种族和民族对美国多囊卵巢综合征不孕妇女体外受精结果的影响

Guido Mora Calderon M.D. , Fabiola D’Ambrosio M.D. , Alan Schwartz Ph.D. , Bert Scoccia M.D.
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引用次数: 0

摘要

目的研究母亲种族和民族对美国白人、亚裔、西班牙裔和非裔美国人伴有和不伴有多囊卵巢综合征(PCOS)的不孕症患者体外受精(IVF)活产率(lbr)的影响。设计回顾性队列研究。我们回顾了2014年至2017年辅助生殖技术临床结果报告系统数据库中的256,018例患者记录,其中128,703例患者符合我们的研究纳入标准,这些患者年龄在21-40岁之间,在体外受精期间进行了第一次非供体新鲜胚胎移植。暴露多囊卵巢综合征妇女的母亲种族和民族。主要结局指标活产率。结果不孕症合并多囊卵巢综合征患者21866例,非多囊卵巢综合征患者106837例。PCOS组的LBR在白人女性中最高(49.5%),而西班牙裔(42.7%),亚洲(41.6%)和非洲裔美国女性(36%)。非pcos组的LBR在白人女性中最高(45.1%),而西班牙裔(40.5%),亚洲(35.4%)和非洲裔美国女性(34.3%)。采用Logistic回归模型比较多囊卵巢综合征女性与非多囊卵巢综合征白人女性作为参照组。患有多囊卵巢综合征的非裔美国人和亚洲妇女活产的可能性明显较低。非裔美国人和西班牙裔多囊卵巢综合征妇女流产的可能性明显更高。在活产的妇女中,多囊卵巢综合征组中亚洲、西班牙和非洲裔美国妇女新生儿死亡的可能性明显更高。结论:这是迄今为止规模最大的体外受精研究,评估了母亲种族和民族对伴有和不伴有PCOS的不孕妇女的活产率和新生儿死亡率的影响。我们的数据表明,在美国,伴有和不伴有PCOS的不孕妇女接受体外受精的结果存在显著的种族和民族差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of race and ethnicity on in vitro fertilization outcomes in infertile women with polycystic ovary syndrome in the United States

Objective

To study the impact of maternal race and ethnicity on live birth rates (LBRs) in white, Asian, Hispanic, and African American women with infertility, with and without polycystic ovary syndrome (PCOS), undergoing in vitro fertilization (IVF) in the United States.

Design

Retrospective cohort study.

Subjects

We reviewed 256,018 patient records from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, from 2014 to 2017, and 128,703 patients met our study inclusion criteria, who were women aged 21–40 years, undergoing their first nondonor fresh embryo transfer during IVF.

Exposure

Maternal race and ethnicity in women with PCOS.

Main Outcome Measures

Live birth rate.

Results

There were 21,866 women with infertility and PCOS and 106,837 women with infertility without PCOS. The LBR in the PCOS group was highest in white women (49.5%), compared with Hispanic (42.7%), Asian (41.6%), and African American (36%) women. The LBR in the non-PCOS group was highest in white women (45.1%), compared with Hispanic (40.5%), Asian (35.4%), and African American (34.3%) women. Logistic regression models were performed comparing women with PCOS vs. white women without PCOS as the referent group. The likelihood of having a live birth was significantly lower in African American and Asian women with PCOS. The likelihood of having a pregnancy loss was significantly higher in African American and Hispanic women with PCOS. In women who had a live birth, the likelihood of a neonatal death was significantly higher in Asian, Hispanic, and African American women in the PCOS group.

Conclusion

This is the largest IVF study to date assessing the impact of maternal race and ethnicity on live birth and neonatal death rates in women with infertility with and without PCOS. Our data suggest that there are significant racial and ethnic outcome disparities in women with infertility with and without PCOS undergoing IVF in the United States.
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来源期刊
FS Reports
FS Reports Medicine-Embryology
CiteScore
3.50
自引率
0.00%
发文量
78
审稿时长
60 days
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