FS Reports最新文献

{"title":"Commentary on ‟Frozen embryo transfer outcomes in patients with prior cesarean delivery: a focus on endometrial lining parameters”","authors":"Amit Jaiswal M.D. (H.O.M.)","doi":"10.1016/j.xfre.2026.02.012","DOIUrl":"10.1016/j.xfre.2026.02.012","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 249-250"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The in vitro fertilization clinic’s worst nightmare: wrong embryo transfer; new considerations","authors":"Steven J. Ory MD , Kristen Ivani PhD , Kathleen Miller PhD , Susan L. Crockin JD","doi":"10.1016/j.xfre.2026.03.001","DOIUrl":"10.1016/j.xfre.2026.03.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 173-176"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The follicle-stimulating hormone receptor unmasked: insights drawn from a case of spontaneous ovarian hyperstimulation syndrome","authors":"Randy Morris M.D.","doi":"10.1016/j.xfre.2026.04.009","DOIUrl":"10.1016/j.xfre.2026.04.009","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 184-185"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automation in the gamete laboratory: have we reached a turning point?","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2026.04.007","DOIUrl":"10.1016/j.xfre.2026.04.007","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 171-172"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous trophectoderm biopsies enable preimplantation genetic testing for monogenic disorders in de novo case of incontinentia pigmenti: case report","authors":"Laura C. Gemmell M.D. ,&nbsp;Stephanie Galloway M.S., C.G.C. ,&nbsp;Katie Rembisz M.S., C.G.C. ,&nbsp;Alyssa Snider C.G.C., Ph.D. ,&nbsp;Paulina Nassab M.S., C.G.C. ,&nbsp;Ana Cristina Cervero Sanz Ph.D. ,&nbsp;Mikaela Wolfkamp M.Sc. ,&nbsp;Georgios Koustas Ph.D. ,&nbsp;Sinem Karipcin M.D.","doi":"10.1016/j.xfre.2026.02.001","DOIUrl":"10.1016/j.xfre.2026.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the use of two simultaneous trophectoderm biopsies as a method to establish linkage analysis for preimplantation genetic testing for monogenic disorders (PGT-M) test development in a case of de novo incontinentia pigmenti (IP).</div></div><div><h3>Design</h3><div>Case report</div></div><div><h3>Subject</h3><div>A 29-year-old nulligravid woman with de novo IP, confirmed to have the common, large deletion of exons 4–10 in the <em>IKBKG</em> gene. Negative maternal testing confirmed the mutation was de novo in our patient.</div></div><div><h3>Exposure</h3><div>Two simultaneous trophectoderm biopsies from a minimum of four embryos were obtained to enable two independent deoxyribonucleic acid preparations. This approach was utilized to complete linkage analysis, facilitating successful test development for PGT-M.</div></div><div><h3>Main Outcome Measures</h3><div>PGT-M test development and subsequent intracytoplasmic sperm injection/PGT-M cycle targeting the <em>IKBKG</em> deletion.</div></div><div><h3>Results</h3><div>PGT-M test development was successful. The patient underwent two antagonist stimulation protocols with intracytoplasmic sperm injection and PGT-M, yielding 10 euploid embryos that tested negative for the <em>IKBKG</em> deletion and were deemed suitable for transfer.</div></div><div><h3>Conclusions</h3><div>PGT-M for de novo IP is particularly challenging given the presence of the <em>IKBKGP1</em> pseudogene, its terminal location, and the fact that indirect linkage analysis is necessary for large gene deletions. Without genetic information from parents and offspring, PGT-M test development is frequently unsuccessful. This case demonstrates that simultaneous trophectoderm biopsies can enable PGT-M in otherwise ineligible cases, offering a viable path forward for patients affected by de novo IP.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 242-246"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When benign mimics malignancy: a call for surgical restraint and clinical nuance in endometriosis-associated ovarian masses","authors":"Farr Nezhat M.D. ,&nbsp;Pegah Rashidian M.D.","doi":"10.1016/j.xfre.2026.04.010","DOIUrl":"10.1016/j.xfre.2026.04.010","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 186-187"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of a one-step warming protocol of vitrified blastocyst stage embryos","authors":"Emma R. Ebinger M.Sc. ,&nbsp;Helena Misurac B.S. ,&nbsp;Alexa M. Giovannini B.S. ,&nbsp;Vrunda B. Desai M.D. ,&nbsp;Nadia De Rosa M.Sc. ,&nbsp;Rita Vassena Ph.D. ,&nbsp;Paul J. Atkinson M.D.","doi":"10.1016/j.xfre.2026.04.004","DOIUrl":"10.1016/j.xfre.2026.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>To study the effect of a one-step warming technique on survival and clinical outcomes of vitrified-warmed blastocysts in a consecutive cohort of patients.</div></div><div><h3>Design</h3><div>Retrospective consecutive cohort study.</div></div><div><h3>Subjects</h3><div>This study included 1,303 transferred embryos from 950 unique patients treated at three clinics.</div></div><div><h3>Exposure</h3><div>The exposure group included embryos warmed using a one-step warming protocol with a 1M sucrose solution for 1 min. The control group included embryos warmed using traditional, multistep warming, where embryos were exposed to 1M sucrose for 1 min, followed by 3 min in 0.5M sucrose, and 10 mins in washing solutions.</div></div><div><h3>Main Outcome Measures</h3><div>The goal of this study was to compare survival, clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR), and live birth rate (LBR) between multi- and one-step warming techniques. Additionally, subgroup analyses by maternal age, embryo morphology, day of vitrification, and mode of fertilization were also performed.</div></div><div><h3>Results</h3><div>Survival rates were comparable across all comparisons. Pregnancy rates were comparable between multistep and one-step groups (CPR: 43.2% vs. 44.4%; OPR: 34.3% vs. 37.9%; LBR: 34.0% vs. 35.6%). Pregnancy probabilities between warming techniques were comparable between groups at any age point (32 – CPR: 42.6% vs. 47.4%; OPR: 34.9% vs. 39.6%; 42 – CPR: 25.8% vs. 20.7%; OPR: 12.6% vs. 12.9%). Good quality embryos (G2) had a lower chance of pregnancy than top quality embryos (G1) overall, but pregnancy rates were similar between groups (G1 – CPR: 52.2% vs. 55.9%; OPR: 45.7% vs. 49.2%; G2 – CPR: 39.0% vs. 39.4%; OPR: 29.2% vs. 33%). Similarly, Day 6 embryos were less likely to achieve pregnancy than Day 5 embryos, but pregnancy rates were comparable between groups (D5 – CPR: 45.5% vs. 46.5%; OPR: 36.3% vs. 40.2%; D6 – CPR: 27.3% vs. 27.6%; OPR: 18.2% vs. 22.4%). Pregnancy rates between intracytoplasmic sperm injection (ICSI) for male factor infertility and in vitro fertilization (IVF) were again comparable between groups (ICSI – CPR: 42.3% vs. 40.7%; OPR: 35.6% vs. 34.5%; IVF – CPR: 45.7% vs. 46.8%; OPR: 35.5% vs. 41.5%).</div></div><div><h3>Conclusion</h3><div>One-step embryo warming provides similar survival and pregnancy outcomes compared with classical multistep warming while decreasing the procedure time by more than 90%.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 3","pages":"Pages 195-202"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine transposition: five live births and counting","authors":"Archana Ayyar M.D.,&nbsp;Rebecca Flyckt M.D.","doi":"10.1016/j.xfre.2026.02.005","DOIUrl":"10.1016/j.xfre.2026.02.005","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 107-109"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desire for reversal after tubal sterilization in the United States, 2006–2023","authors":"Amy Yunyu Chiang M.A., Ph.D. ,&nbsp;Aileen M. Gariepy M.D., M.P.H., M.H.S. ,&nbsp;Daisy Leon-Martinez M.D., M.A.S. ,&nbsp;Kelly M. Treder M.D., M.P.H. ,&nbsp;Eleanor Bimla Schwarz M.D., M.S.","doi":"10.1016/j.xfre.2026.02.002","DOIUrl":"10.1016/j.xfre.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To describe trends in the prevalence of tubal sterilization and subsequent desire for reversal among US women and identify sociodemographic factors associated with desires for reversal.</div></div><div><h3>Design</h3><div>Nationally representative data were collected from US women between 2006 and 2023 in a series of six cross-sectional waves of the National Survey of Family Growth. We employed weighted logistic regression models to assess associations between sociodemographic variables and outcomes of interest.</div></div><div><h3>Subjects</h3><div>Nationally representative samples of US women aged 15<strong>–</strong>49 surveyed between 2006 and 2023.</div></div><div><h3>Exposure</h3><div>Sociodemographic variables including age at interview, race and ethnicity, health insurance status, poverty level, education, marital status, parity, and timing of sterilization.</div></div><div><h3>Main Outcome Measures</h3><div>Tubal sterilization, desire for tubal reversal surgery, and experience with tubal reversal surgery.</div></div><div><h3>Results</h3><div>In 2022–2023, 21.3% of US individuals who had undergone tubal sterilization reported a desire for reversal. Only 0.1% of those who desired reversal had undergone reversal surgery. Rates of tubal sterilization and desired reversal were higher in prior years; in 2006, a desire for reversal surgery was reported by 26.8% of respondents. Desire for reversal was more likely among nulliparous individuals, those younger than 30 years, those living below the federal poverty level, and among Hispanic and Black women compared with White, non-Hispanic women.</div></div><div><h3>Conclusion</h3><div>One of every five US individuals who undergo tubal sterilization subsequently reports a desire for reversal. As &lt;1% of those who desire reversal obtain reversal surgery, efforts to support informed decision-making before permanent contraceptive surgery remain important.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 143-149"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive medicine care in BRCA mutation carriers: an opportunity for early intervention","authors":"Ecem Esencan M.D.,&nbsp;Kara N. Goldman M.D.","doi":"10.1016/j.xfre.2026.02.009","DOIUrl":"10.1016/j.xfre.2026.02.009","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"7 2","pages":"Pages 99-102"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}