Weight loss before conception: effects on atherogenic apolipoprotein lipid particles and endothelial function during pregnancy

FS Reports Pub Date : 2025-06-01 DOI:10.1016/j.xfre.2025.02.009

Robert A. Wild M.D., Ph.D. , Daniel Zhao Ph.D. , Michael J. McPhaul M.D. , Rodney K. Edwards M.D. , Karl R. Hansen M.D., Ph.D. , Elizabeth L. Wolfe M.D. , David S. Wrenn Ph.D.

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Abstract

Objective

To assess atherogenic apolipoprotein lipids and markers of vascular function in pregnancy after prepregnancy weight loss.

Design

Retrospective cohort study.

Subjects

The weight loss cohort included pregnant women who achieved prepregnancy weight loss, and the weight gain cohort consisted of those who gained weight before pregnancy. All patients became pregnant after enrolling in the randomized clinical trial “Improving Reproductive Fitness Through Pretreatment with Lifestyle Modification in Obese Women with Unexplained Infertility” and delivered a single live birth at ≥36 weeks of gestation.

Exposure

Prepregnancy weight loss.

Main Outcome Measures

Apolipoprotein lipid levels.

Results

Prepregnancy weight loss was associated with lower atherogenic apolipoprotein lipid levels during pregnancy and better indicators of vascular function.

Conclusion

Our findings suggest that encouraging prepregnancy weight loss in obese women leads to improved vascular function during pregnancy. Prepregnancy weight loss has significant implications for healthcare professionals because it underscores the potential benefits of weight loss interventions in reducing the risk of cardiovascular disease for women who become pregnant.

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孕前减肥：对动脉粥样硬化载脂蛋白脂粒和妊娠期间内皮功能的影响

目的评价孕前体重减轻后妊娠期血管功能指标及致动脉粥样硬化载脂蛋白。设计回顾性队列研究。减肥组包括怀孕前体重减轻的孕妇，体重增加组包括怀孕前体重增加的孕妇。所有患者均在入选“通过改变生活方式预处理改善不明原因不孕肥胖妇女生殖健康”随机临床试验后怀孕，并在妊娠≥36周时产一胎。孕前体重减轻。主要观察指标：载脂蛋白脂水平。结果妊娠期体重减轻与妊娠期较低的致动脉粥样硬化载脂蛋白脂水平和较好的血管功能指标相关。结论鼓励肥胖妇女孕前减重可改善妊娠期血管功能。孕前减肥对医疗保健专业人员具有重要意义，因为它强调了减肥干预在降低怀孕妇女心血管疾病风险方面的潜在益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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