FS Reports最新文献

{"title":"How to collect immature oocytes from small antral follicles for the Saigon biphasic in vitro maturation protocol","authors":"Lan N. Vuong M.D., Ph.D. ,&nbsp;Ho L. Le M.D. ,&nbsp;Anh H. Le M.Sc. ,&nbsp;Tien K. Le M.D. ,&nbsp;Van T.T. Tran M.D. ,&nbsp;Dung T.P. Nguyen M.Sc. ,&nbsp;Anh H. Dang M.Sc. ,&nbsp;Hoan K. Nguyen M.Sc. ,&nbsp;Johan E.J. Smitz M.D., Ph.D. ,&nbsp;Tuong M. Ho M.D.","doi":"10.1016/j.xfre.2026.03.005","DOIUrl":"10.1016/j.xfre.2026.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>To provide a detailed description of the clinical procedure for aspirating small antral follicles (2.0–8.0 mm) as part of the Saigon biphasic in vitro maturation (IVM) protocol. This includes indications for the procedure, patient and equipment preparation, the aspiration process, laboratory techniques for identifying cumulus-oocyte complexes (COCs), and the timing for embryo transfer.</div></div><div><h3>Design</h3><div>This instructional video presents real-time footage of clinical procedures and embryology practices. It offers step-by-step guidance and practical recommendations for conducting a gonadotropin-free biphasic IVM cycle, also known as capacitation-IVM (CAPA-IVM).</div></div><div><h3>Subjects</h3><div>Patients undergoing IVM treatment. All individuals featured in the video have provided informed consent for its publication and online distribution, including on social media, journal websites, scientific platforms, and other relevant platforms.</div></div><div><h3>Exposure</h3><div>The video includes an introduction and patient consent process; indications for IVM; timing of oocyte aspiration, patient and equipment preparation, including types of aspiration needles; potential technical and clinical complications; timing for fresh embryo transfer; visual demonstration of the aspiration procedure, including ultrasound guidance, needle pressure, flushing, and aspiration technique; and laboratory demonstration of oocyte search and IVM preparation, including filtration of follicular aspirate and identification/classification of compact COCs.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Clinical techniques for immature oocyte retrieval and compact COCs identification for the gonadotropin-free CAPA-IVM protocol.</div></div><div><h3>Results</h3><div>Numerous viable COCs can be retrieved successfully using the oocyte retrieval techniques outlined for gonadotropin-free CAPA-IVM. The video demonstrates an efficient and flexible approach to identifying compact COCs, adaptable to various clinical conditions. Embryo transfer subsequently may be performed as either a fresh or frozen cycle, depending on the patient's choice.</div></div><div><h3>Conclusion</h3><div>(s): In vitro maturation is a safe and effective treatment option for eligible patients, particularly those with high ovarian reserve or polycystic ovary syndrome. This technique enables the retrieval of multiple immature COCs without ovarian stimulation. The procedures outlined may differ from those used in other centers, offering a standardized approach for collecting COCs from small follicles for IVF and gamete banking. The Saigon protocol, which combines gonadotropin-free CAPA-IVM with fresh embryo transfer, underscores the clinical potential of IVM as a practical alternative to conventional stimulation protocols.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 247-248"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert approach to severe oligospermia in a patient with prior cryptorchidism and in vitro fertilization failure","authors":"Jacob A. Brems M.D. ,&nbsp;Robert M. Coward M.D.","doi":"10.1016/j.xfre.2026.02.011","DOIUrl":"10.1016/j.xfre.2026.02.011","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 177-179"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe spaces, valued voices, and altruistic intentions: a qualitative study examining factors influencing Black women experiencing infertility and their willingness to participate in medical research","authors":"Morine Cebert Ph.D. ,&nbsp;Shoshana Aronowitz Ph.D. ,&nbsp;Rose Onyeali M.D. ,&nbsp;Leah Field B.S. ,&nbsp;Lisa Lewis Ph.D.","doi":"10.1016/j.xfre.2026.04.005","DOIUrl":"10.1016/j.xfre.2026.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To explore factors influencing Black women experiencing infertility to willingly engage in a research study, with the aim of informing ethically responsive recruitment strategies.</div></div><div><h3>Design</h3><div>A qualitative secondary data analysis using inductive thematic analysis of semistructured interview data.</div></div><div><h3>Subjects</h3><div>A total of 13 Black women with self-reported infertility who previously participated in a reproductive health research study.</div></div><div><h3>Exposure</h3><div>Participant experiences and perspectives regarding decision-making processes for participation in infertility-related research.</div></div><div><h3>Main Outcome Measures</h3><div>Perceived motivators, facilitators, and contextual factors influencing participation in reproductive health research among Black women.</div></div><div><h3>Results</h3><div>Three major themes emerged as key influences on participation: Safety—participants emphasized the importance of psychological and cultural safety and trust in the research process; Valued voices—participants viewed their contributions as meaningful opportunities to amplify the experiences of Black women in infertility research; and Altruistic intentions—many women expressed a commitment to helping others by advancing awareness and improving care for future patients.</div></div><div><h3>Conclusion</h3><div>Black women’s decisions to participate in reproductive health research are guided by feelings of safety, voice, and altruism. Researchers aiming to improve diversity in infertility studies should center participants’ emotional safety, ensure cultural responsiveness, and explicitly communicate the value of participants’ contributions. These findings provide a practical framework for ethically enhancing recruitment and engagement of underrepresented groups in clinical research.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 224-230"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological distress and coping strategies among women of color diagnosed with infertility","authors":"Binta Alleyne-Green Ph.D. ,&nbsp;Kimberly Grocher Ph.D., L.C.S.W. ,&nbsp;Caitlin Kreutz L.M.S.W.","doi":"10.1016/j.xfre.2026.02.008","DOIUrl":"10.1016/j.xfre.2026.02.008","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the psychological distress and coping strategies among a sample of Women of Color (WOC) diagnosed with infertility.</div></div><div><h3>Design</h3><div>This study used a qualitative description design, including purposive sampling, standardized open-ended interviews, and applied thematic analysis.</div></div><div><h3>Subjects</h3><div>Thirty-six WOC were interviewed to understand the psychological distress they experienced. This was expressed in the form of trauma, depression, and anxiety.</div></div><div><h3>Main Outcome Measures</h3><div>Two research questions were used in this study: the first research question inquired about the impact of infertility on the participant’s mental health, and the second research question, asked what coping strategies have you employed to deal with this situation?</div></div><div><h3>Results</h3><div>Three themes emerged regarding the first research question: psychological distress, cultural messages, and cultural silence. Results of question two drew attention to the different coping mechanisms used by the participants to deal with the psychological distress that came from their infertility diagnosis and experience.</div></div><div><h3>Conclusion</h3><div>Infertility is a significant cause of distress, bringing about feelings of guilt and alienation. The women in the study employed several coping strategies, including connecting with family and friends who understood their struggles, seeking therapy, engaging in mindfulness practices, and relying on their faith.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 231-241"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypoid endometrioma mimicking malignant transformation: a case report and systematic review","authors":"Guillaume Parpex M.D., PhD. ,&nbsp;Louis Marcellin M.D., Ph.D. ,&nbsp;Joëlle Uzan-Augui M.D. ,&nbsp;Michel Richa M.D. ,&nbsp;Amani Hakami M.D. ,&nbsp;Laura Larnaudie M.D. ,&nbsp;Amel Kime M.D. ,&nbsp;Charles Chapron M.D., Ph.D. ,&nbsp;Bruno Borghese M.D., Ph.D.","doi":"10.1016/j.xfre.2026.04.006","DOIUrl":"10.1016/j.xfre.2026.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>To report a case of polypoid ovarian endometrioma mimicking malignant transformation, review the literature on this rare entity, and highlight its implications for surgical management and fertility preservation.</div></div><div><h3>Design</h3><div>Case report and literature review.</div></div><div><h3>Subject</h3><div>One reproductive-age woman with suspected malignant transformation of an ovarian endometrioma.</div></div><div><h3>Exposure</h3><div>Laparoscopic adnexectomy.</div></div><div><h3>Main Outcome Measure</h3><div>Histopathologic confirmation of nonmalignant disease and review of surgical management in previously reported cases.</div></div><div><h3>Results</h3><div>A 38-year-old woman desiring fertility preservation presented with a complex ovarian mass classified as O-RADS 4 on magnetic resonance imaging. Laparoscopic adnexectomy was performed for suspected malignancy. Final histopathologic examination confirmed a benign polypoid endometrioma. Review of the literature identified 22 reported cases, all managed surgically for presumed malignancy, with hysterectomy performed upfront in ten cases despite benign histology.</div></div><div><h3>Conclusion</h3><div>Polypoid ovarian endometrioma is a rare mimic of ovarian malignancy that may lead to extensive surgery before histologic confirmation. Awareness of this entity is essential to reduce overtreatment and to support fertility-preserving management when appropriate.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 208-215"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: the problem with calling it “unexplained infertility”","authors":"Meurig Thomas Gallagher Ph.D ,&nbsp;Eleanor Molloy Ph.D ,&nbsp;Laura L. Jones Ph.D ,&nbsp;Jackson C. Kirkman-Brown Ph.D.","doi":"10.1016/j.xfre.2026.03.011","DOIUrl":"10.1016/j.xfre.2026.03.011","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 253-254"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Only time will tell","authors":"Jason E. Swain Ph.D., H.C.L.D.","doi":"10.1016/j.xfre.2026.04.008","DOIUrl":"10.1016/j.xfre.2026.04.008","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 182-183"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous ovarian hyperstimulation syndrome with a previously undescribed gene mutation of the follicle-stimulating hormone receptor gene: a case report","authors":"Anne-Christin Loheit M.D. ,&nbsp;Ekkehard Schleussner M.D., Ph.D.M. ,&nbsp;Mike Fischer Ph.D. ,&nbsp;Anna Kolterer M.D.","doi":"10.1016/j.xfre.2026.03.006","DOIUrl":"10.1016/j.xfre.2026.03.006","url":null,"abstract":"<div><h3>Objective</h3><div>To present a case of a patient with recurrent spontaneous ovarian hyperstimulation syndrome (sOHSS) and a previously undescribed mutation of the follicle-stimulating hormone receptor (FSHR).</div></div><div><h3>Design</h3><div>Case report.</div></div><div><h3>Subjects</h3><div>A 23-year-old pregnant woman (gravida II) with recurrent spontaneous ovarian hyperstimulation during 2 consecutive singleton pregnancies.</div></div><div><h3>Exposure</h3><div>Spontaneous conception in the presence of a heterozygous FSHR gene mutation</div></div><div><h3>Main Outcome Measures</h3><div>Clinical course of sOHSS, hormonal profile, sonographic findings, molecular genetic results, and maternal and fetal outcomes.</div></div><div><h3>Results</h3><div>The patient presented at 12 weeks’ gestation with massively enlarged bilateral multicystic ovaries (‟kissing ovaries”) and mild ascites, without pleural effusion. Molecular genetic analysis revealed a previously unreported heterozygous FSHR mutation (c.1379T&gt;A, p.Leu460Gln) in the transmembrane domain, classified as likely pathogenic according to American College of Medical Genetics and Genomics criteria. Conservative management resulted in gradual regression of ovarian size from the second trimester onward. The pregnancy was complicated by fetal growth restriction with normal uteroplacental and fetal perfusion parameters. Delivery by elective cesarean section at 38+0 weeks resulted in a healthy neonate.</div></div><div><h3>Conclusion</h3><div>The discovery of a novel FSHR gene mutation, which is likely associated with sOHSS in this case, suggests that genetic factors may influence the development of this rare condition. It underlines the importance of considering genetic testing in managing and diagnosing sOHSS, potentially guiding more personalized and effective treatment strategies for affected women.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 203-207"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors: Commentary on “Frozen embryo transfer outcomes in patients with prior cesarean delivery: a focus on endometrial lining parameters”","authors":"Emily A. Clarke M.D. ,&nbsp;Jing Wu Ph.D. ,&nbsp;Hannah Milad M.D. ,&nbsp;Kerry Flannagan Ph.D. ,&nbsp;Jiarui Wang M.S. ,&nbsp;Joseph Lee B.A. ,&nbsp;Luis Hoyos M.D. ,&nbsp;Meike Uhler M.D. ,&nbsp;Michael Homer M.D. ,&nbsp;Jenna Friedenthal M.D. ,&nbsp;Alan B. Copperman M.D. ,&nbsp;Phillip Romanski M.D. ,&nbsp;Mary Morris M.D., Ph.D.","doi":"10.1016/j.xfre.2026.03.007","DOIUrl":"10.1016/j.xfre.2026.03.007","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 251-252"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the Author: “Unexplained” does not mean, “not understood”","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2026.04.001","DOIUrl":"10.1016/j.xfre.2026.04.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Page 255"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}