FS Reports最新文献

{"title":"Reply of the Authors: The phenomenon of explaining the cause of poor cycle outcomes: looking under the streetlight, or the role of cognitive bias in reproductive endocrinology and infertility practices. In response to: “Unexpected poor oocyte retrieval: the phenomenon of the borderline response to the gonadotropin-releasing hormone (GnRH) agonist trigger”","authors":"Richard J. Paulson M.D., M.S.","doi":"10.1016/j.xfre.2025.01.019","DOIUrl":"10.1016/j.xfre.2025.01.019","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 99-100"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘High rate of isolated teratospermia in a population of fertile men and the questionable clinical utility of sperm morphology’ [F&S Reports 5 (2024) 140-144]","authors":"","doi":"10.1016/j.xfre.2024.11.005","DOIUrl":"10.1016/j.xfre.2024.11.005","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Page 101"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dramatic weight loss with the new injectable medications on reproduction in healthy non–polycystic ovary syndrome obese women","authors":"Zaher Merhi M.D., H.C.L.D.","doi":"10.1016/j.xfre.2024.12.003","DOIUrl":"10.1016/j.xfre.2024.12.003","url":null,"abstract":"<div><div>The intake of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) in obese women with polycystic ovary syndrome (PCOS) demonstrated improvement in metabolic and reproductive symptoms; however, their impact in non-PCOS state is unclear. This review critically analyzes data pertaining to GLP-1 RAs in non-PCOS females in both humans and animals, with a focus on their impact on the hypothalamic-pituitary-ovarian axis and the uterine function. In animal models, studies showed controversial results. The intracerebroventricular GLP-1 administration caused stimulatory reproductive effects, where it increased the amplitude of the luteinizing hormone surge, follicle-stimulating hormone (FSH) secretion, serum progesterone levels, up-regulation in <em>Kiss-1r</em> expression in the hypothalamus, and increase in ovarian Graafian follicles and corpora lutea. However, the intracerebroventricular GLP-1 RA Exendin-4 and the subcutaneous GLP-1 RA liraglutide resulted in opposite effects. Even though GLP-1 up-regulated FSH receptor messenger ribonucleic acid expression in granulosa cells, it led to a suppression in FSH-induced progesterone synthesis. The effect of GLP-1 RA on the uterus also showed controversial findings. Although some data showed that GLP-1 RA had a beneficial antifibrotic effect in intrauterine adhesions model by reducing the deposition area of collagen fibers, other data showed that exposure to GLP-1 RA resulted in destruction of the luminal epithelium with shrinkage in muscle fiber. It is unclear how these GLP-1 RA medications impact future fertility in humans because most studies to date had significant limitations and were performed in animals with contentious findings. There is a clear need to study this relationship because many reproductive-aged women without PCOS are resorting to these medications for weight loss purposes.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 4-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined contribution of zona bound sperm selection together with microinsemination without penetrating the oocyte membrane, a cost-beneficial approach to increase cycle’s efficiency?","authors":"Nicolás Garrido M.Sc., Ph.D.","doi":"10.1016/j.xfre.2024.12.004","DOIUrl":"10.1016/j.xfre.2024.12.004","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 11-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenges of achieving patient satisfaction in the field of reproductive medicine","authors":"Paul R. Brezina M.D., M.B.A.","doi":"10.1016/j.xfre.2025.01.001","DOIUrl":"10.1016/j.xfre.2025.01.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 13-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of media aids in genetic carrier screening education among patients with infertility","authors":"Annabelle Gordon M.D. ,&nbsp;Anthony Leonard Ph.D. ,&nbsp;Suruchi Thakore M.D. ,&nbsp;Kurt Peterson D.O. ,&nbsp;Emily Hurley M.D. ,&nbsp;Megan Sax M.D.","doi":"10.1016/j.xfre.2025.01.003","DOIUrl":"10.1016/j.xfre.2025.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of educational videos on the utilization of preconception genetic carrier screening in patients with infertility.</div></div><div><h3>Design</h3><div>Survey study.</div></div><div><h3>Subjects</h3><div>New patients presenting for infertility consult with one of five providers (4 physicians and 1 nurse practitioner) from November 2021 through February 2022.</div></div><div><h3>Exposure</h3><div>Patients were assigned to the web application EngagedMD video arm or in-person counseling arm for education on preconception genetic screening.</div></div><div><h3>Main Outcome Measures</h3><div>The primary study outcome was completion of genetic carrier screening. The secondary outcomes were provider rating of patient comprehension and provider-rated time demand of counseling.</div></div><div><h3>Results</h3><div>A total of 73 patients were enrolled: 42 in the video arm and 31 in the in-person counseling arm. The survey response rate was 100% for patients and providers. Patients assigned to the video counseling arm were significantly more likely to plan to proceed with carrier screening (78.6%) than those receiving only in-office counseling (41.9%). The odds ratio associating video arm with actual completion of screening was 5.07 (95% confidence interval, 1.84–13.96). Patients who completed EngagedMD videos were perceived by providers to have a noninferior understanding of the purpose of carrier screening compared with those who underwent standard counseling, assessed via “teach-back” method. Providers also rated that multimedia education use significantly decreased demand on appointment time.</div></div><div><h3>Conclusion</h3><div>The use of patient education videos increases utilization of preconception genetic carrier screening and is an acceptable alternative to in-person provider counseling.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 60-66"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attrition rates of in vitro fertilization in patients with male factor infertility using testicular sperm","authors":"SiWon Lee M.D. ,&nbsp;Lauren M. Kendall Rauchfuss M.D. ,&nbsp;Sevann Helo M.D. ,&nbsp;Alessandra J. Ainsworth M.D., M.S. ,&nbsp;Samir Babayev M.D. ,&nbsp;Chandra C. Paff Shenoy M.D.","doi":"10.1016/j.xfre.2024.11.007","DOIUrl":"10.1016/j.xfre.2024.11.007","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the oocyte to blastocyst attrition rate in patients undergoing in vitro fertilization (IVF) with male factor infertility (MFI) using testicular sperm.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Subjects</h3><div>Patients who underwent IVF using testicular sperm for MFI between January 1, 2017, and March 23, 2023.</div></div><div><h3>Intervention</h3><div>Testicular sperm extraction (TESE) with intracytoplasmic sperm injection.</div></div><div><h3>Main Outcome Measures</h3><div>The fertilization and blastulation outcomes.</div></div><div><h3>Results</h3><div>A total of 120 IVF cycles using testicular sperm were identified. For comparison, 122 IVF cycles in patients with unexplained infertility who had normal semen analysis and used ejaculated sperm for intracytoplasmic sperm injection were reviewed as a control group. Testicular sperm cycles were further grouped by prognosis on the basis of the indication for TESE: good prognosis (n = 42, obstructive azoospermia); moderate prognosis (n = 67, increased deoxyribonucleic acid fragmentation, prior failed IVF, and recurrent pregnancy loss); and poor prognosis (n = 11, cryptozoospermia or nonobstructive azoospermia). Female baseline characteristics were similar among the groups except for body mass index. The fertilization rate was lower in all TESE groups than in the control group; however, no differences in fertilization rates were noted within the TESE groups (good vs. moderate vs. poor). The blastulation rates were similar between the good-prognosis TESE and control groups. However, the moderate- and poor-prognosis TESE groups had lower blastulation rates than the control group.</div></div><div><h3>Conclusion</h3><div>This model may help practitioners counsel patients with MFI using testicular sperm to appropriately set expectations for blastocyst outcomes on the basis of the diagnosis.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 31-38"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between congenital uterine anomalies and placenta accreta spectrum","authors":"Savvy Benipal M.D. ,&nbsp;Matthew Givens M.D. ,&nbsp;Amanda A. Allshouse M.S. ,&nbsp;Michelle Debbink M.D., Ph.D. ,&nbsp;Krista Childress M.D. ,&nbsp;Joseph Letourneau M.D. ,&nbsp;Robert M. Silver M.D. ,&nbsp;Brett D. Einerson M.D., M.P.H.","doi":"10.1016/j.xfre.2025.01.006","DOIUrl":"10.1016/j.xfre.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between congenital uterine anomalies (CUAs) and placenta accreta spectrum (PAS) in a large, nationally representative sample.</div></div><div><h3>Design</h3><div>Cross-sectional, observational study using the US National Inpatient Sample from 2017 to 2021. Logistic regression models were constructed to evaluate associations between the exposure and the outcome. Predetermined confounding variables included age, history of a cesarean delivery, and placenta previa. A sensitivity analysis was performed including only patients with a code for placenta accreta spectrum who also underwent hysterectomy. Data were weighted according to National Inpatient Sample complex sampling weights to account for year-to-year variation and to extrapolate estimates to the US population.</div></div><div><h3>Subjects</h3><div>Pregnant patients at ≥20 weeks’ gestation with International Classification of Disease codes for congenital uterine anomalies or PAS.</div></div><div><h3>Exposure</h3><div>Code for at least 1 of the CUAs.</div></div><div><h3>Main Outcome Measures</h3><div>Code for at least 1 of the types of PAS during delivery hospitalization.</div></div><div><h3>Results</h3><div>The study cohort included 17,594,765 (or 3,518,955 unweighted) individuals. CUAs were present in 78,809 (0.45%, 15,259 unweighted) individuals. PAS was more frequent in patients with CUA than in those without (0.42% vs. 0.12%), with a weighted odds ratio (OR) of 3.36 (95% confidence interval [CI], 2.62–4.32; unweighted OR, 3.37 [95% CI, 2.63–4.31]). When controlling for age, prior cesarean, and placenta previa, the odds of having PAS was higher in those with a CUA than in those without (weighted adjusted OR [aOR], 2.46 [95% CI, 1.87–3.17]; unweighted aOR, 2.44 [95% CI, 1.88–3.16]). In the sensitivity analysis including only individuals with PAS who underwent a hysterectomy, CUA continued to be associated with PAS (weighted aOR, 2.26 [95% CI, 1.52–3.36]; unweighted aOR, 2.26 [95% CI, 1.55–3.31]).</div></div><div><h3>Conclusion</h3><div>In this population-based study, CUAs were associated with an increased odds of PAS. Patients with CUA should have careful screening for PAS at the time of routine obstetric ultrasound.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 67-72"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utero-placental (vascular) development throughout pregnancy in women with polycystic ovary syndrome: the Rotterdam Periconceptional Cohort","authors":"Lotte L. Berns M.Sc. ,&nbsp;Rosalieke E. Wiegel M.D., Ph.D. ,&nbsp;Anton H.J. Koning Ph.D. ,&nbsp;Sten P. Willemsen Ph.D. ,&nbsp;Joop S.E. Laven M.D., Ph.D. ,&nbsp;Régine P.M. Steegers-Theunissen M.D., Ph.D.","doi":"10.1016/j.xfre.2024.12.002","DOIUrl":"10.1016/j.xfre.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>To study utero-placental vascular development from the first trimester onward in pregnant women with polycystic ovary syndrome (PCOS) and successful live births, compared with pregnant women without PCOS, after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment or natural conception.</div></div><div><h3>Design</h3><div>Prospective periconceptional cohort study in a single tertiary hospital.</div></div><div><h3>Subjects</h3><div>Participants with ongoing pregnancies with available serial three-dimensional ultrasound scans were divided into 3 groups: women with PCOS; subfertile group, pregnancies who conceived via IVF/ICSI without PCOS; and fertile group, pregnancies who conceived naturally without PCOS.</div></div><div><h3>Exposure</h3><div>PCOS diagnosis.</div></div><div><h3>Main Outcome Measures</h3><div>During the first-trimester, placental volume (PV) and utero-placental vascular volume (uPVV) were measured offline in three-dimensional ultrasound volumes obtained at 7, 9, and 11 weeks’ gestational age (GA) using Virtual Organ Analysis and Virtual Reality. Serial measurements were obtained from uterine artery pulsatility and resistance indices (UtA PI and UtA RI) measured by pulsed-wave Doppler ultrasound as well as mean arterial pressure at 7, 9, 11, 13, 22, and 32 weeks’ GA. Similarly, the umbilical artery PI and RI were measured at 22 and 32 weeks’ GA.</div></div><div><h3>Results</h3><div>We included 206 pregnancies in our study (PCOS n = 41; subfertile n = 63; fertile n = 102). Significantly negative associations were observed between PCOS and placental measurements (PV, uPVV, and their ratio) at 11 weeks’ GA with both the subfertile and fertile group as reference (e.g., uPVV 11 weeks’ GA: beta_PCOS-fertile –0.18 ∛cm³ [95% confidence interval: –0.30; –0.06]). UtA PI and RI were significantly lower throughout pregnancy in women with PCOS compared with the subfertile and fertile group. Women with PCOS showed a negative association with umbilical artery PI and RI at 32 weeks’ GA compared with the subfertile and fertile group as reference.</div></div><div><h3>Conclusion</h3><div>Women with PCOS show decreased first-trimester placental development at 11 weeks’ GA compared with pregnancies without PCOS in the subfertile and fertile group. Additionally, these women also display lower UtA PI and UtA RI compared with women without PCOS. These results support the hypothesis that PCOS impacts early placental development, potentially contributing to adverse pregnancy outcomes. Further research should focus on the underlying pathophysiology and the modifying role of IVF/ICSI treatment.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 79-89"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted sperm fusion insemination improves fertilization rates and increases usable embryos for transfer: a clinical sibling-oocyte study","authors":"Shota Hatakeyama Ph.D. ,&nbsp;Kaori Koizumi B.Sc. ,&nbsp;Goro Kuramoto M.D., Ph.D. ,&nbsp;Yoriko Horiuchi M.D. ,&nbsp;Shirei Ohgi M.D. ,&nbsp;Atsushi Yanaihara M.D., Ph.D.","doi":"10.1016/j.xfre.2024.11.006","DOIUrl":"10.1016/j.xfre.2024.11.006","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of assisted sperm fusion insemination (ASFI), a microinsemination method using sperm bound to the zona pellucida (ZP-sperm) without penetrating the oocyte membrane, compared with conventional intracytoplasmic sperm injection (C-ICSI), on fertilization and embryonic development.</div></div><div><h3>Design</h3><div>Prospective clinical sibling-oocyte study.</div></div><div><h3>Subjects</h3><div>A total of 197 oocytes from 24 patients who underwent 35 oocyte retrieval cycles from January 2023 to April 2024 were analyzed. Patients who underwent retrieval of both, at least 2 metaphase II (MII) oocytes and at least 1 immature or degenerated oocyte, were recruited.</div></div><div><h3>Intervention</h3><div>Metaphase II oocytes were alternately allocated to 2 groups: ASFI and C-ICSI groups. To obtain ZP-sperm for ASFI, immature or degenerated oocytes were incubated with 10,000 motile sperm for 3 hours. After harvesting the ZP-sperm, it was pressed onto the membrane of an MII oocyte for 10 seconds in the ASFI group. Conventional intracytoplasmic sperm injection was performed conventionally in the C-ICSI group.</div></div><div><h3>Main Outcome Measures</h3><div>The rates of 2 pronuclei (2PN), degeneration, blastocyst formation, and usable embryos, defined as the total number of transferred or cryopreserved embryos divided by the number of MII oocytes, were compared between the 2 groups.</div></div><div><h3>Results</h3><div>The 2PN rate of the ASFI group was 88.0% (73/83), which was significantly higher than that of the C-ICSI group (70.2% [80/114]). In addition, a significantly lower degeneration rate was observed in the ASFI group (0% [0/83]) than in the C-ICSI group (8.8% [10/114]). The blastocyst formation rate was equivalent in the 2 groups (ASFI group, 63.9% [39/61]; C-ICSI group, 62.0% [44/71]). However, the usable embryo rate was significantly higher in the ASFI group (45.8% [38/83]) than in the C-ICSI group (28.1% [32/114]).</div></div><div><h3>Conclusion</h3><div>The ASFI group yielded significantly higher 2PN and lower degeneration rates than the C-ICSI group. Consequently, the ASFI group experienced a higher number of embryos usable for implantation, although there was no significant difference in the blastocyst formation rate between the 2 groups. Further studies with a larger number of cases will be needed for more general application of these findings.</div></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"6 1","pages":"Pages 17-24"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}