FS Reports最新文献

{"title":"Personalized medicine in the evaluation of Müllerian anomalies: the role of three-dimensional printing technology","authors":"","doi":"10.1016/j.xfre.2024.05.003","DOIUrl":"10.1016/j.xfre.2024.05.003","url":null,"abstract":"<div><h3>Objective</h3><p>To present the comprehensive methodology for generating personalized three-dimensional (3D) printed uterine models from 3D ultrasound (US) volumes in individuals diagnosed with Müllerian anomalies and discuss potential applications in the field of reproductive endocrinology and infertility.</p></div><div><h3>Design</h3><p>Pilot study.</p></div><div><h3>Setting</h3><p>Single large university-affiliated teaching hospital.</p></div><div><h3>Patient(s)</h3><p>Patients with the presence of a Müllerian anomaly between the ages of 18 and 45 years attending the maternal-fetal medicine as well as reproductive endocrinology and infertility outpatient offices from 2018 to 2023 were included in the study.</p></div><div><h3>Intervention(s)</h3><p>Subjects underwent 3D US transvaginal scanning for the collection of data. The 3D US volumes were acquired, edited, and exported from a US cart Voluson E10 system (GE Healthcare, Chicago, IL). High-definition virtual models were created and modified, making them suitable for printing using Materialise 3-Matic Medical (Materialise NV, Leuven, Belgium). The models were printed on a J5 MediJet 3D printer (Stratasys, Rehovot, Israel). Colors were set to mimic a realistic appearance, and shore values were set before printing.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Successful creation and utilization of personalized 3D-printed uterine models for individuals with Müllerian anomalies.</p></div><div><h3>Results(s)</h3><p>Three-dimensional models were created for a uterus without anomalies, 2 variations of a partial septum, a unicornuate, and a didelphys uterus. Models were used as a tactile and customized tool for patient education, counseling, and medical student and resident teaching. This technique illustrates that the creation of personalized 3D-printed uterine models for utilization in the fields of reproductive endocrinology and infertility is feasible.</p></div><div><h3>Conclusion(s)</h3><p>We propose a novel use of individualized 3D-printed uterine models in the evaluation of individuals with Müllerian anomalies. These models may play a complementary role to standard imaging options in the assessment of these anomalies, with a special potential for application in highly complex or yet-to-be-determined types of anomalies.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 279-284"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000540/pdfft?md5=5af7ade16b3d1ced3d5c0a018a164e52&pid=1-s2.0-S2666334124000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted same-sex conception: reproduction reimagined","authors":"","doi":"10.1016/j.xfre.2024.02.011","DOIUrl":"10.1016/j.xfre.2024.02.011","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 234-236"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000400/pdfft?md5=fe79ac56a5e5edf90a0117e459f87701&pid=1-s2.0-S2666334124000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progesterone in frozen embryo transfer cycles: assays, circulating concentrations, metabolites, and molecular action","authors":"","doi":"10.1016/j.xfre.2024.05.007","DOIUrl":"10.1016/j.xfre.2024.05.007","url":null,"abstract":"<div><p>Programmed or medicated frozen embryo transfer cycles rely on exogenous progesterone (P) administration to prepare the endometrium for implantation and maintain pregnancy. Presently, the optimal route and dose of P replacement for frozen embryo transfer are not known. In addition, there is a paucity of data and insufficient understanding regarding the metabolism and actions of P in implantation and pregnancy maintenance. In the present review, we discuss how different P assay methodologies affect the determination of P thresholds for implantation and pregnancy maintenance. In addition, we discuss the importance of free P and its regulation in the endometrium and show the complexity of molecular signaling that is required for P-dependent endometrial receptivity. We concluded that future studies should focus on defining accurate circulating and endometrial P concentrations, both for total and free P, and how these concentrations correlate with endometrial receptivity and clinical outcomes.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 237-247"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000588/pdfft?md5=1ccf5f84b5dd14e381c28f2913e461e7&pid=1-s2.0-S2666334124000588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B virus in oocytes and embryos: pregnancy outcomes and children’s health","authors":"Xiaoling Hu Ph.D. ,&nbsp;Yingzhi Yang M.D. ,&nbsp;Guofang Feng M.D. ,&nbsp;Xiaoqian Zhou M.D. ,&nbsp;Minyue Tang Ph.D. ,&nbsp;Huanmiao Yan M.D. ,&nbsp;Miao Li M.D. ,&nbsp;Aixia Liu Ph.D. ,&nbsp;Yimin Zhu Ph.D.","doi":"10.1016/j.xfre.2024.07.002","DOIUrl":"10.1016/j.xfre.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate whether the presence of hepatitis B virus (HBV) in oocytes and embryos affects pregnancy outcomes for in vitro fertilization and embryo transfer (ET) as well as is related to the vertical transmission of HBV to children.</p></div><div><h3>Design</h3><p>Retrospective cohort study.</p></div><div><h3>Setting</h3><p>A university-affiliated fertility center.</p></div><div><h3>Patient(s)</h3><p>This study included 167 couples with at least 1 hepatitis B surface antigen–seropositive partner. These couples underwent in vitro fertilization–ET, and the discarded oocytes and embryos had been tested for HBV. Couples with HBV-positive oocytes or embryos were categorized as the positive group, whereas those couples with HBV-negative oocytes and embryos served as the negative group.</p></div><div><h3>Intervention(s)</h3><p>None.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Pregnancy outcomes and the rate of children’s HBV infection.</p></div><div><h3>Result(s)</h3><p>The pregnancy outcomes of fresh and frozen ETs were not associated with the presence of HBV in the oocytes and embryos. Of the 106 infants born, 1 child whose mother tested positive for hepatitis B surface antigen but had negative oocytes and embryos was infected with HBV. Additionally, 26.09% of children who had been administered passive immunization and active vaccinations did not reach protective levels of anti-HBV antibodies (hepatitis B surface antibodies) and became nonresponders. The negative rate of children’s hepatitis B surface antibody was associated with the presence of HBV in oocytes and embryos (odds ratio, 3.01; 95% confidence interval, 1.04–9.25).</p></div><div><h3>Conclusion(s)</h3><p>The presence of HBV in oocytes and embryos did not affect pregnancy outcomes or result in the vertical transmission of HBV to the offspring of HBV carriers. Follow-up is needed for HBV-vaccinated children with an HBV-infected parent. Booster vaccinations are necessary for continued protection.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 272-278"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000795/pdfft?md5=5534de5c5012e8a0ec65524f9ad0ef92&pid=1-s2.0-S2666334124000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The geographic impact on successfully matching into reproductive endocrinology and infertility fellowship","authors":"Megan R. Sax M.D.","doi":"10.1016/j.xfre.2024.08.003","DOIUrl":"10.1016/j.xfre.2024.08.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Page 251"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000849/pdfft?md5=094e9ca0471394ad047000ade85b1589&pid=1-s2.0-S2666334124000849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of transvaginal ultrasound alters physiologic uterine peristalsis in gynecologic participants","authors":"Kelsey Anderson M.D. ,&nbsp;Sicheng Wang Ph.D. ,&nbsp;Stephanie Pizzella M.S. ,&nbsp;Qing Wang Ph.D. ,&nbsp;Yong Wang Ph.D. ,&nbsp;Valerie Ratts M.D.","doi":"10.1016/j.xfre.2024.06.004","DOIUrl":"10.1016/j.xfre.2024.06.004","url":null,"abstract":"<div><h3>Objective</h3><p>To study whether transvaginal ultrasound (TVUS) affected the uterine peristalsis (UP) patterns in nonpregnant participants.</p></div><div><h3>Design</h3><p>Institutional review board–approved, prospective observational cohort study. The noninvasive UP imaging (UPI) system uses electrode patches placed on the patient’s skin just above the pubic bone and on the low back to quantify the 3-dimensional electrical activation pattern during UP by calculating peristalsis frequency, duration, magnitude, and activation ratio. A 20-minute UPI scan was completed without TVUS followed by a 10-minute UPI scan acquired simultaneously during TVUS examination as a comparison.</p></div><div><h3>Setting</h3><p>University medical center.</p></div><div><h3>Patient(s)</h3><p>Twenty-eight participants with regular menstrual cycles not taking hormonal medication and with a normal uterus were included in analysis.</p></div><div><h3>Intervention(s)</h3><p>Subjects were imaged longitudinally during the four phases of the menstrual cycle (menses, proliferative, periovulatory, and secretory) with a UPI scan followed by concurrent TVUS and UPI scan. Serum hormone levels (estradiol and progesterone) and TVUS evaluating follicular development were obtained during each visit to confirm menstrual cycle phase.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Duration, frequency, magnitude, and activation ratio of the UP waves.</p></div><div><h3>Result(s)</h3><p>With the use of simultaneous TVUS, UP waves had a change in at least one of the outcomes measured in all visits. The frequency, magnitude, and duration were significantly higher with TVUS use in all phases of the menstrual cycle. The activation ratio was higher with TVUS during all phases except the periovulatory phase.</p></div><div><h3>Conclusion(s)</h3><p>This study demonstrated that TVUS may inherently affect UP waves. Therefore, noninvasive technology may more accurately measure physiologic peristalsis waves.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 296-303"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000758/pdfft?md5=0fb1a4c84af711e95bcbb2195386d8fe&pid=1-s2.0-S2666334124000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of maternal factors in egg freezing cycles with in vitro fertilization outcomes of both in vivo and rescue in vitro matured oocytes","authors":"Terry Schlenker B.S. ,&nbsp;Ye Yuan Ph.D. ,&nbsp;Elizabeth A. Jannaman B.S. ,&nbsp;William B. Schoolcraft M.D. ,&nbsp;Jason E. Swain Ph.D.","doi":"10.1016/j.xfre.2024.06.005","DOIUrl":"10.1016/j.xfre.2024.06.005","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 333-337"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266633412400076X/pdfft?md5=3691abe4fcdbd31c49aa7e008abcbbe1&pid=1-s2.0-S266633412400076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected poor oocyte retrieval: the phenomenon of the borderline response to the gonadotropin-releasing hormone (GnRH) agonist trigger","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2024.08.001","DOIUrl":"10.1016/j.xfre.2024.08.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 229-230"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000825/pdfft?md5=39443019363727fef6aeb67aab9c58b3&pid=1-s2.0-S2666334124000825-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office of Public Affairs update: a quarterly update from the American Society for Reproductive Medicine Office of Public Affairs on key developments in reproductive health policy","authors":"Rebecca O’Connor J.D.","doi":"10.1016/j.xfre.2024.08.002","DOIUrl":"10.1016/j.xfre.2024.08.002","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Page 233"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000837/pdfft?md5=d455f0dd8a26f9a2c5aa0106695ca72b&pid=1-s2.0-S2666334124000837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracytoplasmic sperm injection versus conventional in vitro fertilization in unexplained infertility","authors":"Aya Iwamoto M.S., M.D. ,&nbsp;Karen M. Summers M.P.H. ,&nbsp;Amy Sparks Ph.D. ,&nbsp;Abigail C. Mancuso M.D.","doi":"10.1016/j.xfre.2024.06.003","DOIUrl":"10.1016/j.xfre.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><p>To compare cumulative live birth rate (CLBR) and cost-effectiveness of intracytoplasmic sperm injection (ICSI) vs. conventional in vitro fertilization (cIVF).</p></div><div><h3>Design</h3><p>Retrospective cohort study of cycles reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System.</p></div><div><h3>Setting</h3><p>Society for Assisted Reproductive Technology (SART) member IVF clinics in the United States.</p></div><div><h3>Patient(s)</h3><p>Patients with unexplained infertility who underwent first autologous retrieval cycles between January 2017 and December 2019 with linked fresh and frozen embryo transfers through December 2021.</p></div><div><h3>Intervention(s)</h3><p>ICSI vs. cIVF.</p></div><div><h3>Main Outcome Measure(s)</h3><p>The primary outcome was CLBR, defined as ≤1 live birth from a retrieval cycle and all linked embryo transfers. Secondary outcomes included two pronuclear (2PN) per oocyte retrieved, miscarriage rate, and total number of transferred or frozen embryos per 2PN. Subsamples with and without preimplantation genetic testing for aneuploidy (PGT-A) were analyzed. Outcomes were adjusted for age, body mass index, number of oocytes retrieved, length of follow-up, and clinic ICSI use rate.</p></div><div><h3>Result(s)</h3><p>A total of 18,805 patients with unexplained infertility were included. No difference in CLBR was found among cycles without genetic testing (54.4% ICSI vs. 57.5% cIVF) and with PGT-A (47.6% ICSI vs. 51.8% cIVF). Intracytoplasmic sperm injection cycles without genetic testing had a higher miscarriage rate (16.4% vs. 14.4%) but no difference was seen in cycles with PGT-A (13.9% ICSI vs. 13.2% cIVF). Intracytoplasmic sperm injection cycles had a significantly lower ratio of 2PN per oocyte retrieved without genetic testing (59.7% vs. 60.9%) and with PGT-A (63.3% vs. 65.8%). The ratio of embryos transferred or frozen per 2PN was not significantly different in cycles without genetic testing (49.4% vs. 49.6%) or with PGT-A (54.2% vs. 55.2%). Total fertilization failure occurred in 216 patients (4%) who underwent cIVF and in 153 patients (1.1%) who used ICSI.</p><p>Compared with cIVF alone, an estimated additional $11,011,500 was charged to patients for ICSI without genetic testing and $9,010,500 was charged to patients for ICSI with PGT-A over 2 years by Society for Assisted Reproductive Technology clinics. On the basis of total fertilization failure rates, 35 patients would require treatment with routine ICSI to avoid a single cycle of total fertilization failure with cIVF.</p></div><div><h3>Conclusion(s)</h3><p>Routine use of ICSI in unexplained infertility is not warranted due to the additional cost and lack of CLBR benefit.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 3","pages":"Pages 263-271"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000746/pdfft?md5=4e1fb926bff87b6361e931652abfd536&pid=1-s2.0-S2666334124000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}