FS Reports最新文献

{"title":"A call for new sperm morphological diagnostics","authors":"Daniel R. Greenberg M.D. , Joshua A. Halpern M.D., M.S.","doi":"10.1016/j.xfre.2024.02.007","DOIUrl":"10.1016/j.xfre.2024.02.007","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 132-133"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000138/pdfft?md5=449b90902ffa3cf95a2d559ba2e42e39&pid=1-s2.0-S2666334124000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Productivity loss due to polycystic ovary syndrome and its relationship to race, mental health and healthcare delivery indices","authors":"Heather Gibson Huddleston M.D. ,&nbsp;Alexander Milani M.D., M.B.A. ,&nbsp;Rachel Blank M.B.A.","doi":"10.1016/j.xfre.2024.02.004","DOIUrl":"10.1016/j.xfre.2024.02.004","url":null,"abstract":"<div><h3>Objective</h3><p>To study the impact of polycystic ovary syndrome (PCOS) on work-related impairments and explore relationships with race, mental health, and healthcare delivery indices.</p></div><div><h3>Design</h3><p>A cross-sectional internet-based survey.</p></div><div><h3>Setting</h3><p>North American women with PCOS between August 2022 and October 2022.</p></div><div><h3>Patients</h3><p>Individuals with a self-reported diagnosis of PCOS.</p></div><div><h3>Intervention(s)</h3><p>Not applicable.</p></div><div><h3>Main Outcome Measures</h3><p>The primary outcome was missed work because of PCOS. The secondary outcomes included leave from work, impacts on the quality of work, and feelings of being held back at work because of PCOS.</p></div><div><h3>Results</h3><p>Of 1,105 respondents, 1,058 reported having PCOS diagnosed by a physician. Of this group, 50.4% reported missing work because of PCOS, 72% felt that PCOS impacted the quality of their work, and 51.5% felt held back at work by PCOS. Multivariate analyses revealed that missing work because of PCOS was independently associated with black race, lack of insurance, requiring multiple doctors for a PCOS diagnosis, needing ≥3 doctors for current care, decreased satisfaction with care, and symptoms of anxiety and depression.</p></div><div><h3>Conclusions</h3><p>Polycystic ovary syndrome significantly impacts employment-related productivity. Factors such as race, mental health, and healthcare delivery appear to play a crucial role in the extent of this impact.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 157-163"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000102/pdfft?md5=4501e68e97f195542f3af0d000667417&pid=1-s2.0-S2666334124000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Live birth from ovarian grafted tissue after pelvic radiation for rectal cancer","authors":"Genia Rozen M.B., B.S. ,&nbsp;Sarat Chander M.B., B.S. ,&nbsp;Alex Polyakov M.B., B.S. ,&nbsp;Iniyaval Thevathasan M.B., B.S. ,&nbsp;Catharyn J. Stern M.B., B.S.","doi":"10.1016/j.xfre.2024.04.004","DOIUrl":"10.1016/j.xfre.2024.04.004","url":null,"abstract":"<div><h3>Objective</h3><p>To study the management of a woman who returned to conceive after high-dose radiation treatment, with documentation of uterine dosimetry, and the efficacy of ovarian tissue grafted into an irradiated pelvis.</p></div><div><h3>Design</h3><p>Case report.</p></div><div><h3>Setting</h3><p>Private and public In Vitro Fertilization units.</p></div><div><h3>Patient</h3><p>A 26-year-old woman underwent radiation treatment for rectal cancer, with half of the uterus and the fundus being exposed to radiation doses of 50 and 25 Gy, respectively. We report the details of the uterine assessment, determining suitability of conception with her own uterus, pregnancy surveillance, and reproductive outcome.</p></div><div><h3>Intervention(s)</h3><p>In Vitro Fertilization stimulation grafted ovarian tissue to assist with pregnancy.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Successful conception and live birth, pregnancy complications and management of high risk pregnancy.</p></div><div><h3>Result(s)</h3><p>The results of magnetic resonance imaging and pelvic ultrasound showed a small uterus with preserved junctional zone anatomy, and although the endometrium was initially thin after high-dose estrogen administration, endometrial thickness increased with time. Twelve grafted ovarian tissue stimulation cycles led to 4 embryo transfers, the last of which resulted in a live birth. She had 2 cervical cerclage procedures because of cervical shortening and delivered a 3.3-kg healthy female neonate at 38 weeks of gestation via lower-segment cesarean section.</p></div><div><h3>Conclusion(s)</h3><p>Successful pregnancy is possible from ovarian tissue grafted into an irradiated pelvis, with high-dose uterine exposure. Careful uterine assessment needs to be undertaken to determine suitability of conception attempt with a patient’s own uterus, in consultation with the medical team. Further studies are needed to correlate imaging and biopsy findings with reproductive outcomes.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 214-218"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000515/pdfft?md5=f90094500b18425d7a61e9f276f8ffec&pid=1-s2.0-S2666334124000515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141037321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office of Public Affairs update: a quarterly update from the American Society for Reproductive Medicine Office of Public Affairs on key developments in reproductive health policy","authors":"Rebecca O'Connor J.D.","doi":"10.1016/j.xfre.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.xfre.2024.05.002","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Page 127"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000539/pdfft?md5=ccd62a995d0d08079c0d73ac369a26ac&pid=1-s2.0-S2666334124000539-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rate of isolated teratospermia in a population of fertile men and the questionable clinical utility of sperm morphology","authors":"Lucille G. Cheng B.A. ,&nbsp;David Miller M.D. ,&nbsp;Daniel Pelzman M.D. ,&nbsp;Anna Wecht R.N. ,&nbsp;Kathleen Hwang M.D.","doi":"10.1016/j.xfre.2024.01.002","DOIUrl":"10.1016/j.xfre.2024.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>To better understand the impact of sperm morphology on fertility by assessing sperm morphology in a population of known fertile men.</p></div><div><h3>Design</h3><p>A prospective cohort study.</p></div><div><h3>Setting</h3><p>Fertility center associated with the university.</p></div><div><h3>Patient(s)</h3><p>Healthy men &gt;18 years of age were recruited to provide one semen sample before a vasectomy appointment scheduled between March 2020 and November 2022. Patients were included in the study when they had at least one biologic child and no history of difficulty achieving pregnancy or fertility procedures.</p></div><div><h3>Intervention(s)</h3><p>None.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Sperm morphology.</p></div><div><h3>Result(s)</h3><p>A total of 68 patients (mean age 36.7 years) were included. Thirty-eight (55.9%) patients had 3% or lower normal sperm morphology, including two patients who had 0 normal morphology. The most common morphologic abnormalities were head-shaped defects (n = 59, 84.3%), followed by coiled tails (n = 14, 20.3%). Count, concentration, motility, and progressive motility were normal in &gt;90% of patients.</p></div><div><h3>Conclusion(s)</h3><p>More than half (55.9%) of fertile male patients had lower than normal sperm morphology in our study. The results of our study further question the clinical relevance of sperm morphology on fertility outcomes and when the current approach in assessing morphology is too strict.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 140-144"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000023/pdfft?md5=1603d4ed582c2591ba5ce1e9cd263b98&pid=1-s2.0-S2666334124000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139537547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of reference growth standards on small- and large-for-gestational age outcomes among pregnancies conceived by fresh and frozen embryo transfers","authors":"Sunidhi Singh M.D. ,&nbsp;Pietro Bortoletto M.D., M.Sc. ,&nbsp;Blair J. Wylie M.D., M.P.H. ,&nbsp;Alexis P. Melnick M.D. ,&nbsp;Malavika Prabhu M.D.","doi":"10.1016/j.xfre.2024.02.005","DOIUrl":"10.1016/j.xfre.2024.02.005","url":null,"abstract":"<div><h3>Objective</h3><p>To describe differences in the frequency of small-for-gestational age (SGA) and large-for-gestational age (LGA) driven by different birth weight curves in assisted reproductive technology (ART)–conceived pregnancies.</p></div><div><h3>Design</h3><p>Retrospective cohort study.</p></div><div><h3>Setting</h3><p>Single academic medical center.</p></div><div><h3>Patients</h3><p>Singleton live births between the gestational ages of 36 weeks and 0 days and 42 weeks and 6 days from fresh or frozen embryo transfer (ET).</p></div><div><h3>Intervention(s)</h3><p>None.</p></div><div><h3>Main Outcome Measure(s)</h3><p>SGA (&lt;10th percentile) and LGA (&gt;90th percentile) classified by Fenton, INTERGROWTH-21, World Health Organization, Duryea, and Oken curves.</p></div><div><h3>Results</h3><p>The median birth weight and gestational age at birth among fresh ET pregnancies were 3,289g (interquartile range [IQR], 2,977–3,600g) and 39.4 (IQR, 38.6–40.3) weeks, respectively, and those among frozen ET pregnancies were 3,399g (IQR, 3,065–3,685g) and 39.4 (IQR, 38.7–40.1) weeks, respectively. The frequencies of SGA neonates using each birth weight standard ranged from 5.8% to 13.4% for fresh ET and from 3.5% to 8.7% for frozen ET. Those of LGA neonates ranged from 5.3% to 14.3% for fresh ET and from 6.6% to 21.2% for frozen ET.</p></div><div><h3>Conclusion</h3><p>The frequency of SGA and LGA neonates among ART-conceived gestations is partially driven by the birth weight standard. Selecting an appropriate standard that best reflects the patient population is critical to quantifying the risk of ART-conceived pregnancies.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 164-169"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000114/pdfft?md5=599803070d43ac9f1e3644a3c0039022&pid=1-s2.0-S2666334124000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dozen years of ovarian tissue cryopreservation at a pediatric hospital: tracking program and patient metrics while adapting to increasing needs","authors":"Kathryn L. McElhinney M.D. ,&nbsp;Tara Kennedy B.S. ,&nbsp;Erin E. Rowell M.D. ,&nbsp;Monica M. Laronda Ph.D.","doi":"10.1016/j.xfre.2024.02.009","DOIUrl":"10.1016/j.xfre.2024.02.009","url":null,"abstract":"<div><h3>Objective</h3><p>To review the program and patient metrics for ovarian tissue cryopreservation (OTC) within a comprehensive pediatric fertility preservation program in its first 12 years of development.</p></div><div><h3>Design</h3><p>Retrospective review.</p></div><div><h3>Setting</h3><p>A tertiary children’s hospital in a large urban center between March 2011 and February 2023.</p></div><div><h3>Patients</h3><p>Pediatric patients who underwent OTC.</p></div><div><h3>Interventions</h3><p>Unilateral oophorectomy for OTC.</p></div><div><h3>Main Outcome Measures</h3><p>Patient demographics and clinical course information were collected for analysis.</p></div><div><h3>Results</h3><p>A total of 184 patients underwent OTC in the first 12 years. One hundred fifteen patients were prepubertal at the time of OTC, and 69 were postpubertal. In total, 128 patients (69.6%) received part of their planned therapy before OTC. Starting in 2018, 104 participants (92.0%) donated tissue to research, 99 participants (87.6%) donated blood, and 102 (90.2%) donated media to research. There was a decrease in the median age of patients who underwent OTC from 16.4–6.6 years and an overall increase in the proportion of patients per year that were prepubertal. Forty-eight (26.0%) patients who underwent OTC were outside referrals and traveled from as far as Seattle, Washington.</p></div><div><h3>Conclusion</h3><p>During the first 12 years of this program, oncofertility research increased, annual tissue cryopreservation cases increased, and the median age of those who underwent OTC decreased. The program was adapted to build a stand-alone gonadal tissue processing suite and specialized in prepubertal ovarian tissue processing. The program will continue to adapt to patient needs in the upcoming decades because restoration technologies advance through research supported by this and collaborating programs.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 197-204"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000151/pdfft?md5=3fdad8a43ff06e90fc78eaa0bafcb6a0&pid=1-s2.0-S2666334124000151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of quantifying the adverse effects on healthcare-related quality of life in people with benign gynecologic conditions","authors":"Elizabeth L. Wolfe M.D.,&nbsp;LaTasha B. Craig M.D.","doi":"10.1016/j.xfre.2024.03.003","DOIUrl":"10.1016/j.xfre.2024.03.003","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 138-139"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000448/pdfft?md5=856167870a47189af2081129dae62357&pid=1-s2.0-S2666334124000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryos as unborn children: the Alabama Supreme Court's ruling and its possible impact for legal rulings in other states","authors":"Perrine Ginod M.D. ,&nbsp;Michael H. Dahan M.D.","doi":"10.1016/j.xfre.2024.03.006","DOIUrl":"10.1016/j.xfre.2024.03.006","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 130-131"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000473/pdfft?md5=03e49eebb4cdcffd6ce503fbaae09af2&pid=1-s2.0-S2666334124000473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The increasing demand for reproductive urologists and male fertility care","authors":"Daniel R. Greenberg M.D. ,&nbsp;Catherine S. Nam M.D. ,&nbsp;Joshua A. Halpern M.D.","doi":"10.1016/j.xfre.2024.05.001","DOIUrl":"10.1016/j.xfre.2024.05.001","url":null,"abstract":"","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 2","pages":"Pages 125-126"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334124000527/pdfft?md5=9c48625ad92d00dfaac40d1a42b0152f&pid=1-s2.0-S2666334124000527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}