FS Reports最新文献_第4页

How adaptive solutions from marine mammal life history could address pressing problems in reproductive biomedicine 海洋哺乳动物生活史中的适应性解决方案如何解决生殖生物医学中的紧迫问题

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.02.004

Michelle R. Shero Ph.D.

{"title":"How adaptive solutions from marine mammal life history could address pressing problems in reproductive biomedicine","authors":"Michelle R. Shero Ph.D.","doi":"10.1016/j.xfre.2025.02.004","DOIUrl":"10.1016/j.xfre.2025.02.004","url":null,"abstract":"<div><div>Trends in modern society show an increase in maternal age due to deferred childbearing, and assisted reproductive technologies often make this possible. However, there are still numerous challenges in the field of reproductive health, ranging from conception to delivery and beyond. Wild animals may provide answers to some of the field’s pressing problems because these species have acquired adaptations to maximize reproductive output under some of the world’s most extreme conditions. Here, I focus on 3 key aspects of marine mammal life history that could provide significant insight into reproductive physiology and function for future study. First, marine mammals are fasting-adapted species that cease feeding activities during portions of their reproductive cycle. Strong selective pressures for lipid mobilization to support energetic demands during fasts result in reversible insulin resistance, similar to gestational diabetes mellitus. Second, marine mammals extensively forage as they recover from fasts, engaging in repeated, long-duration dives. This exposes the females and their pregnancies to prolonged hypoxia, extending far past the limits that human fetuses could withstand during delivery without hypoxic ischemic encephalopathy or asphyxiation. Finally, pinnipeds and polar bears use embryonic diapause to time birth with optimal conditions for successful offspring rearing. The ability to “pause” pregnancy until conditions improve could substantially enhance successful outcomes for assisted reproductive technologies in humans. Lessons learned from marine mammal physiology highlight the value in applying comparative studies toward a One Health approach in reproductive medicine.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 ","pages":"Pages 24-31"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic biology is not just “for the birds”: how avian studies have informed us about vertebrate reproduction 基础生物学不仅仅是“为了鸟类”：鸟类研究如何告诉我们脊椎动物的繁殖

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2024.12.007

George E. Bentley Ph.D., D.Sc. , Sayaka Aizawa Ph.D.

{"title":"Basic biology is not just “for the birds”: how avian studies have informed us about vertebrate reproduction","authors":"George E. Bentley Ph.D., D.Sc. , Sayaka Aizawa Ph.D.","doi":"10.1016/j.xfre.2024.12.007","DOIUrl":"10.1016/j.xfre.2024.12.007","url":null,"abstract":"<div><div>Avian reproductive physiology has been studied for centuries, largely because of the importance of birds as food animals. It is likely that the ubiquity and ease of access to domesticated chickens led to them being used in some of the first experiments on transplantation of endocrine structures—in this case, the testes. Since then, study of seasonal changes in reproductive physiology (photoperiodism) in different orders of bird species has led to advances in the understanding of endocrine regulation of reproductive physiology and behavior. These include mechanisms of adult neuroplasticity, sexual selection, sperm competition, stress physiology, and circadian physiology. Here, we focus mainly on the discovery in birds of a neuropeptide named gonadotropin-inhibitory hormone that mostly has inhibitory effects on reproduction. This hormone has since been shown to exist in all mammals studied to date, including humans (it is known as RFamide-related peptide in mammals). We discuss the history and implications of avian studies on gonadotropin-inhibitory hormone/RFamide-related peptide for human reproductive biology.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 ","pages":"Pages 7-12"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside the box: comparative stem cell insights for fertility biotechnology and conservation 在盒子之外：比较干细胞对生育生物技术和保护的见解

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.02.002

Ashlee M. Hutchinson Ph.D. , Antonia Weberling Ph.D. , Yoshinori Endo Ph.D. , Rhishikesh Bargaje Ph.D.

{"title":"Outside the box: comparative stem cell insights for fertility biotechnology and conservation","authors":"Ashlee M. Hutchinson Ph.D. , Antonia Weberling Ph.D. , Yoshinori Endo Ph.D. , Rhishikesh Bargaje Ph.D.","doi":"10.1016/j.xfre.2025.02.002","DOIUrl":"10.1016/j.xfre.2025.02.002","url":null,"abstract":"<div><div>Leveraging comparative biology could lead to breakthrough discoveries in the development of fertility technologies while supporting conservation efforts. Here, we discuss examples and opportunities to learn from stem cell systems in nontraditional animal models, primarily from the amniote phylum, focusing on challenges and insights in the in vitro derivation of primordial germ cells and gametes, as well as the promise of gonadal stem cells. Embryo models and organoid systems provide a further opportunity to explore germ cell specification and maturation within a proxy ‘in vivo’ context. Additionally, stem cells enable high-throughput molecular studies to explore the mechanisms underlying fertility-related diseases. Using the international effort to derive gametes from stem cells of the Northern White Rhino as a case study, we highlight the contribution of alternative mammalian systems within the field of assisted reproductive treatments and point toward promising directions for future research. Contextualizing stem cell derivation and differentiation within a comparative species framework will be essential for harnessing the full potential of reproductive technologies for human fertility while simultaneously opening new frontiers in wildlife conservation.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 ","pages":"Pages 38-44"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadal tissue preservation technologies and culture offer opportunities to bridge knowledge between wildlife and humans 性腺组织保存技术和培养为野生动物和人类之间的知识桥梁提供了机会

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.009

Andreia Maria Silva Ph.D. , Gabriela Liberalino Lima Ph.D. , Pierre Comizzoli Ph.D. , Alexandre Rodrigues Silva D.V.M., Ph.D.

{"title":"Gonadal tissue preservation technologies and culture offer opportunities to bridge knowledge between wildlife and humans","authors":"Andreia Maria Silva Ph.D. , Gabriela Liberalino Lima Ph.D. , Pierre Comizzoli Ph.D. , Alexandre Rodrigues Silva D.V.M., Ph.D.","doi":"10.1016/j.xfre.2025.01.009","DOIUrl":"10.1016/j.xfre.2025.01.009","url":null,"abstract":"<div><div>Gonadal tissue preservation has emerged as a promising alternative mainly for the creation of wildlife biobanks and the restoration of fertility in humans. This review aims to establish bridges between the knowledge acquired from studies in humans and wild animals, highlighting challenges and advances. Progresses in in vitro culture of tissues and grafting technologies have cross-species implications, driving innovation in both areas. In humans, research is largely focused on optimizing clinical outcomes and expanding accessibility whereas in wild animals, the emphasis is on preserving genetic diversity and addressing technical challenges of noninvasive sampling and preservation. Although gonadal tissue preservation, in vitro culture, and grafting share common foundational methodologies across humans and wild animals, their application requires species-specific adaptations due to anatomical and physiological differences. Leveraging the synergies between human and wildlife research will enhance fertility preservation and biodiversity conservation efforts globally.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 ","pages":"Pages 50-54"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative reproductive pathology, a walk on the wild side 比较生殖病理学，野外漫步

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.010

Anneke Moresco D.V.M., Ph.D. , Dalen W. Agnew D.V.M., Ph.D., Dipl. ACVP

引用次数: 0

One Health and the Exposome: providing insights for wildlife health and reproduction 同一健康和暴露：为野生动物健康和繁殖提供见解

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.02.001

Mary Ann Ottinger Ph.D. , Cullen Geiselman Ph.D.

引用次数: 0

Bridging studies in wild animal species and humans to better understand, assist, and control reproduction 连接野生动物物种和人类的研究，以更好地理解，协助和控制生殖

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.013

Pierre Comizzoli D.V.M., Ph.D. , Richard J. Paulson M.D., M.S.

引用次数: 0

What do women and rhinos have in common? 女人和犀牛有什么共同之处？

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.008

Suzannah A. Williams B.Sc., Ph.D.

引用次数: 0

Connecting microbial ecology to human fertility and reproduction: perspectives from the reproductive microbiomes of animals 将微生物生态学与人类生育和繁殖联系起来：从动物生殖微生物组的角度来看

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.011

Sally L. Bornbusch Ph.D. , Katherine A. Dami B.S.

{"title":"Connecting microbial ecology to human fertility and reproduction: perspectives from the reproductive microbiomes of animals","authors":"Sally L. Bornbusch Ph.D. , Katherine A. Dami B.S.","doi":"10.1016/j.xfre.2025.01.011","DOIUrl":"10.1016/j.xfre.2025.01.011","url":null,"abstract":"<div><div>In all vertebrates, reproduction occurs in the context of host-associated microbiomes, which are increasingly recognized for their contributions to reproductive success. Although host-associated microbiomes are species specific, synthesizing patterns in microbial ecology across human and animal taxa provides perspectives for understanding the factors that shape microbial communities and their contributions to reproduction. Additionally, the fertility and reproductive physiology of animals under human care—particularly endangered species—is often meticulously monitored to maximize reproductive opportunities. In this mini-review, we examine current knowledge on reproductive microbiomes in animals, focusing, when available, on the sparse literature for wildlife species. We suggest ways in which studying animal microbial ecology may advance human fertility and reproduction by focusing on 3 microbial communities—vaginal, milk, and seminal microbiomes—which represent a large portion of literature and have clear implications for reproductive health. We identify avenues of future research that will further strengthen the linkages between reproductive research in wildlife species and humans and provide potential guidelines for practical applications of microbiome science to human reproductive health.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 ","pages":"Pages 45-49"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amphibians and their impact on human reproduction research 两栖动物及其对人类生殖研究的影响

FS Reports Pub Date : 2025-04-01 DOI: 10.1016/j.xfre.2025.01.005

Vance L. Trudeau PhD, Jeffrey P. Ethier MSc

引用次数: 0