian function, whereas without ovarian transposition, the ovaries would have received at least 4,200 cGy, which would have certainly caused premature primary ovarian insufficiency (POI). Additionally, the uterus received a modestly lower dose than it would have without the uterine pexy. This collaborative approach resulted in a decreased likelihood of early menopause, underscoring the importance of centralized and coordinated care.</div></div><div><h3>Conclusion</h3><div>This case study underscores the importance of a multidisciplinary approach involving fertility, gynecology, and radiation oncology departments to ensure an integrated care model focused on preserving fertility and ovarian function. It supports the growing body of evidence that standardized coordination among these specialties is essential and aligns with broader efforts to prioritize fertility preservation in cancer care planning.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 218-224"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black sperm donors: motivations and hesitations","authors":"Alyssa M. Newman Ph.D.","doi":"10.1016/j.xfre.2025.03.004","DOIUrl":"10.1016/j.xfre.2025.03.004","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 231-233"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen parameters in transgender women and gender-diverse people assigned male at birth using gender-affirming hormones: cohort study and scoping review","authors":"Renee Tristano B.S. ,&nbsp;Alexis Hood M.D. ,&nbsp;Bridget Huepful B.S. ,&nbsp;Omer Raheem M.D. ,&nbsp;John Schneider M, D, M.P.H. ,&nbsp;Amanda Adeleye M.D.","doi":"10.1016/j.xfre.2025.03.002","DOIUrl":"10.1016/j.xfre.2025.03.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To assess semen parameters, hormone levels, and the psychological experience of transgender (TG) women and gender-diverse (GD) people assigned male at birth using gender-affirming hormones (GAH) and to summarize the current literature on this topic.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Cohort study and scoping review.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patients&lt;/h3&gt;&lt;div&gt;Fifteen people assigned male at birth identifying as TG or GD using GAH (12 TG women and 3 GD people).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;div&gt;Gender-affirming hormone therapy (estradiol, antiandrogen, +/- progesterone).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;The primary outcomes of the cohort study were semen parameters (volume, concentration, motility, and total motile count). Secondary outcomes included serum levels of gonadotropins, estradiol, and testosterone. Secondary outcomes also included qualitative data about the specimen collection experience. The primary outcome of the scoping review was to evaluate the current literature on semen parameters of TG women and GD people on GAH by determining the number of studies, key objectives, and findings.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Cohort study: Fifteen participants attempted to produce a semen sample. Thirteen participants (87%) produced a specimen for analysis; 8 were azoospermic (61.5%) and 5 contained sperm (38.5%). Of all included participants, only 4 participants (26.7%) were able to produce a sample with motile sperm. The median concentration was 25.0 million/mL (range: 0.2–99.0), motility 22% (range: 0–70%), and total motile count 2.5 million (range: 0–70.0). All participants with motile sperm had luteinizing hormone (median: 3.8 IU/L, interquartile range [IQR]: 1.9–5.2) and testosterone levels (median: 193 ng/dL, IQR: 94.5–330.5) that were significantly higher than the remainder of the cohort. Estradiol (median: 147 pg/mL, IQR: 100.5–410) and follicle-stimulating hormone (median: 0.4, IQR: 0.2–1.55) levels among participants with motile sperm did not differ significantly compared with the remainder of the cohort. Producing a specimen was rated as moderately difficult physically (median: 4.0, IQR: 2.0–7.5) and psychologically (median: 4.0, IQR: 2.0–6.0) (where 1=easy, 9=difficult). Participants advised that assuring sound-proofed collection rooms or home collection could improve the collection experience.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Scoping review&lt;/h3&gt;&lt;div&gt;682 abstracts were eligible for screening. 12 sources were included in the final analysis. Most studies demonstrated that GAH negatively impacted semen parameters. One case report, and no cohort studies, examined hormonal profiles at the time of specimen collection.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Consistent with prior limited data, in a cohort of TG women and GD people assigned male at birth using gender-affirming hormones, semen parameters were abnormal and often azoospermic. The ability to produce motile sperm may be associated with less ","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 129-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need to integrate mental health treatment into the care of Mayer–Rokitansky–Küster–Hauser","authors":"Teni Davoudian Ph.D., A.B.P.P. ,&nbsp;Emily Hills M.D.","doi":"10.1016/j.xfre.2025.03.008","DOIUrl":"10.1016/j.xfre.2025.03.008","url":null,"abstract":"<div><div>This mini review examines the psychological burdens of Mayer–Rokitansky–Küster–Hauser (MRKH) and encourages collaborations between medical and mental health providers who treat this condition. The psychological comorbidities of MRKH emerge in adolescence and persist into adulthood. For several years, The American College of Obstetricians and Gynecologists and researchers in this field have called for the provision of psychological counseling for individuals with MRKH. However, referrals to qualified mental health professionals remain sparse leaving many to confront the emotional complexities of MRKH with little to no support.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 116-119"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in perinatal outcomes among births to same-sex and different-sex married couples: a cross-sectional study using birth certificate data","authors":"Kendall A. Lawley M.S., M.P.H. ,&nbsp;Brittany M. Charlton Sc.D. ,&nbsp;Elizabeth Rubin M.D. ,&nbsp;Paula Amato M.D. ,&nbsp;Jae Corman Ph.D.","doi":"10.1016/j.xfre.2025.04.005","DOIUrl":"10.1016/j.xfre.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate differences in birth outcomes for infants born to parents in same-sex versus different-sex marriages.</div></div><div><h3>Design</h3><div>Cross-sectional study</div></div><div><h3>Subjects</h3><div>Birth certificate data from Ohio for 318,616 singleton infants born to married parents from 2016 to 2020.</div></div><div><h3>Exposure</h3><div>We estimated the associations of having a parent in a same-sex marriage (SSM) vs. a different-sex marriage (DSM).</div></div><div><h3>Main Outcome Measures</h3><div>Preterm birth, low birth weight, macrosomia, small infant for gestational age, large infant for gestational age, and whether these outcomes differed by use of assisted reproductive technologies.</div></div><div><h3>Results</h3><div>A total of 1,661 singletons were born to married birthing people in SSM. Preterm birth was more common in birthing persons in SSM compared with those in DSM (11.0% vs. 7.6%), and this difference remained significant on multivariate analyses controlling for covariates. Size for gestational age was similar among infants with parents in SSM and DSM. Among those who used assisted reproductive technologies, infants born to parents in SSM had a 1.58 (95% CI: 1.15, 2.12) higher odds of macrosomia compared with those in DSM.</div></div><div><h3>Conclusion</h3><div>People in SSM may face modestly increased risks for some perinatal outcomes, including preterm birth. Understanding the risks and resiliency among diverse sexual minority populations may provide important insights into the ways in which people in same-sex partnerships achieve healthy perinatal outcomes.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 2","pages":"Pages 177-184"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}